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Antibiotic. The main ingredient - clindamycin . The active ingredient belongs to the group of lincosamides. Klindatsin bacteriostatic. The mechanism of action is based on binding to the 50S ribosome subunit membrane and inhibition of protein synthesis in the cell of microorganism. When exposed to certain groups of Gram-positive cocci manifest bactericidal effect . The drug affects the staphylococci , Streptococci, korinobakterii, microaerophilic gram-positive cocci, anaerobes (spore-forming, nonspore), eubacteria, actinomycetes. Before therapy is required to conduct antibiotikogrammy . Klindatsin has no effect on the course of infections caused by Helicobacter pylori, Mycoplasma, Ureaplasma. There was a cross-resistance between antibacterial drugs linkomitsin and clindamycin. The drug is prescribed for asymptomatic carriage of diphtheria (course duration - 7 days). Klindatsi available in tablet dosage form, in the form of gel, ointment, syrup, granules, capsules, solutions, suppositories.
Indications:
Klindatsin prescribed for infectious lesions Respiratory (fibrosing alveolitis, bronchitis, empyema, lung abscess, pneumonia) Otolaryngology (sinusitis, tonsillitis, otitis media, pharyngitis), joints and skeletal system ( septic arthritis , Osteomyelitis) pelvic and intra-abdominal infections (abscesses in the abdominal cavity, peritonitis ), Purulent infection of the soft tissue and skin (erysipelas, felon, acne, abscesses, cellulitis , Boils, infected wounds, impetigo) in sepsis (anaerobic infection), and gynecological pathology ( pelviperitonit , Salpingitis, adnexitis, abscesses of the ovaries and fallopian tubes, endometritis , Colpitis), infectious lesions of the oral cavity (periodontal abscess), and diphtheria, chlamydia , Pneumonia, malaria, toxoplasmosis encephalitis, endocarditis , Scarlet fever. Klindatsin cream is prescribed for acne. Candles Klindatsin prescribed for vaginitis .
Contraindications:
Instructions for use of the drug is not recommended for Klindatsin medication intolerance active ingredient clindamycin. The drug is not used in pediatric patients until the age of one month. When carrying a pregnancy, ulcerative colitis, asthma, breast-feeding, severe liver disease and kidney system in myasthenia Klindatsin prescribed after consulting experts.
Side effect:
Bodies of blood: thrombocytopenia , Agranulocytosis, leukopenia and neutropenia. Nervous system: rarely observed disorders of neuromuscular transmission. The digestive tract: dysbacteriosis, jaundice, hyperbilirubinemia , Hepatotoxicity, esophagitis, epigastric pain, diarrhea syndrome, pseudomembranous enterocolitis , nausea, vomiting. Cardiovascular system: with the rapid intravenous injection of holding a sharp drop in blood pressure, it is possible collapse . Against the background of treatment Klindatsin may develop an allergic response in the form of urticaria, maculopapular rash, pruritus, anaphylactoid reactions , Eosinophilia, vesiculobullous dermatitis. The injection site may develop thrombosis, rarely appears soreness. Treatment with antibacterial drugs often lead to the development of superinfection .
Mode of application:
Klindatsin taken orally every 6 hours at 150 mg (for adults). In severe infectious pathology of antibiotics may be increased up to 300-450 mg. The dosage for children is calculated according to the scheme of 8-25 mg (depending on the severity) to 1 kg per day, (3-4 hours). When obesity Caused by chlamydia is shown receiving antibiotic for 10-14 days 4 times a day 450 mg. Klindatsin solution was administered intravenously or intramuscularly twice a day at 300 mg. When infectious diseases of moderate severity: 2-4 times a day for 150-300 mg; in infectious diseases, severe severity 2, 7 grams per day (2-4 injections). If life-threatening infections administered intravenous 4, 8 grams of clindamycin per day. Prior to intravenous administration, a solution with a concentration of antibiotic less than 6 mg / ml; the resulting solution is administered intravenously, the duration of infusion 10-60 minutes. It is unacceptable the introduction of 1 hour more than 1, 2 grams of the drug. The solution is kept not more than a day. Candles Klindatsin vaginally administered at night, the therapy is designed for 3-7 days. Treatment colitis clostridia It is recommended to combine with the simultaneous reception vancomycin scheme: 500-2000 mg for 10 days to 3-4 hours. In severe liver disease and renal systems necessary to carry out the correction dosing regimen of the antibiotic. Cream Klindatsin applied to the affected area 2-3 times a day.
Special instructions:
Rarely logged development pseudomembranous colitis during treatment with antibiotic Klindatsin. In 3-15% of cases the disease develops within 2-3 weeks after therapy. Pseudomembranous colitis manifested epigastric pain, diarrhea syndrome, fever, leukocytosis . In less severe enough to discontinuation of the drug and the appointment of ion exchange resins (cholestyramine and colestipol). In severe prescribed vancomycin, bacitracin, metronidazole, compensate the lack of protein, electrolytes and fluids. Not to prescribe medications that inhibit intestinal motility. Data on the safety of the drug for newborns there. Premature babies may develop vagal syndrome It means the presence in the formulation benzyl alcohol . With long-term treatment of children is obligatory control over the functional state of the liver, blood parameters. Therapy requires a high dosages dynamic monitoring of the concentration of active substance in the blood of clindamycin. The drug is not applicable for the treatment of meningitis. With rapid intravenous possible sharp drop in blood pressure and the development of acute left ventricular failure .
Drug Interactions:
Klindatsin incompatible with solutions that contain vitamins, barbiturates , Phenytoin, ampicillin, calcium gluconate, aminophylline, aminoglycosides magnesium sulfate. FROM chloramphenicol and erythromycin antagonism registered. The drug is able to enhance the effect of competitive muscle relaxants . Simultaneous drug therapy, opioid analgesics leads to increased respiratory depression caused by them (may develop sleep apnea). The risk of pseudomembranous colitis increases with the appointment of antidiarrheal medications that reduce the motility of the digestive tract. Klindatsin increases the effectiveness of rifampicin (mutual effect). The spectrum of antimicrobial effects of expanding the appointment of aminoglycosides.
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