Ksizal

Description overdue on 07/11/2014

• Latin name: Xyzal
• ATC code: R06AE09
• Active substance: Levocetirizine (Levocetirizine)
• Manufacturer: YUSB PHARMA SA (Belgium), UCB Pharma, S.p.A. (Italy), FARCHIM, S.A. (Switzerland)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Cautions
• Instructions for use Ksizala (method and dosage)
• Babies
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

In the 1 tablet contains 5 mg levocetirizine dihydrochloride .

In 1 ml of liquid medication contained 5 mg of active substance.

Other ingredients that are part of Ksizala:

• sodium acetate;
• sodium saccharin;
• propylene glycol;
• 85% glycerol;
• methyl parahydroxybenzoate;
• Propyl;
• acetic acid;
• purified water.

Film-coated tablets consisting of macrogol 400 Opadry Y-1-7000.

Product form

Ksizal is available in two dosage forms:

• As 5 mg tablets Coated membrane shell. Available Xyzal tablets for 7, 10, 14 and 20 pieces in one package.
• As oral drops . Drops Xyzal available in bottles of 10 and 20 ml. Bottles of dark color with a dropper.

Pharmacological action

Ksizal drug is pronounced anti-allergic and antihistamine orientation. The blocking effects on histamine receptors in the human body levocetirizine two times higher than the cetirizine .

The drug has an effect on   antihistamine phase allergic reaction .

Exposure of the drug to the patient is that it prevents the development of allergies, upon the occurrence of an allergic reaction facilitates its course, has a antiexudativ and antipruritic effect .

The active ingredient of the drug levocetirizine :

• reduces the permeability of blood vessels;
• slows eosinophils ;
• inhibits the activity of mediators of inflammation and Cytokine .

On serotonin and cholinergic receptors Levocetirizine has almost no effect.

Sedation when receiving Ksizala practically absent.

Pharmacodynamics and pharmacokinetics

Ingestion medicine perfectly absorbed in the gastrointestinal tract. It may appear insignificant metabolism . When receiving medication with food level of bioavailability and absorption rate does not change.

The maximum concentration of levocetirizine in the blood plasma is reached after 1 hour after ingestion. Clinical effects retained more than 24 hours. The half-life of the drug in adult patients is 6 to 10 hours, in children it is somewhat shorter.
About 13 percent of the drugs coming out of the body through the intestine, about 85% - excreted by the kidneys. Patients suffering from renal insufficiency, the half-life of the drug is prolonged. In patients undergoing hemodialysis, displayed no more than 10% of the active substance.

The main component of the preparation levocetirizine It has the ability to penetrate into breast milk.

Indications

The main indications for use Ksizala are:

• if the patient has an itch;
• sneezing;
• lacrimation ;
• nasal congestion;
• inflammation of the mucous membranes of the nose and the eye (conjunctiva);
• pollen disease ;
• season   or chronic conjunctivitis   and allergic rhinitis ;
• rhinorrhea ;
• hives   in chronic ;
• angioedema ;
• allergic dermatitis .

Contraindications

The drug is contraindicated in patients with hypersensitivity to Levocetirizine As well as to other components within the composition of the drug. Ksizal not prescribed to people with severe renal failure .

During pregnancy   and   Lactation   the drug is contraindicated (data about the safety of Ksizala pregnant and lactating women are not available).

Side effects

The main side effects that can occur when taking the drug are drowsiness . fatiguability . headache . dry mouth , stomach ache, asthenic syndrome .

Very rarely observed adverse reactions such as a breach of view, nausea . diarrhea . convulsions . hallucinations . hives , Rash, itching . tachycardia . breathlessness , muscle aches, dyspnea . hepatitis .

Noted isolated cases of changes in body weight.

Reported are extremely rare negative side effects as anaphylactic shock   and angioedema (angioedema ).

Cautions

Before the drug is recommended to refrain from driving vehicles and other activities that require high concentration of attention, as well as clarity and quickness of psychomotor reactions.

Instructions for use Ksizala (method and dosage)

Drops Ksizal   recommended pre-diluted in the drinking water of 10 ml., and then taken through the mouth using a teaspoon.

Dosage reception drops:

• for children from 2 to 6 years is assigned to 5 drops 2 times a day;
• children older than 6 years and adults to take up to 20 drops a day, you can at once.

Tablets Ksizal   Instructions for use for adults and children over 6 years:

• to take on an empty stomach or with food intake;
• swallow without chewing;
• drink water.

Dosage - 1 tablet 1 time per day.

Babies

Ksizal in tablets Film-coated, is contraindicated in children younger than 6 years.

The drug in the drops   not recommended for children under the age of 2 years due to a lack of data on the safety of medicines.

Overdose

If overdose may experience the following symptoms:

• adults - drowsiness ;
• children - increased irritability . excitability . anxiety It is turning into drowsiness.

If an overdose of the drug is recommended in the first place to make the patient a gastric lavage or provoke artificial vomiting. Next, you need to spend a supportive and symptomatic therapy. For the treatment of an overdose of the drug shows Activated carbon .

No specific antidote for poisoning by medication does not exist.

Cooperation

When applied together with Ksizala theophylline   It may increase the half-life levocetirizine   excreted.

It is not recommended during treatment Ksizalom drink alcohol, and drugs that suppress the central nervous system, since it is possible uncontrolled increase in their effects on the human body.

Terms of sale

Ksizal drug dispensed in pharmacies by prescription.

Storage conditions

AND pills And drops   Ksizal drug should be stored in a dark, place inaccessible to children, where the temperature is maintained above 25 degrees C.

Shelf life

Tablets Ksizal   in the shell are not stored for more than 3 years from the date of manufacture.

Drops Ksizal   should be stored no longer than 2 years from the production date printed on the package. Opened bottle of drops can not be stored for more than 3 months.

Analogs Ksizala (if you are hypersensitive)

Match code ATC 4th level:

• Parlazin
• Aleron
• Cetirizine
• Tsetrin
• Zodak
• Zyrtec

Instead Ksizala for the same indications can be applied analogs: suprastineks, glentset, eltset, tsezera, Aleron, alerzin .

