Atrovent

Description overdue on 07/29/2014

• Latin name: Atrovent
• ATC code: R03BB01
• Active substance: Ipratropium bromide (Ipratropium bromide)
• Manufacturer: Boehringer Ingelheim International (Germany)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Atrovent (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Synonyms
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The solution Atrovent   Inhalation is composed of active substance (INN)   ipratropium bromide (250 mg), and it includes additional components: EDTA, benzalkonium chloride, sodium chloride, hydrochloric acid and water.

Atrovent H   aerosol inhalation, the composition has a   ipratropium bromide   (21 mg in a single dose, the monohydrate form) as well as additional ingredients: citric acid, ethanol, water prepared. Propellant: tetrafluoroethane.

Product form

The drug is available in the form of metered aerosol for inhalation solution. Aerosol - a colorless transparent liquid in which there are no visible particles. Available in 10 ml vials (containing 200 doses) and 15 ml (containing 300 doses). The single dose of the preparation - 20 mg of active substance. The drug contained in cans made of steel, equipped with a metering valve and a mouthpiece.

Atrovent inhalation solution - a colorless transparent liquid, 1 dose containing 250 mg of active substance. Prepacked solution in amber glass vials of 20 ml.

Pharmacological action

The active ingredient of the drug - ipratropium bromide, a blocker of M-cholinergic receptors. The molecule of the substance resembles acetylcholine. Getting into the tracheobronchial tree, it binds to the acetylcholine receptors.

Under the influence of Atrovent is blocked acetylcholine receptors in muscles of the bronchi. Thus almost not observed unwanted anticholinergic effect on the smooth muscles of the urinary tract, the digestive tract etc.

As a consequence, there is bronchodilatory effects, reduced secretion of glands of bronchial mucosa. In applying means possible to prevent reflex bronchospasm, occurring due to the influence of the factors that provoke the development of bronchospasm (cool air, cigarette smoke, etc.).

Atrovent also prevents the development of bronchospasm, which develops as a result of the pathological effects of the vagus nerve. In the treatment according to drug people suffering asthma Significantly improves the respiration. Manifestation of bronchodilation observed about 10 minutes after inhalation and lasts for six hours.

Pharmacodynamics and pharmacokinetics

Atrovent provides pronounced bronchodilator effect and prevents symptoms of bronchospasm. Under its influence is reduced secretion of the glands of the bronchial mucosa.

If the drug is injected into the body by inhalation, absorption at this level is very low. The level of concentration of the active substance in the blood plasma is very low, so it can be determined only in the case of receiving large doses of ipratropium bromide.

Because the body is released mainly through the intestine, while 25% goes unchanged, the remnants of the substance are allocated in the form of metabolites.

Indications

Atrovent Atrovent Aerosol and N is assigned the following diseases and conditions of the organism:

• chronic obstructive pulmonary disease Accompanied by emphysema ;
• chronic obstructive pulmonary disease Without emphysema ;
• bronchial asthma   (exception - a severe form of the disease);
• bronchial asthma, which are marked with associated vascular disease, heart;
• bronchospasm Triggered by colds and infectious diseases;
• bronchospasm That develops after surgery;
• Diagnosis of reversibility of bronchial obstruction;
• prepare for the introduction of aerosol means.

Contraindications

Atrovent should not be prescribed in the following cases:

• a high level of sensitivity to ipratropium bromide, atropine, an additional ingredient of the agent;
• suspected pregnancy;
• first trimester of pregnancy;
• the presence of pathologies of bronchopulmonary system in children who are under 6 years old (do not use an aerosol);
• pathological manifestations of bronchopulmonary system in children under five years (do not use saline).

Be wary appoint patients with Atrovent closure glaucoma . prostatic hyperplasia . urinary disorders . cystic fibrosis As well as women in breastfeeding.

Side effects

When using Atrovent in solution and spray in the treatment may experience a number of adverse events:

• dry mouth, nausea;
• headache,
• thickening of mucus;
• tachycardia , Atrial fibrillation;
• deterioration of motor function of the gastrointestinal tract;
• urinary retention, constipation ;
• swelling, paresis ;
• erythema multiforme;
• laryngospasm, bronchospasm, cough;
• glaucoma;
• rash, irritation of the nasal mucosa.

Instructions for use Atrovent (method and dosage)

If the patient uses Atrovent, instructions for use should be carefully studied and they complied.

As a rule, the dosage is set individually. Instructions for use Atrovent inhalation provides the drug for adult patients and children who have turned six appoint two inhalations, 4 times per day.

For the treatment of children means should be used only under medical supervision and keeping of the dosage, which he appointed.

