Description overdue on 05/16/2014
- Latin name: Fluimucil
- ATC code: R05CB01
- Active substance: Acetylcysteine (Acetylcysteine)
- Manufacturer: Zambon, Switzerland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Fluimucil (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 tablet It contains acetylcysteine 600 mg additional substances: sodium bicarbonate, citric acid, lemon flavoring, Aspartame .
1 packet of granules It contains acetylcysteine 200 mg Excipients: beta-carotene . Aspartame , Sorbitol, orange flavor.
1 ml solution for injections and inhalations It contains 100 mg of acetylcysteine , 1 vial - 300 mg acetylcysteine , Additional substances: sodium hydroxide, disodium edetate and water.
Product form
Pills effervescent, soluble in water, and two blisters 10 pcs.
Granules in multilayer packages to dissolve in water and of a solution.
The solution in dark glass vials 3 ml.
Pharmacological action
It has a mucolytic effect. Acetylcysteine It breaks the disulfide bonds in mucopolysaccharides sputum, thereby facilitating its dissolution and separation. Even in case of purulent sputum maintains its effectiveness.
The drug inhibits the adhesion of bacteria to the epithelium of the bronchial mucosa and stimulates the cells that synthesize substances cleaving fibrin strands. The same effect acetylcysteine It has on the secret of mucous upper respiratory tract.
The product provides Antioxidant effect has cytoprotective action and neutralize toxins.
Acetylcysteine anti-inflammatory effect due to the property to suppress the formation of free radicals responsible for the development of inflammation in the lung tissue.
Pharmacodynamics and pharmacokinetics
After the maximum concentration of the drug in the blood occurs within 1-3 hours. Bioavailability is about 10%. It penetrates into the lungs, bronchial secretion, liver and kidneys; through the placenta.
Excreted in the urine, elimination half-life - 1 hour, cirrhosis is 8 hours.
Indications
- difficulty in expectoration in the pathology of the respiratory system ( laryngotracheitis , Tracheitis, bronchitis . pneumonia , Bronchiolitis, a lung abscess, emphysema, cystic fibrosis, bronchiectasis, atelectasis, which is caused by obstruction of the bronchi of the mucous plug);
- otitis . sinusitis (catarrhal and purulent);
- facilitating separation of viscous secretion from respiratory organs (post-traumatic and post-operative states);
- rinsing the nasal passages, middle ear, sinuses, abscesses, fistulas, the treatment areas of intervention during operations on the mastoid or the nasal cavity;
- Preparation for aspiration drainage, bronhografii, bronchoscopy.
Contraindications
- aggravation of gastric ulcer and duodenal ulcer;
- idiosyncrasy acetylcysteine ;
- lactation;
- to granules - Children up to two years;
- to effervescent tablets - Children and adolescents under 18 years.
Reception of a solution prepared from granules Children under 2 years of age is permitted under the supervision of a physician for health reasons.
In gastric ulcer, hemoptysis, asthma , Hypertension, pulmonary hemorrhage, phenylketonuria , Kidney and liver failure, varicose veins of the esophagus are used carefully.
Intravenous administration of the drug to children under 1 year of exercise for health reasons, under the supervision of a physician.
Side effects
Digestive System : Nausea, vomiting, heartburn, heaviness in the stomach, diarrhea .
Allergic reactions : There are cases bronchospasm . hives , Itchy skin.
Other symptoms may be very rare: tinnitus, nasal bleeding, collapse.
In the case of a Aerosol : Irritant effect on the respiratory tract, cough reflex character, rhinorrhea, rarely - bronchospasm.
Intramuscular administration may cause hives, burning at the injection site, in the case of long-term use - abnormalities in the kidneys and liver.
Instructions for use Fluimucil (method and dosage)
For adult use inside effervescent tablets - 1 tablet (600 mg) once a day, after dissolving in a third of a glass with water.
Granules used for both adults and children, is soluble in water (one-third cup).
Dosage:
- Children older than 6 years and adults - 600 mg per day in 3 divided doses;
- for children 2 - 6 years prescribed 200 mg twice a day;
- 1 - 2 years - 100 mg twice daily.
