Miropriston

Description overdue on 07/25/2014

• Latin name: Miropristone
• ATC code: G03XB01
• Active substance: Mifepristone (Mifepristone)
• Manufacturer: JSC "Obninsk chemical and pharmaceutical company" (Russia)

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• Composition
• Product form
• Pharmacological action Miropristona
• Pharmacodynamics and pharmacokinetics Miropristona
• Indications
• Contraindications
• Side effects
• Instructions on Miropriston (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition medicament

The preparation as an active (active) substances, 200 mg of mifepristone   ( Mifepristone ).

As additional ingredients, the preparation contains:

• 264.4 mg - microcrystalline cellulose ;
• 16.2 mg - talc ;
• 5.4 mg - calcium stearate ;
• 54 mg - sodium carboxymethyl starch .

Product form

Miropriston available as 200 mg tablets in blister №3, pale yellow or greenish color.

Valium pill form, on the outside there is risk and chamfer.

Pharmacological action Miropristona

The drug has Miropriston antigestagens activity (blocks the action of a hormone progesterone   at the receptor level).

Pharmacodynamics and pharmacokinetics Miropristona

Active substance formulation mifepristone   is a synthetic steroid drug antigestagens (blocks the action of the hormone progesterone   at the receptor level) and has, thus, progestogenic activity. Seen antagonism glucocorticosteroids   manifested through competition at the level of drug interactions with receptors.

Mifepristone   It increases the contractile function of the myometrium, thereby stimulating in horiodetsidualnyh cells release IL-8 (interleukin-8) , Increasing the sensitivity of the myometrium   to prostaglandins . The result of the drug is the decidua desquamation and, consequently, the excretion of a fertilized egg.

After receiving a single dose of 600 mg, the maximum content of active substance in plasma at 1, 3 hours (1, 98 mg / l). The bioavailability is approximately 69%.

Mifepristone in plasma binds to proteins   98% ( albumin   and sour alpha1-glycoprotein ). Excretion of the drug, after the distribution phase is slow, with a decrease of its concentration doubled between 12-72 hours, after 72 hours of removal occurs faster. The half-life of the drug is usually 18 hours.

Indications

• Miropriston drug, in combination with Misoprostol , Applied to interrupt diagnosed masterbatch pregnancy   in its early stages (up to 42 days of amenorrhea).
• Artificial excitement of labor (induction of labor).

Contraindications

• individual sensitivity to this drug;
• acute or chronic disease of the kidneys and liver;
• adrenal insufficiency;
• long-term treatment with glucocorticosteroids ;
• porphyria ;
• anemia   (at the level of Hemoglobin   less than 100 g / l);
• hemostatic disorders   (including an earlier therapy with anticoagulants );
• acute inflammatory diseases of female genital mutilation;
• severe extragenital diseases;
• hysteromyoma ;
• smoking (for patients older than 35 years, without consulting your doctor).

Use for abortion :

• period of the alleged pregnancy of more than 42 days amenorrhea ;
• confirmed ectopic pregnancy   or suspicion of its ability;
• no confirmation of pregnancy;
• the possibility of pregnancy, which occurred against the backdrop of Use intrauterine contraceptive devices ;
• the possibility of pregnancy after cancellation hormonal contraceptive drugs .

Use for field of labor   and preparation of birth:

• Preeclampsia ;
• preeclampsia   severe;
• eclampsia ;
• disparity in the size of the fetal head and pelvis mothers;
• Prolonged or preterm pregnancy;
• unreasonable bleeding from the genital organs;
• abnormal fetal position;
• hemolytic disease of the fetus severe;
• premature discharge of amniotic fluid.

With care prescribe:

• at hypertension ;
• at asthma ;
• chronic obstructive pulmonary diseases system;
• rhythm disturbances of the heart muscle;
• when diagnosed Heart Failure .

Side effects

At reception mifepristone :

• hives ;
• hyperthermia ;
• dizziness ;
• headache ;
• general weakness;
• discomfort in the abdomen;
• nausea and vomiting.

