Description overdue on 14/10/2014
- Latin name: Valacyclovir
- ATC code: J05AB11
- Active substance: Valacyclovir (Valaciclovir)
- Manufacturer: Ltd. Technology of medicines, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use of valaciclovir (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As part of a single tablet is 556 mg valacyclovir hydrochloride (500 mg, based on valacyclovir ).
Product form
Tablets are film coated, in cardboard packs or glass jars for 10 pieces.
Pharmacological action
Antiviral .
Pharmacodynamics and pharmacokinetics
Active substance means depresses livelihoods DNA polymerase Virus Herpes It does not provide synthesized viral DNA and inhibits processes Replication .
After entering the body, valacyclovir transformed into acyclovir and L-valine Then reactions occur phosphorylation and acyclovir turns into acyclovir triphosphate . The resulting compound is able to inhibit DNA polymerase malware agent (virus) on competitive mechanisms.
Phosphorylation occurs generally in two steps. The first reaction is catalyzed by the enzyme thymidine kinase . The drug is particularly active in relation to the Herpes simplex To Varicella zoster it is less sensitive. Displayed substance kidneys or in feces, the half-life of about three hours.
Indications
The medicine is prescribed:
- for the treatment of diseases of the mucous membranes and skin, are caused by a virus Herpes simplex ;
- for the prevention of recurrence of disease caused by the same virus;
- at shingles ;
- as prophylaxis cytomegalovirus infection after Organ Transplantation .
Contraindications
The tool is contraindicated:
- bone marrow transplantation and kidney;
- at allergies to the active substance;
- HIV-infected If CD4 + lymphocytes does not exceed 100 mg / l;
- Children up to 18 years (exception - organ transplants, while drug use at age 12).
Side effects
The drug was well researched. As a result, laboratory studies and observations of patients with Shingles and herpes virus (including concomitant immunocompromised ) Accepted valacyclovir It has been identified almost all possible side reactions.
FEATURES:
- nausea, pain epigastric region, vomiting, anorexia and diarrhea , Elevated liver enzymes, hepatitis ;
- abnormalities in the kidneys, photosensitivity , Shortness of breath, thrombocytopenia ;
- headaches, dizziness, . hallucinations . depression . agitation . ataxia . psychosis . ataxophemia , Impaired consciousness and coma ;
- rash, itching, anaphylaxis . hives . angioedema ;
- neutropenia . aplastic anemia . vasculitis . thrombocytopenia ;
- nasopharyngitis . swelling of the face . tachycardia , Increasing Blood Pressure , Fatigue;
- rhinorrhea . fever and dehydration .
Instructions for use of valaciclovir (method and dosage)
Means taken orally without regard to meals.
Valacyclovir Tablets, instructions for use
When shingles single dosage of 1000 mg (2 tablets) 3 times daily. The course of treatment - 7 days. The sooner after onset of symptoms began receiving funds, the more effective the treatment will be.
Herpes (including the prophylactic) daily dose - 1000 mg. It is recommended to be divided into 2 doses, morning and evening, one tablet. Duration of treatment - from 5 to 10 days (severity of disease).
If the patient has irregularities in the kidneys, the dose should be adjusted.
Overdose
There is no evidence of drug overdose.
Cooperation
No clinically significant interactions between tablets with other agents was not observed.
However, the active substance is excreted through the kidney by kanaltsievoy secretion . Any medicines that will be appointed at the same time Valacyclovir, would interfere with its normal excretion from the body. This primarily refers to cimetidine and other drugs that block the secretion mechanism kanaltsievoy.
When combined with mycophenolate Concentration acyclovir in the blood plasma increases.
When combined with funds cyclosporine . tacrolimus and drugs that disrupt the normal functioning of kidneys, the load on these organs increases.
Terms of sale
We need a recipe.
Storage conditions
In a cool place at a temperature no higher than 25 degrees.
Shelf life
2 years.
Cautions
When violations of the kidneys to use the drug should be with caution. Perhaps the development of Acute renal failure , Disorders of the central nervous system.
For elderly patients dose adjustment is required, however, should increase fluid intake.
During treatment Genital herpes It is to abstain from sexual intercourse, since the drug does not protect against transmission of the virus to the partner.
In the treatment of patients with liver disease should be careful.
No clinical experience of the use of funds for children up to 12 years in connection with this medication is not prescribed for children.
If the patient had a bone marrow transplant, or kidneys, detected clinically severe form HIV infection Manifested acute immunodeficiency Then the drug can lead to thrombocytopenic purpura . hemolytic uremic syndrome and death.
If during treatment means observed hallucinations, seizures, agitation, confusion and delirium The drug should be discontinued.
Analogs of valacyclovir
Famvir
Ribavirin
Valtrex
The closest analogues: Waiora, Canon Valaciclovir, Valacyclovir Hydrochloride, Valogard, Valtsikon, Virdel, Valavir, Valvira, Valtrex, Vatsireks .
What is better - or Valacyclovir Valtrex?
Valtrex - import analogue with the same active ingredient. On the effectiveness and frequency of side reactions of drugs are identical. However, the cost is much higher than Valtrex Valacyclovir.
During pregnancy and lactation
Studies that proved harmless means for pregnant and lactating women, almost none. In this regard, the doctor has to prescribe a drug.
Valacyclovir (a metabolite of acyclovir) well into the breast milk.
During studies in rats and rabbits, when receiving means is not provided teratogenicity exposure did not cause Fertility females and males.
Reviews of valacyclovir
Reviews good. The product eliminates the long Herpes , The side effects most frequently manifest nausea and problems with the gastrointestinal tract. Many are satisfied with the relatively low cost of the medication.
Price valacyclovir
The price for Valacyclovir Tablets in Russia - about 600 rubles per 10 pieces.
However tablets are generally used ointment containing valacyclovir.
Price valacyclovir in Ukraine is somewhat higher. Buy drug can be for UAH 360 (10 tablets).
No comments:
Post a Comment