Reviews

The online reviews of Ksizale people put on a forum of medical orientation. Patients suffering allergic reactions   and experienced the effect of the drug, noted its rapid effectiveness and ease of administration.

At the same time, taking Ksizal patients are advised to take into account his strong hypnotic effect, especially for those who drive vehicles.

When using the drug for children Reviews of Ksizale mostly positive.

Price Ksizala where to buy

In urban pharmacies drug drops   It is located within 345-420 rubles.

On Tablets Ksizal   the price is about 240-290 rubles. 1 pack of 7 tablets. Packing of tablets number of 10 pieces of pharmacies is from 270 to 360 rubles. Price package of 14 tablets varies between 435-530 rubles.

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Elidel

Description overdue on 06/23/2014

• Latin name: Elidel
• ATC code: D11AH02
• Active substance: Pimecrolimus (Pimecrolimus)
• Manufacturer: Novartis, Germany

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Elidel (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

1 g of cream contains 10 mg pimecrolimus . As auxiliary component di- and monoglycerides, stearyl alcohol, sodium hydroxide, triglycerides Cetyl alcohol citric acid Sodium tsetilstearilsulfat, oleyl alcohol, propylene glycol , Benzyl alcohol and water.

Product form

Cream white for external use produced in aluminum tubes, and in volume 15, '30

Pharmacological action

Elidel Cream - hormonal or not?

It is a non-hormonal drug. The main mechanism of action - inhibition of the production and release inflammatory mediators . Cytokine mast cells and T lymphocytes . This ensures that the anti-inflammatory effect.

Pimecrolimus   inhibits calcineurin   (calcium dependent phosphatase), which leads to inhibition of proliferation T-lymphocyte   and slow production interleukin-2 . tumor necrosis factor - α . γ - interferon   and other cytokines.

The drug reduces the secondary immune response   T cells in the skin, which were obtained from patients atopic dermatitis .

The active ingredient of the drug has no effect on the growth of endothelial , Keratinocytes and fibroblasts. Selective effect on the immune cells do not interfere with the function of cells of monocytic origin and Langerhans cells It does not affect the differentiation T cells What distinguishes pimecrolimus   from corticosteroids .

The drug showed a high effect in reducing inflammation in systemic and local administration.

With allergic contact dermatitis   cream significantly reduces the inflammation reaction of the skin under the effect of stimuli, is equal in efficacy Clobetasol - 17 - propionate and Fluticasone One of the most active corticosteroids. Thus there is no skin atrophy or changes its structure. Cream reduces inflammation in the skin, itching, reduces symptoms histopathology, thus acting selectively on the skin - demonstrates minimal penetration than glucocorticosteroids   or tacrolimus .

The main advantage of Elidel is local (on the skin) selective antiinflammatory effect   combined with minimal effect on the systemic immune response .

The treatment course of 6 weeks for children of different ages (ranging from three months) makes it possible to significantly reduce the signs of skin inflammation - redness, racoma , Infiltration, lichenification and itching. Application during the year to reduce the number of exacerbations, prevent the development of atrophy and improve skin hypersensitivity.

Elidel Cream is not phototoxic and causes photosensitivity .

Pharmacodynamics and pharmacokinetics

Pimecrolimus   It has no systemic action and its blood concentration is so low that it can not estimate the parameters of metabolism.

Indications

Treatment eczema   ( atopic dermatitis ) In adults and children from 3 months.

Contraindications

• idiosyncrasy;
• children up to 3 months;
• skin lesion at the site of acute infection of various origins (viral, bacterial, fungal).

Not recommended use:

• systemic erythroderma   and Netherton syndrome   at risk of increased systemic absorption of the drug;
• with a decrease in immunity, since there is no experience with this category of patients;
• on the skin with suspected malignant or dysplastic lesion.

Side effects

With the highest frequency observed local reactions in the form of burning, irritation, redness and itching of the skin; can be folliculitis   (pustular infection).

Sometimes there Dermatitis , Eczema, herpes, paresthesia, molluscum contagiosum , Worsening of the disease.

Rarely - angioedema . hives , Anaphylactic reactions; intolerance alcohol Manifested in itching, rash, redness of the face.

Also, in rare cases, it may be a violation of skin pigmentation.

Instructions for use Elidel (method and dosage)

For the best possible treatment is initiated at the first sign of the disease to prevent progression.

The cream is applied to the skin with a thin layer and rub until completely absorbed. Apply the ointment two times a day until recovery. In case of preservation over 6 weeks of symptoms diagnosed atopic dermatitis It needs to be clarified.

If the treatment was discontinued, but developed symptoms again should resume application of the drug.

Instructions on Elidel recommended tool to soften the skin after cream applied, and in the case of receiving water procedures - before the cream.

The maximum daily dose is not, as its systemic effect is minimal.

In case of contact with mucous membranes or eyes should be washed with water.

For children, the drug is dosed as well as adults.

Overdose

No cases of overdose were reported.

Cooperation

Considering the low systemic absorption of the cream, the risk of interaction with other drugs for systemic use is unlikely.

Using children did not affect the effectiveness of the vaccine. Do not apply to the area of ​​administration of the vaccine.

Elidel Ointment should not be mixed and applied together with other medicines for the local treatment.

Terms of sale

The pharmacy is sold by prescription.

Storage conditions

Keep out of the reach of children, to comply with the temperature not exceeding 25 ° C.

Shelf life

When opening the package store up to 12 months. Shelf life 2 years unopened cream.

Cautions

During treatment calcineurin inhibitors Including Elidel and, in rare cases, seen the emergence of malignant diseases ( lymphoma and skin tumors ). However, the link between drugs and these diseases has not been reliably established.

When lymphadenopathy   unknown origin or suspicion of mononucleosis should stop the drug.

Influence of cream on the appearance of skin lesions associated with exposure to ultraviolet light, not installed, but should avoid exposure to the sun during treatment with Elidel.

Analogs of Elidel

Match code ATC 4th level:

• Protopic

The only analogue is Protopic .

However, one can say that glucocorticoids analogues Elidel as their use for the treatment atopic dermatitis . The most popular are: Advantan . Diprosalik . Kenalog . Deperzolon . Akriderm . Lorinden . Flukort . Tselestoderm . Apulein .