During the procedure medical abortion :

• pain in the abdomen;
• bleeding from the genital tract ;
• inflammation of the uterus and its appendages.

Instructions on Miropriston (method and dosage)

The drug Miropriston as tablets taken orally (by mouth). The drug should be prescribed and used only in specialized hospitals, have trained and trained personnel, as well as the necessary diagnostic and treatment equipment.

To abort an unwanted pregnancy in the early stages

Assign 600 mg (three 200 mg tablets) once through 1-1, 5:00 after eating, drinking plenty of water. The drug is indicated for use only in the presence of the attending physician. After receiving 3 tablets Miropristona 36-48 hours the patient is prescribed Misoprostol   400 mcg and left under dynamic supervision of the attending physician for 2 hours. US control and repeated clinical examination is appointed for 10-14 hours after the start of Mifepristone . If necessary, define the content of human chorionic gonadotropin, in order to confirm a successful medical abortion.

With a negative or incomplete effect of the use of therapy (ongoing pregnancy or incomplete abortion) at 14 days after administration of drugs recommended holding vacuum aspiration to further histological studies.

To prepare and artificial excitation of labor

Prescribers Miropriston as tablets for induction of labor at a dose of 200 mg (1 tablet) once (only in the presence of a doctor). One day (24 hours) to re-appoint 200 mg Miropristona. Assessment of the birth canal is carried out in 48-72 hours after receiving repeated doses of the drug. If needed, apply prostaglandins   and Oxytocin .

Overdose

Receiving Miropriston drug at a dose of 2 grams does not lead to undesirable reactions. Due to the strict conditions of mifepristone, which should only be used in specialized clinics, its overdose is unlikely.

In case of accidental overdose may occur adrenal insufficiency .

Cooperation

When receiving Miropristona is not necessary to conduct therapy with nonsteroidal antiinflammatory drugs (NSAIDs) .

When combined therapy and drugs group Miropristonom glucocorticosteroids It is necessary to adjust the dose glucocorticoids   towards its increase.

Terms of sale

Miropriston drug sold by prescription only and is used only in specialized medical obstetrical institutions that belong to the public health system.

Use of the drug is possible in hospitals, in private or municipal property, if the license for this kind of activity.

Storage conditions

The drug belongs to the list Miropriston A.

Store in a dry place, protected from direct sunlight, out of reach of children.

Storage temperature should not exceed 30 ° C.

Shelf life

5 years (not used after the expiry date).

Cautions

Patients who take Miropriston to terminate an unwanted pregnancy in the early stages, should have complete information about the effects of the drug. In particular, the absence of effect of the drug on day 10-14 ( ongoing pregnancy   or incomplete abortion ), Pregnancy must be interrupted by another doctor recommended way to avoid the risk of congenital malformations in the fetus.

The application requires a warning Miropristona Rh alloimmunization   and other general-purpose events that accompany an abortion.

During pregnancy and lactation

After receiving Miropristona for the purpose of medical abortion should stop for 3 days breast-feeding .

Application Miropristona for initiating labor does not affect the subsequent lactation.

Reviews Miropristone

Reviews on the forums about the drug Miropriston, as a means to terminate an unwanted pregnancy, mostly positive. Among the advantages of this drug more often pay attention to the possibility of an abortion without surgical intervention. Among the shortcomings - pain in the abdomen . vomiting   and discomfort after administration of the drug. Side effects and adverse effects of mifepristone tend to occur while taking the drug at home without a doctor's advice.

Virtually no negative reviews of Miropristone in childbirth. This drug is used in obstetric practice is widely and successfully.

Price Miropristona where to buy

Price Miropristona the pharmacy (Table. 0.2g N3) ranges from 535 to 692 hryvnia, depending on the medical establishment.

In Ukraine, you can buy Miropriston only by prescription, with a further application in a specialized clinic, under the strict supervision of the attending physician.

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