Description overdue on 08/01/2014
- Latin name: Mifegyne
- ATC code: G03XB01
- Active substance: Mifepristone (Mifepristone)
- Manufacturer: EXELGYN Laboratoires, MACORS Laboratoires (France)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Mifegin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As part of a biconvex tablet Mifegin light yellow color, coated with 167V code contains 20 mg. active active compound micronized mifepristone .
Corn starch, colloidal silica, magnesium stearate, microcrystalline cellulose, and povidone part of the drug as auxiliary substances.
Product form
Mifegin produced in tablet form. In one carton is usually 3 blisters with medicament total nominal volume is 200, 400 or 700 mg.
Pharmacological action
The drug has antiprogestagennoe impact .
Pharmacodynamics and pharmacokinetics
Since a part of chemical compounds have drug antigestagens exposure , At the level of Mifegin receptors blocks the action progesterone . Due to this connection receptors When using the drug observed antagonism with GCS .
In addition, the drug stimulates horiodetsidualnyh cells release process IL-8 Thereby increasing the contractility of at myometrium And sensitivity to prostaglandins .
Under the influence of the drug takes place expulsion of the ovum and decidua desquamation. To enhance the effectiveness of Mifegin often combined with synthetic analogs prostaglandin .
The necessary concentration of active compound in the active body reached after 1 and 3 hours after receiving a single medicament. Getting in plasma mifepristone It binds acidic alpha1-glycoprotein and albumin 98%.
In step removing the active compound for 12-18 hours, gradually decreases its concentration in the body. Fully mifepristone excreted from the body within 72 hours after the end use of the product.
Indications
The drug is used, generally at medical abortion for up to 42 days, as well as at home as a tool Emergency Contraception within 72 hours after unprotected intercourse. Everything else, Mifegin apply for term pregnancy for induction and preparation for Childbirth As well as in the treatment of uterine leiomyoma .
Contraindications
The main contraindications to the use of the drug are the following diseases and conditions:
- adrenal insufficiency;
- kidney or liver failure Including chronic or acute forms of diseases;
- hypersensitivity to the constituent components of the drug;
- a long period of treatment glucocorticoids ;
- a scar on the uterus ;
- porphyria ;
- heavy extragenital pathology ;
- diseases of the genital organs;
- anemia;
- abnormalities in hemostasis.
It is forbidden to use Mifegin abortion in the presence of:
- suspected ectopic pregnancy;
- pregnancy The duration of which exceeds 42 days after the last menstrual period;
- uterine fibroids .
At induction or preparing for childbirth the drug is not recommended for use in the presence of:
- preeclampsia;
- eclampsia;
- preeclampsia;
- uterine fibroids;
- perenoshennoy or full-term pregnancy.
The drug is not used during the treatment uterine leiomyoma in the presence of:
- pregnancy The duration of which exceeds 12 weeks and lactation;
- ovarian tumors;
- submucosal fibroids location;
- endometrial hyperplasia.
Side effects
When using the drug may experience side effects such as: weakness, discomfort in the lower abdomen, headache, vomiting or nausea, dizziness, diarrhea, skin rash, and gipetermiya .
Apart from the above ailments with the use of the drug during medical abortion may have more side effects such as the bleeding, worsening of reproductive tract infections and urinary tract infections , and inflammation of the uterus and appendages .
When sharing and Mifegin Misoprostol may be reduced hemoglobin levels Evolve indigestion, fatigue and vaginitis . Furthermore, there may be fainting and disturb pains in the legs.
Use of a preparation as Emergency Contraception may cause menstrual disorders and bloody issues . During treatment leiomyoma using Mifegin may develop amenorrhea.
Instructions for use Mifegin (method and dosage)
In accordance with the instructions on Mifegin, the drug is intended solely for use under medical supervision in a medical facility. The drug is not recommended for use for permanent Contraception And does not protect against diseases, sexually transmitted diseases .
To abortion taking 600 mg. means in the presence of medical personnel that have over 2 hours should monitor the patient. After 48 hours of using the drug, the patient should do US And 14 days - repeat ultrasound and be examined by a gynecologist, to finally confirm the termination of pregnancy.
As a preliminary to the Childbirth means taking the drug at a dose of 200 mg. in the presence of physicians. Within 24 hours, shows repeated reception of the drug at the same dose. After a lapse of 72 hours after the second dose, as well as following evaluation condition the birth canal doctors can appoint Oxytocin or prostaglandin.
Overdose
When used in the body for safe doses not exceeding 2 years, Mifegin does not cause undesirable side reactions. If overdose occurs adrenal insufficiency.
Cooperation
Effective treatment Mifegin should be avoided within 12 days after treatment using nonsteroidal anti-inflammatory drugs.
Terms of sale
Sold for the needs of specialized medical institutions licensed to provide obstetrical services.
Storage conditions
The drug belongs to the group A and requires a certain temperature storage (not strictly above 25 ° C).
Shelf life
3 years.
Cautions
As used for Mifegin medical abortion Patients should be informed of the need for mandatory medical examination within 14 days after the direct use of the drug. In cases where the drug does not reach its target (continued pregnancy, incomplete abortion) immediately conduct vacuum aspiration, since mifepristone provokes severe malformations Development fetus.
The drug should be used in a medical facility because prior to his admission as to the operational abortion you need to pass some specific studies, such as a warning Rh alloimmunization .
During treatment with Mifegin patients infective endocarditis or artificial heart valve, to be used simultaneously antibiotics .
Analogs Mifegin
Esmiya
Zhenale
Miropriston
Ginepriston
Mifepristone
Penkrofton
Currently, the following analogs of active Mifegin active component:
- Mifepreks;
- Agesta;
- Gynestril administration;
- Miropriston;
- Penkrofton;
- Mifepristone;
- Ginepriston;
- Zhenale;
- Gynestril administration.
Which is better: Mifepristone or Mifegin?
At its core, both are designed for preparation medical abortion And used in preparation for Childbirth stage. Mifepristone, as well as Mifegin It has an extensive list of contraindications and approved for use only in hospitals, where in the event of side effects or complications, doctors will be able to provide immediate assistance to the patient.
During pregnancy (and lactation)
Nursing mothers should abandon breast-feeding during use of the product, and during the next 14 days.
Reviews Mifegin
It is not always possible to meet Mifegin positive feedback on the forums. Some women who use the drug for abortion, noted the occurrence of side effects that are not always disappear quickly after use of the drug. Also, quite often there are reports of poor-quality forgeries of the drug and its analogs, which were acquired through the network of electronic pharmacies or informal distributors that do not require a doctor's prescription.
Price Mifegin where to buy
Cost Mifegin tablets may vary depending on the region. It is therefore advisable to specify yourself how much it costs in pharmacies of your city this medication. Buy Mifegin in Moscow, as in other cities of the Russian Federation is not a problem.
The average price in pharmacies Mifegin country will be about 3,000 rubles per pack.
Average price Mifegin in Ukraine reaches 1700 hryvnia per pack.
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