Description overdue on 09/26/2014
- Latin name: Bivalos
- ATC code: M05BX03
- Active substance: Strontium ranelate (Strontium ranelate)
- Manufacturer: Les Laboratoires Servier (France)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Bivalos (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One sachet contains 2532 milligrams of the drug Strontium ranelate hydrate or 2000 milligrams of active substance is equivalent to anhydrous strontium ranelate . As part of the drug Bivalos contain adjuvants such as: mannitol, aspartame, and maltodextrin.
Product form
Bivalos produced in the form of pale yellow powder. The drug is used for the preparation of opaque white suspension. In one carton tend to be 7, 14, 28, 56, 84 or 100 sachets, each containing 2 grams of the active drug compound.
Pharmacological action
The drug helps to correct the metabolism of cartilage and bone.
Pharmacodynamics and pharmacokinetics
The results of the research in the face invitro (i.e., in vitro), it was found that strontium ranelate promotes formation bone . Besides being useful compound involved in collagen synthesis and stimulates the production of precursors osteoblasts .
Bivalos reduces speed bone resorption Thus kupiruya the process of osteoclast differentiation . Under the influence of the drug compound the process of destruction of bone changes in the direction of its formation. One can say that the drug triggers recovery of bone tissue in the human body during osteoporosis.
In long-term therapeutic treatment (over three years), patients have an increase in the level of biochemical markers Responsible for bone formation (I C-terminal propeptide procollagen) as well as reduced maintenance Markers Which leads to bone resorption (N-terminal and C-terminal telopeptide).
Bivalos effective in treating postmenopausal osteoporosis in women during which increases the risk fractures . The drug has also shown excellent results when used during osteoarthritis . The active agent is involved in the development of cartilage matrix As well as the impacts on human chondrocytes Thus slowing down the process of tissue destruction. Thanks inhibition of subchondral bone resorption tissue the drug has a positive effect on the pathophysiology of osteoarthritis .
Indications
The drug used in the treatment of:
- Osteoporosis in the menstrual period in women for the prevention and prevention fractures;
- Osteoporosis hip or knee joints;
- osteoporosis in men.
Besides Bivalos used as part of a therapeutic treatment of fractures , eg, hip .
Contraindications
The drug is contraindicated in:
- hypersensitivity;
- VTE (venous thromboembolism);
- vein thrombosis;
- pulmonary embolism;
- immobilization;
- coronary artery disease;
- artery and cerebrovascular diseases;
- hypertension.
Besides Bivalos forbidden to use in the treatment of patients who have not yet reached 18 years of age. With extreme caution and only under medical supervision, you can use the drug to patients suffering from renal failure And when venous thromboembolism .
Side effects
During use of the drug may occur following side effects gastrointestinal tract, nervous and cardiovascular system:
- headache;
- convulsions;
- impaired memory and consciousness;
- diarrhea;
- vomiting;
- nausea;
- diarrhea;
- stomatitis;
- mucous (eg mouth sores);
- venous thromboembolism.
On top of that there may be different allergic reactions when using this drug, and expressed in appearance rashes on the skin, itching, hives, dermatitis or eczema.
Instructions for use Bivalos (method and dosage)
In accordance with the instructions on Bivalos formulation intended for oral administration. Before direct use should be prepared from the powder in a sachet liquid drug suspension Which it is recommended to use at bedtime. And immediately after taking the medicine should take a horizontal position for maximum therapeutic effect.
The recommended daily dosage is 2 grams Bivalos (ie one sachet). To avoid overdose should not arbitrarily increase the dose of medication without consulting your doctor, since the course of treatment is designed for a long period of time. To prepare the suspension to dissolve one sachet Bivalos at least 1/3 cup of water.
Due to the fact that many of the foods and food supplements containing in its composition calcium their use should be avoided for at least two hours before taking the drug, because it reduces absorption of strontium ranelate And, consequently, its effectiveness. During the administration of the drug in patients with shortages vitamin D , and Calcium should be given additional medicines that will saturate the body with the necessary elements of the patient.
Overdose
Even though in excess of recommended dosages of the drug in patients rarely have side effects in overdose should still take measures to reduce absorption in the stomach of the active drug contained in the chemical composition of the drug. To do this, use milk or dairy products. In addition, it is recommended to vomit from the body to remove residues of the active compounds.
Cooperation
To avoid reducing the efficiency of BIVALOS should not be taken for at least two hours after eating milk or milk products. The same rules should be followed while using strontium ranelate and antacid drugs. It is worth noting that the efficacy antibiotics, belonging to quinoline and tetracycline drugs Significantly reduced when concomitantly with Bivalos.
Terms of sale
Buy Bivalos a pharmacy only if you have a prescription.
Storage conditions
Although special storage conditions for the drug is not provided, it is best to store Bivalos dry and inaccessible place for children.
Shelf life
3 years.
Cautions
When using this drug in the treatment of patients with renal failure should constantly monitor the proper functioning kidney . Since taking Bivalos can develop VTE (venous thromboembolism) and the reasons for this phenomenon have not been installed by specialists until now, physicians should be aware of this factor in the appointment of the drug to patients at risk.
When receiving the drug may exhibit different skin reactions , eg Stevens-Johnson syndrome, drug rash, eosinophilia, epidermal necrolysis , and DRESS-syndrome . If you have symptoms of the above ailments should immediately stop using Bivalos.
As contained in the product strontium affects the results colorimetric Research attendance Potassium blood or urine, for the most accurate estimate, use other methods, such as spectrometry, atomic emission or absorption atomic spectrometry and others.
Contained in the chemical composition Bivalos Aspartame can provoke unwanted adverse reactions in patients phenylketonuria . The drug does not affect the ability of people to accept it, to drive vehicles or does not interfere with work with dangerous to life and health mechanisms or units.
Analogs Bivalos
Osteogenon
The list includes the following unique Bivalos drugs:
- Strontium ranelate ;
- Stromos ;
- Strait ;
- Osteogenon ;
- Iksdzheva .
Patients leave the various reviews Bivalos analogues, however, as on the preparation itself.
Babies
The drug is not recommended for use in the treatment of pediatric patients.
During pregnancy (and lactation)
This drug is not recommended for use in the treatment of pregnant women. It is strictly forbidden to take during Bivalos Lactation As contained in a preparation strontium ranelate excreted in breast milk.
Reviews Bivalos
Although the bulk of the patients on Bivalos reviews are positive, some patients taking the drug, a negative to say about this drug. Negative feedback on the forums Bivalos still occur, albeit less frequently, and are reduced primarily to the fact that people complain about the list of contraindications and side effects of the drug.
Price Bivalos where to buy
The cost of the drug depends on the region, but you can buy it in the vast majority of pharmacies. Average price Bivalos in Ukraine (pack with 28 sachets) up to 400 UAH.
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