Poludan

Description overdue on 07/31/2014

• Latin name: Poludanum
• ATC code: S01AD
• Active substance: Complex Polyadenylic and polyuridylic acids
• Manufacturer: Lance-Pharm Ltd. (Russia)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Poludan (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Babies
• With alcohol
• Reviews
• Price, where to buy

Composition

The active ingredient of the drug is represented by complex Polyadenylic   and polyuridylic acids 100 U :

• 0, 107 mg - potassium poliribouridilata ;
• 0, 1 mg -   potassium poliriboadenilata .

As auxiliary components are present:

• 8, 5 mg - sodium chloride ;
• 0, 408 mg - Potassium dihydrogen phosphate ;
• 2 mg -   sodium hydrogen phosphate .

Product form

This drug is available in a 3-pharmacological forms of representing lyophilisate   for further manufacturing: Injection Solution   (packing №10), and eyedrops   (package №3) and nose drops   (package №1 and №3).

Pharmacological action

Antiviral and immunomodulatory .

Pharmacodynamics and pharmacokinetics

Poludan is a complex biosynthetic poliribonukleotidnym   acids poliribouridilovoy   and   poliriboadenilovoy . Induces work Interferon Contained in the body, and other Cytokine .

The mechanism of action is based on stimulation of the complex interferon alpha   more, and interferon beta   and Gamma-interferon   to a lesser extent, as well as induction of interferon synthesis in leukocytes, blood, organs   and tissues . High content Interferon   support everyday introductions throughout the course of therapy.

Poludan takes a direct antiviral activity against different strains virus influenza   and other SARS . When the virus infecting organism cells triggers cytokine response .

Indications

Diseases of viral etiology (including influenza, herpes conjunctivitis, adenovirus infections, keratoconjunctivitis, keratitis and keratoiridocyklites, keratouveitis, iridocyclitis, stromal keratitis, chorioretinitis ) And caused by exposure to the virus, optic neuritis .

Contraindications

• During the injection in the anterior chamber of the eye: conjunctivitis , The detection of pathogenic microorganisms in the crop , Keratoiridocyklites   with a visible front ulceration of the cornea, infectious diseases of the teeth and sinuses.
• Hypersensitivity   the components of the drug.

Side effects

• If you use drops can sometimes develop allergic reactions .
• With injected,   available swelling of the lower eyelid Occasionally increased intraocular pressure   and the formation of small hemorrhage .

Instructions on Poludan (method and dosage)

Basic pharmaceutical form of the drug is eyedrops Poludan , Instructions for use and preparation of which is shown below.

• The preparation Poludan as eyedrops   used in adult patients during therapy   herpetic   and adenoviral conjunctivitis, keratitis   and superficial keratoconjunctivitis . Buried prepared solution to the inner corner of the patient's eye (conjunctival sac). The recommended daily intake for adults 6-8 instillations (for children 3-4), 1-2 drops. As the action of the drug and reduce inflammation, the number of instillations per day gradually reduced to 3-4 times in adults and in children 2-3 times. Solution preparation: The contents of one vial of preparation (200 mg) was dissolved in 2 ml of distilled water.
• Nasal drops   prescribed for the treatment of adult patients Flu   and other SARS . Buried pre-prepared solution of 5 times a day 2 drops in each nostril. Started treatment not later than 2 days after the detection of symptoms and continued for 5 days. Preparation of the solution: the contents of one bottle (100 IU) is dissolved with distilled water to a label located on the label.
• Solution for injection   used for therapy uveitis, stromal keratitis, horeoretinitov , and optic neuritis viral nature. Injections are performed once a day or every other day for conjunctiva In a dose of 100 mg (0, 5 mL of solution). The course of therapy generally requires from 15 to 20 injections. In therapy   Viral lesions of view   in children, the injections are administered in half a dose of 8-10 injections per treatment. Preparation of the solution: The contents of one vial Poludan dissolved in 1 ml water for injection 1 ml or 0, 5% novocaine .

Overdose

There is no reliable information about overdose Poludanom.

Cooperation

• Clinical efficacy Poludan reduced when coadministered with enzymatic means Because of their damaging effect on interferon .
• Poludan most often used in combination with   antibiotics   and other drugs used for the treatment of viral diseases.

Terms of sale

Poludan released from pharmacies by prescription.

Storage conditions

In the refrigerator at a temperature not exceeding 4 ° C.

Shelf life

4 years.

Cautions

Side effects Poludan disappear on their own within 1-3 days after discontinuation. At therapeutic doses, the drug is not characterized by pyrogenicity .

Babies

Poludan approved for pediatric use in the treatment of viral eye diseases .

With alcohol

Do not take together with drinks containing alcohol.

Reviews

Reviews Poludane, as Antiviral agents   ( nasal drops ) Are exceptionally positive. Good results were found using the product and in gynecology for the treatment of Genital herpes   (in the complex therapy).

Also, a positive assessment, with the exception of some rare passing side effects noted in a review of the eye drops Poludan   and solution for injection .

Price, where to buy

Pharmacies price Poludan in pharmaceutical form nasal drops   №1, is approximately $ 100; №3 about 190 rubles.

Cost eye drops Poludan   №3 varies from 100-200 rubles.

Price Injection Solution   №10 greatly varies in the range from 100 to 500 rubles.

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