Description overdue on 05/19/2014
- Latin name: Rinza
- ATC code: N02BE71
- Active substance: Acetaminophen (Paracetamol), Caffeine (Coffein), Phenylephrine Hydrochloride (Phenylephrine), Chlorphenamine maleate (Chlorphenamine)
- Manufacturer: UNIQUE PHARMACEUTICAL Laboratories, India
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Rinzai
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- For children
- With alcohol
- With antibiotics
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
The composition of the Rinzai
The preparation includes the Rinzai (per tablet): paracetamol - 500 mg phenylephrine hydrochloride - 10 mg, caffeine - 30 mg, chlorphenamine maleate - 2 mg.
Additional material: magnesium stearate, sodium methyl parahydroxybenzoate, corn starch, carboxymethylstarch sodium, colloidal silicon dioxide, povidone (K-30) talc, carmine dye.
Product form
It is available in tablets of round flat shape without a shell with a notch on one side and the beveled edge, pink with white patches or maroon color. 10 of these tablets in a blister, in a cardboard bundle one blister.
Pharmacological action
- psychostimulant;
- antikongestivnoe (reduction of edema);
- antihistamine;
- analgesic;
- antipyretic.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Rinzai - combination drug, the list of its effects is the sum of the effects of the components of the drug.
Paracetamol has analgesic and antipyretic effect . Relieves pain in the head, back, joints, throat, pain arising from colds, and reduces fever.
Paracetamol inhibits enzymes cyclooxygenase-1 and cyclooxygenase-2 It reduces synthesis prostaglandins and affects the thermoregulatory center of the nervous system. In inflamed tissues is blocked by specific enzymes, so inactivation COX-1 and -2 in them is insignificant, it explains insignificant anti-inflammatory . However paracetamol effectively stops the production of prostaglandins in the cells of the nervous system, as a result it only reduces the elevated temperature does not affect the normal body temperature. Paracetamol has no effect on the gastric mucosa, in contrast to the other NSAIDs . Acceptance of paracetamol in therapeutic doses has no effect on the water and mineral metabolism and other types of exchange.
Phenylephrine It refers to alpha-agonists. It reduces the vessel lumen, resulting in edema and hyperemia pass nasal mucosa, the nose and sinuses.
Chlorphenamine a histamine receptor blocker and has antiallergic And reduces mucosal edema and hyperemia nasopharyngeal cavity, nasal and sinus weakens exudative phenomena.
Caffeine It has a stimulating effect on the nervous system, which reduces fatigue and sleepiness, increases mental and physical performance. Enhances and accelerates the analgesic effect of paracetamol.
Pharmacokinetics
Paracetamol is rapidly absorbed enough of the middle parts of the digestive system, is actively bound to plasma proteins. The highest concentration in the blood - at 1 hour after ingestion. Paracetamol can penetrate blood-brain barrier and placenta.
Indications
From what Rinzai medicine help? Most people, at least once visited the pharmacy, they see on the shelf this drug and ask this question.
In winter and autumn easy to catch colds, accompanied by nasal congestion and fever, from which helps Rinzai. The drug relieves headache and toothache, pain in the joints, muscles, neuralgia Pain in burns and injuries. However, not all patients dislike taking pills from what they prefer drug analogs in other forms (e.g., powder).
Coryza (including allergic) pharyngitis and sinusitis They are also indications for administration of the drug.
Contraindications
- hypersensitivity the drug and its components;
- arterial hypertension severe;
- severe atherosclerosis vessels of the heart;
- severe Heart Failure Including arrhythmias ;
- severe kidney and hepatic insufficiency ;
- pyloroduodenal obstruction ;
- the inherent increase in bilirubin in blood;
- Dubin-Johnson syndrome ;
- bronchial asthma ;
- chronic obstructive pulmonary disease with symptoms;
- pheochromocytoma ;
- hyperthyroidism ;
- diabetes ;
- blood diseases;
- reduction of leukocytes or Hemoglobin in blood;
- elevated intraocular pressure and glaucoma ;
- sleeplessness;
- hyperplasia Prostate with difficult urination;
- epilepsy and convulsive conditions;
- alcohol addiction;
- age up to 15 years;
- pregnancy and lactation;
- hypersensitivity to derivatives xanthine ( theobromine . theophylline ).