Babies

Apply to children from three months. In the younger age effect of the drug has not been studied.

During pregnancy and lactation

The efficacy and safety have not been studied. Because the drug has a very low degree of absorbability, probable risk is negligible.

Nursing women should not put the cream on the breasts.

Comments about Elidel

Major reviews Elidel can be found on the forums of young mothers, as recently in young children diathesis   It has become a very common disease, and ointment is often used for infants. Elidel cream reviews suggest that it can quickly go moist crusts on the cheeks, the rash can be easily removed. For newborn medicine is not used up to 3 months because monitoring efficacy and safety have not been carried out.

Many mothers find effective substitute cream ointment with hormones at dermatitis As well as the use of hormones   many parents of children is alarming, and they fear that there may be side effects. A disadvantage of some called addictive, and a high price, which is compensated by safety and effect.

Reviews of doctors indicate that Elidel is widely used for children. Doctors point out as an advantage the possibility of long-term use, that distinguishes the ointment from hormonal methods. Outs referred to the high cost of the drug and that it strongly dries the skin. But it can be corrected using the mitigation of ointments and creams. Also, according to the doctors, it is necessary to remember that Elidel can not get rid of allergies Main reason atopic dermatitis . This is a problem of the whole organism and the treatment requires a comprehensive approach, excluding allergens .

Price Elidel where to buy

In Russia, the price of Elidel cream is from 936 rubles. to 990 rubles. 15-gram tube.

In Moscow, the cost of the drug is on average 967 rubles.

Price ointments Elidel in Kiev (Ukraine), about 246 USD. for '15

Buy in Minsk medicine can be for 230 500 rubles.

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Lorinden

Description overdue on 08/09/2014

• Latin name: Lorinden
• ATC code: D07AB03
• Active substance: Flumethasone (Flumetasone)
• Manufacturer: Jelfa S.A., Poland "VALEANT" LLC, Russia

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• Composition
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• Instructions for use Lorinden (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

This means comprises an active ingredient:   flumethasone pivalate - 0, 2 mg, and additional components: methylhydroxybenzoate   and propyl.

Product form

Available Lorinden as a lotion in n / et vials of 15 ml.

Pharmacological action

Lorinden has prominent local anti-inflammatory, anti-allergic   and antipruritic   action.

Pharmacodynamics and pharmacokinetics

The use of this tool allows you eliminate itching, inflammation   and some of the manifestations allergic reactions .   This reduces the permeability and changes the structure of cell membranes of tissue and reduced migration of macrophages and lymphocytes to the site of inflammation, and softens burning pain, block the production of substances causing inflammation, etc.

Lean foundation lotion can be used for the treatment of various lesions of the mucous membranes or the hairy skin.

Indications for use of the drug

Lorinden Lotion is indicated for:

• various forms of acute and subacute   eczema;
• hives;
• pruritus generalized and limited;
• skin itch Caused by allergies;
• diaper rash, no complications of the infection;
• erythema multiforme;
• bullous and seborrheic dermatitis ;
• psoriasis;
• various kinds of burns and so on.

Contraindications

Do not use the lotion to patients:

• hypersensitivity;
• bacterial, e.g., Tuberculosis   or syphilis , Fungal, viral and neoplastic diseases of the skin;
• trophic ulcers of the lower leg, including varicose.

Side effects

When treating Lorindenom may experience undesirable effects in the form of:   contact eczema, allergic reactions, steroid acne, purpura, telangiectasia, skin atrophy, striae, dryness and depigmentation of the skin , Dermatitis   and so on.

Instructions for use Lorinden (method and dosage)

This is an external agent in the form of lotion, apply a thin layer to the affected skin or mucous. Allowed to use a sterile gauze bandage. The drug must be used 3-5 times daily. When the condition improves, the treatment is reduced to 1-2 procedures a day, who spend 2-3 days. Acute conditions require treatment for 1-2 weeks.

When treating children the lotion may be applied only on a small surface of the skin. Application to extensive damage requires strict short-term treatment.

Overdose

Prolonged use of high dosages lotion can result in the development of systemic adverse GCS effects, for example, Cushing's syndrome , Muscle weakness, erosive lesions of the gastrointestinal tract, suppression of the adrenal cortex   or osteoporosis . It is recommended to give up the use of the drug and conduct symptomatic treatment.

Cooperation

Concomitant use Lorinden and other external agents is contraindicated. When the lotion is applied to extensive areas of skin, due to absorption flumethasone still possible lowering effect of insulin and other hypoglycemic agents, and anticoagulants and antihypertensive drugs. In addition, the gain increases the risk of negative action x olinoblokatorov, androgens, oral contraceptives, anabolic steroids, bucarban, antipsychotic drugs, estrogen, azathioprine, tricyclic antidepressants, nitrates, diuretics, cardiac glycosides   and antihistamines   drugs. The presence of an immunosuppressive effect required during application Lorinden refrain from doing Vaccination   and immunization.

Terms of sale

Pharmacies Lorinden available without a prescription.

Storage conditions

The lotion should be stored in a cool place inaccessible to children.

Shelf life

2 years.

Analogs

Match code ATC 4th level:

• Afloderm
• Ftorokort
• Dermoveyt
• Lokoid

It is an analogue of the drug Flumethasone and other tools created on its basis, for example, A Lorinden   and With Lorinden .

Alcohol

Drinking alcohol does not significantly affect the action of Lorinden.

Reviews Lorindene

The network meets a lot of reviews about this vehicle. According to many users, Lorinden is a very effective drug that helps to eliminate itching, irritation and flaking. Some patients are prescribed a lotion, but most people choose it yourself. However, they also point out its positive effects on the skin.

However, not all users were satisfied with the action of external agents. There are reports that the efficacy of the drug is stored only for a short time and then returned to the defeat.

According to experts, such a situation just occur when the drug is used without an appointment. Therefore, they are advised to consult with your doctor, who can recommend a competent treatment. Otherwise, the therapy may not only be ineffective, but also lead to complications of the disease.

Price Lorinden where to buy

This drug is released in different pharmacies without a prescription. The price of a lotion is 237-260 rubles, depending on the manufacturer.

