Description overdue on 06/18/2014
- Latin name: Chlorprothixen
- ATC code: N05AF03
- Active substance: Chlorprothixene (Chlorprothixene)
- Manufacturer: Zentiva k.s (Czech Republic)
- Composition
- Product form
- Pharmacological action
- Indications chlorprothixene
- Pharmacodynamics and pharmacokinetics
- Contraindications
- Side effects
- Instructions for use chlorprothixene (Method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As part of a single tablet chlorprothixene contains 15 or 50 mg hydrochloride (depending on the form issue).
Excipients: lactose monohydrate . calcium stearate , Corn starch, talc, saccharose .
The composition of the shell of the tablets: Valium . macrogol , Opaspray M-1-1-6181, talc.
Product form
Pills Coated in blisters 10 pcs. The carton pack contains three blisters.
There is also an option drops and solution was for injections in ampoules at 2ml (50mg) in packages of 10 or 100 vials.
Pharmacological action
The drug is antipsychotic means ( neuroleptic ) That occurs due to the fact that dopamine receptors it has a blocking effect. By blocking these receptors, the drug has also analgesic and antiemetic action.
In addition, chlorprothixene has antihistamine and hypotensive acts by blocking α1-adrenergic receptors . 5-HT2-receptors , and H1-histamine receptors .
Indications chlorprothixene
Chlorprothixene - a sedative anxiolytic Having a wide range of indications, which include:
- hangover abstinence symptom Occurring when drug and alcohol abuse;
- psychoses , Including mania and schizophrenia That occur with anxiety, agitation and agitation;
- behavioral disorders in children;
- insomnia ;
- excitation of, hyperactivity, irritability, sputannosti of consciousness y people of old age;
- Pain (drug used in conjunction with analgesics ).
Pharmacodynamics and pharmacokinetics
When oral bioavailability chlorprothixene is approximately 12%. Because intestinal drug is rapidly absorbed, and after 2 hours reached maximum serum concentration of the drug.
Poluvydeleniya period from the body is about 16 hours. The drug penetrates placenta and a small amount excreted in breast milk. Antipsychotic activity metabolites They have no secretion occurs in the urine and feces.
Contraindications
The drug is contraindicated in:
- any depression of the central nervous system, including the oppression caused by the intake opiates . alcohol or barbiturates ;
- vascular collapse;
- comatose states ;
- pheochromocytoma ;
- diseases of the blood-forming organs;
- increased sensitivity to the presence in the chlorprothixene components.
Side effects
For the digestive system: there may be a psychomotor inhibition, fatigue, ill-defined extrapyramidal syndrome . dizziness . In some cases, it may be a significant increase in anxiety, which manifests itself most frequently in schizophrenics or patients with mania.
For the cardiovascular system: possible orthostatic hypotension , ECG changes, tachycardia .
For the digestive system: there is a probability of occurrence cholestatic jaundice .
For the hematopoietic system: possible leukocytosis . hemolytic anemia . agranulocytosis . leukopenia .
For the organs of vision: you may receive the clouding of the lens and cornea, followed by blurred vision.
For the exchange of of substances: It can disrupt the carbohydrate metabolism, increased sweating, weight gain and appetite.
For the endocrine system: amenorrhea . gynecomastia . galactorrhea , Weakening of libido and potency.
Dermatological reactions: you may receive photodermatitis . photosensitization .
The effects caused by anticholinergic action: accommodation disturbances, constipation . dysuria , Dryness in a mouth.
Instructions for use chlorprothixene (method and dosage)
If hangover withdrawal syndrome caused by alcoholism or drug addiction
The daily dose in tablets of 500mg and is divided into 2-3 doses. Generally, treatment continues for 7 days. When the withdrawal symptoms disappear gradually reduce the dose. The daily maintenance dose of 15-45mg is equal, it is enough to reduce the risk of another binge and stabilize the patient's condition.
During psychosis, including schizophrenia and manic states
Treatment begins with a daily dose in 50-100mg, dosage gradually increases until not will be achieved optimum effect, as a rule, till 300mg. For individual cases, the dosage should be increased to 1200mg per day. The daily maintenance dose is about 100-200mg. As a rule, the daily dose is divided into two or three doses, it is recommended to use a smaller dose in the daytime and in the evening - much of that is due to sedating drug.
