Description overdue on 06/20/2014
- Latin name: Infanrix
- ATC code: J07CA02
- Active substance: A vaccine for the prevention of diphtheria, pertussis and tetanus (Vaccine diphtheria, pertussis and tetanus)
- Manufacturer: Bayolodzhikalz GlaxoSmithKline SA, Belgium.
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Infanrix vaccine (one dose - 0 5 mL) is composed of not less than 40 IU tetanus toxoid . pertussis toxoid (25 micrograms) filamentous hemagglutinin (25 micrograms) pertactin (8 mg).
Also in the vaccine have further substances: sodium chloride, the preservative 2-phenoxyethanol, aluminum hydroxide, water.
Product form
Manufacturers produce a vaccine in the form of a slurry that is injected intramuscularly. One dose (0, 5 mL) fit into the syringe 1, 0. The package may contain one syringe 10 or syringe. The kit also includes a corresponding number of needles. Also implemented in vials 3, 0. package may contain 1, 10, 50, 100 vials.
Pharmacological action
Infanrix - a combined trivalent vaccine is a purified, action against pertussis . Diphtheria , and Tetanus . Vaccination has Infanrix as the basis of a mixture of three antigens pertussis, purified.
The drug is sorbed aluminum hydroxide , It is produced for the purified water and as a preservative in the composition includes 2-phenoxyethanol.
If the drug is administered to the patient by a well-defined scheme, as a result the person has specific immune protection against these diseases.
Efficacy of vaccination with approximately 88%.
When the primary vaccination (three doses in the first six months of a child's life) in one month in 99% of children's titles antibodies to the diphtheria and tetanus toxoids are equal to & gt; 0, 1 IU / ml.
Secondary immunity to pertussis vaccine antigens is seen in 95% of children who have been immunized.
After the booster at the second year of life of children who have received primary immunization, titers of antibodies to diphtheria and tetanus toxoid are & gt; 0, 1 IU / ml.
Secondary immunity antigens Pertussis vaccine is seen in 95% of children who have been revaccination.
Increase in body temperature, anxiety, appearance infiltrate seen after injection is relatively rare.
Pharmacodynamics and pharmacokinetics
No data on the pharmacokinetics and pharmacodynamics of the vaccine.
Indications
Indications for use - prevention in children . Tetanus and Diphtheria . The drug is used to primary vaccination children after the age of three against pertussis, tetanus and diphtheria.
It is also used for the purpose of re-vaccination of children had previously received three doses DTP .
Contraindications
Do not use the vaccine in the following cases:
- When serious complications, which appeared as a result of previous vaccination doses of Infanrix.
- With high sensitivity to component.
- With encephalopathy Which has developed over one week after the administration of previous vaccination with pertussis means. In this situation, the vaccination is recommended to continue the course with diphtheria-tetanus vaccines That is, preparation without pertussis component.
- With anemia If the analysis of the blood observed indicators Hemoglobin less than 80 g / l. In such a situation before getting vaccinated, you should increase the amount of hemoglobin.
- The caution is used for people with vaccination coagulopathy . thrombocytopenia . febrile convulsions history.
Side effects
As a result of extensive research was marked by a low reactogenicity of the vaccine compared with the whole-cell DTP vaccines .
hives . angioedema . rash . In very rare cases, may occur convulsions . collapse . shock-like state . All of the above adverse reactions were fast and did not lead to serious negative consequences.
In addition, drug observed after vaccination dermatitis . otitis media . respiratory tract infections .
During the Infanrix booster following primary vaccination in patients recorded these side effects: respiratory tract infections . cough . bronchitis . rhinitis . pharyngitis . respiratory disorders . otitis media .
During the re-vaccination after primary immunization whole-cell DTP vaccine in patients fixed such side effects: otitis media . bronchitis . pharyngitis . cough As well as other respiratory tract infections.
Sometimes children who had been immunized Infanrix, during the first two days after inoculation manifested general malaise That is accompanied by fever, weakness. Also available are local manifestations (pain, swelling, redness at the site where the vaccine was introduced).
If side effects occur when using the whole-cell DTP vaccine, you should gently apply Infanrix. Yet it is - not a contraindication for the use of Infanrix.
Instructions for use (method and dosage)
Instructions for use of the drug as follows: inserted deep intramuscular injection, during the course of vaccination injection site tools need to be alternated. Contraindicated administered subcutaneously and intravenously means.
A single dose - 0, 5 ml. A full course of vaccination includes 4 inoculation.
If the primary immunization of children from three months of life using the following scheme: the drug is administered in 3-4 months, then in 5-6 months.
Infanrix vaccine used for revaccination in 1, 5 years old children who have not received three doses of whole-cell DTP or acellular vaccine.
