Description overdue on 04/03/2014
- Latin name: Capoten
- ATC code: C09AA01
- Active substance: Captopril
- Manufacturer: JSC "Chemical-Pharmaceutical Plant QUINACRINE" Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications application Capote
- Contraindications
- Side effects
- Instructions for use Capote (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- With alcohol
- Analogs
- Reviews
- Price, where to buy
Composition
As part of a single tablet Capote (Capoten) contains 25 mg of active substance - captopril And auxiliaries such as a starch . lactose . MCC and stearic acid .
Product form
Capoten (INN - Captopril) is available as tablets of 25 mg in blister packs of 14 tablets, in a cardboard blister pack is 1-4.
Pharmacological action
It has hypotensive effect. It is an ACE inhibitor. The drug can prevent the emergence of Angiotensin II It reduces its ability to narrow the arterial and venous vessels.
Pharmacodynamics and pharmacokinetics
In the annotation to Kapotenu indicated that the drug reduces the afterload and preload Lowers arterial pressure And also reduces the atrial pressure and in pulmonary circulation . Increases cardiac output Decreases Level of in the adrenal glands aldosterone .
After receiving about 75% of the material is rapidly absorbed through the gastrointestinal tract. In simultaneous ingestion rate of absorption of the drug is reduced. Over 90% of the drug is excreted through the kidneys, with approximately 50% is excreted in unaltered form, the remaining part of the substance - in the form of metabolites.
How fast is valid hood? Within 10 minutes after taking the drug begins its action, but the maximum effect is one and a half hours and lasts up to 6 hours.
Indications application Capote
From what Capoten can help? Indications for use of the hood as follows:
- myocardial infarction ;
- congestive heart failure (combination therapy);
- arterial hypertension (monotherapy, are also possible combination with other drugs);
- diabetic nephropathy in diabetes (1 degree).
The main symptom of which Capoten pills can help - high pressure .
Contraindications
This drug has a number of contraindications:
- the patient's condition after surgery for kidney transplantation;
- aortic stenosis and similar diseases that impede blood flow;
- artery stenosis sole kidney with possible progressive azotemia;
- a history of hypersensitivity ;
- angioedema ;
- bilateral renal artery stenosis ;
- breast-feeding and pregnancy ;
- functional disorders of the liver and kidney ;
- hyperkalemia ;
- children and adolescents up to 18 years;
- intolerance to one of the components of the preparation.
The medicine should be taken with caution while suppression of bone marrow hematopoiesis . cerebral ischemia At autoimmune connective tissue disease , Patients who are currently on hemodialysis and patients who comply with the power supply system with a controlled level of sodium intake, elderly patients.
Side effects
Use of drugs can lead to the appearance of the following side effects:
- orthostatic hypotension . peripheral edema and tachycardia ;
- bronchospasm . dry cough . pulmonary edema ;
- swelling of the extremities . mucosal laryngeal . swelling of the lips . language . general swelling of the face ;
- hyperkalemia . proteinuria . hyponatremia . acidosis Large concentration of blood urea nitrogen;
- agranulocytosis . anemia . thrombocytopenia . neutropenia;
- taste disturbance, thrush , Dry mouth, increased liver enzymes; in rare cases may be palpable abdominal pain, gingival hyperplasia . hepatitis . diarrhea ;
- rash Which is usually accompanied by itching and rarely - increase in temperature; vesicular rash and bullous type Frequent flushing, photosensitization . erythema ;
- drowsiness . ataxia . dizziness and headaches, blurred vision, paresthesia.
Instructions for use Capote (method and dosage)
How to take the bonnet: under the tongue or drink? The prescribing physician pills pressure Capoten taken orally one hour before meals. You can also take Capoten under the tongue. Dosage is assigned individually.
How to take medicine for blood pressure? At hypertension drug treatment begins with the smallest dose that is determined individually for each patient. At weak (moderate) the degree of manifestation hypertension the initial dose of the medication - 12, 5 mg (1/2 tablet) twice per day. When necessary, the dosage is increased gradually, the interval should be 2-4 weeks. Effective portion - 50 mg (2 tablets) twice daily. At severe hypertension volume of the initial dose should not exceed 12, 5 mg (half tablets) in 2 divided doses per day. The dose should be gradually increased to maximum - 150 mg (three times a day, 50 mg).
How to use the drug in Heart Failure : Treatment should take place only under the supervision of a doctor. To maximize the effect of the weakening of transient hypotension, it should be from the beginning of the course of treatment prescribed dosage of no more than 6, 25 mg (1/4 tablet) 3 doses per day. The optimal maintenance dosage - 25 mg (1 tablet) for 2-3 hours. If necessary, every 14 days, the dose can be increased up to a maximum - 150 mg.
When treating myocardial infarction may begin therapy after 3 days after the onset of a heart attack. Optimal initial dose - three times a day for 6, 25 mg (1/4 tablet), gradually increasing the dose necessary to 1 tablet (25 mg) three times a day.
