Elokim

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Glucocorticosteroid . Elokim - a synthetic drug, a derivative group of glucocorticoid hormones of the adrenal cortex, mometasone furoate   an active substance. Available exclusively in the forms intended for external topical (Elokim ointment, cream and solution). Like any other drug group of corticosteroids, mometasone furoate has expressed antiexudative, anti-inflammatory, vasoconstrictor and desensitizing effect. The active ingredient acts on the membrane of immune system cells responsible for development   exudative processes   in the inflammation. Mometasone furoate inhibits the release of inflammatory mediators Furthermore acts on red blood cells ( Neutrophils . eosinophils   and macrophages) by preventing the accumulation of the latter in the hearth. It has an effect on the metabolism of arachidonic acid than to block the development of inflammatory reactions (inhibits the activity of phospholipase A2) reduces the production of interleukins and prostaglandins It reduces the release of inflammatory mediators. It induces reuptake of serotonin and histamine, which leads to a decrease in their concentration in the inflammation. Influenced Elokoma reduced production of cytokines, leukotrienes and histamine. Mometasone stops the development of the "immediate" reaction allergies (just by influencing the metabolism of arachidonic acid), and by reducing the production factors chemotaxis   It decreases the expression "late" reaction allergies.

Indications:

Elokim used in the treatment of skin diseases, in which are shown adrenocortical hormones. Assigned locally at atopic dermatitis . eczema   (including the disgidroticheskoy form) seborrheic dermatitis , The radiation beam dermatitis . psoriasis Bounded neurodermatitis   (chronic zoster)   itching dermatoses , Insect bites, benign pemphigus Guzhero-Hailey-Hailey, sunburn, burns of the first degree, discoid lupus erythematosus At lichen planus .

Contraindications:

Do not appoint Elokim in case of hypersensitivity to mometasone furoate, during breastfeeding. Is contraindicated in pediatric patients up to two years. Care must be taken to appoint Elokim pregnant patients Tuberculosis   (both active and latent forms). Contraindications (relative) is a viral, bacterial or fungal infection. Elokim is contraindicated in the presence of infections caused by herpes viruses, when the process goes to the symptoms of the eyes. Elokim is not recommended if you have previously performed (or performed) prolonged systemic therapy with hormones of the adrenal cortex.

Side effect:

Since Elokim ointment is applied locally, the side effects are usually limited to the skin at the area of ​​application: a burning sensation at the site of the active substance, itchy skin and impaired sensitivity ( paresthesia ). Often these phenomena are accompanied by skin rash . When persistent and persistent course of illness requiring prolonged use of mometasone furoate, a number of patients recorded the development of atrophic skin changes. This side effect is caused by the fact that Elokim, like any corticosteroid, has a catabolic action, ie it contributes to the breakdown of protein and depletion of tissue, which leads to atrophy . Against the background of Elokoma can not be excluded as other effects typical of glucocorticoids, such as dry skin, reducing the production of melanin pigment, hypertrichosis , Joining secondary infections. Very rarely observed side effect boils   and exacerbation of skin pathology. Possible disruption of the digestive system, which often will be manifested in the form of nausea. For prolonged course of therapy, especially in young patients (up to 18) may work adrenocortical suppression and reduction of endogenous corticosteroids, inhibition of function of the entire hypothalamic-adrenal system.

Mode of application:

Elokim cream is applied evenly to the affected area with a thin layer once per day. Duration of the course depends entirely on the character and nature of the disease and identify the expert. Similarly, applied to the affected areas and Elokim Elokim lotion ointment.

Special instructions:

Elokim not used in the ophthalmic practice. During the course of therapy should be systematically monitor the function of the adrenal cortex, to determine the level of endogenous corticosteroids. With the development of side effects of drug therapy should be discontinued immediately Elokim. If during treatment with mometasone joined secondary infection, shows antimicrobial therapy . In generalized extensive skin lesions, when there is a need to apply Elokim over a large area, can develop side effects with systemic corticosteroids. When pregnancy Elokim is used only in cases where the actual benefit to the mother is higher than the hypothetical risk to the unborn child; preferably in this case to use dosages lower than traditional therapy and minimize. Breastfeeding during treatment Elokomom (and other corticosteroids) should be suspended.