Losap

Description overdue on 04/10/2014

• Latin name: Lozap
• ATC code: C09CA01
• Active substance: Losartan (Losartan)
• Manufacturer: ZENTIVA, a.s. (Slovak Republic)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Lozap (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The preparation includes Losap losartan potassium   (active substance), povidone . microcrystalline cellulose . Croscarmellose sodium . mannitol . magnesium stearate . Valium . talc . macrogol . Yellow dye . dimethicone   (Excipients).

INN Losap Plus: losartan + hydrochlorothiazide.

Product form

Is produced in the form of tablets, which are covered by a white film coating. Tablets are oblong, biconvex. Blisters with tablets 10 pcs. realized in cardboard packs of 30, 60, 90 pcs.

Pharmacological action

Losap H is a antihypertensive drug. Its effect is based on the binding of angiotensin obstacle 2 receptor AT1. As a consequence, there is a series-leveling effects AT2:

• hypertension ;
• release Renin   and aldosterone, vasopressin, catecholamines ;
• development LVH .

Under the influence of medication does not occur blocking angiotensin-converting enzyme, so bradykinin   does not accumulate and impact on kinin system   is performed.

The active metabolite formed during Lozap biotransformation   and having antihypertensive effects   on the body. Therefore, the drug is prodrug .

The drug works on patients equally, regardless of their age, race and gender.

Pharmacodynamics and pharmacokinetics

Losap - hypertensive drug antagonistretseptorov specific angiotensin II. It reduces peripheral vascular resistance, reduces adrenaline   and aldosterone   in blood. Under its influence reduced pressure in the pulmonary circulation develops diuretic effect decreases afterload. Losap prevents hypertrophic myocardium processes, increases exercise tolerance in people suffering from heart failure.

The maximum hypotensive effect after a single use drug observed after 6 hours, then gradually reduced over 24 hours. The systematic treatment of the maximum effect (reduction in blood pressure) occurs in three to six weeks after initiation of therapy.

Keep in mind that people who have cirrhosis of the liver , Significantly increases the concentration of the active substance ( losartan ) In the blood plasma. Therefore, such patients assigned a special, reduced dosage.

Absorption from the gastrointestinal tract of man is fast. Bioavailability is about 33%. After oral administration of the highest concentration present in the plasma after one hour. The highest concentration of the metabolite of the drug observed after 3-4 hours. The half-life of losartan - 2 hours, active metabolite - 9 hours. 35% of the drug excreted in the urine, about 60% - through the intestines.

Indications

Losap applied in the following cases:

• disease hypertension ;
• heart failure, chronic form   (the drug included in the combination therapy is used to treat patients with intolerance to ACE inhibitors, or where indicated ineffectiveness);
• the need to reduce the risk of cardiovascular diseases   (including stroke ) In humans suffering from hypertension and left ventricular hypertrophy;
• development diabetic nephropathy   patients with diabetes   2 diabetes and hypertension.

Indications Losap Plus are the same. However, it has a combined structure, so the indications for use of the drug Losap Plus include conditions with hypertension, that require additional treatment with diuretics.

Contraindications

Contraindications for the treatment of the following:

• intolerance to the components that make up the product;
• hyperkalemia ;
• hypotension ;
• pregnancy   and time Lactation ;
• childhood and adolescence (18 years);
• dehydration .

Side effects

The most common side effects in the treatment of the drug are not marked. With the development of side effects of their nature is transient, so the cancellation of the drug is usually not required. Rarely can be confusing for the following phenomena:

• Functions of the sense organs and the nervous system:   fatigue, headaches, dizziness , Insomnia, fatigue. Less than 1% of cases develop drowsiness, anxiety, memory disorders, depression , Paraesthesia, tremor, hypoesthesia, migraine , Impaired hearing, sight, taste.
• Functions of the respiratory system : Symptoms of upper respiratory tract infections. Less than 1% of the cases develop bronchitis , Dyspnea, rhinitis.
• The functions of the digestive system : Abdominal pain, nausea, diarrhea . Less than 1% of cases there is a dry mouth, gastritis, vomiting, toothache, flatulence . constipation .
• The functions of the locomotor system : Pain in the back, legs, chest; cramps, myalgia. Less than 1% of the cases observed arthritis , Arthralgia, pain in the shoulder, knee.
• Functions of the cardiovascular system : Dose-dependent hypotension, tachycardia   or bradycardia . angina , Arrhythmia, anemia.
• The functions of the genitourinary system : Less than 1% of drug negatively affects the potency observed urinary tract infections, kidney malfunction.
• It is also rarely observed dry skin, sweating, allergic reactions, hyperkalemia.

Instructions for use Lozap (method and dosage)

The drug is taken orally, is not depending on the meal. Tablets need to be taken once a day. Hypertensive patients taking the drug at 50 mg per day. To achieve a noticeable effect, sometimes increase the dose up to 100 mg. How to take Losap in this case, the doctor makes recommendations individually.

