Description overdue on 10/11/2014
- Latin name: Medrol
- ATC code: H02AB04
- Active substance: Methylprednisolone (Methylprednisolone)
- Manufacturer: PFIZER ITALIA, S.r.L. (Italy)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Medrol (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet Medrol includes 16, 32 or 4 mg methylprednisolone .
Other ingredients: liquid paraffin, calcium stearate, lactose, corn starch, sucrose.
Product form
Medrol - a white oval pills, with one end labeled with two notches in the form of a cross, the other - a letter engraving.
Tablets 4 mg are available dosage:
- 10 pieces in a blister; 3, 1 or 10 in the blister pack;
- 30 pieces in darkened glass vials, one vial per bundle.
Tablets 16 mg dose produced:
- 10 pieces in a contour package 5 packs in the pack;
- 14 pieces in a contour package 1 pack in the pack;
- 50 units in darkened glass vials, one vial per bundle.
Tablets 32 mg dose produced:
- 20 or 50 in darkened glass vials, one vial per bundle.
Pharmacological action
Glucocorticoid - The main effect of Medrol.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Methylprednisolone - Glucocorticoid hormone. Penetrates the cell membrane, binds to specific receptors in the cytoplasm into the nucleus, binds to DNA It activates transcription mRNA and enzyme synthesis. It has a significant impact on the process of inflammation, immune response, and the protein, carbohydrate and fat metabolism. It affects the circulatory system, the skeletal muscles and the nervous system.
Methylprednisolone has immunosuppressive, anti-inflammatory and antiallergic properties. It reduces the content of immunoactive cells near the inflammation of the hearth; stabilizes lysosomal membranes; decreases vasodilation ; suppresses phagocytosis ; reduces synthesis prostaglandins and similar compounds.
Methylprednisolone catabolic effect on proteins. Formed amino acids are metabolized in the liver glycogen and glucose . In peripheral tissues is reduced using Glucose tissue that gives rise to glycosuria and hyperglycemia .
Methylprednisolone has lipolytic and lipogeneticheskim effect in different areas of the body that leads to a redistribution of fat deposits.
Pharmacokinetics
Absorption occurs in the small intestine. Protein binding is about 40-90%.
The metabolism takes place in the liver. Methylprednisolone decomposes into 20p-hydroxy-6a-metilprednizon and 20p-gidroksimetilprednizolon Which are excreted in the urine.
The half-life from the blood is about 3 and 5 hours. The half-life of the organism as a whole - one and a half days.
Indications
Endocrine disorders:
- adrenal insufficiency;
- adrenal hyperplasia (congenital);
- subacute or chronic thyroiditis ;
- hypercalcemia when cancer.
The lesions of the musculoskeletal system (as an adjunct therapy for the elimination of the state of deterioration):
- psoriatic arthritis ;
- rheumatoid arthritis and juvenile rheumatoid arthritis;
- ankylosing spondylitis;
- acute tenosynovitis;
- osteoarthritis after injuries;
- synovitis at osteoarthritis ;
- sharp bursitis ;
- sharp arthritis at gout ;
- epicondylitis.
Systemic connective tissue disorders (in the acute phase):
- sharp rheumatic heart disease ;
- systemic lupus erythematosus ;
- systemic dermatomyositis;
- giant cell arteritis.
Skin diseases:
- pemphigus;
- severe psoriasis ;
- bullous dermatitis herpetiformis;
- exfoliative dermatitis;
- Stevens-Johnson syndrome;
- severe seborrheic dermatitis;
- mycosis fungoides.
Allergic reactions:
- nasal allergy ;
- contact dermatitis;
- atopic dermatitis;
- serum sickness;
- bronchial asthma;
- allergy drug.
Eye Disorders:
- inflammation of the anterior eye;
- rear uveitis and choroiditis (diffuse form);
- Allergic ulcers cornea;
- sympathetic ophthalmia;
- keratitis ;
- allergic conjunctivitis ;
- chorioretinitis ;
- optic nerve damage;
- iritis and iridocyclitis .
Lung disease:
- symptomatic sarcoidosis ;
- berylliosis;
- tuberculosis light (lightning or disseminated forms);
- Loffler's syndrome;
- aspiration pneumonitis.
Hematologic Disorders:
- thrombocytopenic purpura of unknown etiology;
- autoimmune hemolytic anemia;
- erythroblastopenia;
- secondary thrombocytopenia;
- erythroid hypoplastic anemia .
Palliative treatment of cancer such as:
- leukemia and lymphoma .
