Description overdue on 05/06/2014
- Latin name: Longidaza
- ATC code: V03AX
- Active substance: Hyaluronidase + Azoksimera bromide (Hyaluronidase + Azoximer)
- Manufacturer: Petrovax farm NGOs (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Longidaza (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With antibiotics
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
A preparation in the form of suppositories for rectal or vaginal use in the composition has conjugate is of hyaluronidase with soluble macromolecular carrier ( polioksidoniem ) And additional ingredients (cocoa butter).
One vial of powder intended for solution Longidaza contained conjugate of hyaluronidase with a copolymer And auxiliaries ( mannitol ).
Product form
The tool is available as a lyophilisate for solution for injection. It is white or yellowish-white porous mass are hygroscopic, which is contained in ampoules or vials of dark glass by 15 mg (1500 IU dosage) or 20 mg (3000 IU dosage).
AT contour blister PVC contains 5 vials or ampoules. One carton pack accommodates 5 vials.
Suppositories Longidaza contained in Valium planimetric in multiples of 5 pieces, in a cardboard unit is 1 or 2 boxes means.
Pharmacological action
Longidaza is a macromolecular complex proteolytic enzyme hyaluronidase with a macromolecular carrier. The drug has a high hyaluronidase activity . On the body Longidaza has decongestant, immunomodulatory, anti-oxidant, anti-inflammatory, chelating effects. In the application of Longidaza is celebrated protivofibrozny effect .
In applying the drug markedly improved trophism and tissue permeability, resolve hematoma , Reduces swelling, increases the level of elasticity of scars.
View glycolysis glycosaminoglycans significantly reduced or disappear completely adhesions and contracture. There is an increase joint mobility.
The highest efficiency is observed when using the drug in the initial stages of diseases and pathological processes.
Antioksidantnoe impact is achieved due to binding active substance preparation ions iron, activating freely-radical reactions. Also it is happening pronounced activation of collagen synthesis.
The drug improves the humoral immunity, reduces the severity of acute inflammatory processes.
Given the fact that the drug does not cause deterioration of the patient during surgery, it is used for prevention of rough scars and development adhesions .
Under the influence Longidaza increased bioavailability of other drugs, activates the topical anesthetic.
Nizkotoksichen drug, so it has no negative effect on the immune system and reproductive functions. It does not have a body on mutagenic, carcinogenic, teratogenic influence.
Pharmacodynamics and pharmacokinetics
When administered parenterally, the active ingredient quickly reaches the systemic circulation where its maximum concentration is reached after 20-25 minutes. The substance is rapidly distributed in the body, its bioavailability is at least 90%. The active substance is able to penetrate into all tissues and organs.
Hyaluronidase in the body is subjected to hydrolysis , Also occurs decay carrier till low-molecular compounds, derivable in two phases through the kidneys. On the first day the kidneys derived roughly 45-50% gut - about 3%. After this process is slowing down. Fully drug excreted from the body within 4-5 days.
In applying Longidaza rectally her active substance rapidly absorbed into the bloodstream. Its maximum plasma concentration is observed approximately 1 hour. When used rectally or vaginally bioavailability is 70%. The half-life may thus be from 42 to 84 hours.
Indications
Longidaza assigned to adult patients in the complex treatment and prophylaxis of diseases in which the notes hyperplasia of the connective tissue .
- Gynecology : Therapy and prevention of adhesions in the pelvic organs in diseases of inflammatory nature ( endometritis . infertility . intrauterine adhesions ).
- Urinology : Interstitial Cystitis . chronic prostatitis .
- Cosmetology, dermatovenereology : Keloid, emerging, hypertrophic scarring Limited scleroderma .
- Surgery : adhesions after surgery, hypertrophic scarring . wounds That do not heal for a long period.
- Pulmonology, phthisiology : pneumosclerosis . tuberculosis . fibrosing alveolitis t .
- Orthopedics : arthrosis . joint contractures . ankylosing spondylitis . hematoma .
Furthermore, Longidaza used to increase the bioavailability of the application of some antibacterials as well as to enhance the effect of local anesthetics .
Which is better, injections or suppositories - determined by the physician in each case individually. Before starting treatment, the patient should be sure to inform the doctor about the medicines he takes.
Contraindications
Not applicable Longidaza the following diseases and conditions:
- high sensitivity to the funds on the basis of hyaluronidase ;
- hemoptysis . pneumorrhagia ;
- acute infectious diseases;
- recently occurred vitreous hemorrhage;
- malignant tumor;
- renal failure ;
- childhood and adolescence up to 18 years.
Side effects
Rarely when using the drug patients noted manifestation of local or systemic allergic reactions .
Also, as the side effects observed soreness at the point where the solution is introduced, and redness . itch . All local manifestations disappear on the expiration of 2-3 days.
Instructions for use Longidaza (method and dosage)
If the patient are appointed by the nyxes Longidaza 3000 , The instruction indicates that the solution should be administered subcutaneously under the revised scar tissue or near the affected area. Also, the drug can be administered intramuscularly. Depending on the disease treatment is assigned, which includes 5-25 injections. Honey injections interval can range from 3 to 10 days. If there is such a need, re-treatment is given 2-3 months.
