Thursday, February 14, 2019

Motilium

Description overdue on 19.03.2012

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 Motilium  Antiemetics tsentralgy antagonist of dopamine receptors. Active, active component is domperidone . The principle of operation based upon the blocking of the central and peripheral dopaminergic receptors trigger zone   brain. The drug increases motor activity of the stomach evacuation and eliminates the inhibitory effect of dopamine in the motor function of the digestive system. Motilium eliminates nausea, soothes hiccups It possesses antiemetic effect increases prolactin   in blood. Motilium produced as a suspension, in a tablet form.

Indications:

Motilium is prescribed for nausea and vomiting of various origins (in the face of infections, organic and functional disorders, in violation of the diet, radiation therapy, reception bromocriptine , Levodopa, apomorphine, morphine, during the X-ray contrast and endoscopic digestive system). The drug is effective in atony of the digestive system When the need to accelerate intestinal peristalsis during the X-ray contrast studies at the hiccups. The drug is prescribed for heartburn , Belching, gastralgii , Flatulence, abdominal distension, esophagitis , Gastroesophageal reflux, delayed gastric emptying.


Contraindications:

Motilium is not indicated in pregnancy, mechanical intestinal obstruction, bleeding in the digestive system, intolerance to domperidone at   prolaktome In Pediatrics - up to five years. When breastfeeding, liver disease and kidney administered with caution.

Side effects and overdose:

The digestive tract:   transient intestinal cramps. Nervous system: extrapyramidal disorder . Perhaps the development of allergic reactions, hyperprolactinemia . Overdose is characterized by extrapyramidal disorders disorientation , Increased sleepiness. Requires reception enterosorbents introduction of antihistamines, antiparkinsonian, anticholinergics in the development of extrapyramidal disorders.

Mode of application:

Take Motilium before meals inside. Chronic diarrheal disorders: three times a day to 10 mg. Severe emesis, and nausea: three times a day, and before bedtime to 20 mg. In the pathology of the renal system and the adult prescribe halving the dose.

Drug Interactions:

Anticholinergic drugs   neutralize the effects of domperidone. Sodium bicarbonate cimetidine   billogicheskuyu reduce the availability of the drug Motilium. Antibiotics, macrolides, nefazodone, HIV protease inhibitors, azole antifungals increased drug levels in the blood. Motilium is compatible with dopaminergic agonists receptors neuroleptics . Digoxin and acetaminophen do not have influence on the pharmacological action of the drug.

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