Description overdue on 05/12/2014
- Latin name: Nebivolol
- ATC code: C07AB12
- Active substance: Nebivolol (Nebivolol)
- Manufacturer: Salyutas Pharma GmbH, Germany
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Nebivolol (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
Composition
In 1 tablet of the drug is contained 5 milligram of Nebivolol .
Product form
This drug is available in tablets, 30 tablets in a blister.
Pharmacological action
The drug is racemic, which consists of two enantiomers: L-nebivolol and D-nebivolol .
One-time use of the drug:
- It reduces the heart rate and blood pressure during exercise and at rest;
- is an antianginal effect in humans suffering from ischemic heart disease;
- increases ejection fraction;
- reduces pressure filling and OPSS, reduces finite diastolic pressure left ventricle.
Steady hypotensive effect developed after 1 to 2 weeks of regular use of the drug, in some cases, may develop a month. Stable effects observed after one to two months.
Anti-arrhythmic effects of the drug at the expense of suppressing abnormal automaticity of the heart and slowing AV-conduction. The hypotensive effects occur by reducing the activity of the renin-antgiotenzinovoy system.
Pharmacodynamics and pharmacokinetics
Both nebivolol enantiomers are very rapidly absorbed from the gastrointestinal tract. The food on drug absorption is not affected. People with fast metabolism bioavailability averaged 12 percent of people with slow metabolism It is almost complete. Therefore, depending on the metabolism , The dose is determined individually. The blood plasma nebivolol It binds mainly albumin .
Displays 48 percent through the intestine and kidney by 38 percent.
Indications
Indications for use of the drug are:
- congestive heart failure ;
- CHD (prevention);
- arterial hypertension .
Contraindications
The drug should not be used when:
- hypersensitivity to Nebivolol ;
- childhood and adolescence to 18 years;
- depressions ;
- myasthenia ;
- severe peripheral vascular occlusive disease ( Raynaud's syndrome . intermittent claudication );
- asthma and bronchospasm history;
- significant violations of the liver;
- metabolic acidosis ;
- pheochromocytoma ;
- cardiogenic shock;
- bradycardia (heart rate less than 60 beats per minute);
- AV-blockade of second and third degree (with the absence of artificial pacemaker);
- SSS, including sinoatrial blockade;
- pretty hypotension (systolic blood pressure less than 90 mm Hg. v.);
- Chronic Heart Failure decompensated;
- acute Heart Failure .
Side effects
There may be side effects following the use of drugs:
- With chronic heart failure : often enough - dizziness and bradycardia , and swelling of the feet Blockade of the first degree, orthostatic hypotension , Increasing signs of the disease.
- On the side reproductive system : In rare cases - impotence .
- On the side skin Sometimes - erythematous rash and itch ; very rarely - hypersensitivity reactions and an increase in symptoms psoriasis .
- On the side gastrointestinal tract : often enough - diarrhea . nausea . constipation Sometimes - dyspeptic syndrome .
- On the side respiratory system: often enough - breathlessness Sometimes - bronchospasm .
- On the side Cardiovascular Sometimes - strengthening of intermittent claudication, hypotension . cardialgia , Abnormal heart rhythm, slowing AV-blockade / conductivity heart failure . bradycardia .
- On the side organs of vision In some cases - visual impairment.
- On the side peripheral and central nervous systems In some cases - nightmares insomnia . drowsiness , Poor concentration, depression . paresthesia . fatigue . dizziness . headache .
Instructions for use Nebivolol (method and dosage)
According to the instructions for use of nebivolol recommended adult ingested from 2, 5 to 5 milligrams of the drug per day (in the morning). If necessary, the daily dose may be increased to 10 mg. Stable effect observed after 1 to 2 weeks with regular use, in some cases - after a month.
For people Seniors age groups initial dose medicinal preparation varies 2, 5 milligram per night (maximum - 5 milligram).
Overdose
In case of overdose of this medicinal drug can be observed the following symptoms: acute heart failure . bronchospasm . hypotension and bradycardia .
Treatment consists of gastric lavage and the appointment of laxatives and Activated Carbon . If necessary, intensive therapy in hospital.
Cooperation
If you take the medicine at the same time with hypoglycemic agents and insulin May mask signs hypoglycemia (tachycardia) .
Simultaneous administration of the medication with drugs that inhibit the reuptake Serotonin Can increase the concentration Nebivolol in plasma blood and slow down metabolism, that raises risk Development bradycardia .
Simultaneous treatment with Cimetidine nebivolol increases the concentration in plasma.
Simultaneous treatment with tricyclic antidepressants Derived phenothiazine . barbiturates It enhances the antihypertensive effect of nebivolol.
Simultaneous treatment with medicines for anesthesia increases the risk of hypotension and suppresses reflex tachycardia .
Simultaneous treatment with sympathomimetic inhibits pharmacological activity of nebivolol.
Simultaneous treatment with antihypertensive drugs, calcium channel blockers slow or nitroglycerin causes the development of large hypotension .
Simultaneous administration Verapamil and receiving Nebivolol can cause cardiac arrest.
Simultaneous treatment with antiarrhythmic drugs of the first class may enhance the negative inotropic effects and inhibits the AV-conduction.
Terms of sale
The drug prescription.
Storage conditions
Store this medication should be at or above 25 degrees.
Shelf life
Nebivolol Shelf life is 3 years.
Analogs of Nebivolol
Biprol
Bisoprol
Concor Cor
Lokren
Concor
Niperten
Betaloc ZOK
Betalok
Coronal
Egilok
Nebilet
Atenolol
Metoprolol
Nebivolol analogues are:
- Nebilet
- Binelol
- Nevotenz
- Nebivator
Reviews of nebivolol
According to the opinion of many people, the drug is highly effective, but it has many side effects that often occur.
Price Nebivolol where to buy
In Moscow, the price Nebivolol Canon an average of 400 rubles. Average price Nebivolol Sandoz Ukraine is 60 hryvnia. Trading name - Nebivolol-Teva .
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