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Lomilan

Description overdue on 09/26/2014

• Latin name: Lomilan
• ATC code: R06AX13
• Active substance: Loratadine (Loratadine)
• Manufacturer: LEK d.d., Slovenia

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• Composition
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• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Lomilana (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Babies
• Reviews
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Composition

AT tablets   contains 10 mg loratadine As auxiliaries used corn starch, lactose, magnesium stearate, pregelatinized starch.

As a part of suspension loratadine   1 mg, including excipients - White sugar, concentrated glycerol, magnesium stearate, sodium citrate dihydrate, purified water, Polysorbate 80, Avicel RC 591 FMC, sodium citrate dihydrate, wild cherry flavor, citric acid monohydrate, propylene glycol, sodium benzoate.

Product form

Lomilan available as tablets   and suspension .

• White 10 mg tablets have a flat shape, on the one hand and the notch chamfer located. The cardboard pack is 1, 2 or 3 blisters to 7 or 10 tablets each.
• The homogeneous suspension is white. The cardboard packaging is made of dark glass bottle of 120 ml, and the dosage spoon.

Pharmacological action

Infectives for systemic use blocks histamine H1-receptor. It has antiexudative, antipruritic and antiallergic effects.

Pharmacodynamics and pharmacokinetics

Lomilan reduces capillary permeability, relieve spasms of smooth muscles, prevent the development of edema. The drug has antiexudative effect   erythematous and helps reduce symptoms. Half an hour after receiving Lomilana develops antiallergic effect, reaching its maximum at an average of 8-12 hours. The duration of effect - 24 hours.

The drug has no effect on the central nervous system and ECG readings, as it does not cause addiction. Do not use Lomilan to assist in the event of a serious allergic reaction, as the effect of its application is developed to an hour.

After receiving the drug is completely absorbed from the gastrointestinal tract. Slower absorption is the presence of food. The maximum serum concentration reached within one hour. Lomilan metabolized in the liver, forming an active metabolite descarboethoxyloratadine .

The half-life is on average 8 hours increases with alcoholism   and in the elderly. Excreted by the kidneys and the bile.

Pharmacokinetics virtually unchanged in the case of chronic renal failure in a patient and during hemodialysis.

Indications

The drug Lomilan has the following indications:

• pseudoallergy reaction;
• allergic conjunctivitis ;
• nasal allergy ;
• reactions to insect stings;
• allergic skin disease, including chronic idiopathic urticaria .

Contraindications

The drug is not administered in the following cases:

• galactose malabsorption glucose- ;
• children under two years (suspension), up to three years (tablets);
• lactase deficiency ;
• during pregnancy and lactation;
• lactose intolerance ;
• Hypersensitivity to Loratadine   or any other component.

With careful preparation is indicated for hepatic and renal failure .

Side effects

Receiving medicament may be accompanied by the following phenomena:

• anaphylactic reactions ;
• nervous irritability, drowsiness , Fatigue, headache . dizziness   and insomnia ;
• syncope, tachycardia . arrhythmia , Palpitations;
• gastritis , Increased appetite, dry mouth, nausea;
• abnormal liver function;
• allergic reactions in the form of rash . alopecia .

In addition to these effects in children may develop sedation .

Instructions for use Lomilana (method and dosage)

Tablets Lomilan, instructions for use

Inside, it can be received at the same time food is allowed to chew the tablet in the presence of necessity. To wash down with milk or water should be.

Adults and children over 12 years old should take one tablet per day (10 mg), children aged 2-12 years of age with a weight greater than 30 kg - 10 mg knocks (1 tablet), weighing less than 30 kg - 5 mg per day ( poltabletki).

The suspension

Recommended Lomilan taken as a suspension for children up to 12 years.
Ingested orally, possibly in conjunction with food, drinking water or milk.
Adults and children over 12 years, as well as children aged 2-12 years of age with a weight over 30 kg is recommended to take once a day 10 ml (two dosing spoon), weighing less than 30 kg - 5 ml (one dosing spoon).

Special groups of patients

Patients with impaired liver function is assigned to a smaller dose of the drug: adults and children (with a weight greater than 30 kg) - 10 ml or 10 mg per day. The treatment period depends on the duration of symptoms of disease. If the status of the patient for 3 days did not improve, then the drug should be considered ineffective.

The dosage to patients with renal impairment and the elderly are not adjusted.

The initial dose for patients with kidney failure are as follows: children from 6 years and adults - 10 mg a day, fly to 3 years - 5 mg every other day.

Overdose

Symptoms of overdose: headache . drowsiness , Palpitations, lasting a long time. While taking the drug excess doses should wash out the stomach, cause an artificial vomiting, take the absorbent (eg, Activated carbon ).

To this drug is no specific antidote. With hemodialysis is not displayed. No information for the moment, whether the vehicle is derived using peritoneal dialysis. After providing the necessary assistance should be a specific time to monitor the patient.

If symptoms of the nervous system or the heart is necessary to address to experts.

Cooperation

Together with the admission inductors makrosomalnogo oxidation ( barbiturates . tricyclic antidepressants . ethanol . Rifampicin . phenytoin ) Decreases the effectiveness of loratadine.

Reducing the concentration of drug in the blood can cause its interaction with erythromycin . quinidine . Fluoxetine . Ketoconazole . Itraconazole . This can result in increased side effects from taking the drug.

Terms of sale

The drug is intended for non-prescription.

Storage conditions

Lomilan in suspension and in the form of tablets should be stored at temperatures up to 25 ° C.

Shelf life

4 years.

Cautions

It is recommended to stop taking the drug for at least 2 days prior to removal of skin allergy tests, as Lomilan may affect the results.

While driving patients taking Lomilan should be cautious as possible of side effects.

Babies

Yes, currently there is insufficient data on the efficacy of the drug and its safety for children up to 2 years.

Reviews

Reviews Lomilane indicate that the drug really good relieves swelling and allergic reactions. In general note and good tolerability of the drug. The downside, some buyers believe that the effect of the drug becomes noticeable only an hour after his admission. Some also mention the occurrence of side effects such as irritability and nervousness in children.