Instructions on Losap H stipulates that heart failure patients take the drug for 12, 5 mg 1 time per day. Gradually increasing the dose two times at intervals of one week until until it is 50 mg once a day.

Instructions for use Losap Plus includes receiving one tablet once a day. The largest dose - 2 tablets a day.

If a person simultaneously receives high doses drugs, diuretics Daily dose Lozap reduced to 25 mg.

Elderly and patients with impaired renal function (including those who are on hemodialysis ) Do not need to adjust the dosage.

Overdose

When receiving too high doses in humans may occur tachycardia   or bradycardia And expressed hypotension . Treatment involves removal of the drug from the body and application of symptomatic therapy.

Cooperation

The drug at the same time rifampicin   and fluconazole   It leads to a decrease in content of the active metabolite in the blood plasma.

Note that Losap may enhance the effects of other antihypertensive agents effect: adrenoblkatorov, diuretics, ACEI. Patients with dehydration resulting from treatment with high doses of drugs, diuretics can celebrate after taking Lozap marked reduction in blood pressure.

In the case of simultaneous application of drugs, potassium, potassium-sparing diuretics need to constantly monitor the level of potassium, because of the risk of hyperkalemia.

The hypotensive effect of the drug after ingestion decreases Indomethacin   and other NSAIDs.

Clinically significant interaction with hydrochlorothiazide . digoxin . cimetidine . warfarin . phenobarbital   and erythromycin   not marked.

Terms of sale

The preparation is available in pharmacies by prescription.

Storage conditions

Keep the medication you need in a dry place, protected from direct light. The air temperature must not be above 30 degrees Celsius.

Shelf life

The shelf life of the preparation - 2 years.

Cautions

Cure pressure Losap prescribed with caution for people who have previously received high doses of diuretics.

Before you take the tablets on the pressure, it is necessary to exclude the presence of liver disease. Patients with liver disease should be taking pills for high blood pressure Losap in small doses.

The drug is used with caution in people suffering stenosis of the renal artery only , and bilateral renal artery stenosis .

Under the influence of drugs preserved the ability to manage traffic and interact with complex mechanisms.

Analogs

Match code ATC 4th level:

• Diovan
• Mikardis
• Vasari
• Valz
• Lorista
• Kandesar

The pharmacy offers Lozap counterparts from different manufacturers. The price is unique both lower and higher than the cost of the drug. Patients should be aware that this medicine and its analogues can affect the body in different ways, so if you need to purchase or analogues Losap Losap Plus, be sure to consult with your doctor.

Analogs that contain a similar active substance is drugs Cozaar . prezartan . Centaur . losartan . footmen . lorista . lozarel   and others. The analogues have the same indications for use, different dosage, manufacturer, value.

Losap or Lorista - which is better?

The active ingredient of the drug from Lorista   is the same as that Lozap. Lorista prescribed to patients suffering from hypertension and chronic heart failure. The cost of the drug Lorista lower. If the price of Lozap (30 pcs.) Is about 280 rubles., The cost of 30 tablets of the drug Lorista - 130 rubles. However, you can use the analogue only after consultation with the doctor, and after will be carefully read annotation.

What is different from Losap Losap Plus?

If you want to be treated with this drug it is often the question arises, what is better - or Losap Losap Plus? When choosing a drug should be noted that in the Losap Plus combined losartan and hydrochlorothiazide, which is a diuretic and has diuretic effects on the body. Therefore, these tablets are shown to those patients who require combination therapy.

Synonyms

Losartan.

Babies

Do not set the effectiveness of the impact and safety of the children, so the drug for the treatment of children is not applicable.

With alcohol

You can not drink alcohol at the same time with the treatment drug. Joint use of alcoholic beverages and Lozap increases the body's concentration of active ingredient of the drug, making tablets can cause negative side effects.

During pregnancy and lactation

Losap left untreated during pregnancy. In the treatment in the second and third trimesters of drugs that affect the renin-angiotensin system, may occur defects in fetal development and even his death. Once pregnancy occurs, the drug should be immediately discontinued.

If Losap must be taken during lactation, breast-feeding should be immediately discontinued.

Reviews

Reviews on Losap Plus and Losap indicate that most of the drugs are effective in reducing arterial pressure and have a positive impact on the health of people with diseases of the cardiovascular system. Patients visiting a specialized forum to leave reviews on Losap 50 mg, note that as the side effects are sometimes observed cough, dry mouth, impaired hearing. But in general, the reviews are positive patients about medication. This medical reviews suggest that the drug may not suit all people suffering from hypertension. So initially it should be taken under strict supervision of a specialist.

Price, where to buy

Price Losap pharmacies varies from 230 rubles. (Losap 12.5 mg, 30 pcs.) To 760 rubles (Losap 100 mg, 90 pcs.). The price for 50 mg tablets Losap in Moscow and in other cities is about 270-300 rubles. Sometimes you can buy the drug at a lower price by promotional offers. Price Losap Plus 50 mg (90 tablets) - from 720 rubles.

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