Description overdue on 08/30/2014
- Latin name: Pylobact Neo
- ATC code: A02BD05
- Active substance: Amoxicillin (Amoxicillin), omeprazole (Omeprazole), Clarithromycin (Clarithromycin)
- Manufacturer: Ranbaxy Laboratories Ltd. (India)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Pilobakta Neo (The method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
Composition
Pills Amoxicillin It contains as active substance Amoxicillin in shape trihydrate And auxiliary components such as colloidal anhydrous silica, MCC, polyethylene glycol, sodium starch, magnesium stearate, talc, Parmas, titanium dioxide, a yellow-orange dye.
Capsules Omeprazole They have the active ingredient is omeprazole , Plus the following additional components: non-Parel granules, corn starch, povidone, sodium lauryl sulfate, hydroxypropyl methylcellulose phthalate, titanium dioxide, sucrose, mannitol, talc, hydrogenated sodium orthophosphate anhydrous, diethyl phthalate.
Pills Clarithromycin incorporate such active components as clarithromycin And the following excipients: colloidal anhydrous silica, povidone, magnesium stearate, croscarmellose sodium, hydroxypropyl cellulose, sorbitan, quinoline yellow dye, opakod S-1-27794 black, MCC, talc, stearic acid, hydroxypropyl methylcellulose, propylene glycol, titanium dioxide, vanillin.
Product form
Pilobakt Neo is a combined set, designed for oral use. Clarithromycin and amoxicillin - coated tablets. Omeprazole - Capsules.
Pharmacological action
The drug acts as an antibacterial agent in the Helicobacter pylori .
Pharmacodynamics and pharmacokinetics
Pilobakt Neo - a drug designed to eradication therapy Helicobacter pylori . It is designed for one-week course.
Amoxicillin represents antibiotic Belonging to the semisynthetic penicillins That have bactericidal action . It is due to the fact that the active drug may inhibit the synthesis of bacterial cell walls. Tablets are effective against Helicobacter pylori .
Omeprazole represents proton pump inhibitor . It reduces the secretion of hydrochloric acid in the stomach and helps to block the final step of acid secretion. Because of this reduced level basal and stimulated secretion . Duration of caps - more than a day. They significantly reduce the amount of gastric juice and increase the concentration of other components of the complex Pilobakt Neo in the gastric mucosa, in addition, increase the level of acidity in the stomach and provide optimal conditions for the antimicrobial activity.
Clarithromycin It is macrolide antibiotic Which acts as an antibacterial agent against many microorganisms, including Helicobacter pylori . It inhibits the synthesis of proteins. Resistant to acidic medium in the stomach.
All components of the complex Pilobakt Neo characterized by a good degree of absorption following oral administration.
Amoxicillin rapidly absorbed in the gastrointestinal tract and is not cleaved in acidic medium in the stomach. Take this medication can be relatively free meals. Its maximum concentration in plasma is achieved in 60-120 minutes. The half-life of the drug - about 60-90 minutes. 60% is excreted in the urine in unchanged form. Relationship to plasma proteins - 20%.
Bioavailability Omeprazole - About 40%. The time of its plasma half-life - about half an hour or an hour. The drug has a good connection to plasma proteins. About 80% while excreted through the kidneys as metabolites .
The content of active substance Clarithromycin in body fluids and tissues is many times higher than the concentration in serum. You can take the drug regardless of meals. About 20% is split to form Clarithromycin 14 hydroxyclarithromycin. The time of its half-life - about 6 hours. About 20% of the drug is excreted in the kidneys unchanged and 15% as a 14-hydroxyclarithromycin.
Indications
Combination set Pilobakt Neo taken if necessary eradication therapy Helicobacter pylori in adult patients who have duodenal ulcer and stomach .
Contraindications
The drug can not be used if you are hypersensitive to its components, and other macrolides , and beta-lactam antibiotics . In addition, before the course is necessary to exclude malignancy, as the course Pilobakt Neo may hinder its diagnosis.
This drug also can not be taken at pregnancy . Lactation Children up to 16 years and patients with infectious mononucleosis , Blood dyscrasias and leukemoid tests lymphatic type.
Side effects
Tablets and capsules of the combined set of Pilobakt Neo is usually well tolerated by patients, side effects are easily and quickly.
Undesirable effects while taking Amoxicillin It appears mainly in the form of hives . In addition, in rare cases may occur convulsions . hyperkinesia . dizziness , Nausea, colitis . vomiting . itch . diarrhea . angioedema . Stevens-Johnson syndrome . hives . anaphylactic shock . erythema multiforme . interstitial nephritis . leukopenia . hemolytic anemia . thrombocytopenia . agranulocytosis .
Application Omeprazole can lead to side effects such as vomiting, headache . flatulence . nausea . constipation , abdominal pain, diarrhea . photosensitization . Stevens-Johnson syndrome . itch . alopecia . erythema multiforme Symptoms Arthritis and myalgia , Rash, joint pain, muscle aches, muscle weakness. In rare cases, there is also:
- sleep disturbance ;
- fatigue;
- paresthesia ;
- weakness;
- vertigo ;
- drowsiness ;
- dizziness ;
- hallucinations ;
- agitation ;
- depression ;
- confusion;
- candidiasis Gastrointestinal;
- dry mouth;
- stomatitis ;
- increase in liver enzymes;
- hepatitis ;
- encephalopathy ;
- gynecomastia ;
- pancytopenia ;
- thrombocytopenia ;
- agranulocytosis ;
- leukopenia ;
- reducing the concentration of sodium in the blood;
- blurred vision;
- excessive sweating;
- breach of taste sensations;
- peripheral edema.