Price Lomilana where to buy

Moscow value slurry (120 ml) is from 91 to 125 rubles.

Price Lomilan tablets: pack of 10. is from 143 to 164 rubles., 7 pcs. - From 105 to 118 rubles.

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Stopdiar

Description overdue on 08/26/2014

• Latin name: Stopdiar
• ATC code: A07AX03
• Active substance: Nifuroxazide (Nifuroxazide)
• Manufacturer: Gedeon Richter (Hungary)

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• Composition
• Product form
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• Pharmacodynamics and pharmacokinetics
• Indications Stopdiara
• Contraindications
• Side effects
• Instructions for use Stopdiara
• Cooperation
• With alcohol
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Enterofuril or Stopdiar - which is better?
• Reviews
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Medicine Stopdiar - composition

Tablets are film coated. The composition of one tablet are:

• active substance nifuroxazide 100 mg;
• Excipients: talc . colloidal silica .   potato starch .   gelatin . magnesium stearate ;
• film coating composition: talc . Valium . titanium dioxide . polyethylene glycol 20000 . quinoline yellow dye .

Oral suspension in 5 ml suspension contains:

• active substance nifuroxazide   220 mg;
• Excipients: Carbomer . saccharose . sodium hydroxide . citric acid monohydrate .   30% simethicone emulsion antifoaming . methyl parahydroxybenzoate . Banana flavor .

Product form

Pills in A film coated yellow color, round, convex with both sides. 24 tablets are in a blister pack, placed in a cardboard box.

Oral suspension light lemon color, odor banana in dark glass bottles of 125 ml (suspension in 90 ml vial). The vial is placed in a cardboard box, there is a double (at both ends) measuring spoons 5 and 2, 5 ml.

Pharmacological action

The drug has antibacterial effect   in relation to the causative agents of intestinal infection.

Pharmacodynamics and pharmacokinetics

The active substance Stopdiara nifuroxazide   It refers to the group of nitrofurans and ingestion exerts an antibacterial effect on pathogenic and opportunistic microorganisms that cause intestinal infections. Nifuroxazide   active against gram-positive ( staphylococci, streptococci ) And Gram-negative ( Salmonella . Shigella . Klebsiella . E. coli ) Bacteria, which often are the causative agents of intestinal infections.

Stopdiara action due to the suppression action of enzymes involved in cellular metabolism pathogens. Due to the metabolic break down the cell membranes of bacteria and cells die.

Activity Stopdiara against the infectious agent is not reduced even during prolonged treatment. However, he does not destroy the intestinal microflora, so after his application for restoration of the digestion process takes less time than with the use of antibiotics. Effect of the drug independent of pH in the intestines.

After ingestion of capsules or suspensions of the active ingredient is practically not absorbed in the intestine, not into the blood stream and has no systemic effects on the body. It operates directly in the intestine, and then excreted naturally by the faeces.

Indications Stopdiara

The drug is prescribed in the following diseases:

• acute intestinal infections , Caused by susceptible to nifuroxazide causative agents of;
• chronic bowel disease ( enteritis and enterocolitis ) An infectious nature.

Contraindications for use Stopdiara

Contraindications to the use of the tablets:

• allergies to medications   from the group of 5-nitrofuran ;
• A hypersensibility of the organism to other components of the drug;
• the age of six.

Contraindications to the use of the suspension:

• allergies to medications   from the group of 5-nitrofuran ;
• hypersensitivity to other components of the drug;
• the age of two months;
• prematurity.

Precautions are advised to take the medication at the time of pregnancy   and breast-feeding   child as clinical tests on these categories of patients was conducted.

Side effects Stopdiara

The drug is usually is well tolerated by all patients and only in single instances are manifested its side steps:

• The stomach and intestine   - May appear transient abdominal pain, nausea, diarrhea symptoms intensify; it does not require interruption of treatment;
• allergic reactions   - hives . angioedema , Respiratory disorders. In such circumstances you should immediately stop taking the drug.

Instructions for use Stopdiara

Instructions on pills Stopdiar Tablets are swallowed without chewing and drinking water every 6 hours. Stopdiara reception does not depend on the power mode. Adults and children after six years should take 200 mg (2 tablets) four times a day for a week.

Instructions on Stopdiar - suspension for children : Suspension give the child every 6 - 8 hours, without associating it with feeding; the vial before applying carefully is shaken, achieving homogeneity a suspension of, after which is dosed the suspension was with the help of dimensional spoons of (1 small dimensional spoon on 2.5 mL contains 110 mg of the drug, 1 large dimensional spoon on 5 ml of - 220 mg). Guide for Children recommends the following age dosage of the drug:

• 2 - 6 months: 110 - 220 mg of (1-2 scoops 2.5 ml) twice per day;
• 6 months - 6 years: 220 mg (1 measuring spoon on 5 ml) thrice per day;
• 6 - 18 years and adults: 220 mg (1 scoop 5 ml) four times a day.

Duration of use   Stopdiar suspension for children   It should not exceed one week. Treatment should be under medical supervision, because the intestinal infection, especially in young children, often leads to dehydration and related serious complications. Therefore, a constantly replenish lost fluids.

Stopdiara Interaction with other drugs

The drug is practically not absorbed in the intestine and enters the blood, so it can not interact with any other drugs. But if at the same time with Stopdiarom ingest some other drug Stopdiar adsorbs it on its surface and bring the body. Therefore Stopdiara between ingestion and other drugs should be a break 2 - 3 hours.

Interaction with alcohol

During treatment Stopdiarom not take alcoholic drinks, since the reception of the drug greatly increases the body's sensitivity to alcohol. Even if accidentally eating small amounts of alcohol may develop severe teturamopodobnoy reaction : A patient is sharply reduced arterial pressure Appear nausea, vomiting Sometimes loss of consciousness and seizures.

Terms of sale

The preparation is available on medical prescription.

Storage conditions

The tablets were stored in a dry, dark place at a temperature of 15-25 ° C. The suspension should be stored at a temperature not exceeding 25 ° C. Medications should be available for children.

Shelf life

Shelf life Tablets - 4 years, the suspension - 3 years.

