Description overdue on 07/11/2014
- Latin name: Xyzal
- ATC code: R06AE09
- Active substance: Levocetirizine (Levocetirizine)
- Manufacturer: YUSB PHARMA SA (Belgium), UCB Pharma, S.p.A. (Italy), FARCHIM, S.A. (Switzerland)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Cautions
- Instructions for use Ksizala (method and dosage)
- Babies
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
Composition
In the 1 tablet contains 5 mg levocetirizine dihydrochloride .
In 1 ml of liquid medication contained 5 mg of active substance.
Other ingredients that are part of Ksizala:
- sodium acetate;
- sodium saccharin;
- propylene glycol;
- 85% glycerol;
- methyl parahydroxybenzoate;
- Propyl;
- acetic acid;
- purified water.
Film-coated tablets consisting of macrogol 400 Opadry Y-1-7000.
Product form
Ksizal is available in two dosage forms:
- As 5 mg tablets Coated membrane shell. Available Xyzal tablets for 7, 10, 14 and 20 pieces in one package.
- As oral drops . Drops Xyzal available in bottles of 10 and 20 ml. Bottles of dark color with a dropper.
Pharmacological action
Ksizal drug is pronounced anti-allergic and antihistamine orientation. The blocking effects on histamine receptors in the human body levocetirizine two times higher than the cetirizine .
The drug has an effect on antihistamine phase allergic reaction .
Exposure of the drug to the patient is that it prevents the development of allergies, upon the occurrence of an allergic reaction facilitates its course, has a antiexudativ and antipruritic effect .
The active ingredient of the drug levocetirizine :
- reduces the permeability of blood vessels;
- slows eosinophils ;
- inhibits the activity of mediators of inflammation and Cytokine .
On serotonin and cholinergic receptors Levocetirizine has almost no effect.
Sedation when receiving Ksizala practically absent.
Pharmacodynamics and pharmacokinetics
Ingestion medicine perfectly absorbed in the gastrointestinal tract. It may appear insignificant metabolism . When receiving medication with food level of bioavailability and absorption rate does not change.
The maximum concentration of levocetirizine in the blood plasma is reached after 1 hour after ingestion. Clinical effects retained more than 24 hours. The half-life of the drug in adult patients is 6 to 10 hours, in children it is somewhat shorter.
About 13 percent of the drugs coming out of the body through the intestine, about 85% - excreted by the kidneys. Patients suffering from renal insufficiency, the half-life of the drug is prolonged. In patients undergoing hemodialysis, displayed no more than 10% of the active substance.
The main component of the preparation levocetirizine It has the ability to penetrate into breast milk.
Indications
The main indications for use Ksizala are:
- if the patient has an itch;
- sneezing;
- lacrimation ;
- nasal congestion;
- inflammation of the mucous membranes of the nose and the eye (conjunctiva);
- pollen disease ;
- season or chronic conjunctivitis and allergic rhinitis ;
- rhinorrhea ;
- hives in chronic ;
- angioedema ;
- allergic dermatitis .
Contraindications
The drug is contraindicated in patients with hypersensitivity to Levocetirizine As well as to other components within the composition of the drug. Ksizal not prescribed to people with severe renal failure .
During pregnancy and Lactation the drug is contraindicated (data about the safety of Ksizala pregnant and lactating women are not available).
Side effects
The main side effects that can occur when taking the drug are drowsiness . fatiguability . headache . dry mouth , stomach ache, asthenic syndrome .
Very rarely observed adverse reactions such as a breach of view, nausea . diarrhea . convulsions . hallucinations . hives , Rash, itching . tachycardia . breathlessness , muscle aches, dyspnea . hepatitis .
Noted isolated cases of changes in body weight.
Reported are extremely rare negative side effects as anaphylactic shock and angioedema (angioedema ).
Cautions
Before the drug is recommended to refrain from driving vehicles and other activities that require high concentration of attention, as well as clarity and quickness of psychomotor reactions.
Instructions for use Ksizala (method and dosage)
Drops Ksizal recommended pre-diluted in the drinking water of 10 ml., and then taken through the mouth using a teaspoon.
Dosage reception drops:
- for children from 2 to 6 years is assigned to 5 drops 2 times a day;
- children older than 6 years and adults to take up to 20 drops a day, you can at once.
Tablets Ksizal Instructions for use for adults and children over 6 years:
- to take on an empty stomach or with food intake;
- swallow without chewing;
- drink water.
Dosage - 1 tablet 1 time per day.
Babies
Ksizal in tablets Film-coated, is contraindicated in children younger than 6 years.
The drug in the drops not recommended for children under the age of 2 years due to a lack of data on the safety of medicines.
Overdose
If overdose may experience the following symptoms:
- adults - drowsiness ;
- children - increased irritability . excitability . anxiety It is turning into drowsiness.
If an overdose of the drug is recommended in the first place to make the patient a gastric lavage or provoke artificial vomiting. Next, you need to spend a supportive and symptomatic therapy. For the treatment of an overdose of the drug shows Activated carbon .
No specific antidote for poisoning by medication does not exist.
Cooperation
When applied together with Ksizala theophylline It may increase the half-life levocetirizine excreted.
It is not recommended during treatment Ksizalom drink alcohol, and drugs that suppress the central nervous system, since it is possible uncontrolled increase in their effects on the human body.
Terms of sale
Ksizal drug dispensed in pharmacies by prescription.
Storage conditions
AND pills And drops Ksizal drug should be stored in a dark, place inaccessible to children, where the temperature is maintained above 25 degrees C.
Shelf life
Tablets Ksizal in the shell are not stored for more than 3 years from the date of manufacture.
Drops Ksizal should be stored no longer than 2 years from the production date printed on the package. Opened bottle of drops can not be stored for more than 3 months.
Analogs Ksizala (if you are hypersensitive)
Parlazin
Aleron
Cetirizine
Tsetrin
Zodak
Zyrtec
Instead Ksizala for the same indications can be applied analogs: suprastineks, glentset, eltset, tsezera, Aleron, alerzin .
Reviews
The online reviews of Ksizale people put on a forum of medical orientation. Patients suffering allergic reactions and experienced the effect of the drug, noted its rapid effectiveness and ease of administration.
At the same time, taking Ksizal patients are advised to take into account his strong hypnotic effect, especially for those who drive vehicles.
When using the drug for children Reviews of Ksizale mostly positive.
Price Ksizala where to buy
In urban pharmacies drug drops It is located within 345-420 rubles.
On Tablets Ksizal the price is about 240-290 rubles. 1 pack of 7 tablets. Packing of tablets number of 10 pieces of pharmacies is from 270 to 360 rubles. Price package of 14 tablets varies between 435-530 rubles.
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