Mifepristone

Description overdue on 31.03.2012

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Antiprogestagen . The basic substance blocks the activity of progesterone   at gestagenovyh receptors. The drug is antigestagens, steroidal agents of synthetic origin. When interacting with corticosteroids logged antagonism. Mifepristone increases the sensitivity of the myometrium to the effects of prostaglandins, the active ingredient stimulates the production of interleukin horiodetsidualnyh in cells that provides increased contractility of the myometrium. The action of the drug is aimed at decidua desquamation with subsequent excretion of the ovum. Mifepristone is available in tablet form.

Indications:

Mifepristone is prescribed to interrupt matochnoy early pregnancy (the maximum term - 42 days from the first day of the last menstrual period). When preterm pregnancy drug may be assigned to induction of labor .

Contraindications:

Mifepristone is not prescribed for adrenal insufficiency, uterine myoma, porphyria, severe estragenitalnoy pathology. The drug is contraindicated in inflammatory diseases of the reproductive system, violations hemostasis , Recent treatment with anticoagulants, anemia, the presence of uterine scar, renal failure system, prolonged glucocorticosteroid therapy, liver disease, intolerance. Not to prescribe mifepristone smoking women over 35 years old. When abortion contraindications are: gestational age of more than 42 days, pregnancy with complete hormonal contraception, pregnancy, emerged against the background of the WFC, suspicion ectopic pregnancy Clinically unconfirmed pregnancy. For induction of labor contraindications include: prolonged pregnancy, eclampsia , Preeclampsia, severe preeclampsia, preterm pregnancies. In CHF, cardiac arrhythmias, hypertension, severe cases of bronchial asthma, COPD prescribed after careful examination, expert advice.

Side effect:

Mifepristone can cause subinvolution uterus metrorragii , Lohiometru, weakness, discomfort in the abdomen, vomiting, hyperthermia, light dizziness, stool, vomiting, aggravation of infectious diseases of the urinary system, uterus, nausea. In the combined treatment in conjunction with misoprostol may develop anemia, fatigue, vaginitis , Decreased hemoglobin, insomnia, fainting, anxiety, pain in the legs. If overdose is registered adrenal insufficiency, treatment posindromnoe.

Mode of application:

The drug Mifepristone is to be carried out exclusively in a hospital or in a specially equipped facility with trained medical personnel .  For the purpose of drug abortion once take 600 mg of mifepristone in the presence of Dr. .  The desired time of reception - a half hour after a light breakfast .  To enhance the effect of the drug is further administered a synthetic analogue of prostaglandin E1 - 400 mg of misoprostol .  Within two hours after taking the pill the patient should be under the supervision of a physician, medical personnel .  After 36-48 hours of a compulsory ultrasound control .  The survey was repeated after 8-14 days, further define the level of the hormone beta-hCG to confirm the completion of a complete miscarriage .  With the ineffectiveness of the drug Mifepristone and ongoing pregnancy on the 14th day (continuing pregnancy, incomplete abortion) is carried out vacuum aspiration, aspirate examined histologically .  For induction of labor: in the presence of a doctor once a patient takes 200 mg of mifepristone .  Repeated receiving similar doses a day .  After 48-72 hours assess the condition of the birth canal, in some cases the appointment of Oxytocin , Prostaglandin.

Special instructions:

Patients should be warned before prescribing the drug mifepristone, in the case of its ineffectiveness, the current pregnancy will be terminated by the surgery, since the drug causes birth defects. After taking the pill is stopped breast feeding for 2 weeks. It is necessary to conduct common activities that accompany abortion and preventive Rh alloimmunization. Patients suffering   infective endocarditis As well as with artificial heart valves to further carry out preventive treatment with antibiotics.

Drug Interactions:

Mifepristone is not allowed to assign, while the use of drugs of the NSAID.