Do not use with antidepressants . beta-blockers Inhibitors monoamine oxidase (MAO), and for a crescent after reception of MAO inhibitors.
Side effects
In most cases, the drug is well tolerated. Side effects are rare, and this is usually associated with long-term use of the drug in doses exceeding those specified in the instruction.
The following side effects:
- violations of the digestive - Heartburn, stomach pain, excessive salivation, poor appetite, nausea, vomiting, constipation, diarrhea, elevated liver enzymes, and other disorders of the liver, gepatonekroz (when using high doses);
- metabolic disease - hypoglycemia ;
- cardiac disorders - heart palpitations, bradycardia , Rhythm disturbance, shortness of breath, pain in the heart;
- vascular disorders - increase Blood Pressure ;
- neurological disorders - anxiety, weakness, headache, irritability, insomnia, irritability, depression, dyskinesia , Tinnitus, convulsive state, coma ;
- mental disorders - hallucinations ;
- disorders of the genitourinary system - jade . dysuria . renal colic , Difficulty urinating;
- Hematopoietic system - anemia (including aplastic and hemolytic) pancytopenia . neutropenia . agranulocytosis . thrombocytopenia . leukopenia ;
- disorders of the respiratory organs - bronchospasm in patients with allergy to aspirin and other nonsteroidal anti-inflammatory drugs;
- disorders of the organs of vision - dry eyes, mydriasis, disturbance of accommodation, increased intraocular pressure;
- disorders of the immune system - skin rash, hives . itch . toxic epidermal necrolysis . anaphylactic shock . Stevens-Johnson syndrome . angioedema .
Instructions for use Rinzai
Instructions on Rinzai speaks clearly about how to take the pills, and no different magnification mode and the reception of the instructions on the powder Rinzai vulture.
Mode of application - oral . Adults and children under 15 years old to take one tablet every 6-8 hours to five days. The drug should be carried out in half an hour after eating. Wash down the necessary quantity of water. The maximum dose - 4 tablets a day.
Overdose
An overdose of paracetamol. Acetaminophen has a toxic effect on adult after taking a dose of 10-15 grams. Manifestations of overdose:
- pale skin, loss of appetite, nausea, diarrhea , Discomfort in the stomach area;
- level increase bilirubin , Reduced values prothrombin ;
- hepatotoxic effects - Pain in the right hypochondrium, weakness, sweating, jaundice . hepatomegaly , Increase in liver enzymes;
- in rare cases can develop gepatonekroz with the addition of liver encephalopathy (deterioration of cognitive functions and performance of the higher nervous activity) disseminated intravascular coagulation , Metabolic acidosis, hypoglycemia , Rhythm disturbances, convulsive state, Coma , Brain edema, collapse .
Even more rarely, liver damage may develop at lightning speed with the simultaneous addition of renal failure. When you receive a very large doses possible: confusion, agitation, sleep disturbances, dizziness, heart rhythm disorders, the development of pancreatitis. When long-term high doses of the drug may develop aplastic anemia . neutropenia . agranulocytosis . pancytopenia . leukopenia . thrombocytopenia .
Phenylephrine hydrochloride Overdose symptoms: dizziness, confusion, arrhythmia , Tremor of limbs, nervousness, anxiety.
Overdose symptoms hlorfenmin maleate: dilated pupils, photophobia, dry mouth, hyperthermia , Intestinal, bradycardia . hypotension .
Symptoms of overdose caffeine Headache, tremor, anxiety, appearance of premature beats.
Treatment of overdose: gastric lavage, Activated Carbon Symptomatic therapy ( methionine after 8 hours and N-acetylcysteine 12 hours overdose), monitoring indicators of external respiration and cardiac activity. When seizures recommended intake diazepam .
Cooperation
Avoid receiving Rinzai combination with other drugs containing Phenylephrine . paracetamol . chlorphenamine or caffeine .
Rinzai enhances the effect of beta-blockers . MAO inhibitors and sedatives drugs. Upon receipt of Rinzai with antidepressants, antipsychotics and antiparkinsonian drugs may appear urinary retention, dry mouth, and constipation.
