Description overdue on 07/09/2014
- Latin name: Buserelin Long
- ATC code: L02AE01
- Active substance: Buserelin (Buserelin)
- Manufacturer: JSC "F-Synthesis", Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Active substance: 3, 75 mg buserelin.
Additional ingredients:
- 200 mg - dl-lactic and glycolic acids;
- 30 mg - carmellose sodium;
- 85 mg - d-mannitol;
- 2 mg - polysorbate-80.
The solvent used is 0 8% solution mannitol in 1 ml of water for injection.
Product form
Lyophilisate for making a suspension (depot) for intramuscular injection. One pack contains one vial of the drug + solvent.
Pharmacological action
Antiandrogen, antineoplastic.
Pharmacodynamics and pharmacokinetics
Buserelin Long - anticancer drug is an analogue GRF.
The mechanism of action of buserelin is its ability to cause short-term increase in plasma sex hormones due to competitive binding to the cell receptors present on the anterior lobe pituitary gland.
Administering the drug in therapeutic doses lead to complete blockage gonadotrophic pituitary function (an average of 12-14 days). Buserelin lowers the production of LH, FSH, and Testosterone and leads to inhibition of synthesis in the gonads sex hormones. Women concentration Estradiol reaches postmenopausal values, men content Testosterone It falls to values postcastration period.
With continuous treatment, which lasts for 2-3 weeks, the concentration of Testosterone significantly decreased, reaching a state orchiectomy That is happening pharmacological castration.
Following the intramuscular injection of high bioavailability.
TCmax, it reached within 2-3 hours after administration of a single dose of 3, 75 mg and stored at a level sufficient for further suppression pituitary (not less than 4 weeks), synthetic gonadotropins.
Indications
- hormone dependent prostate cancer (prostate cancer);
- endometriosis (before surgery and after);
- uterine fibroids;
- mammary cancer;
- hyperplastic endometrial pathology;
- As part of the program IVF (in vitro fertilization) To infertility treatment.
Contraindications
- hypersensitivity to the components of the drug;
- period pregnancy and Lactation .
Side effects
In men:
- progression or worsening of the underlying disease, as well as increased pain in the bones, requiring symptomatic treatment - during therapy Prostate Cancer (the first week of treatment);
- flushing;
- gynecomastia;
- sweating;
- transient increase in androgen concentrations in the blood;
- edema (feet, eyelids, face);
- muscle weakness in the legs;
- urinary retention;
- reduced potency (sometimes can require cancellation or replacement therapy);
- fixed rare cases Pressure on the spinal cord and ureteral obstruction.
Women:
- menstrualnopodobnye bleeding;
- depression;
- sleep disorders;
- frequent changes of mood;
- headache;
- increased sweating;
- hot flashes;
- vaginal dryness;
- Pain in the lower abdomen;
- decreased libido.
General:
- flushing of the skin;
- hives;
- bone demineralization (there is a risk of osteoporosis );
- very rare (described in a few cases) - and dyspeptic symptoms pulmonary embolism undetermined origin.
Instructions for use (method and dosage)
In appointing the drug Buserelin Long instructions for use refers to its administration by intramuscular injection only.
Suspension for intramuscular injection is performed immediately before administration using the solvent belongs to the packaging.
Manufacturing finished suspension, as well as the process of entering the drug, should be engaged in only by trained medical personnel.
The following are the recommended dose, duration of therapy and the recommendation to use the drug Buserelin Long in different pathologies.
Hormone-dependent prostate cancer - Single intramuscular injection at doses of 3, 75 mg every 4 weeks.
Hyperplastic changes in the endometrium and endometriosis - Therapy is started within the first 5 days menstrual cycle 3 in a single dose, 75 mg administered every 4 weeks, with course of treatment of 4-6 months.
Hysteromyoma - Single dose intramuscular injection of 3, 75 mg buserelin Long, every 4 weeks. Treatment is initiated in the first 5 days menstrual cycle , With a course of therapy before surgery - 3 months, 6 months, and in other cases.
Treatment of infertility (IVF program) - Instructions for use 1 recommends the appointment of injections Buserelin Long at 3, 75 mg administered intramuscularly on day 2 of the menstrual cycle (possible injection at 21-24 days of the menstrual cycle) before hyperstimulation. After confirmation of oppression pituitary function We are talking about a decrease in the serum concentration estrogen (not less than 50%) prescribed application gonadotropins. Treatment is carried out in the absence of ovarian cysts Under the control of concentrations Estradiol and using ultrasound monitoring.
Overdose
There are no confirmed data on the cases of drug overdose Buserelin Long.
Cooperation
Concurrent therapy with Buserelin Long and drugs, which include sex hormones (e.g., in the process of ovulation induction ), May contribute to the syndrome ovarian hyperstimulation.
Buserelin Long may reduce the effect of hypoglycemic agents At their simultaneous application.
Terms of sale
Prescription.
Storage conditions
The drug Buserelin Long refers to the list of AB should be stored in a dark, inaccessible place for children, at a temperature no higher than 25 ° C.
Shelf life
24 months.
Cautions
Men
In order to effectively prevent potential side effects, mainly observed in the first phase of action-Long buserelina recommend appointment antiandrogenic agents, applied for 2 weeks prior to the first injection and 2 weeks after injection.
Women
When signs depression , During the therapy with Buserelin-Long, the patient should be under constant supervision of a doctor.
Ovulation induction It is carried out under strict control, in a special clinic, a physician with experience in such therapy. The patient has to go through all the procedures and assigned to follow all the recommendations of the medical staff.
At the beginning of therapy with the drug Buserelin-Long, in some cases, seen the development of ovarian cysts.
Prior to the appointment of therapy should be excluded pregnancy and suspend the use of hormonal contraceptives , With the transition to other contraceptives during the first 2 months of treatment.
After discontinuation of the drug Buserelin Long ovarian function It recovered usually after 3 months.
Be careful when driving or at work that requires high concentration of attention.
Analogs
Zoladex
Buserelin Depot
Diferelin
Buserelin
- Diferelin;
- Lyukrin;
- Dekapeptil;
- Zoladex;
- Eligard etc.
Synonyms
- Buserelin spray;
- Buserelin Depot.
Babies
There is no reliable information on the use of the drug Buserelin Long childhood.
With alcohol
It should abandon the use of alcoholic beverages during the treatment.
During pregnancy and lactation
Contraindicated.
Reviews of Long Buserelin
Reviews of doctors about the effectiveness of the drug Buserelin Long, for the treatment of the above diseases in mostly positive, Buserelin is particularly well established in the conduct of infertility treatment within the IVF program.
However, all of the doctors conducting the therapy of this group of drugs, frequent negative phenomena observed in the course of treatment, which is confirmed by reviews of the side effects Buserelin Long on user forums.
Among the side effects of the drug often referred to: hot flashes, bleeding, depression, decreased libido and mood swings.
Price Buserelin Long where to buy
The drug Buserelin Long you can buy in Moscow, about 4 000.
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