Analogs Stopdiara

Match code ATC 4th level:

• Ersefuril
• Nifuroxazide
• Entoban

Analogs - a variety of dosage formulations groups which are used to treat the same disease. The analogue of Stopdiara is a Furazolidone   - Preparation of nitrofurans group, but with a different active ingredient. Furazolidone - it is one of the first products from the group of nitrofurans, who were appointed in the treatment of intestinal infections. Its efficiency is definitely lower than Stopdiara.

Synonyms are drug Enterofuril, ersefuril, Diastat, nifuroxazide . All these medicines active substance is nifuroxazide.

Enterofuril or Stopdiar - which is better?

This is absolutely identical preparations, which have a one and the same active substance, are issued in identical dosage forms for adults and children, have identical indications and contraindications for the application of.

Both drugs let out pharmaceutical companies with a good reputation: Stopdiar   - Gedeon Richter (Hungary) Enterofuril   - Bosnalek (Bosnia and Herzegovina).

Reviews Stopdiare

Reviews   Only about tablets positive . Produced the drug in a convenient dosage form, effectively interrupts the majority of intestinal infections, has virtually no side effects and contraindications for use.

The suspension Stopdiar reviews also has a purely positive. This drug from an intestinal infection for children is widely used in outpatient practice and hospital.

Price Stopdiara

The price of one pack of pills Stopdiar in Moscow varies from 128 to 158 rubles;
Suspensions Stopdiar price from 214 to 247 rubles.

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Neo Pilobakt

Description overdue on 08/30/2014

• Latin name: Pylobact Neo
• ATC code: A02BD05
• Active substance: Amoxicillin (Amoxicillin), omeprazole (Omeprazole), Clarithromycin (Clarithromycin)
• Manufacturer: Ranbaxy Laboratories Ltd. (India)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Pilobakta Neo (The method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

Pills Amoxicillin   It contains as active substance Amoxicillin   in shape   trihydrate And auxiliary components such as colloidal anhydrous silica, MCC, polyethylene glycol, sodium starch, magnesium stearate, talc, Parmas, titanium dioxide, a yellow-orange dye.

Capsules Omeprazole   They have the active ingredient is omeprazole , Plus the following additional components: non-Parel granules, corn starch, povidone, sodium lauryl sulfate, hydroxypropyl methylcellulose phthalate, titanium dioxide, sucrose, mannitol, talc, hydrogenated sodium orthophosphate anhydrous, diethyl phthalate.

Pills Clarithromycin   incorporate such active components as clarithromycin And the following excipients: colloidal anhydrous silica, povidone, magnesium stearate, croscarmellose sodium, hydroxypropyl cellulose, sorbitan, quinoline yellow dye, opakod S-1-27794 black, MCC, talc, stearic acid, hydroxypropyl methylcellulose, propylene glycol, titanium dioxide, vanillin.

Product form

Pilobakt Neo is a combined set, designed for oral use. Clarithromycin and amoxicillin - coated tablets. Omeprazole - Capsules.

Pharmacological action

The drug acts as an antibacterial agent in the Helicobacter pylori .

Pharmacodynamics and pharmacokinetics

Pilobakt Neo - a drug designed to eradication therapy Helicobacter pylori . It is designed for one-week course.

Amoxicillin   represents antibiotic Belonging to the semisynthetic penicillins That have bactericidal action . It is due to the fact that the active drug may inhibit the synthesis of bacterial cell walls. Tablets are effective against Helicobacter pylori .

Omeprazole   represents proton pump inhibitor . It reduces the secretion of hydrochloric acid in the stomach and helps to block the final step of acid secretion. Because of this reduced level basal   and stimulated secretion . Duration of caps - more than a day. They significantly reduce the amount of gastric juice and increase the concentration of other components of the complex Pilobakt Neo in the gastric mucosa, in addition, increase the level of acidity in the stomach and provide optimal conditions for the antimicrobial activity.

Clarithromycin   It is macrolide antibiotic Which acts as an antibacterial agent against many microorganisms, including Helicobacter pylori . It inhibits the synthesis of proteins. Resistant to acidic medium in the stomach.

All components of the complex Pilobakt Neo characterized by a good degree of absorption following oral administration.

Amoxicillin   rapidly absorbed in the gastrointestinal tract and is not cleaved in acidic medium in the stomach. Take this medication can be relatively free meals. Its maximum concentration in plasma is achieved in 60-120 minutes. The half-life of the drug - about 60-90 minutes. 60% is excreted in the urine in unchanged form. Relationship to plasma proteins - 20%.

Bioavailability Omeprazole   - About 40%. The time of its plasma half-life - about half an hour or an hour. The drug has a good connection to plasma proteins. About 80% while excreted through the kidneys as metabolites .

The content of active substance Clarithromycin   in body fluids and tissues is many times higher than the concentration in serum. You can take the drug regardless of meals. About 20% is split to form Clarithromycin 14 hydroxyclarithromycin. The time of its half-life - about 6 hours. About 20% of the drug is excreted in the kidneys unchanged and 15% as a 14-hydroxyclarithromycin.

Indications

Combination set Pilobakt Neo taken if necessary eradication therapy Helicobacter pylori   in adult patients who have duodenal ulcer and stomach .

Contraindications

The drug can not be used if you are hypersensitive to its components, and other macrolides , and beta-lactam antibiotics . In addition, before the course is necessary to exclude malignancy, as the course Pilobakt Neo may hinder its diagnosis.

This drug also can not be taken at pregnancy . Lactation Children up to 16 years and patients with infectious mononucleosis , Blood dyscrasias and leukemoid tests lymphatic type.

Side effects

Tablets and capsules of the combined set of Pilobakt Neo is usually well tolerated by patients, side effects are easily and quickly.

Undesirable effects while taking Amoxicillin   It appears mainly in the form of hives . In addition, in rare cases may occur convulsions . hyperkinesia . dizziness , Nausea, colitis . vomiting . itch . diarrhea . angioedema . Stevens-Johnson syndrome . hives . anaphylactic shock . erythema multiforme . interstitial nephritis . leukopenia . hemolytic anemia . thrombocytopenia . agranulocytosis .