Before you make an injection syringe or vial is shaken until it does not form a homogeneous mass. Before vaccination specialist must ensure that the appearance of the vaccine has not changed, that it has no impurities that would indicate unsuitability for use of the drug.
If not marked on the bottle, its integrity has been compromised or medication improperly stored, you can not use it. It is unacceptable store opened vials.
With the introduction of the vaccine is required to check the vaccination carried out on the appropriate form.
Overdose
Overdose No data.
Cooperation
Infanrix should not be administered on the same day, when the introduction of other manufactured Inactivated vaccines Which are listed in the calendar of preventive vaccinations, as well as vaccines, which are held on epidemic indications.
Acceptable mixing and Infanrix Hiberiksa . If you want to hold such a combination, instead of the solvent, which is attached to the drug Hiberiks applied Infanrix vaccine.
Terms of sale
Tool sold only by prescription.
Storage conditions
Store must be at a temperature of 2-8 degrees Celsius. The drug should not be frozen. When transporting means you need to carefully follow the same temperature conditions. Opened vaccine vial can not be stored.
Shelf life
Infanrix Shelf life - 3 years.
Cautions
Vaccination is only allowed after a medical examination of the child, the study of its history. The specialist should inquire about adverse reactions during the previous administration of the vaccine.
Defer carrying out vaccination should be in the case if the child suffers from an acute illness in which the temperature rises. If there is a mild form of infectious disease and the body temperature normal, vaccination is carried out.
Care is necessary to conduct ongoing monitoring for half an hour after the vaccination.
thrombocytopenia and bleeding disorders , Infanrix used with caution.
It is possible to vaccinate people with HIV infection .
If a person passes immunosuppressive treatment or has been diagnosed immunodeficiency
After the injection, it is desirable to press down on the place where an injection was made in order to prevent bleeding. Rub this place is not necessary.
It should not be administered with pertussis vaccine for children who suffer from progressive neurological disorders, uncontrolled epilepsy , Progressive encephalopathy. Apply the vaccine is possible only after permission of the doctor in each case.
Infanrix vaccination shall also be prematurely born children and children with respiratory Distress Syndrome But during the injection should be the fate of the likelihood of apnea these children, so you need to keep track of their respiratory function for 3-3 days after vaccination.
Infanrix If stored properly, the suspension is sometimes divided into white precipitate and the clear liquid. Such a vaccine is suitable for use.
You can not enter a drug that has previously been frozen. It is strictly forbidden to enter the vehicle intravenously.
On the mental and motor reactions Infanrix is not affected.
Analogs
Infanrix hexa
Analogues of a vaccine for the active substance is DTP vaccine . . Infanrix hexa .
Is it better or Infanrix hexa Infanrix?
Infanrix hexa - a comprehensive vaccine with which the human immune system is formed not only against Tetanus . Diphtheria and pertussis But also protection against Hepatitis B . Polio And infection, which is caused by Haemophilus influenzae type B . What is the vaccine should be used in each case - Infanrix, Infanrix hexa or another - defines a doctor. Can I apply if Infanrix after Infanrix hexa, as determined by a specialist.
Which is better: DTP or Infanrix?
To determine which vaccine is best suited for a child - or DTP Pentaxim or Infanrix should know about the properties of these drugs. DTP - a whole-cell vehicle, which contains tetanus and diphtheria toxoids, pertussis dead cells. So after a DPT often develop reactions to the vaccine. Besides DTP not used for children older than four years, whereas no such restriction Infanrix. However, when discussing vaccination with DTP or Infanrix, Komorowski and other pediatricians say the high quality of both vaccines.
Is it better or Infanrix Pentaxim?
Often gets a choice to parents that opt for vaccination - Pentaxim or Infanrix. Reviews about which vaccine is best, do not always allow adequate conclusions. Both drugs are safe acellular vaccine containing only fragments of antigens diseases. However, it also has Pentaxim composed dead genes polio.
Comparing Infanrix vaccination or Pentaxim, Komorowski focuses on what Pentaxim contains five components, that is opposed to another, and diseases that are caused by Hib and polio. However, the vaccine Infanrix tolerated by the body more easily, as the reaction to it is developing very rare.
Babies
Infanrix is used for vaccination from the sixth week of life.
During pregnancy and lactation
Reviews of Infanrix
Responses to the vaccine Infanrix the Internet, usually positive. Parents rarely celebrate the manifestation of certain side effects, such as a short rise in temperature, lethargy child, local reactions. Also positive are the doctors and reviews about the vaccine, which indicate its good tolerability and efficacy.
The price of the vaccine Infanrix averages from 700 to 1000 rubles. Buy Infanrix in Moscow can be online pharmacies, but the vaccine can often be purchased in the medical establishments where vaccination is carried out.
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