The recommended dose diabetic nephropathy may be 75-100 mg (3-4 tablets) for 2 or 3 times per 24 hours.
Moderate and weak stage of renal dysfunction It requires daily dose amounting to 3-4 tablets (75-100 mg) three times a day. Doctors recommend starting with portions not exceeding half a tablet (12, 5 mg) under highly severe impairment of kidney function . If this dose is not effective, then it should be increased gradually until a therapeutic effect.
How to drink tablets in elderly patients? Persons older than 65 years Dose selected individually physician. It is recommended to start treatment with the lowest dose, and continue to support it at the same level during the entire course of the drug.
Before taking Capoten at high pressure and other symptoms, consult a doctor.
Overdose
Symptoms of overdose is a strong drop in blood pressure.
The course of treatment is carried out by introducing plazmozameshchath drugs As well as of Hemodialysis .
Cooperation
Capote enhanced hypotensive effect when used with diuretics . blockers and ganglioblokatorami . Increasing the concentration level of potassium in the blood may be caused by potassium-sparing diuretics ( spironolactone . triamterene . amiloride ) Or potassium nutritional supplements.
Indomethacin and clonidine reduce the antihypertensive effect of the drug on the pressure.
The combination with the hood allopurinol or procainamide can lead to neutropenia and / or Stevens-Johnson syndrome .
Such as the immunosuppressants cyclophosphamide and azathioprine while Kapotenom used to increase possibility of hematologic disorders type.
Application ACE inhibitors and lithium It leads to an increase in the level of lithium in the blood, which increases the risk of side effects of drugs lithium.
Terms of sale
Prescription.
Storage conditions
It is recommended to store the drug at an average temperature of 15-25 ° C.
Shelf life
3 years.
Cautions
When checking urine for acetone content can give a false positive reaction.
Instructions on the hood for patients who are on salt-free or malosolevoy diet : The drug should be prescribed with caution, treatment should start with small doses, as there is the probability of hypotension. If after receiving the hood there hypotension, the patient is recommended to take a horizontal position and lift legs.
Under medical supervision Capoten should be applied to patients suffering from chronic heart failure.
Approximately 20% of patients with long-term course of treatment Kapotenom an increase of more than 20% of urea and creatinine in the blood.
Month must be kept under control white blood cell count for the first three months of administration of the drug, after - 1 every 3 months. Patients with autoimmune diseases have to control the level of white blood cells every 2 weeks during the first 3 months, then - every 2 months. Complete blood count should be carried out when the total number of white blood cells is less than the level of 4000 / mm. The course of drug therapy is recommended to complete if the level of white blood cells is less than 1000 / l.
The drug should be abolished and a medical examination in the event of angioedema . If swelling appear on the face, then it is possible to reduce the use of antihistamines, other treatment is required. If the swelling spread to the pharynx, larynx or tongue should be done immediately injected 0.1-percent solution of epinephrine (adrenaline) in a volume of 0.5 ml.
Initially, the course of treatment may develop dizziness So during treatment, patients are advised to refrain from DMV and any work that requires quick reaction and attention.
Hood and alcohol
When receiving the drug should completely refrain from taking alcoholic beverages. Alcohol affects the absorption of potassium, its deficiency may cause hypertension Action aimed at filling the bonnet of this element, and alcohol blocks the increase in its reserves. Thus, the interaction of hood with alcohol can cause severe hypertonic disease.
Capote analogues
Captopril
Monopril
Renitek
Charter
Fozikard
Amprilan
Ramipril
Perindopril
Prestarium
Perineva
Berlipril
Akkupro
Diroton
Enap
Enalapril
Analogs Capoten tablets on the composition of the active ingredients: captopril . kapozid . akkupro . Berlipril . diroton . zokardis . lizinokol et al. Analogs can differ in release form.
Which is better: the hood or captopril?
In fact, Capoten and Captopril - the same drug that helps in heart failure and hypertension.
Kapozid or hood?
Kapozid prescribed to patients if the use of the hood proved to be ineffective. Kapozid - drug captopril in addition to containing diuretics. Thus, in its composition except 50 mg of captopril is 25 mg gidrohlotiziada. This combination enhances the hypotensive effect of the drug, as well as the duration of its effects on the body, allowing it to take once a day.
Reviews on the hood
Overall Rating preparation of 4, 5 points out of 5. Patients say that fast acting pills, reduce the pressure, as mentioned, and convenient form of release. Some patients complain of side-effects, in particular, a slight numbness language.
Reviews of doctors: before use should consult a doctor, who will determine the need for the use of the drug and establish dose. In general, the drug acts quickly and efficiently, with a minimum of side effects with proper dosage.
Price on the hood, where to buy
Price in Moscow on these tablets is 110-130 rubles. for a pack of 14 tablets; pack of 28 tablets - 160-188 rub., a package of 40 tablets - 230-254 rub.
The price of the tablet Capote in Ukraine on average from 160 to 280 UAH. depending on the volume.
For detailed information, how much is the drug and where you can buy, you can find in a drugstore.
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