Description overdue on 11/25/2014
- Latin name: Herpevir
- ATC code: D06BB03
- Active substance: Acyclovir (Aciclovir)
- Manufacturer: Corporation "Arterium" (Ukraine)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use gerpevir (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Reviews
- Price, where to buy
Composition
Medicine in the form of an ointment It contains acyclovir .
Pills also have as active substances acyclovir And auxiliary components such as calcium stearate . potato starch . low molecular weight polyvinyl Medical .
Product form
In the pharmacies sold ointment and tablets Gerpevir.
Pharmacological action
The drug is antiviral agent Which prevents the synthesis of viral DNA.
Pharmacodynamics and pharmacokinetics
This tool is especially useful for simple viruses Herpes and shingles . Furthermore, it acts on the Cytomegalovirus and Epstein-Barr virus . The drug interacts with enzymes viruses and prevents their reproduction.
After penetration into the infected cell is converted into the active substance acyclovir monophosphate And then successively acyclovir diphosphate and acyclovir triphosphate . Last and prevents the synthesis of viral DNA. In healthy cells at the same time, he has almost no effect.
When Herpes prevent the spread of drug rash, accelerates the formation of crust, reduces the risk of visceral complications and cutaneous dissemination , Reduces the severity of pain during exacerbation herpes zoster . Gerpevir also has immunostimulatory properties.
Tablets perooralnogo after use partly absorbed (about 20%). Their active agent penetrates well into the tissues and fluids and breast milk.
The maximum content of the drug depends on the dosage. On average, it is observed after 90-120 minutes after administration. Half-life - about 3 hours, and in the case renal failure - 19 for 5 hours.
The drug is derived mainly through the kidneys unchanged. With age, the time of removal increases.
When topically applied ointment Gerpevir hardly absorbed into the systemic circulation. Systemic effects are not significant. To the affected skin by using therapeutic concentration of the drug is formed, which remains constant for at least 5 hours.
Indications
Medicine appointed physician in infectious lesions of the mucous membranes and skin, which are triggered by viruses Herpes simplex and Varicella zoster . In addition, it is used for prevention and treatment of primary and recurrent herpetic lesions patients immunocompromised And when varicella .
Contraindications
Do not use this tool at:
- hypersensitivity to its active substance;
- infections caused by viruses, against which Gerpevir does not work;
- Lactation In children younger than 3 months;
- pregnancy .
Side effects
The medicine can cause:
- dizziness . Headache , Fatigue;
- absence Appetite , Vomiting, intestinal colic , Nausea, diarrhea ;
- rash, swelling . itching . fever ;
- deterioration in the blood;
- increase in bilirubin . creatinine . urea . hepatic transaminases .
In rare cases, it may also appear bald patch .
Instructions for use gerpevir (method and dosage)
Those who apply the ointment Gerpevir, instructions for use states that it should be done only externally. It is desirable to use rubber gloves to the infection does not spread. Therapy is desirable to begin at an early stage of the disease.
The ointment should be applied thinly to the skin accurately and external mucous membranes, where there is a failure. Adults ointments strip 12, 5 mm should be applied about 25 sq. See defeat 4-5 times / day. She rubbed lightly for about a minute. Babies ointment is applied at a dosage of 250 mg per 1 square. m skin.
Instructions on Gerpevir recommends applying ointment and adjacent to the affected skin.
Use the tool you need regularly. But if once missed, double the next dose is not necessary.
The recommended course of treatment - 10 days, even if symptoms have disappeared.
If there is no effect in the application of ointments, experts advise to use Gerpevir in pill form.
In this case, a means used orally. It can also be applied at the first sign of disease. It is desirable to combine the pills with the use of large amounts of fluid.
In the case of infections due to Heroes simplex (Type 1 or 2) children give tablets of 0, 2 g of the following dosages:
- up to 2 years - appointed 2, 5 tablets per day with an interval of 4:00;
- age 2 years - administered 5 tablets a day, which are divided into 5 receptions at intervals of 4 hours (except for a night's sleep).
Therapy - from 5 to 7 days.
The recommended dosage for adults is 1 tablet of 5 times / day. Therapies designed for 5 days. Take the tablet at 0, 2 years
People with immunocompromised Experts recommend taking one pill (0, 4 g), or two tablets (0, 2 g). This should be done 5 times a day. Therapy - from 5 to 10 days.
In order to prevent infections provoked Herpes simplex (Type 1 or 2), under normal Immunity you need to use on a tablet 4 times / day. The time interval between doses should be 6 hours. Suitable tablets for 0, 2 years is also allowable to take medication dosage 0, 4 g This should be one tablet 2 times / day at intervals between doses in 12 hours. If necessary, the dosage may be reduced to 0, 6 g of the drug, divided into 2 or 3 doses.
In case of significant Immunodeficiency desirable to take one tablet (0 4 g) or two tablets (0, 2 g) of the drug four times / day. In each case, the duration of prophylactic administration specialist sets individually.
In the case of infections due to Varicella zoster virus children give tablets of 0, 2 g of the following dosages:
- up to 2 years - one tablet four times / day;
- age 2-6 years - you must take 2 tablets for the reception 4 times / day;
- 6 years of age - it is necessary to take 4 pills 4 times per day. Furthermore, it is possible to use 2 tablets (0, 4 g) with the same frequency.
Therapy for at least 5 days.
Adults with normal immunity it is desirable to use the pills to 0, 4 of them are inside 2 tablets 5 times / day, making the span of 4 hours (except for a night's sleep). Therapy for at least a week.
If the kidney function, as well as people in older age dose selected individually.
Overdose
Ointment at the site of an overdose can cause erythema . burning sensation . peeling . burn . All these symptoms disappear after discontinuation of treatment.
When used tablets gerpevir in high doses may diarrhea . headache . renal failure . nausea . convulsions . vomiting . breathlessness . lethargy . coma .
As treatment is carried out to maintain vital functions. Assign hemodialysis .
Cooperation
Probenecid It increases the excretion gerpevir.
Drug interactions with other drugs ointment for external use is not known.
When combined with tablets nephrotoxic agents It can be enhanced nephrotoxicity .
Terms of sale
This means you can get in the pharmacy network with a prescription.
Storage conditions
Store Gerpevir need at temperatures up to 25 ° C, but not in the refrigerator. The place should be available for children.
Shelf life
Keep the medication should be no longer than 2 years.
Reviews gerpevir
The drug received a variety of responses. Different views can be heard most often on the ointment. To some it quickly and effectively helped, and some reports are completely useless treatment. Negative reviews of ointment also leave people dissatisfied with this form of drug release. They say that the drug flows leaves an unpleasant greasy luster and does not promote healing. However, there are positive reviews of gerpevir, which says that to get rid of Herpes able to quickly and painlessly.
Public opinion about this drug in pill form is much better. Patients note the convenient form of release of the drug. Reviews of tablets mainly talk about their effectiveness. People like the fact that the tool can be used for prevention.
Price gerpevir where to buy
Gerpevir Price may vary depending on the release form. This tool is quite often found in drug stores. Patients say that its value is readily available.
Cost tablets Gerpevir at 0, 2 g of about 325 rubles, or 60 hryvnia. The cost of funds in the form of tablets to 0, 4 g is similar. Cost ointment Gerpevir somewhat lower. It can cost from 230 rubles or 40 hryvnia per box of 15 g
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