Application Omeprazole   can lead to side effects such as vomiting, headache . flatulence . nausea . constipation , abdominal pain, diarrhea . photosensitization . Stevens-Johnson syndrome . itch . alopecia . erythema multiforme Symptoms Arthritis   and myalgia , Rash, joint pain, muscle aches, muscle weakness. In rare cases, there is also:

• sleep disturbance ;
• fatigue;
• paresthesia ;
• weakness;
• vertigo ;
• drowsiness ;
• dizziness ;
• hallucinations ;
• agitation ;
• depression ;
• confusion;
• candidiasis   Gastrointestinal;
• dry mouth;
• stomatitis ;
• increase in liver enzymes;
• hepatitis ;
• encephalopathy ;
• gynecomastia ;
• pancytopenia ;
• thrombocytopenia ;
• agranulocytosis ;
• leukopenia ;
• reducing the concentration of sodium in the blood;
• blurred vision;
• excessive sweating;
• breach of taste sensations;
• peripheral edema.

Clarithromycin   may cause the following side effects:

• CNS : Temporary hearing loss, psychosis , Disorientation, nightmares, anxiety, hallucinations . insomnia . parosmiya . anosmia . dizziness , Taste change, depersonalization, ringing in the ears, vertigo . confusion . dizgevziya . ageusia , Seizures, headache .
• Digestive system : Discoloration of tongue, liver dysfunction, hepatocellular jaundice . cholestatic jaundice . candidiasis   oral hepatitis . cholestatic hepatitis . hepatic failure , Discoloration of teeth, stomatitis . acute pancreatitis . pseudomembranous colitis . glossitis , Vomiting, dyspepsia , Abdominal pain, nausea, diarrhea .
• The urinary system : renal failure . interstitial nephritis .
• The immune system Hypersensitivity, anaphylactic   reaction.
• CCC : ventricular tachycardia Lengthening QT interval .
• Skin and subcutaneous tissue : Stevens-Johnson syndrome . angioedema before anaphylaxis . hives . skin rash .
• Blood and lymphatic system : thrombocytopenia . leukopenia .
• Metabolism : hypoglycemia .

Instructions for use Pilobakta Neo (The method and dosage)

Instructions on Pilobakt Neo provides its use during the week. One day, it is taken 1 blister, which includes 2 pills amoxicillin, 2 capsules of omeprazole and 2 tablets Clarithromycin.

Instructions for use Pilobakta Neo reports that in the morning should take 1 capsule of omeprazole and amoxicillin and clarithromycin tablet. In the evening, their reception is repeated in the same dosages.

Overdose

At higher doses Amoxicillin   you may receive nausea . diarrhea . vomiting and crystalluria . If this happens, you should immediately stop taking the medication. If overdose occurred recently, can cause vomiting. In other cases, prescribe hemodialysis .

Omeprazole   at high doses can cause nausea, dizziness . diarrhea . vomiting . abdominal pain . Headache . apathy . confusion . depression . All symptoms are reversible. Treatment is symptomatic.

Clarithromycin may cause an overdose allergy And problems with the gastrointestinal tract. As treatment is prescribed gastric lavage .

Cooperation

Time-life and maintenance Amoxicillin   plasma enhanced when combined with Probenecid . Oxyphenbutazone . Sulfinpirazon . Phenylbutazone   and Acetylsalicylic acid . Concurrent use with oral contraceptives may cause bleeding   and reducing their effectiveness. At the same time, the bactericidal action of amoxicillin neutralized when combined with bacteriostatic drugs, and with Ampicillin   increased incidence of skin reactions.

Omeprazole   in combination with drugs that are cleaved by enzymes in the liver systems P450 It can increase their concentration. In combination with Clarithromycin   this tool can also increase the concentration of both.

Clarithromycin   contraindicated for use in conjunction with Cisapride . Terfenadine   and Pimozide . Astemizole . Ergotamine . Dihydroergotamine , and benzodiazepines That are metabolized by CYP3A. You may need a dosage adjustment or cancellation of Clarithromycin in combination with potent inducers of enzymes P450 . Ritonavir . When combined with Quinidine   or Dizopiramid   you may receive ventricular tachycardia So that it is necessary to closely monitor their concentration in the blood serum.

Clarithromycin   also increases the concentration of HMG-CoA reductase and potentiate the effect of oral anticoagulants. Furthermore, in conjunction with it may increase the concentration phosphodiesterase inhibitors . Theophylline   or Carbamazepine   plasma, so they may need adjustment of the dose. Also, in some cases, the dosage should be adjusted when combined with Tolterodine .

FROM Triazolam   Clarithromycin may provoke the occurrence of side effects from the CNS. Therefore, their joint application requires careful monitoring specialists. Clarithromycin and other macrolides can inhibit CYP3A and P-glycoprotein. And in combination with Digoxin   it can increase its concentration in the blood serum. Thus dosage should be well controlled.

In HIV-infected patients and clarithromycin Zidovudine   may reduce the equilibrium concentration in the serum. Reception interval between them should be strictly adhered to. Probably well as bilateral cooperation with Atazanovirom . Saquinavir   and Itraconazole .

Terms of sale

The drug is sold strictly on prescription.

Storage conditions

Keep Pilobakt Neo should be dry and out of reach of children. At this temperature should be 25 ° C.

Shelf life

Shelf life - 2 years.

Analogs

Match code ATC 4th level:

• Pilobakt AM
• Pilobakt

Analogs Pilobakta Neo is not so common. The only widely known is complex preparation Ornistat . However, the components of the Neo Pilobakt a generation later. In addition, it is the Indian drug, and Ornistat   - English. So many patients still prefer Ornistat , Despite the fact that its cheaper counterparts.

Reviews of Neo Pilobakt

On Pilobakt Neo reviews of people on the Internet and other sources meet the most different. For example, some say that the drug was ineffective. And someone claims that his action is already noticeable in a few days. In addition, reviews of the Neo Pilobakt rarely report the appearance of any side effects, so that the vehicle is considered safe for use.

Price Pilobakta Neo

Buy Neo Pilobakt possible, mainly in the Ukrainian pharmacies. Although there appears this drug is rare. Price Pilobakt Neo, on average, 150 hryvnia. This tool is considered very affordable compared to their English counterparts. In addition, it should be remembered that this is a complex preparation, so the price Pilobakt Neo is given three drugs at once.

