Arifon

Description overdue on 26.06.2012

Related Articles:

• Broncho-Vaxom
• Reviews Dermazole
• From what Kordafleks pills?
• Influcid

Tweet

Antihypertensive drugs, diuretics . The active component acts indapamide . The drug has   vasodilating effects . By its pharmacological mechanism of action is similar Arifon with thiazide diuretics: disruptive to the reabsorption of sodium in the cortical division in the loop of Henle. The preparation enhances the excretion of chloride ions, sodium excretion, as well as magnesium and potassium. The drug selectively blocks the "slow" calcium channels, reduces peripheral vascular resistance, increases the elasticity of the artery walls. Arifon no effect on carbohydrate metabolism, blood lipids, reduces the size of the hypertrophied left ventricle. The medicament reduces the sensitivity of the vessel walls to the effects of norepinephrine, angiotensin-2, stimulates production of prostacyclin, prostaglandins , Reduces the production of stable, oxygen free radicals . Assigning higher dosages no effect on blood pressure lowering is proportional diuresis. With regular use, a stable result is observed in the second week of therapy. Arifon available in tablet form, in the form of capsules. Prolonged Arifon retard form of medication is available in capsules.

Indications, contraindications:

Arifon prescribed for hypertension. The drug is contraindicated in severe renal pathology system in anurii , Encephalopathy, hypokalemia, indapamide intolerance, diabetes with ketoacidosis   (dekampensirovannaya form), in acute circulatory disorders of the brain, with galactosemia , Lactose intolerance. In the pathology water-electrolyte metabolism When hyponatremia, heart failure, coronary artery disease, ascites, mild renal insufficiency, breastfeeding, hyperparathyroidism, gout , The elderly, with gestation pregnancy   Arifon used with caution.

Side effect:

Severity of adverse events is dose-dependent. The digestive tract:   epigastric pain, diarrhea . constipation , Dyspepsia, nausea, dry mouth, stomachalgia , Vomiting, appetite disorders. Nervous system:   nervousness, dizziness, headache, asthenia, vertigo , Somnolence, asthenia, fatigue, agitation, irritability, muscle spasm,   nervousness , Malaise, weakness, lethargy, depression, and sleep disorders. Senses:   conjunctivitis , Disorders of visual perception. Respiratory system:   sinusitis, cough, pharyngitis, rhinitis. Cardiovascular system:   hypokalemia reflected on the ECG, orthostatic hypotension, palpitations, arrhythmia. Urinary system:   polyuria, nocturia. It is also possible to develop an allergic response, chest pain, flu-like syndrome, back pain, infectious lesions, hyperglycemia, hyperuricemia, hypercalcemia, increased urea nitrogen in plasma, hypercreatininemia , Hypochloremia, vasculitis, rash, itching, hives .

Overdose:

Manifested by excessive fall in blood pressure, respiratory depression, problems with the digestive system, vomiting, weakness, nausea, water and electrolyte disorders . Individuals suffering   cirrhosis of the liver It develops hepatic coma. Requires symptomatic therapy, correction of fluid and electrolyte balance, gastric lavage. The specific antidote is not developed.

Mode of application:

Arifon recommended to take in the morning. Initial dose indapamide for hypertension is 1, 25-2, 5 mg per day. Arifon retard administered in the morning at a dose of 1, 5 mg. In the case of treatment failure within a month is added to the treatment medication with other principles of action. It is not recommended to increase the dosage of the drug due to the risk of increasing the severity of side effects.

Special instructions:

It requires systematic control over the level of magnesium ions, sodium, potassium, blood plasma concentration of residual nitrogen, uric acid, blood sugar, the pH level. Patients who take laxatives medicines cardiac glycosides   We need to monitor the level of creatinine, potassium. More careful monitoring is required in patients with liver cirrhosis. Particular attention should be paid to patients ascites , Swelling due to the risk metabolic alkalosis Which increases in hepatic encephalopathy. The first control level of potassium in the blood is carried out for a week. Diagnosing drug in the treatment of hypercalcemia Arifon retard may indicate undiagnosed hyperparathyroidism . It is important to regularly evaluate the dynamics of the sugar curve. In the first days of therapy may replace lost fluids, requires control over the renal system. During the   Doping Control   while taking the drug Arifon possible unreliable results. Safety of use in children, the effectiveness of the drug in patients in this age group have not been established.

Drug Interactions:

Arifon slows excretion of lithium in the urine, leading to its accumulation, NEPHROTOXICITY impact. In the application of iodinated contrast in high doses increases the risk of renal pathology system. Before the introduction of iodinated contrast medicines need to recover lost fluids. Against the background of the drug may reduce the effectiveness Arifon anticoagulants , Indandiona derivatives, coumarin derivatives. The drug is able to increase the severity of the blockade of neuromuscular transmission, which is formed when receiving non-depolarizing muscle relaxants. Corticosteroids , Thiazide and loop saluretics tetrakozaktid, laxatives medicines amphotericin B can cause hypokalemia. Digitalis intoxication   recorded while receiving cardiac glycosides. Intravenous erythromycin, astemizole, vincamine, trefenadina, sultopride, pentamidine, disopyramide, quinidine, sotalol, amiodarone, bretylium tosylate cause arrhythmia type feasts of synergistic effects. Tetrakozaktid, steroids, adrenostimulyatorov reduce the severity of the hypotensive effect of the drug, the opposite effect is registered in the appointment baclofen . Acute renal failure, hypotension   develop against supplementation ACE inhibitors. Antipsychotic medications, tricyclic, imipraminovye antidepressants increases the risk of orthostatic hypotension, increase the severity of the hypotensive effect. Hypercreatininemia diagnosed cyclosporine.