Thiotriazoline

Description overdue on 07.10.2011

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The drug has a membrane-stabilizing, anti-ischemic, immunomodulatory, anti-oxidant effect. Thiotriazoline prevents damage, destruction of liver cells, reduces the degree of fatty infiltration, border tsentrolobulyarnogo hepatic necrosis, stabilizes metabolism, activates processes regenaratsii hepatocytes, normalize the chemical composition of the liver, increases the rate of synthesis, the rate of bile. The drug increases the anaerobic glycolysis   due to compensatory activation. PM activates antioxidant system, reduces the rate of oxidation of lipids in the ischemic myocardium It reduces the sensitivity of the heart muscle to catecholamines, stabilizes and reduces the zone of necrosis, myocardial ischemia. Due to the activation of the fibrinolytic system improves the rheological properties of blood.

The antioxidant effect is achieved due to the presence of the molecule thiol sulfur   (has okislitelno-reducing properties) and tertiary nitrogen (binds the excess hydrogen ions). Thiotriazoline contact with lipid radicals and reactive oxygen species by reducing properties of the thiol group reactivates antiradical enzymes ( catalase, superoxide dismutase, glutationperoksiaza ).

Relative bioavailability of drug when taken orally is 64%, half-life period of 1 3 hours. The drug is accumulated in the myocardium, kidney, liver, colon, spleen in large numbers. In low doses - in the small intestine and lungs. Displayed kidney .

Dosage Form:

Pills. Solution for injection.

Indications:

CHD: myocardial infarction   (acute small- and macrofocal) angina   rest, stress, cardiac arrhythmias, myocardial infarction. Cirrhosis of the liver . hepatitis   various etiologies (chronic form).

Contraindications:

Renal failure, allergies, childhood (up to 5 liters), pregnancy.

Side effect:

Tablet form of the drug Thiotriazoline at therapeutic doses does not have pronounced side effects. In the elderly while taking other medicines there is a general weakness, tinnitus, dizziness, tachycardia , Dyspepsia, dyspnea, suffocation Dry mouth.

A method for receiving:

Pills:

• liver diseases: to 1 m. to 4 times a day for a month;
• PEAKS, myocardial infarction, angina at rest, stress: for 1-2t. 4 p. per day for a month;
• cardiac arrhythmias: 1 m under the tongue 3 times a day.

Injection:

• cirrhosis: 50 mg 3 times a day in tech. 5 days, then the rate to continue taking the tablets: 100 mg three times a day;
• PEAKS, myocardial infarction, angina   resting tension, chronic hepatitis: 2 ml 10 mg / ml solution Thiotriazoline three times per day. The course of treatment - a month.

Overdose:

In case of overdose with urine, a large amount of potassium and sodium. You must refuse to accept the drugs. Specific antidote   does not exist.

Special instructions:

It does not affect the rate of reactions. Experience in pediatric use has not been studied.

Drug Interactions:

Thiotriazoline as cardioprotective agents can be combined with basic therapy drugs CHD.   As hepatoprotector can be used simultaneously with drugs for the treatment of hepatitis .