For newborns drug use under the supervision of a specialist for health reasons, following the dose of 10 mg / kg body weight of the child. Children in the first year of life, give drink syrup from the spoon or bottle.
The course of treatment is on average in the acute course - 5-10 days, chronic - a few months.
In physiotherapy for inhalation using a 10% solution in an amount of 3-9 ml. The duration of inhalation 20 min, 2 to 4 times per day.
In the case of using the drug in bronchoscopy for therapeutic purposes, is used for washing ampoules 1-2 bronchi.
The external auditory meatus is instilled in a dose up to 300 mg per once.
For use in rhinitis There is a special form - nose drops.
When administered intravenously (bolus or slow infusion) or intramuscular dose was determined as follows:
- adults - 300 mg 2 times a day;
- children 6-14 years 150 mg 2 p / day;
- children up to 6 years - a rate of 10 mg / kg.
Children under the age of 1 year acetylcysteine is administered in a hospital for health reasons.
The duration of treatment depends on the patient's condition.
In the case of cough for children under 6 years of age should be given preference for oral administration.
For intravenous administration of the preparation is diluted 0, 9% NaCl solution in equal amounts. The duration of treatment in the case of intravenous administration, must not exceed 10 days.
In elderly patients, the instruction in Fluimucil points to the need to apply the minimum effective dose.
Overdose
Taking the drug in an amount of 0, 5 c. per kg per day does not cause overdose.
Cooperation
Joint reception with a cough medicine that suppress the cough reflex, contribute to the stagnation of phlegm.
The use of tetracyclines (except doxycycline), amphotericin and ampicillin reduces the effect of both antibiotics And acetylcysteine Therefore the interval between the administration of these groups of drugs should not be less than 2 hours.
Antiplatelet and vasodilatory effect nitroglycerin is enhanced by concomitantly with Fluimutsilom.
Acetylcysteine It can reduce the toxic effect paracetamol liver.
With other medicinal solutions compatible pharmaceutically.
Terms of sale
OTC - pills and granules .
Prescription - solution .
Storage conditions
Away from children, storage temperature not exceeding 25 ° C.
Shelf life
3 years - pills and granules .
5 years - solution .
Cautions
Fluimucil prescribed to patients with asthma and obstructive bronchitis with caution and under constant control of patency of the bronchi.
Not recommended to be used in patients with phenylketonuria Because the drug contains Aspartame .
To dissolve only use glass containers and avoid contact with rubber and metal surfaces.
Sulfur smell arising when opening the package with the granules, a conventional odor peculiar active substance.
Analogs
Ambroxol
Fluifort
Flavamed
Ambrogeksal
ACC
Atsistein
Mucosolvan
Bromhexine
ACC . Wicks-asset ekspektomed
Fluimucil or ACC - which is better?
Both formulations contained the same active ingredient. Manufacturer and differ only in price, and even then only slightly. For example, bags 6 ACC dose of 600 mg cost 127 rubles. And Fluimucil - 10 tab. 174 rubles. So, what drug to choose for themselves to decide the buyer.
Babies
Apply on the testimony according to the instructions on the drug.
During pregnancy and lactation
If you need to use a medicine when pregnancy You need to weigh the benefits to the mother and the risk to the fetus.
During the period of lactation when the need for use of the drug-feeding should be discontinued.
Reviews Fluimutsile
Fluimucil quite popular for use cough. Numerous reviews tend to be positive. There have been good results of cough - Fluimucil quite effective in both adults and children. The forums at the request of the young mothers recommend a good cough syrup Fluimucil many recall exactly. Perhaps the only drawback of the drug is the formation of large amounts of phlegm.
Also, nasal drops are popular - a lot of positive feedback for use in the case of rhinitis.
Price Fluimucil where to buy
In Russia, the average price of tablets Fluimucil is 200 rubles. In Moscow, pack of 10 tablets of 600 mg dose is 174 rubles., And granules can be bought for 186 rubles. 20 packages.
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