Description overdue on 07/21/2014
- Latin name: Valz H
- ATC code:
- Active substance: Valsartan + Hydrochlorothiazide (Valsartan + Hydrochlorothiazide)
- Manufacturer: Actavis Group hf.
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Valz H (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The structure includes a means Valz H valsartan and hydrochlorothiazide (active ingredient), and microcrystalline cellulose, lactose monohydrate, povidone K29-32, croscarmellose sodium, magnesium stearate, talc, colloidal silicon dioxide (additional substance).
Product form
Valz H produced in the form of tablets (80 mg and 12 mg 5) biconvex shape, which are coated with a film pink shell. On one side of the tablet is present mark "V", on the other - "H".
The tablets are placed in blister packs of 7 pieces, which are packed in a box made of cardboard.
Pharmacological action
Valz H - drug combination-type has on the body hypotensive effects. It consists of an angiotensin II receptor blocker and a thiazide diuretic.
Substance valsartan is a peripheral vasodilator, it affects the body as a diuretic and antihypertensive. Valsartan is a specific blocker of angiotensin II AT1 receptors, it inhibits ACE. The substance has no effect on the level cholesterol , Glucose, triglycerides, uric acid. By reducing the pressure in humans is not marked change in heart rate.
Substance hydrochlorothiazide - A diuretic average power. Compared with furosemide its diuretic effect is weaker. Under the influence of the substance is enhanced potassium excretion in the urine, as well as the removal of hydrocarbons and phosphates.
Hydrochlorothiazide increases the excretion Magnesium In the body under his influence delayed calcium ions and urate . Arterial pressure decreases due to the decrease in BCC, the change in reactivity walls of blood vessels, increase the depressive effects on the ganglia and reduce the pressor effect of reducing substances with vasoconstrictor properties.
Pharmacodynamics and pharmacokinetics
This reaction does not affect the overall effectiveness of the compounds in combination.
Valsartan is rapidly absorbed, absorbed variably. The level of its bioavailability is 23%. The highest concentration of the substance is celebrated in two hours after the consumption of drugs. Blood protein linked to valsartan 94-97%. The time of its half-life of 9 hours. Excreted mostly unaltered, 70% - through the intestines, 30% - through the kidneys.
Hydrochlorothiazide after oral rapidly absorbed and its bioavailability is 60-80%. The highest concentration of the substance is achieved in 2-5 hours. With plasma proteins hydrochlorothiazide The time of its half-life is equal to 6 to 15 hours.
The greatest effect of an antihypertensive drug for the treatment noted in the first two to four weeks of therapy.
Indications
Valz Preparation H is assigned to treat hypertension . Given to patients, provided that monotherapy valsartan It is not sufficiently effective. Also, funds designated for the purpose of reducing the risk of cardiovascular disease in people suffering left ventricular hypertrophy and those who suffer hypertension .
Contraindications
Do not use H Valz for treatment, if a person has observed the following conditions and diseases:
- high sensitivity to component products;
- bile duct obstruction ;
- biliary cirrhosis ;
- state hypercalcemia . hyponatremia . hyperuricemia . hypokalemia ;
- anuria ;
- Pregnancy and breast-milk.
Caution should be used when vehicle renal artery stenosis .
Side effects
In the treatment of drug Valz H can mark a number of adverse events, in particular:
- fatigue, dizziness ;
- nausea, diarrhea;
- symptoms pharyngitis Rhinitis;
- viral infection;
- hypercreatininemia, hyperkalemia;
- chest pain;
- arthralgia;
- allergic reactions;
- abnormalities in the kidneys.
In addition, the potential for adverse reactions in the application of valsartan are insomnia , Swelling, fatigue, decrease in sexual desire. Hydrochlorothiazide can cause symptoms disorders of water and electrolyte balance, loss of appetite, hives, decreasing potency .
Instructions for use Valz H (method and dosage)
Take the drug should be administered orally, regardless of the meal. The tablet should be plenty of drink. Initially, the patient is assigned to receive one tablet (80 mg and 12.5 mg) a day, then, if necessary, appointed Valz H 160 mg. People who have violated the kidneys, in the absence of the phenomena of cholestasis correct dose Valz H is not necessary.
Overdose
In case of overdose there may be a significant means of lowering blood pressure.
In this case, immediate gastric lavage is performed, the patient is injected intravenously 0.9% sodium chloride solution. Hemodialysis is effective only with respect to hydrochlorothiazide.
Cooperation
Also increases the effectiveness of the impact curariform relaxants.
quinidine .
At the same time it reduces the effectiveness of the treatment of oral hypoglycemic drugs, protivopodagricakih drugs epinephrine . norepinephrine .
Increased incidence of allergic reactions to allopurinol .
H Valz reduces excretion of cytotoxic drugs through kidney, and increases their myelosuppressive effects.
Drugs that bind rapidly in the body with blood proteins ( clofibrate , Indirect anticoagulants, NSAIDs), increase the diuretic effect.
Increased hypotensive effect observed while taking barbiturates , Vasodilators, phenothiazines, beta-blockers, ethanol, tricyclic antidepressants.
Simultaneous reception Valz H and methyldopa can provoke hemolysis .
Terms of sale
Valz H can be purchased by prescription.
Storage conditions
The tool should be stored in a place protected from the reach of children, where the temperature does not exceed 30 ° C.
Shelf life
Cautions
Before the appointment of treatment the correction of sodium levels in the blood, the BCC.
It is important to control the level of uric acid, potassium, lipids, glucose, plasma creatinine.
When pregnancy is detected once treatment is stopped.
During therapy is sometimes necessary to adjust the dose of insulin or other hypoglycemic agents.
There is evidence that thiazide diuretics may provoke an aggravation of a person who is sick systemic lupus erythematosus .
During treatment, keep in mind that Valz H can affect the level of concentration and speed of psychomotor reactions.
Analogs Valz H
Atacand Plus
Co-Diovan
Mikardis Plus
Vasari H
Lorista N / ND
Drug analogues Valz H are the following drugs: Valsacor H . Atacand Plus . Vazotenz H . Losartan H . Lorista H . Prezartan H . Kandekor H . Lackeys H and etc.
Babies
Valz H does not apply for the treatment of children and adolescents under 18 years of age.
With alcohol
Under the influence of alcohol hypotensive influence Valz H increases.
During pregnancy and lactation
Reviews Valz H
Reviews on Valz H 80 mg of the network patients are left mostly positive. In particular, it is noted that H Valz when taken regularly effectively lowers blood pressure and can achieve consistent results. About side effects, manifested as a result of taking the drug, in a review, is rare.
Price Valz H, where to buy
Depending on the dosage Valz H price ranges from 270 to 350 rubles per pack 28 pcs. The cost of the package Valz H 98 pcs. It equals from 700 to 870 rubles.
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