Description overdue on 05/22/2014
- Latin name: Dexalgin
- ATC code: M01AE17
- Active substance: Dexketoprofen trometamol
- Manufacturer: Menarini Group, Berlin-Chemie AG, Germany
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Deksalgina (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
One tablet of the drug dexketoprofen trometamol 0 369 r + auxiliaries ( corn starch, glycerol palmitostearate, microcrystalline cellulose, sodium carboxymethyl starch, titanium dioxide, propylene glycol, hypromellose, macrogol 6000 ).
Deksalgin injectively 1 vial contains the active active substance ( dexketoprofen trometamol 0, 738 g) + adjuvants ( sodium chloride, water for injection, ethanol, sodium hydroxide ).
Product form
The tablets are white, smooth, round and convex on both sides of the risks. Cartons 10, 30 and 50 tablets in blisters.
The clear, colorless solution intramuscular or Intravenous administration VO2 ml ampoule. Packages 1, 5 or 10 units.
Pharmacological action
Anti-inflammatory, antipyretic, analgesic.
Pharmacodynamics and pharmacokinetics
The drug belongs to a non-steroidal anti-inflammatory drugs. Active substance deksketoprofen inhibited system cyclooxygenase and reduces the intensity of synthesis prostaglandins . Thus, after half an hour after administration of the drug and reduces pain subsides temperature. The drug exhibits anti-inflammatory effect.
At reception orally It reaches the maximum concentration after 40 minutes. The half-life of the kidneys up to 2 hours. About 99% of the substance is bound to blood proteins. At simultaneous reception with food maximum concentration in the blood will be slightly lower and will take longer to reach its maximum value.
At Intravenous and Intramuscular Pharmacokinetics of drug administration is the same as when receiving tablets. Achieving maximum concentration occurs after 10 minutes.
Indications
From what is prescribed pills Deksalgin? For pain relief:
- after operations;
- algomenorrhea . radiculitis ;
- toothache, menstrual pain ;
- ischialgia and neuralgia ;
- rheumatoid arthritis, osteoarthritis, bone metastases, low back pain, spondylitis .
Injections of the drug is prescribed, when the use of tablets is impossible or unreasonable, for example, postoperative pain After serious injuries, while renal colic .
Contraindications
- drug allergy ;
- bleeding and gastrointestinal diseases ;
- gastric ulcer ;
- Parallel treatment anticoagulants ;
- bronchial asthma ;
- acute cardiac, renal failure, liver disease ;
- pregnant and lactating women, children.
Side effects
- nausea and vomiting ;
- palpitations, increased blood pressure ;
- allergic reactions in the skin, rash, dermatitis, urticaria, chills ;
- anemia, headache, dizziness, fainting, insomnia ;
- dry mouth, diarrhea, anorexia Possible bleeding .
Upon receipt of the tablet form of the drug is possible heartburn and stomach discomfort.
Deksalgina Injections can cause fever and pain at the site of drug development hematoma or inflammation.
Instructions for use Deksalgina (method and dosage)
According to the instructions on Deksalgin pills, the dosage should be prescribed by a doctor individually.
On average, a single dose should not exceed two tablets (2 to 25). Reception from 2 to 6 times a day. The maximum daily dose of 0, 75 grams (6 tablets). Do not take more than five days.
Injections of the drug administered intramuscularly or intravenously, depending on the doctor's recommendation.
Intramuscular Ampoules with drug (2 ml) was added slowly and deeply. 50 mg every 8-12 hours. The maximum daily dose - 0, 15 grams. Do not use more than two days.
Intravenously : The dosage is administered intramuscularly. The drug is administered slowly, not less than 15 seconds.
Infusions : In 2 ml of the drug is diluted 100 ml saline. Solution or r-ra glucose. The administration time from 15 minutes to an hour.
Overdose
If overdose occurs headache, nausea, insomnia, disorientation .
Therapy is conducted according to exhibited symptoms, possible to carry out gastric lavage and Hemodialysis .
Cooperation
Deksalgin 25 (tablets) in combination with salicylates, anticoagulants, ticlopidine, heparin, other NSAIDs, citalopram, drugs of low molecular weight heparin, pentoxifylline, sertraline and fluoxetine It increases the risk of bleeding.
Precautions Use with sulfonamides, methotrexate, lithium preparations, hydantoins due to increased toxic effects on the body. Zidovudine, quinolones, cardiac glycosides, thrombolytics, tsiklosprorin, sulfonylureas and tacrolimus should not be combined with the drug without medical supervision.
Combination with diuretics and ACE inhibitors may cause acute renal failure .
The solution for injection should not be mixed in the syringe with pethidine, prometezinom, Hydroxyzine, dopamine, pentazocine . It can be mixed with morphine, heparin, theophylline and lidocaine .
When mixing the solution for infusion to avoid the combination with promethazine and pentazocine . But it is completely compatible with pethidine, dopamine, Hydroxyzine, morphine, heparin, lidocaine and theophylline .
Terms of sale
It requires a prescription.
Storage conditions
In the reach of children, dark, cool place. The temperature should not exceed 25-30 degrees.
Shelf life
The tablets are stored for 2 years in its original packaging.
The vials of the drug can be stored 5 years. The mixed solution - 24 hours in a dark place at a temperature of 3-9 degrees.
Analogs Deksalgina
Bonifen
Inflexion
Flamaks
Novigan
Ibuklin
Brufen
Ibuprofen
Nurofen
Depiofen, brufen, bofen, vimovo, brustan, deksifen, LP-tech ibupreks, Ibuprom, ibunorm, ibufen, ibuprofen, ibutard, have ketonal, ivalgin, irfen, naproff, mazhezik-sanovel, novigan, Nurofen, nurosan, faspik, Promax .
Price analogs are often very different from the original.
With alcohol
It is desirable to combine the drug with alcohol, has a strong toxic effect liver. Perhaps the increased side effects.
Reviews Deksalgine
Reviews on pills good. The drug relieves pain very well, even very strong and inexpensive. Many store it in a home medicine cabinet just in case. The disadvantage is considered to be the inability to receive a long and rather serious side effects.
Reviews injections Deksalgina too good. It helps for a few seconds to get rid of the pain. However, the process is quite painful, can form "bumps" and then a long time to heal.
Price Deksalgina (Where to buy)
Cost injections Deksalgina - About 100 USD for 5 ampoules. The average price tablets Deksalgin (25 mg) is 55 UAH per plate (10 tablets).
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