In some diseases, the doctor may prescribe long Longidaza supportive treatment in which injections are given once in 10-14 days.
Before use, the contents of the vial or ampoule is dissolved in 1-2 ml of solution procaine (0, 25 and 0, 5%). When hypersensitive patient procaine agent is dissolved in the same volume of water for injection or sodium chloride 0 to 9%.
If the drug is given to increase the bioavailability of other drugs, the contents of the vial or ampoule Longidaza 3000 It is dissolved in 2 ml of sodium chloride 0, 9%, and the contents of the vial or ampoule Longidaza 1500 - 1 ml of solution. Introducing in this case, the solution should be in the same manner and in the same place as the original drug, but for 10-15 minutes prior to administration of a basic drug.
The solvent ampoule is introduced slowly, then allowed to stand for 2-3 minutes. Stir is necessary cautiously, sharply not shaking the. The solution can not be stored, it is not administered intravenously.
Do not take alcohol during treatment with the drug.
Instructions for use of candles Longidaza
Rectal they have to enter after the intestinal cleansing. Vaginal administration is carried out at night when lying down.
In urology 1 suppository administered 1 time in 48 hours, rectally, after 10 doses of a break between the injections continued for 2-3 days. One treatment includes 20 suppositories.
- In gynecology 1 suppository 1 time in 3 days inserted rectally or vaginally. One course of treatment consists of 10 suppositories.
- AT dermatology: 1 suppository 1 time in 2-3 days administered rectally. One course of treatment includes 10-15 suppositories.
- In surgery: 1 suppository 1 once a 2-4 of the day is introduced rectally. One course of treatment consists of 10 suppositories.
- In Pulmonology and Tuberculosis: 1 suppository 1 every 3-5 days is administered rectally. One course of treatment includes 10-20 suppositories.
Repeated treatment is appointed not earlier than 3 months after the first course of treatment.
People suffering chronic renal failure And those who have recently had bleeding , Shows the introduction of not more than 1 suppository Longidaza 7 days.
Overdose
Overdose in the application of the solution may provoke a feeling Longidaza chills . dizziness . temperature rise , Reduced blood pressure. In this case, you need to stop the introduction of tools and symptomatic treatment.
An overdose when using suppositories Longidaza were noted.
Cooperation
Longidaza in combination with other drugs increases the effectiveness diuretics . antimicrobials . anesthetics local impact.
If Longidaza applied simultaneously with large doses estrogen . salicylates . antihistamines . Cortisone . adrenocorticotropic hormone , Its effectiveness is reduced.
Longidaza not appointed at the same time phenytoin . furosemide . benzodiazepines .
Longidaza allowed joint reception and antiviral, antifungal agents, and antibiotics . bronchodilators .
Terms of sale
In pharmacies by prescription.
Storage conditions
Preserve the drug need to in a dark and dry place, the temperature of at the same time should not exceed 15 ° C. Longidaza should be protected from access by children.
Shelf life
Store the tool can be 2 years.
Cautions
If you want to stop therapy, cancel Longidaza possible without gradual dose reduction.
If involuntary admission of reception of the next dose can be administered it immediately as soon as people remember it. Further treatment continues in the usual way.
Before the drug is observed effect on the ability to manage transport and handling mechanisms as possible.
Analogs Longidaza
Oscillococcinum
Baby Dantinorm
Korizaliya
Gomeovoks
Given the relatively high cost of the drug, many patients try to find in pharmacies cheaper analogues candles and means for injection Longidaza. To date, analogues suppositories by active ingredient does not exist. Specialists can offer some products that have a similar effect. It Lidaza . Lidaza - M, Lidaza injection . Ronidaza .
Price analogs listed above, a low, but they do not have absolutely the same Longidaza effects on the body.
Babies
It does not apply to 18-lenogo age of the patient.
C antibiotics
Longidaza compatible with antibiotics.
With alcohol
The official summary there is no information about whether the combined alcohol and Longidaza. However, doctors do not recommend combining alcohol and drug treatment. This combination can cause an unexpected negative reaction.
During pregnancy and lactation
The drug at Longidaza pregnancy and breast-fed baby is not recommended. If necessary, this treatment is necessary to interrupt the process of lactation.
Reviews Longidaza
The forums and specialized sites are found mainly positive reviews injections Longidaza 3000 As well as reviews of Candlelight Longidaza .
Very often women report a positive effect of the drug in gynecology. In particular it helps to get rid of adhesions It is effective in ovarian cyst In the treatment of Endometriosis and others. There are reviews that after the treatment of gynecological diseases Longidaza, finally, came the long-awaited pregnancy.
It is important to choose the right treatment regimen and stick to it exactly. The feedback is sometimes referred to that as a short-lived side effects occur allergic reactions .
Price Longidaza
Cost injections Longidaza 3000 It is an average of 1450-1500 rubles. 5 pcs. Cost candles Longidaza 3000 u approximately 1250-1450 rubles. 10 pcs. Buy drug injection in Ukraine can be as low as 600 to 700 UAH. How much are candles, it depends on the place of sale. On average they 500-600 UAH. 10 pieces.
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