Paracetamol reduces the effectiveness of diuretics and increases the possibility of toxic effects on the liver when taken with barbiturates, carbamazepine, phenytoin, rifampin .
Barbiturates reduce the antipyretic effect of paracetamol. The speed of absorption in the digestive tract of paracetamol may be increased when combined with metoclopramide and domperidone . Effects of paracetamol enhanced by its combination with ascorbic acid, codeine, chlorphenamine, scopolamine, propyphenazone and caffeine . Admission paracetamol NSAIDs increases the risk of renal complications. One of the main components of the drug phenylephrine hydrochloride exhibits Adrenomimeticalkie properties when combined with tricyclic antidepressants .
The use of tablets reduces the ability of Rinzai guanetidina reduce the pressure. Sharing of phenylephrine hydrochloride digoxin tablets and other cardiac glycosides can lead to Arrhythmia and even heart attack . Reduce the effectiveness of phenylephrine beta-blockers and other antihypertensive agents (eg, reserpine and methyldopa ).
Chlorphenamine maleate increases sedative effect barbiturates . neuroleptics . tranquilizers . anesthetics . narcotic analgesics .
Caffeine as part of Rinzai improves bioavailability other analgesics, antipyretics , Enhances the effects of some derivatives xanthine . alpha and beta-agonists , Psychoactive agents. Cimetidine . isoniazid . hormonal Contraceptives potentiate the effects of caffeine. Caffeine reduces the effect of the reception Opioid analgesics . sedatives , Means for anesthesia and drugs which depress the central nervous system. Caffeine reduces the concentration of lithium in the blood.
Terms of sale
The drug is available without prescription.
Storage conditions
Store at temperatures up to 250 ° C, dry, protected from sun light. Keep away from children.
Shelf life
3 years.
Cautions
Do not exceed the dose specified in the instructions. Do not use together with sedatives . hypnotics and other drugs containing paracetamol or other substances present in the composition Rinzai.
The drug is given only as a doctor in the event of a patient: hypertension . BPH . arrhythmias . pheochromocytoma , Delays urination.
If the drug is to be used for a long time, required monitoring liver function and condition of the blood.
During the period of use of the drug should not be abused coffee, strong tea and other soft drinks, as well as possible problems with sleep, as well as the appearance of irritability, palpitations , Dizziness, Arrhythmia .
Application Rinzai could affect the outcome on Doping Control .
If the temperature rise is maintained for more than three days, you should consult your doctor.
Analogs Rinzai
Neo Sedalgin
Rinzasip
Kaffetin Light
Kaffetin
Rinikold
Koldakt Flew Plus
Tsefekon
Antigrippin
Tylenol
Coldrex
Theraflu
Flyukold
Farmatsitron
Solpadein
Paracetamol
Fervex
Efferalgan
Panadol
Rinzai are analogues of the drug Antigrippin . Gripaut, Gripeks asset, Coldrex, Paralia Extras Antiflu, Theraflu . Fervex . Kombigripp Hotsip . Rinzasip .
Rinzai or Theraflu - which is better?
The most frequently asked question of comparative efficiency of this group of drugs. In Rinzai paracetamol content higher than Terflu, and the latter is not caffeine. Hence the expected therapeutic effect of taking higher than Rinzai from taking Theraflu. However, it is worth remembering that the higher content of active substances increases the risk of side effects.
For children
Children under the age of 15 the drug is contraindicated.
With alcohol
During treatment with this drug should abandon the use of alcohol.
With antibiotics
It should refrain from co-administration of Rinzai and hepato- and nephrotoxic antibiotics.
Rinzai during pregnancy and lactation
Pregnancy and breast-feeding is a contraindication to receiving Rinzai.
Reviews of Rinzai
Numerous reviews of doctors and patients have a positive coloration cases of overdose or occurrence of side effects is practically no messages.
Often there is a dispute among consumers about the drug - it antibiotic or not? Rinzai not apply antibiotics or their substitutes and has no antibacterial action.
Price Rinzai
Price tablets in Russia 80 rubles - about as much as the cost tablet of similar composition. Price package Rinzasip (powder 10 pcs.) by about 30% more expensive than tablets.
In Ukraine, the average cost of Rinzai - 113 hryvnia.
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