Diseases of the digestive system:
- ulcerative colitis .
Nervous system disorders:
- swelling of the brain caused by the tumor;
- multiple sclerosis .
Other indications for use:
- tuberculous meningitis in combination with a subarachnoid block;
- trichinosis ;
- organ transplantation.
Contraindications
Allergies to the drug.
Be wary of peptic ulcer . gastritis . esophagitis . intestinal anastomosis . diabetes . hyperlipidemia, osteoporosis, acute psychosis, heart disease, ulcerative colitis, hypothyroidism and hyperthyroidism . myocardial infarction . hypertension , Severe liver or kidney disease, varicella, glaucoma, herpes, measles, HIV, tuberculosis, severe viral or bacterial diseases.
Side effects
- On the part of metabolism: congestive heart failure , Sodium retention, high blood pressure, loss of potassium, a negative nitrogen balance.
- From the musculoskeletal system: osteoporosis , Muscle weakness, tendon ruptures, steroid myopathy, aseptic necrosis tubular bones.
- From the digestive system: peptic ulcer, pancreatitis , Gastric bleeding, esophagitis .
- From the nervous system: increased intracranial pressure, psychiatric disorder.
- Skin reactions: delayed wound healing, petechiae , Thinning of the skin.
- On the part of the hormonal system: hirsutism , Violation of menstrual suppression pituitary-adrenal axis , Growth retardation in children age persons, the increase in the need for insulin in patients with diabetes .
- From the eye: increased intraocular pressure, exophthalmos .
- Other side effects: allergic reactions , A manifestation of latent infections, withdrawal syndrome.
Instructions on Medrol (method and dosage)
Instructions for use Medrol requires taking the drug orally.
Starting Medrol dose can range from 4 mg to 48 mg per day. High doses can be administered at swelling of the brain - 200-900 mg per day, multiple sclerosis - 200 mg per day, Organ Transplantation - 7 mg per kilogram body weight per day. If after an adequate period of time the expected clinical effect is not obtained, the drug should be repealed and assign the patient to a different type of therapy.
For children, the dose determined by the attending physician based on the weight or body surface area. For example, when adrenal insufficiency administered 3.3 mg / m2 or 0.18 mg / kg daily in three divided doses, with other indications - 12-50 mg / m2 or 0.4-1.65 mg / kg daily in three divided doses. Abolition Medrol after prolonged treatment recommended gradually.
Overdose
The syndrome of drug overdose is extremely rare.
Symptoms: multiple re-admission for a long time can cause Cushing's syndrome and other complications.
Treatment: symptomatic therapy.
Cooperation
In a joint application with cyclosporine there is mutual slowing metabolism.
Ephedrine, Phenobarbital, Theophylline, Phenytoin, Rifampicin reduce the therapeutic effect methylprednisolone .
Ketoconazole, oleandomycin , Oral contraceptives inhibit the metabolism methylprednisolone .
Methylprednisolone increases clearance A Spirin and the effects of changes anticoagulants .
Medrol increases the risk of side effects cardiac glycosides and acetaminophen .
Alcohol and NSAIDs together with methylprednisolone can cause intestinal ulceration and bleeding.
Simultaneous use antacids reduces adsorption methylprednisolone .
Medrol reduces the effectiveness of vaccines.
The drug increases metabolism mekselitina and AND zoniazida .
Terms of sale
Strictly prescription.
Storage conditions
Keep away from children. Store in a temperature range from 20 to 25 degrees.
Shelf life
Five years.
Cautions
There are cases of occurrence Kaposi's sarcoma in individuals treated with Medrol (after cancellation may occur in remission).
Analogs
Flosteron
Depo-Medrol
Solu-Medrol
Diprospan
Kenalog
Analogs of the drug Medrol: Deltason . Prednisolone . Metipred . Depo-Medrol . Solu-Medrol .
Babies
Prescribe drugs with extreme caution. It is necessary to take into account body weight or body surface area.
During pregnancy (and lactation)
You may not use Medrol between pregnancy or Lactation in order to avoid severe complications for the mother and the fetus (baby).
Reviews Medrol
Reviews of people taking the drug Medrol indicate greater efficacy in comparison with the Prednisolone and Metipred But side effects (nausea, vomiting, dry skin, stomach pain, changes in the analyzes, etc.) are quite common.
Price Medrol, where to buy
Price Medrol 4 mg №30 in Ukraine is an average of 133 hryvnia. Buy drug in Russia the same dose will cost 120-168 rubles, bought in Moscow - 125-181 rubles.
No comments:
Post a Comment