When the complex treatment of bronchial asthma for children under 12 years: 1-2 inhalations every six hours, if necessary.

In order to treat COPD may be used as a solution Atrovent Inhalation. The inhaler is filled with 10-20 drops drug inhalation conducted as needed. Thus adults should not receive more than 2 mg per day, children -1 mg agent.

The nebulizer interfere with the desired dose of the drug, which has been previously diluted nat. solution. The result should 4ml solution. The dose should be prepared each time before the inhalation .

Overdose

Not recorded specific symptoms in overdose. Can enhance the intensity of the side-effects of an overdose of funds, in particular, may be a manifestation of tachycardia, dry mouth, paresis. There should be symptomatic therapy.

Cooperation

If Atrovent appointed simultaneously with kromoglitsievoy acid may decrease the effectiveness of both. In simultaneous treatment with xanthine derivatives, β2-adrenergic agonist indicated a more pronounced effect of bronchodilators.

Anticholinergic effects Atrovent is enhanced by concurrent therapy antiparkinsonian agents, tricyclic antidepressants, quinidine.

Cisapride reduces the severity of the effect of Atrovent. In a joint treatment Atrovent agonists and β2-adrenergic receptors may increase the state of patients with angle-closure glaucoma.

You can not practice in parallel with the aerosol treatment disodium cromoglycate as two aerosol can interact physically.

Terms of sale

Atrovent is sold in pharmacies by prescription.

Storage conditions

Aerosol Atrovent and the solution should be stored at a temperature not exceeding 25 degrees Celsius in a dry place. Frosting can not be the solution.

Shelf life

Atrovent can be kept for 3 years.

Cautions

The solution for inhalation contains the preservative benzalkonium chloride and a stabilizer. Therefore, there is information that the application of high doses of these substances means may trigger bronchoconstriction.

It does not take a dose that exceeds the permissible daily, both in short and long-term therapy.

Carefully apply a treatment for people suffering from narrow-angle glaucoma and disorders of urination, manifested in connection with benign prostatic hyperplasia.

If the solution gets into your eyes accidentally closed-angle glaucoma patient, it may rise intraocular pressure . If one observes a feeling of discomfort or pain in the eyes, blurred vision, the appearance of spots before the eyes, it may be signs of narrow-angle glaucoma. In this case, you must use the drops, narrowing the pupil, and immediately consult an ophthalmologist.

When deterioration in the course of treatment or when there is no sign of improvement need to consult with your doctor to determine a plan for further treatment. With a sudden burst of shortness of breath   should immediately contact a specialist.

Atrovent should not be used for emergency relief of asthma attacks.

In the treatment of cystic fibrosis patients the drug can slow down the digestive tract motility.

You must use Atrovent N dosed strictly according to instructions.

Synonyms

Ipratropium bromide . Itrop . Vagos . Arutropid . Ipravent . Normosekrol . Normosekretol .

Analogs

Match code ATC 4th level:

• Flomax

Analogues of drugs are the following tools: Ipravent   (aerosol) Ipratropium Ster-Neb   (solution for inhalation) Ipramol Ster-Neb   (solution for inhalation) Flomax   (solution and capsules), Truvent . Troventola   (aerosol), and others.

Is it better to Atrovent or Flomax?

Both of these drugs belong to a group of medicines to the bronchodilator effect. But Flomax   It is a comprehensive tool, which are contained in the composition of the substance ipratropium bromide and fenoterol hydrobromide . Atrovent has a relatively slow therapeutic effect on the body, so for the relief of severe attacks it is not used. Flomax because of the combination of two strong components quickly and effectively relieves bronchial spasms. But it should be noted that the drug Flomax broader list of side effects and contraindications. Consequently, when initial therapy is increasingly used Atrovent.

Babies

Atrovent can be used to treat children only after the treating specialist and under its strict control. The spray is used to treat children with the age of six, the solution - from five. The caution administered to children who suffer from chronic lung disease, Down's syndrome, brain damage, paralysis.

During pregnancy and lactation

Do not use Atrovent women in the first trimester of pregnancy. In the later stages of the drug can be administered if its benefits outweigh the potential risk. During the research did not reveal teratogenic and toxic effects on the fetus. When lactation Atrovent used with caution.

Comments about Atrovent

Patients who have practiced this means of treatment, left mostly positive reviews. There its efficiency expressed as in the treatment and as a maintenance agent. The majority of patients tolerate Atrovent or point of side effects during treatment.

Price Atrovent where to buy

In any pharmacy you can buy Atrovent aerosol, whose price ranges from 350 to 400 rubles per 10 ml spray. Price Atrovent inhalation is an average of 240 rubles per 20 ml vial.

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