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Valacyclovir

Description overdue on 14/10/2014

• Latin name: Valacyclovir
• ATC code: J05AB11
• Active substance: Valacyclovir (Valaciclovir)
• Manufacturer: Ltd. Technology of medicines, Russia

Photos of the drug

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use of valaciclovir (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

As part of a single tablet is 556 mg valacyclovir hydrochloride (500 mg, based on valacyclovir ).

Product form

Tablets are film coated, in cardboard packs or glass jars for 10 pieces.

Pharmacological action

Antiviral .

Pharmacodynamics and pharmacokinetics

Active substance means depresses livelihoods DNA polymerase   Virus Herpes It does not provide synthesized viral DNA   and inhibits processes Replication .

After entering the body, valacyclovir   transformed into acyclovir   and L-valine Then reactions occur phosphorylation   and acyclovir   turns into acyclovir triphosphate . The resulting compound is able to inhibit DNA polymerase   malware agent (virus) on competitive mechanisms.

Phosphorylation occurs generally in two steps. The first reaction is catalyzed by the enzyme thymidine kinase . The drug is particularly active in relation to the Herpes simplex To Varicella zoster   it is less sensitive. Displayed substance kidneys or in feces, the half-life of about three hours.

Indications

The medicine is prescribed:

• for the treatment of diseases of the mucous membranes and skin, are caused by a virus Herpes simplex ;
• for the prevention of recurrence of disease caused by the same virus;
• at shingles ;
• as prophylaxis cytomegalovirus infection   after Organ Transplantation .

Contraindications

The tool is contraindicated:

• bone marrow transplantation and kidney;
• at allergies   to the active substance;
• HIV-infected If CD4 + lymphocytes   does not exceed 100 mg / l;
• Children up to 18 years (exception - organ transplants, while drug use at age 12).

Side effects

The drug was well researched. As a result, laboratory studies and observations of patients with Shingles   and herpes virus (including concomitant immunocompromised ) Accepted valacyclovir It has been identified almost all possible side reactions.

FEATURES:

• nausea, pain epigastric   region, vomiting, anorexia   and diarrhea , Elevated liver enzymes, hepatitis ;
• abnormalities in the kidneys, photosensitivity , Shortness of breath,   thrombocytopenia ;
• headaches, dizziness, . hallucinations . depression . agitation . ataxia . psychosis . ataxophemia , Impaired consciousness and coma ;
• rash, itching, anaphylaxis . hives . angioedema ;
• neutropenia . aplastic anemia . vasculitis . thrombocytopenia ;
• nasopharyngitis . swelling of the face . tachycardia , Increasing Blood Pressure , Fatigue;
• rhinorrhea . fever   and dehydration .

Instructions for use of valaciclovir (method and dosage)

Means taken orally without regard to meals.

Valacyclovir Tablets, instructions for use

When shingles single dosage of 1000 mg (2 tablets) 3 times daily. The course of treatment - 7 days. The sooner after onset of symptoms began receiving funds, the more effective the treatment will be.

Herpes (including the prophylactic) daily dose - 1000 mg. It is recommended to be divided into 2 doses, morning and evening, one tablet. Duration of treatment - from 5 to 10 days (severity of disease).

If the patient has irregularities in the kidneys, the dose should be adjusted.

Overdose

There is no evidence of drug overdose.

Cooperation

No clinically significant interactions between tablets with other agents was not observed.

However, the active substance is excreted through the kidney by kanaltsievoy secretion . Any medicines that will be appointed at the same time Valacyclovir,   would interfere with its normal excretion from the body. This primarily refers to cimetidine   and other drugs that block the secretion mechanism kanaltsievoy.

When combined with mycophenolate Concentration acyclovir   in the blood plasma increases.

When combined with funds cyclosporine . tacrolimus   and drugs that disrupt the normal functioning of kidneys, the load on these organs increases.

Terms of sale

We need a recipe.

Storage conditions

In a cool place at a temperature no higher than 25 degrees.

Shelf life

2 years.

Cautions

When violations of the kidneys to use the drug should be with caution. Perhaps the development of Acute renal failure , Disorders of the central nervous system.

For elderly patients dose adjustment is required, however, should increase fluid intake.

During treatment Genital herpes   It is to abstain from sexual intercourse, since the drug does not protect against transmission of the virus to the partner.

In the treatment of patients with liver disease should be careful.

No clinical experience of the use of funds for children up to 12 years in connection with this medication is not prescribed for children.

If the patient had a bone marrow transplant, or kidneys, detected clinically severe form HIV infection Manifested acute immunodeficiency Then the drug can lead to thrombocytopenic purpura . hemolytic uremic syndrome   and death.

If during treatment means observed hallucinations, seizures, agitation, confusion   and   delirium The drug should be discontinued.

Analogs of valacyclovir

Match code ATC 4th level:

• Famvir
• Ribavirin
• Valtrex

The closest analogues: Waiora, Canon Valaciclovir, Valacyclovir Hydrochloride, Valogard, Valtsikon, Virdel, Valavir, Valvira, Valtrex, Vatsireks .

What is better - or Valacyclovir Valtrex?

Valtrex - import analogue with the same active ingredient. On the effectiveness and frequency of side reactions of drugs are identical. However, the cost is much higher than Valtrex Valacyclovir.

During pregnancy and lactation

Studies that proved harmless means for pregnant and lactating women, almost none. In this regard, the doctor has to prescribe a drug.

Valacyclovir (a metabolite of acyclovir) well into the breast milk.

During studies in rats and rabbits, when receiving means is not provided teratogenicity   exposure did not cause Fertility   females and males.

Reviews of valacyclovir

Reviews good. The product eliminates the long   Herpes , The side effects most frequently manifest nausea and problems with the gastrointestinal tract. Many are satisfied with the relatively low cost of the medication.

Price valacyclovir

The price for Valacyclovir Tablets in Russia - about 600 rubles per 10 pieces.

However tablets are generally used ointment containing valacyclovir.

Price valacyclovir in Ukraine is somewhat higher. Buy drug can be for UAH 360 (10 tablets).

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