Dermazol

Description overdue on 08/13/2014

• Latin name: Dermazol
• ATC code: D01AC08
• Active substance: Ketoconazole (Ketoconazole)
• Manufacturer: Kusum Healthcare (India)

Photos of the drug

Tweet

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Dermazol (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
• Price, where to buy

Composition

All forms release drug contain, as the main active ingredient ketoconazole .

Cream Dermazol   for external application, moreover, has the following additional components: polysorbate 80, disodium EDTA, white soft paraffin, 1000 ketomakrogol, anhydrous sodium sulfite, propylene glycol, purified water, alcohol ketosterilovy , Paraffin, light liquid.

Pills   in addition to the main active ingredient contain additional ingredients such as microcrystalline cellulose, magnesium stearate, butylhydroxytoluene, croscarmellose sodium, colloidal silicon dioxide.

Part shampoo   includes the following excipients: sodium lauryl sulfate, sodium chloride, flavor, sodium hydroxide, butylated gidroksitoluen, purified water, kokodietanolamid, hydrochloric acid, dye, disodium sulfosuccinate monolauril ether, propylene glycol.

Product form

The drug is available in tablet form for oral administration, a cream to lubricate the affected places of skin, as well as in the form of a shampoo for washing the hair and vaginal suppositories.

Pharmacological action

Dermazol - an antifungal drug broad spectrum. It is used for local and systemic treatment fungal infections .

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug can have both fungicidal And fungistatic   action aimed at dermatophytes . dimorphic . eumitsety   and yeasts .

The fungicidal action   It is to change the structure and reducing the strength of the fungal cell membrane, leading to the death of fungi.

Fungistasis   the active substance is preventing formation of new colonies of fungi. In addition, the drug is marked antimicrobial activity against most staphylococci   and streptococci .

Penetrated into fungal cells Dermazol prevents the synthesis of compounds, which are the basis of the cell membrane of the fungus. Due to this, there are various permanent changes in the structure of the cell membrane.

It is effective against many fungal infections. With prolonged use of marked decrease in the biosynthesis Testosterone   and other androgenic hormones .

Tablets Dermazol   well absorbed in the intestine. Bioavailability in this case - 75%. The high concentration in biological fluids and tissues. Active substance accumulates mainly in the liver, lung, kidney and cardiac muscle. It has good permeability through blood-brain barrier Also known for its high levels of plasma protein binding. Studies have shown a pronounced dose-dependent effect.

The maximum concentration of drug in blood plasma occurs within 1-2 hours after application. Withdrawal is carried out in two stages. Cleaves to form inactive metabolites. Mainly excreted in the bile, about 15% - with urine. It may be isolated in the form of active metabolites and unaltered.

When used in the form of cream   and shampoo   drug does not have general systemic effects and does not reach the bloodstream.

Indications

For each specific fungal disease Only a doctor can prescribe an effective scheme of application of this drug. If the drug release form or duration of treatment will be selected properly, it may lead to relapse. It is necessary to determine the type fungus-pathogen As in some cases, a complex therapy, and the use of only one Dermazola will not be enough.

Before using the drug orally it is necessary to check the condition of the liver. At the same time, if applied ointment Dermazol, is not necessary.

The preparation for external use is indicated for the treatment and prevention fungal infections   skin, jock itch . tinea   smooth skin athlete hands and feet, as well as candidiasis   skin.

For topical medication used for the treatment of relapsing vaginal candidiasis And in some cases for the prevention fungal infections of the vagina .

Tablets Dermazol prescribed most often in inaccessible and intolerant of other therapies. They are used in the case of blastomycosis . histoplasmosis . paracoccidioidomycosis . coccidioidomycosis   and chromomycosis .

Contraindications

Dermazol release in any form is contraindicated if you are hypersensitive to use the components of the drug.

Tablets should not be used in the presence of liver disease and children aged up to 3 years, and during pregnancy   and breast-feeding .

Precautions should be taking medication for patients with adrenal insufficiency.

Side effects

Possible side effects:

• from the gastrointestinal tract - nausea, violation of stool, vomiting, pain   epigastric ;
• From the CCC - thrombocytopenia , Increased intracranial pressure;
• CNS - headache, photophobia, dizziness ;
• allergies   - itching . hives , Rash, in rare cases nasal allergy .

In addition, some patients were observed and adverse effects such as menstrual disorders, hair loss, paresthesia . impotence . gynecomastia .

The local application may cause irritation, burning, itching at the site of application of the drug. Shampoo Dermazol can produce side effects such as hair loss and / or change of hair color.

If you experience side effects is an urgent need to stop the use of drugs and seek medical advice.

