Roncoleukin

Description overdue on 09/19/2014

• Latin name: Roncoleukinum
• ATC code: L03AC
• Active substance: Interleukin-2 human recombinant (Interleukin-2 human recombinant)
• Manufacturer: Biotech Ltd., Russia

Photos of the drug

Tweet

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Roncoleukin (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The solution contains 100000, 2500000, 1000000 and 500000 IU human recombinant interleukin-2.

Auxiliary ingredients accordingly Active ingredients:

• 1 mg / 2 5 mg / 5 mg / 10 mg -   sodium lauryl sulfate;
• 5 mg / 12 mg / 25 mg / 50 mg - mannitol;
• 0, 79 mg - ammonium bicarbonate;
• 0, 08 mg - DTT;
• to 1 ml - water for injection.

Product form

A solution for subcutaneous or intravenous injection.

One package contains 3 or 5 vials of 1 ml solution.

Pharmacological action

Immunomodulatory effects.

Pharmacodynamics and pharmacokinetics

Roncoleukin is immunostimulant   and has antifungal, antitumor, antiviral and antibacterial activity.

Interleukin-2   actively affects the startup process and further the immune response, exhibits multiple effects on various units and components of the human immune system.

Activates proliferation T-lymphocyte That causes them to act as cytotoxic killer cell lytic effects spectrum with expanded capabilities to effectively combat various pathogenic microorganisms and cancer cells.

Also stimulates B-lymphocytes immunoglobulin It increases the functionality of the tissue macrophages and monocytes.

Indications

Roncoleukin drug used in the treatment of patients adulthood:

• at combined immunodeficiency;
• during normal Variability th immunodeficiency;
• at acute peritonitis;
• at osteomyelitis;
• at acute pancreatitis;
• at endometritis;
• at sepsis;
• at pulmonary tuberculosis;
• in severe pneumonia;
• at puerperal sepsis;
• when infected with thermal and chemical burns;
• while others expressed generalized and localized infections;
• in locally and disseminated forms renal cell carcinoma.

In childhood, ranging from 0 months, the drug shows:

• at combined immunodeficiency;
• during normal variable immunodeficiency;
• at acute peritonitis;
• at osteomyelitis;
• at acute pancreatitis;
• in severe pneumonia;
• at sepsis;
• at bacterial sepsis of newborn;
• ceteris generalized and expressed localized infections.

Contraindications

• Hypersensitivity to Roncoleukin ingredients, including the anamnesis;
• pregnancy;
• diagnosed allergy to yeast;
• autoimmune disease;
• heart failure   (Grade 3);
• metastases to the brain;
• pulmonary heart disease   (Grade 3);
• clear-cell carcinoma   in the terminal stage .

With extreme caution should be used when chronic renal   and decompensated liver disease.

Side effects

In rare cases, after the procedure of administration Roncoleukin watching brief chills and fever. These reactions are not an indication to cancel the introduction of Roncoleukin and discontinuation of therapy and simple cropped therapeutics.

During the hypodermic had local reactions - redness, induration and tenderness at the injection site.

Instructions for use Roncoleukin (method and dosage)

Instructions on Roncoleukin recommends a single subcutaneous or intravenous (in the form of infusions) administering the drug in doses of 0, 5 mg - 1 mg intermittently for 24 hours to 3 days. The course of treatment typically consists of 1st-3 administrations.

For intravenous administration the contents of one ampoule preparation is dissolved in 400 ml injecting isotonic sodium chloride solution . Infusion was performed for 4-6 hours. The drug solution is colorless and transparent without any inclusions.

Immunotherapy   using the drug Roncoleukin shown after pressing, complex surgeries, which are aimed at eliminating the negative effects of illness or injury, the patient's life-threatening; sanitation, as well as draining the infection.

In the treatment of severe sepsis   administered from 1 to 3 courses of treatment Roncoleukin. The course includes 2 held intravenous infusion of the drug at a dose of 0, 5 mg every other day. The indications for the purpose of further courses of therapy is lymphopenia,   continuing in the course of treatment.

When first diagnosed   infiltrative destructive pulmonary tuberculosis   designate holding 3 in the form of intravenous infusion at a dose of 0, 5 mg at intervals of two days at the background of special chemotherapy.