Clarithromycin may cause the following side effects:
- CNS : Temporary hearing loss, psychosis , Disorientation, nightmares, anxiety, hallucinations . insomnia . parosmiya . anosmia . dizziness , Taste change, depersonalization, ringing in the ears, vertigo . confusion . dizgevziya . ageusia , Seizures, headache .
- Digestive system : Discoloration of tongue, liver dysfunction, hepatocellular jaundice . cholestatic jaundice . candidiasis oral hepatitis . cholestatic hepatitis . hepatic failure , Discoloration of teeth, stomatitis . acute pancreatitis . pseudomembranous colitis . glossitis , Vomiting, dyspepsia , Abdominal pain, nausea, diarrhea .
- The urinary system : renal failure . interstitial nephritis .
- The immune system Hypersensitivity, anaphylactic reaction.
- CCC : ventricular tachycardia Lengthening QT interval .
- Skin and subcutaneous tissue : Stevens-Johnson syndrome . angioedema before anaphylaxis . hives . skin rash .
- Blood and lymphatic system : thrombocytopenia . leukopenia .
- Metabolism : hypoglycemia .
Instructions for use Pilobakta Neo (The method and dosage)
Instructions on Pilobakt Neo provides its use during the week. One day, it is taken 1 blister, which includes 2 pills amoxicillin, 2 capsules of omeprazole and 2 tablets Clarithromycin.
Instructions for use Pilobakta Neo reports that in the morning should take 1 capsule of omeprazole and amoxicillin and clarithromycin tablet. In the evening, their reception is repeated in the same dosages.
Overdose
At higher doses Amoxicillin you may receive nausea . diarrhea . vomiting and crystalluria . If this happens, you should immediately stop taking the medication. If overdose occurred recently, can cause vomiting. In other cases, prescribe hemodialysis .
Omeprazole at high doses can cause nausea, dizziness . diarrhea . vomiting . abdominal pain . Headache . apathy . confusion . depression . All symptoms are reversible. Treatment is symptomatic.
Clarithromycin may cause an overdose allergy And problems with the gastrointestinal tract. As treatment is prescribed gastric lavage .
Cooperation
Time-life and maintenance Amoxicillin plasma enhanced when combined with Probenecid . Oxyphenbutazone . Sulfinpirazon . Phenylbutazone and Acetylsalicylic acid . Concurrent use with oral contraceptives may cause bleeding and reducing their effectiveness. At the same time, the bactericidal action of amoxicillin neutralized when combined with bacteriostatic drugs, and with Ampicillin increased incidence of skin reactions.
Omeprazole in combination with drugs that are cleaved by enzymes in the liver systems P450 It can increase their concentration. In combination with Clarithromycin this tool can also increase the concentration of both.
Clarithromycin contraindicated for use in conjunction with Cisapride . Terfenadine and Pimozide . Astemizole . Ergotamine . Dihydroergotamine , and benzodiazepines That are metabolized by CYP3A. You may need a dosage adjustment or cancellation of Clarithromycin in combination with potent inducers of enzymes P450 . Ritonavir . When combined with Quinidine or Dizopiramid you may receive ventricular tachycardia So that it is necessary to closely monitor their concentration in the blood serum.
Clarithromycin also increases the concentration of HMG-CoA reductase and potentiate the effect of oral anticoagulants. Furthermore, in conjunction with it may increase the concentration phosphodiesterase inhibitors . Theophylline or Carbamazepine plasma, so they may need adjustment of the dose. Also, in some cases, the dosage should be adjusted when combined with Tolterodine .
FROM Triazolam Clarithromycin may provoke the occurrence of side effects from the CNS. Therefore, their joint application requires careful monitoring specialists. Clarithromycin and other macrolides can inhibit CYP3A and P-glycoprotein. And in combination with Digoxin it can increase its concentration in the blood serum. Thus dosage should be well controlled.
In HIV-infected patients and clarithromycin Zidovudine may reduce the equilibrium concentration in the serum. Reception interval between them should be strictly adhered to. Probably well as bilateral cooperation with Atazanovirom . Saquinavir and Itraconazole .
Terms of sale
The drug is sold strictly on prescription.
Storage conditions
Keep Pilobakt Neo should be dry and out of reach of children. At this temperature should be 25 ° C.
Shelf life
Shelf life - 2 years.
Analogs
Pilobakt AM
Pilobakt
Analogs Pilobakta Neo is not so common. The only widely known is complex preparation Ornistat . However, the components of the Neo Pilobakt a generation later. In addition, it is the Indian drug, and Ornistat - English. So many patients still prefer Ornistat , Despite the fact that its cheaper counterparts.
Reviews of Neo Pilobakt
On Pilobakt Neo reviews of people on the Internet and other sources meet the most different. For example, some say that the drug was ineffective. And someone claims that his action is already noticeable in a few days. In addition, reviews of the Neo Pilobakt rarely report the appearance of any side effects, so that the vehicle is considered safe for use.
Price Pilobakta Neo
Buy Neo Pilobakt possible, mainly in the Ukrainian pharmacies. Although there appears this drug is rare. Price Pilobakt Neo, on average, 150 hryvnia. This tool is considered very affordable compared to their English counterparts. In addition, it should be remembered that this is a complex preparation, so the price Pilobakt Neo is given three drugs at once.
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