Description overdue on 05/12/2014
- Latin name: Emoxipine
- ATC code: C05CX
- Active substance: Metiletilpiridinol (Methylethylpiridinol)
- Manufacturer: Emoksipin: Moscow Endocrine Plant (Russia), Tallinn Pharmaceutical Plant (Estonia); Emoksipin-Belmed: Belmedpreparaty RUE (Belarus)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications emoksipin
- Contraindications
- Side effects
- Instructions for use emoksipin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Reviews
- Price, where to buy
Composition
One vial contains 1 ml of solution, which contains 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride ( emoxipine ) 0, '01 The vials used to enter Emoksipin intramuscularly or intravenously.
Emoksipin 1 Which is used in ophthalmology, has a similar structure of the active substance, only different form of: ampoule replaced by more convenient bottle with dosing at the end that allows you to measure exactly one drop of material for each eye.
Product form
The drug produced in vials with different dosages. Each package contains five ampoules emoksipin a dosage indicated on the package.
Eye drops releasing vial with 5 ml pipette.
Pharmacological action
Emoksipin (INN - Emoxipine) - is angioprotector which reduces the permeability of vascular wall by accelerating free radical processes, as the drug is antioxidant and antihypoxant . Emoksipin reduce the level of blood viscosity, permeability of vascular walls and the tendency of hemorrhage. In addition, the active ingredients of the drug will increase the level of cyclic nucleotides in brain tissues and blood platelets.
Fibrinolytic activity of the drug is that in the case of the acute period heart attack , Reception is able to expand coronary vessels, thereby limiting the growing focus Necrosis . Also, it will be improved and the conductive cardiac contractility.
As an ophthalmic agent Emoksipin has retinoprotektornye properties, it protects the retina from the effects of high-intensity light rays. Drops emoksipin help resolve intraocular hemorrhage and improve microcirculation in the eye.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Positive impact on the blood clotting : By reducing the overall index coagulation and reduce platelet aggregation drug prolongs the time of blood clotting. The membranes of cells and blood vessels under the influence of the drug stabilize erythrocytes increase their resistance hemolysis and potential mechanical injury.
Effective inhibition of free-radical oxidation of lipids contained in the biological membranes. Increasing the activity of enzymes responsible for the antioxidant function. Able to provide lipid-lowering effect by reducing the synthesis of triglyceride.
Admission emoksipin able to reduce symptoms cerebral gemodisfunktsii . It has a positive effect on the stability of the cerebral cortex to the ischemia and hypoxia . Corrects autonomic dysfunction in cases of cerebral circulation.
Emoksipin has a pronounced cardioprotective effect. Cardiovascular system will be protected in the event of ischemic myocardial injury : Drug blocks its spread is also expanding coronary vessels.
As eye drops Emoksipin protects the retina from potential damage due to exposure to high-intensity light beams. In addition, due to possible drug resorption of hemorrhages within the eye.
Pharmacokinetics
In the case of intravenous administration dose of 10 mg per 1 kg weight of the patient, there is a very low figure elimination half-life of the drug . Constant elimination - 0, 041 minutes; apparent volume of distribution - 5, 2 L; total clearance rate - 214 8 ml per minute.
The drug quickly into the organs and tissues of the human body and it is its metabolism .
Pharmacokinetics emoksipin may vary depending on the patient's condition. For example, in the case of a pathological condition coronary occlusion It will be reduced the rate at which the drug is output, whereby it becomes more bioavailable.
In the case of optic emoksipin administration, the active ingredients of the drug almost immediately appear in the blood, a consistently high level is maintained for two hours, and 24 hours after receiving a trace of reception virtually non-existent in the blood. A certain concentration of the drug is retained in the ocular tissues.
Indications emoksipin
As eyedrops indications for use are:
- intraocular hemorrhage ;
- thrombosis in the central retinal vein and its branches;
- glaucoma ;
- protection of the retina after photocoagulation and a high intensity light (in case of solar and laser burns).
Indications injections emoksipin :
- diabetic retinopathy ;
- complicated myopathy ;
- central chorioretinal dystrophy.
