Tivortin

Description overdue on 01/12/2014

• Latin name: Tivortin
• ATC code: B05XB01
• Active substance: Arginine Hydrochloride
• Manufacturer: LLC "Jury-Farm", Ukraine

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• Composition
• Product form
• Pharmacological action
• Pharmacokinetics and pharmacodynamics
• Indications
• Contraindications
• Side effects
• Instructions for use Tivortina (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The preparation contains the active substance Tivortin arginine hydrochloride And saline as an additional substance.

Product form

The drug release in the form of solution for infusion, it is contained in bottles of 100 ml capacity.

Pharmacological action

The facility Tivortin contains the active ingredient the amino acid arginine, which is a group conditionally essential. Amino acids   from this group are synthesized in the body part, but their number is not enough to meet the daily need. As a consequence, it is necessary to constantly arginine from food.

Arginine is a protector, he is involved in the regulation of metabolism in cells affected by a number of important functions of tissues, organs, giving them protection, if necessary, to overcome the critical situation.

Arginine acts as antihypoxia .   detoxification . antioxidant . tsitoprotektornoe . membrane stabilizing .   antiastenicheskoe means . It participates in reactions of energetic substrate, but also to some extent helps to maintain hormonal balance in the blood. Under the influence of arginine increases the amount of insulin . somatotropin . glucagon . prolactin   in blood.

This substance is involved in the production of polyamines and amino acid proline participates in the reaction, depolarization of cell membranes, in the process of spermatogenesis, and fibrinolysis.

Arginine - is the basis for the enzyme NO-synthase, which acts as a catalyst in the synthesis of nitric oxide in vascular cell membranes. With the active formation of NO occurs dilation of peripheral vessels and reduction in total peripheral resistance. As a consequence of reduced oxygen starvation of tissues, reduces blood pressure.

Under the influence of the drug prevents the formation of atherosclerotic plaques. Also, inhibition of production of endothelin occurs, the removal of lactic acidosis, decreased blood glucose, there is regulation of acid-base balance. This substance has a strong vasoconstrictor action that stimulates the division of smooth muscle cell walls of blood vessels.

Arginine stimulates the process of neutralization of ammonia, activates its transformation into a non-toxic urea, which is then actively removed from the body by the kidneys. Preparation resists stress changes neurotransmitter metabolism in the central nervous system, increases oxidative phosphorylation of several proteins. There antiamnestic and nootropic activity funds.

Pharmacokinetics and pharmacodynamics

If carried out by intravenous infusion at a rate of 30 drops per minute, the highest concentration of arginine in the blood 20 minutes after start of administration. If the drug is used inside, the active substance is absorbed for 15-20 minutes. Arginine is able to penetrate the blood-tissue barrier is its uniform distribution in tissues and organs. Mainly excreted through the kidneys.

Indications

Defines the following indications for the use of this medicine:

• Cardiovascular diseases : CHD atherosclerosis   receptacles, angina , Recovery myocardial infarction , Cardiomyopathy, hypertension, heart failure, chronic, diabetic angiopathy, postembolic pulmonary hypertension.
• Neurological diseases : Changes in cerebral vessels with signs of hypoxia associated with atherosclerosis, acute disorders of blood flow in the brain and disorders associated with them.
• Respiratory diseases : Interstitial pneumonia, chronic obstructive pulmonary disease, bronchitis   with signs of obstruction.
• Liver Disease : Hepatitis, chronic and acute.
• Metabolic disorders : Hypercholesterolemia, hyperammonemia, metabolic alkalosis.
• Pathological processes during pregnancy : Pre-eclampsia, preeclampsia.
• Asthenic states after infectious diseases and surgeries.
• Lowering the function of the thymus gland.

Contraindications

Do not use to treat Tivortin in such cases:

• intolerant means in which there is a high hypersensitivity ;
• hepatic and renal failure in severe;
• hyperchloraemic acidosis;
• age of the child up to three years.

Side effects

When administered intravenously, the drug perhaps feeling the heat and burning in the body, headache , Inflammation at the injection sites. Rarely can manifest allergic reactions, mainly manifested in the form hives .

Instructions for use Tivortina (method and dosage)

Instructions on Tivortin includes intravenous drip at an initial rate of 10 drops per minute. 20 minutes after commencement of the speed should be increased to 30 drops per minute. Instructions for use provides that a day you can take 100 ml of the product. If the agent is administered orally, the dose Tivortina job should be 25 ml. You can deposit funds to eight times a day, the course of therapy may continue up to 2 weeks.

Overdose

In overdose funds marked hypoglycemic condition whose symptoms - weakness . Sweating . tremor of the extremities . anxiety . tachycardia . allergy . In these forms you need at the time to stop treatment, conduct treatment with antihistamines and alkalizing drugs saluretikami, crystalloid solutions.

Cooperation

If carried out simultaneous treatment with   Aminophylline Can increase the amount of insulin in the blood, is shown hypoglycemia.

If Tivortin applied after treatment Spironolactone And other potassium-sparing diuretics, the patient may appear resistant hyperkalemia (increased potassium level in the blood).

When receiving Tivortina amplifies the effect of nicotine, alcohol, psychostimulants.

There incompatibility with the drug thiopental.

Terms of sale

Buy Tivortin possible by prescription.

Storage conditions

It should be stored in Tivortin dark and dry place. The tool should be stored at a temperature of 16-24 degrees Celsius. You can not freeze the medicine.

Shelf life

After the bottle was opened with a solution, it can be stored for two weeks.

Cautions

If Tivortin used to treat people suffering from chronic renal insufficiency forms should be carried out biochemical blood and monitor the level of potassium in it.

If during treatment with this drug show signs of fatigue, you need this tool to discontinue therapy.

Caution is indicated for disorders of the endocrine glands, and water and electrolyte balance, as well as people suffering pyelonephritis .

The product does not affect the reaction in the management of human transport and work with dangerous machinery.

In the course of treatment should eat balanced, do not use the funds, stimulants, alcohol, nicotine to give up.

Analogs

Analogs Tivortina - a drug Neo Aminosol . Amine type . Aminol . Aminoplazmal   and other drugs. Any of these can be used instead Tivortina only after the approval of a specialist.

Babies

The medicine administered to children from 3 years if indicated.

Tivortin during pregnancy and lactation

The active ingredient of the drug penetrates fetoplacental barrier and therefore pregnant women should take this medication strictly on the testimony. Tivortin at pregnancy   medication administered in the case of an expectant mother preeclampsia   and preeclampsia   to stabilize the blood pressure, the prevention of threatened abortion and fetal hypoxia. In pregnancy, the means should be used strictly according to the scheme, which is prescribed by a doctor. Lactation   in the treatment of this drug should be discontinued.

Reviews Tivortine

Reviews Tivortine suggest that this drug is effective in reducing blood pressure, overcomes the other unpleasant symptoms. However, there are also negative feedback on the development of side effects, such as headaches, Arrhythmia . Reviews Tivortine pregnancy mostly positive, the women say that the drug significantly improves when gestoze .

Price Tivortin where to buy

Price Tivortin / O is an average of 250 rubles per bottle of 100 ml.

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