Description overdue on 18/09/2014
- Latin name: Phencarol
- ATC code: R06AX
- Active substance: Hifenadina (Quifenadine)
- Manufacturer: JSC Olainfarm, Latvia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Phencarolum
- Contraindications
- Side effects
- Instructions for use Phencarolum (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Cautions
- Babies
- Reviews
- Price, where to buy
Composition
The tablets of the drug are dosage 25 or 10 mg of active substance - hifenadina hydrochloride in one piece. Also, the preparation contains auxiliary ingredients: sucrose, calcium stearate, potato starch.
In one milliliter solution for injection / m contains 10 mg hifenadina + Water purified for injection, glutamic acid .
Product form
- Pills - White, round, have a chamfer. Form - flat cylinder. 10 pieces per package contour, 2 packing in carton box.
- Solution is a transparent liquid is colorless and odorless, is sold in vials of 1 or 2 ml of 10 pieces in the package.
Pharmacological action
Antiallergic effect, reduces swelling.
Pharmacodynamics and pharmacokinetics
The active ingredient of the drug - derived hinuklidil carbinol It reduces the effect of histamine (which is produced as an immune response to allergen ) On the body. In its present structure cyclic kernel quinuclidine , The material has a significant distance between the nitrogen and a group difenilkarbinola .
Hifenadina blocks H1- receptors in the competitive principle, wherein the activating enzyme diaminoksidazu . This enzyme able to split the order of 30% histamine . Thus, the drug is more effective than other means of allergies .
Across blood-brain barrier drug penetrates small, almost no effect on desamidization Serotonin in the brain, on monoamine oxidase .
The tool removes spasms of smooth muscles in the intestine . itch and discomfort with allergies. The drug reduces the hypotensive activity It maintains normal permeability capillaries , Wherein visibly without affecting the blood pressure and the heart muscle. Unlike well-known and common dimedrol and pipolfen , Means does not inhibit the CNS, brain tissues present in minor amounts. However, if the patient develops a reaction to a specific component may be weak sedation .
In intramuscular a maximum concentration of active ingredient is achieved in half an hour. When receiving a tablet form - in one hour. It accumulates primarily in the liver, kidney and lungs. Then undergoes reaction metabolism Their products are excreted in the urine.
Indications Phencarolum
For the treatment of allergy, tablets or injection (Severe, acute necessity).
From what Fenkarol pills?
From hay fever . hives . food allergy or medicines . hay fever , Other allergic diseases.
Also Phencarolum indications for use are:
- dermatosis ( itching . eczema . neurodermatitis );
- rinopatiya Which is allergic in nature;
- angioedema ;
- response to allergen accompanied bronchospasm.
Contraindications
Direct contraindications to the drug are:
- allergy on the components of the means;
- first trimester of pregnancy ;
- lactation ;
- age less than 18 years (for solution for injection).
Caution must be exercised in the presence of diseases of the cardiovascular system, liver, kidneys, stomach and intestines.
Side effects
Side effects are very rare.
If the patient is particularly sensitive to hifenadina, it may appear:
- dry mouth and mucous membranes;
- indigestion and a slightly bitter taste in the mouth;
- nausea and vomiting;
- weakly expressed sedation ( drowsiness . lethargy );
- headache and loss of consciousness .
If you have gastrointestinal disease, the probability of side effects increases.
If you have any of these reactions or if there is new, you should contact your doctor.
Instructions for use Phencarolum (method and dosage)
If necessary, use a suitable dosage form (tablets or solution for injection) and the dosage depending on the age, symptoms and adverse reactions.
Tablets are taken after meals with water or other liquid.
Instructions on Fenkarol, 25 mg
Assign usually adults. 1-2 tablets three or four times a day. The day may be taken no more than 200 mg.
For children from 12 years of daily dose is 50-75 mg, respectively, 1 tablet for 2-3 hours.
The duration of treatment ranged from 10 to 20 days.
Instructions on child Fenkarol (dosage of 10 mg)
Inside, orally.
- Children aged 3 to 7 years appoint one tablet 2 times a day;
- At the age of 7 to 12 - 1 tablet 2 or 3 times per day;
- For children of 12 years - 2 tablets 2-3 times daily.
The course of treatment should be agreed with your physician. It ranges from 10 days before the crescent.
Instructions on solution for intramuscular injection
At hay fever appoint / m injections of 2 ml, 2 times daily for 3 days. Thereafter, the dosage was reduced to 2 ml per day for 2 days.
At angioedema or hives the first 5 days of injections of 2 ml, 2 times a day. Then another 3 days to 2 ml per day.
Maximum per one injection can introduce 20 mg (2 mL) means the maximum per day - 40 mg.
If a severe allergic reaction has been cropped, the recommended switching to tablet form.
Overdose
Admission to 300 mg per day should not cause major disruptions to the body.
If there were specific symptoms: headache, dry mouth, nausea, vomiting, indigestion and stomachache Should take Activated carbon and produce symptomatic therapy.
Cooperation
The drug does not produce amplification effects of alcohol and sedatives.
When combined with drugs Phencarolum may change the concentration in the blood is slowly absorbed in the stomach and equipment ( coumarin , eg).
Terms of sale
To purchase a prescription drug is not required.
Storage conditions
In a cool, dark place.
Shelf life
5 years - for tablets .
2 years - injection .
Analogs
Dramina
Lordestin
Lomilan
Kestin
Loratek
Aerius Feksadin
Claritin
Telfast
Loratadine
Diazolin
Analogs Phencarolum: Alerik . Alersis . Alergomaks . Alernova . Alergostop . Gistafen . Diazolin . Kestin . Ketotifen . Laurent . Loratadine . Lourdes . Lorizan . Sempreks . Tigofast . Feksomaks . Feksofen-Sanovel . Eden . Aerius . Erolin . Eridez . Fribris . Feksofast . Treks Neo . Telfast . Peritol . Laurent OTD . Claritin . Altiva .
Cautions
When operating machinery, driving a car and operating machinery should be careful.
The preparation contains sucrose This fact should be considered for people with diabetes .
Babies
For better convenience, aged less than 12 years, it is recommended to use a special Fenkarol for children, wherein the amount of active ingredient in one tablet -10 mg.
The drug has good reviews for the children. It is used as a means of emergency (child ate something wrong) or expressed allergic reactions accompanied by edema. Fenkarol for children is well tolerated.
Reviews Phencarolum
Generally, people leave good reviews about Phencarolum. The tool helps with severe bronchospasm, relieves swelling in the bronchitis, acute respiratory infections and rhinitis . The drug is inexpensive, effective. However, you may experience side effects, most often - nausea and a bitter taste in the mouth.
Reviews on Fenkarol for children on the Internet
On various forums people write that Fenkarol - quick acting and effective medicine, which is transferred, as a rule, well, there are reports of adverse reactions.
The drug can not be children under one year, some consider it a disadvantage.
Price, where to buy
Price Phencarolum tablets - 153 rubles, 20 pieces, 10 mg.
The cost of the same amount, but the dose of 25 mg - about 220 rubles.
Check rates Phencarolum in ampoules at the moment is difficult.
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