Instructions on Dermazol (method and dosage)

Pills   adults and children weighing more than 30 kg administered at a dose of 200-400 mg per day. Children weighing less than 30 kg - 4-8 mg / kg per day. Medication taken 1 time a day during meals. Duration of treatment is determined by a physician. For example, fungal infections of the course is from 2 to 6 weeks, with Candida infections   skin and oral mucosa - 2-3 weeks at onihomikozah   - From six months to a year, if the system mycosis   - From 1-6 months, and at pityriasis versicolor - 10 days. After the disappearance of the symptoms of the medication should be continued for at least a week.

In addition, it is recommended to use the drug in the same time to ensure that the concentration of active substance in plasma was stable. If a pill for whatever reason, is postponed until the next time the reception is less than 4 hours to take the next pill.

For local and topical guide to Dermazol provides dosage and duration of the course, depending on the evidence and applied dosage form.

Cream for topical application   Lesion applied 1-2 times per day. With Candida infections   skin, as well as pityriasis versicolor   Course application is designed for 3-4 weeks. When seborrheic dermatitis   ointment applied 2-4 weeks. Before and after its application, it is desirable to wash your hands well.

Instructions on Shampoo Dermazol   it involves applying a wet clean hair. It is necessary to leave the vehicle for a few minutes and then thoroughly rinse the hair. The shampoo is used 1 time per day. A course of treatment tinea versicolor   in this case it is intended for 5 days. To get rid of seborrheic dermatitis   agent is used within 3 days. For the treatment and prevention Dandruff   Shampoo Dermazol used 1 every 1-2 weeks.

Overdose

Overdosing is possible only drug when administered orally. In this case there is nausea . headache . vomiting . dizziness . Too high doses may cause spasms   and   prickle .

Use of the drug should be discontinued immediately. Patients underwent gastric lavage, chelators . Treatment is symptomatic.

Cooperation

Carefully monitor the dosage needed while applying it to antacid   means, as because they reduce the absorption of active substances from the blood.

Also the bioavailability of the drug may be reduced due to a combination with powerful inducers of CYP3A4 : Isoniazid . Rifampicin . Phenytoin . Nevirapine . Rifabutin . Carbamazepine . Efavirenz . The dosage of the drug should be strictly monitored and adjusted if necessary.

Powerful inhibitors of CYP3A4 Conversely, in some cases, increase the bioavailability of the drug. Treatment should be under medical supervision. If necessary, the dosage is reduced.

Dermazol can inhibit CYP3A4-mediated metabolism   drugs. This affects the efficiency and strength of their action.

Simultaneously with this drug is not recommended to take the following medications: Tamsulosin . Rifabutin .   Carbamazepine . Nilotinib . Salmeterol . Fentanyl . Rivaroxaban . Dasatinib . Trabectedin . If this can not be avoided, careful monitoring of the patient, in time to eliminate the risk of side effects. If necessary, the dosage of drugs are reduced.

With caution should be combined with ketoconazole medicines such as: Alfentanil . Oxycodone . Coumarins . Repaglinide . Praziquantel . Eletriptan . Busulfan . Erlotinib . Ixabepilone . Trimetrexate . Alprazolam . Brotizolam . Haloperidol . Perospiron . Ramelteron . Maraviroc . Saquinavir . verapamil . Aprepitant . Ciclesonide . Dexamethasone . Methylprednisolone . Tacrolimus . Atorvastatin . Fesoterodine . Sildenafil . Tadalfil . Alitretinoin   (p.o.) Mozavaptan .

Careful monitoring of the patient is also required in a joint application with Dermazola Buprenorphine . Digoxin . Cilostazol . Saxagliptin . Ebastine . Bortezomib . Docetaxel . Imatinib . Lapatinib . vinca alkaloids . Aripiprazole . Buspirone . Midazolam   (internal administration) Quetiapine . Risperidone . Indinavir . Nadolol . Aliskiren . Budesonide . Cyclosporine . Fluticasone . Sirolimus . Temsirolimus . Reboxetine . Imidafenatsinom . Solifenacin . Tolterodine . Cinacalcet   and Tolvaptanom .

If necessary, the dosages are adjusted.

Terms of sale

The drug is sold strictly on prescription.

Storage conditions

Store this medication should be in a dry, dark place at room temperature.

Shelf life

Regardless of the form of issue, expiration date medicines - 3 years.

Reviews Dermazole

Numerous accolades about Dermazole indicate that the facility is really effective for treatment candidiasis . Dandruff . fungal infections skin and other fungal diseases. With its objectives it is fully cope. Very often you can find reviews of shampoo Dermazol as an excellent remedy against dandruff. Many say that it is not cheap, but effective.

Price Dermazola where to buy

Price Dermazola pharmacies may be very different. Much depends on the form of the drug. So the price shampoo Dermazol   50 ml is about 220 rubles. Cost ointment   30 grams - an average of 180 rubles.

Honey and infrequent type of issue - pills . Cost Dermazola for oral use - about 260 rubles.

Get the best price and buy