During the preoperative preparation of a patient suffering from progressive FTC (fibro-cavernous tuberculosis) light Provided passing specific chemotherapy   recommend carrying 3 intravenous infusion at a dose of 1 mg, with an interval of 48 hours.

In the case of common FTC light   with focal dissimination   bilateral nature 7 intravenous infusions administered at a dose of 1 mg, with the first 3 of them during the first week, with a break of 48 hours. Subsequent injections carried out in the same dose 2 times a week for 14 days. The course Immunotherapy   must be completed in 7-10 days prior to surgery.

Roncoleukin with the disease pulmonary tuberculosis   deficient patient body weight more than 30% is impractical.

The course of therapy locally advanced or disseminated forms of renal cell carcinoma   carried out for 24 hours prior to surgery, using a single subcutaneous or intravenous dose Roncoleukin 0, 5 mg.

During the 8-week course immunochemotherapy   recommends an intravenous infusion of the drug during the first 4 weeks of treatment at a dose of 2 mg in 0 hours. Repeated courses of treatment carried out in 1-2 months.

Child patients designate Roncoleukin as an intravenous infusion with preservation treatments for adult patients with single doses, depending on the age:

• from 0 months to 1 month in a dose of 0 1 mg diluted in 30-50 ml of a 9% sodium chloride injection solution;
• aged 1 month to 12 months at a dose of 0, 125 mg diluted in 100 ml of solution;
• aged to 7 years in a dosage of 0, 25 mg diluted in 200 ml of solution;
• the age of 7 years, at a dosage of 0, 5 mg diluted in 200 ml of solution;
• older than 14 years in a dose of 0, 5 mg diluted in 400 ml of solution.

In parallel with the preparation Roncoleukin for human pharmaceutical industry produces a medicament for use in veterinary medicine, particularly for the treatment of domestic animals.

Roncoleukin for cats and dogs used for the treatment of various diseases, ranging from infectious and ending cancer.

The dosage and method of use of the drug Roncoleukin for cats, dogs and other pets vet picks up on the basis of information about weight, age and diagnose animal diseases.

Overdose

After administration of a single dose of 7 mg Roncoleukin more symptoms were observed in the form of heart rhythm disorders, fever, dermatological allergic reactions, hypotension.

These symptoms disappear on their own after the abolition of injecting, if necessary, appoint symptomatically.

Cooperation

Treatment with Roncoleukin may be carried out in combination with other drugs.

With the passage of a long course of patient therapy using glucocorticosteroids   Roncoleukin activity may be reduced.

Not be mixed in the same vial or syringe Roncoleukin and other injectables.

Terms of sale

Prescription.

Storage conditions

At a temperature of 2-8 ° C (in a refrigerator).

Shelf life

24 months.

Cautions

Roncoleukin during storage at 2 to 8 ° C (in a refrigerator), the formation of crystals sodium lauryl sulfate.   At room temperature the crystals must dissolve in the solution during an hour. To speed up this process, you can tilt the vial of the drug, avoiding sharp sbaltyvaniya solution and foam.

Analogs

Analogs of the drug Roncoleukin presented two drugs as Valium for p / and / in the introduction Betaleukin   and Proleukin.

Babies

Appointed pediatric patients from birth, with recommended single doses.

During pregnancy and lactation

The drug Roncoleukin contraindicated during pregnancy.

Reviews on Roncoleukin

Reviews on Roncoleukin in the treatment of various pathologies in humans is rather small, but mostly positive. There are fast action of the drug, reducing the time course of the disease, lack of side effects. Due to the small amount of feedback can be concluded that the treatment of humans using Roncoleukin is in the process of "trial and error" in turn without interfering with the considered drug to show good results.

Roncoleukin for the prevention and treatment of domestic animals, especially cats and dogs, judging by the reviews of the owners, is an exceptionally positive evaluation. Sometimes referred to some of the side effects of the local character in the field of administration, which is not like is not reflected in its overall efficiency.

Price Roncoleukin where to buy

Price Roncoleukin for man in pharmacy chains in Russia is very uneven depending on the region and the mass of the active ingredient.

Buy Roncoleukin in Moscow, you will be able to approximate the price of 3500 rubles 250,000 IU №5 .

The medicament for Roncoleukin 500,000 IU №5   you can buy in St. Petersburg for about 45,000 rubles.

Get the best price and buy