Also injections emoksipin apply in the case of chronic and acute circulatory disorders of the brain If the cause of these disorders become hemorrhagic and ischemic disorders. If necessary, the drug can be administered as an intramuscular injection, and intravenous injection as in ampoules.
Contraindications
The use of this drug is contraindicated during pregnancy and in the case of individual hypersensitivity to one of the components.
Side effects
As side reactions may occur excitation That after a short time period will change sleepiness . Maybe increased blood pressure and the emergence of rash . Local reactions may occur with pain, itching, burning sensation, redness and seal paraorbital tissues.
Instructions for use emoksipin (method and dosage)
Instructions on Emoksipin - Eye Drops
In the case of retrobulbar introduction of the drug - one percent solution at a dose of 0, 5 ml of lead 1 times a day for 10-15 days. If the medication is administered subconjunctivally and parabulbarly, then 1 is administered once a day from 0, 2 to 0, 5 ml of the drug over 10-30 days.
If necessary, protection of the retina, the drug is administered retrobulbarly in a dosage of 0, 5 ml per day, and one hour before the laser treatment. The course depends on the degree burns received during lazerokoagulyatsii, in most cases, used retrobulbarno drops once a day for two to ten days.
Instructions on Emoksipin - injection
In cardiology and neurology drug mainly used intravenously with a dropper at a rate of 20-40 drops per minute. The dose is 20-30 ml three percent solution. Drippers can bet from one to three times a day for 5-15 days. The duration of treatment depends on the type of disease to the patient. Upon completion droppers move on intramuscular injections of the drug: inputting 3-5 ml of 3% solution 2-3 times a day. The course of intramuscular administration of 10 to 30 days.
Emoksipin not let in tablet form Because you can not take pills emoksipin, because they simply do not exist.
Overdose
In case of overdose or drug may cause increased side effects. With an overdose of the drug or its analogs, may rise arterial pressure It appears excessive agitation or drowsiness , Pain in the heart region, headache, nausea Discomfort in the abdomen. Perhaps disturbed blood clotting.
Treatment of overdose emoksipin and analogues emoksipin is the abolition of the preparation and carrying out of procedures symptomatic therapy if necessary.
Cooperation
In the case of using together with α-tocopherol acetate Perhaps a more active display of the antioxidant properties of emoksipin. In general, the drug is not recommended to be combined with the use of any other drugs without authorization, by the attending physician.
Terms of sale
Terms of sale of the drug are not limited.
Storage conditions
Store this medication must be in a dark place at a temperature not exceeding 25 degrees Celsius.
Shelf life
3 years from the date of issue.
Reviews
Emoksipin - is a highly effective modern tool. His only drawback - it is a strong local irritation during use. People faced with a serious eye disease, left very positive feedback about emoksipin because they strictly follow the doctor's instructions and because of the seriousness of the problem is clearly aware of the need for treatment. If the drug is used for treatment of minor ophthalmological disorders, while reviews of the drops are not as positive: the fact that not everyone is willing to put up with the discomfort of burning time after ingestion.
Doctors about Eye drops - Only positive. The drug copes with its task, though it causes temporary discomfort for patients.
Injections emoksipin effectively counteract the effects of strokes and heart attacks have a lot of patients worldwide. Also, the drug helps in the short term to reduce the various manifestations of neurological disorders. Logically, such a positive experience in the application is displayed in the positive feedback, both from patients and from physicians.
Price emoksipin where to buy
You can without any problems buy in Kiev Emoksipin: drug or its analogues can be found in virtually every pharmacy. That's just the cost can vary slightly depending on the pharmacy, however, almost all the eye drops in Ukraine, and other products vary in price. It depends not only on the margin drug pharmacy, but also from the place of manufacture, batch release, etc.
Average price eye drops Emoksipin 1% in 5 ml vial on the market varies around 60 USD. Pack of five vials 1 ml of one percent emoksipin №10 will cost the pharmacy about 50 USD.
No comments:
Post a Comment