Tinidazole

Description overdue on 03.01.2012

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The antimicrobial, antiprotozoal agent. Is a high proliferative drug can penetrate into the anaerobic microorganisms, Trichomonas . The mechanism of action is based on the recovery using nitroreductase followed by inhibition of synthesis, disruption of the structure of DNA. Tinidazole is active against   clostridia , Fuzobakterii, peptostreptokokki. Available in tablet form.

Indications and contraindications:

Tinidazole is prescribed for amebiasis . amoebic dysentery , Giardiasis, trichomoniasis . juccuya , Nonspecific vaginitis, ulocace   acute form. The drug is effective against anaerobic infections: abscesses, sepsis, peritonitis, piosalpinks, endometritis , Empyema, pneumonia. The combination therapy is used for the eradication of Helicobacter pylori. The drug is not prescribed for diseases of the nervous system of an organic nature, tinidazole intolerance, pregnancy, suppression of bone marrow hematopoiesis, breastfeeding. Not available in pediatrics before reaching 12 years of age.

Side effects and overdose:

Nervous system : Locomotor ataxia, fatigue, dizziness, headache, incoordination, peripheral neuropathy . ataxophemia Rarely observed seizures, weakness in the whole body. Digestive system : Diarrhea, dry mucous membranes of the mouth, dyspepsia, "metallic" taste in the mouth, loss of appetite. The drug Tinidazole may be accompanied by an allergic reaction: angioedema . itching . Rarely observed transient leukopenia . In overdose recorded increased severity of the above side effects. Tinidozola specific antidote is not recommended to perform the dialysis.

Mode of application:

Tinidazole taken after a meal inside. Giardiasis : Single 2 gram dose for children calculate individual 50 mg / kg. In case of failure of the therapy course is repeated in the same dosage. Antilyamblioznaya therapy involves the simultaneous treatment of all family members, the contact persons. Urogenital trichomoniasis : 2 grams once or three times per day with 150 mg over 5 days, or twice daily at 150 mg for one week. Treatment of vaginal trichomoniasis include additional local treatment. Intestinal amebiasis : Twice a day, 600 mg for 5 days or 2 grams per day for 3 days. In the absence of effect on the 5th day of treatment is extended up to 10 days. Hepatic amoebiasis For three days to 1, 5-2 milligrams per day or 5-10 days at 600 mg twice a day. Non-specific vaginitis, ulcerative gingivitis : 2 grams once. Anaerobic infection   (clostridia, fuzobakterii, etc.): the first day of 2 grams, the next few days to 1 gram per day, 5-6 days of treatment. Prevention of postoperative infectious complications : 12 hours before the surgery take 2 grams of the drug Tinidazole.

Special instructions:

During treatment of genital trichomoniasis   necessary to carry out the treatment of the sexual partner. Tinidazole contributes to staining of urine a dark color. The interaction of the drug with ethanol disulfiramopodobnye develop reactions, it is recommended total abstinence from alcohol during the treatment period. While taking the drug for more than 6 days, requires a control analysis of peripheral blood. Data on the safety of the drug in the treatment of Tinidazole anaerobic infections in children under 12 years there. The drug affects the management of complex machinery, driving a vehicle, perform complex work.

Drug Interactions:

Tinidazole not compatible with antibacterial Drug Facility (cephalosporins, rifampicin, erythromycin . aminoglycosides ) sulfonamides . Phenobarbital   to accelerate the process of metabolism. Tinidazole is not appointed to the Ethionamide . Enhances the effect of tinidazole anticoagulants , Reducing the dosage of the drug can reduce by half the risk of bleeding.