If nervousness, depression and psychosomatic disorders
Alone or as an adjunct to therapy using antidepressants, the drug is used for depression, especially in such conditions, which are combined with anxiety. When psychosomatic disorders that are accompanied by depressive disorders and anxiety, as well as in the neuroses can be assigned to a daily dose of 90mg. Typically, the daily dose is divided into several stages. Given the absence of the drug, depending on the formulation or development of habituation to it, can be quite a long time without much risk to take chlorprothixene.
Instructions for use for insomnia
An hour before sleep takes 15-30 mg of the drug.
When the pain
The drug can potentiate the analgesic action, therefore can be used to treat patients suffering from pain. In such cases, the drug is administered together with analgesics , The dosage is 15-300mg.
Overdose
In the case of an overdose the following symptoms may occur: Hyper - Or hypothermia . convulsions , Extrapyramidal symptoms, drowsiness , Shock or coma.
In case of overdose Hlorprotiksenom made supportive and symptomatic treatment. As soon as possible to do a gastric lavage is also recommended intake sorbent . It requires to take measures, which are directed at maintaining of activity of cardiovascular and respiratory systems. Do not use adrenaline Because it may cause a lowering of blood pressure. Extrapyramidal disorders can be arrest biperidenom and convulsions - diazepam.
Cooperation
Simultaneous treatment with the drug ethanol or preparations containing ethanol, as well as anesthetics . hypnotics . sedatives , Neuroleptic and opioid analgesics may enhance the inhibitory effect chlorprothixene the central nervous system.
The drug enhances the effect of a redstv hypotensive action .
At simultaneous reception with chlorprothixene adrenaline may occur tachycardia and hypotension .
The drug lowers the threshold for seizure activity, so patients epilepsy require additional correction dose antiepileptic drugs.
Simultaneous treatment with the drug Haloperidol . Metoclopramide . Reserpine or phenothiazines may cause extrapyramidal disorders.
Property chlorprothixene blocking dopamine receptors, also reduces the effectiveness of the drug Levodopa .
Terms of sale
The preparation is available in pharmacies by prescription.
Storage conditions
Keep the medication chlorprothixene should be in a cool place with an ambient temperature of not more than 25 ° C and the absence of light.
Shelf life
The drug is stored for 2 years.
Cautions
Precautions should be prescribed the drug chlorprothixene patients who suffer Parkinson . epilepsy In the case of dispositions to collapse, with severe respiratory and cardiovascular disease, diabetes Expressed violations kidney and liver, prostate hypertrophy, expressed cerebrovascular .
The drug may cause a false positive result for immunobiological pregnancy test using urine, changes in QT intervals on the ECG, as well as an erroneous increase in the blood level bilirubin .
The drug has a negative impact on the activity that is associated with a high rate of physical and mental reactions - control vehicles, working at height, maintenance of machines and so on.
When treating Hlorprotiksenom advised to avoid high sunlight exposure ( insolation ).
Analogs chlorprothixene
Klopiksol
Truksal
Chlorprothixene 15 Lechiva . Chlorprothixene 50 Lechiva . Truskal .
Synonyms
Tarazan . Chlorprothixene hydrochloride . Vetakalm . Minitiksen . Taktaran . Trux . Hlotiksen . Triktal . Taraktan . Truksal .
Babies
For the correction of behavioral disorders in children drug prescribed rate of 0, 5-2mg per kilogram body weight of the child.
With alcohol
It is recommended to give up the consumption of alcoholic beverages during the course of treatment.
During pregnancy and lactation
If possible, chlorprothixene should not be administered for the treatment during pregnancy and lactation.
Reviews Hlorprotiksene
Judging by the reviews of Hlorprotiksene forums, it is a great hypnotic . As for his actions when psychosis , Then here opinions diverge - some consider, that the drug (of manufacture of company Zentiva) excellent relieves psychoses, while others (which the majority of) believe, that for these purposes the drug weakly is suitable. In general, the opinions of those who spoke, from which tablets chlorprothixene, boiled down to the fact that it is the perfect sleeping pill that helps in psychosis.
Among the negative reviews can be identified drowsiness Which occurs after taking the drug and a small retardation. Some appear much anxiety caused by hallucinations . But with the greatest number of comments - positive.
Doctors about Hlorprotiksene boil down to the fact that this is a good neuroleptic, but with strict indications. The drug should not be taken together with alcohol and must strictly abide by the dosage.
Price chlorprothixene where to buy
The cost of 30 tablets of 15mg chlorprothixene starts from 135r.
Buy in Moscow on 30 tablets of 50mg chlorprothixene can be from 219 to 271r per pack.
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