Description overdue on 09/16/2014
- Latin name: Depo-Provera
- ATC code: G03DA02
- Active substance: Medroxyprogesterone acetate (Medroxyprogesterone acetate)
- Manufacturer: Pfizer (Belgium)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Depo-Provera (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Reviews
- Price, where to buy
Composition
The drug in its composition contains such an active substance, such as medroxyprogesterone as acetate .
In addition, it contains the following additional components: polyethylene glycol 3350, sodium chloride, methylparaben, polysorbate 80, propylparaben, water for injection.
Product form
It is produced in the form of sterile suspensions for internal administration.
Pharmacological action
Progestogens and antitumor agent .
Pharmacodynamics and pharmacokinetics
Depo-Provera when administered intramuscularly characterized by prolonged action. Thus it has no androgenic and estrogenic activity. This tool blunts the secretion of pituitary gonadotropins , Because of which the female patients not ripen follicles and delayed ovulation . It also inhibits the secretory changes endometrial It increases the viscosity cervical mucus and the number of intermediate cells in the maturation index vaginal epithelium , Relieves vasomotor symptoms during Menopause .
When Depo Provera is used for protection against pregnancy significantly reduces the risk of inflammatory processes in the reproductive system, vulvovaginal candidiasis . In addition, the possible partial or complete regression of endometrial hyperplasia.
In men, there is a decrease of activity Leydig cells That reduces the endogenous testosterone secretion .
The antitumor effect of the medicine is characterized by a complex effect on pituitary . steroid metabolism at the tissue level and estrogen receptor . In high doses, it has GCS activity .
Maximum plasma concentration of active ingredient is observed after 4-20 days after the first dose. His connection to plasma proteins - about 95%.
Medroxyprogesterone acetate well supplied through blood-brain barrier . Cleaves to form metabolites . Write mainly in the feces and bile in the form metabolites or unchanged. Still about 44% is excreted unchanged in the urine. Half-life - six weeks.
Indications
In gynecology, the tool used for:
- treatment Endometriosis ;
- Contraception ;
- treatment vasomotor symptoms during Menopause .
In oncology, the drug is prescribed for metastases and / or relapses Kidney Cancer . endometrial . Breast . prostate .
Contraindications
The drug should not be used when:
- hypersensitivity to its components;
- severe violations of the liver;
- malignancies breast cancer (if appointed as a contraceptive drug);
- pregnancy and bleeding from the vagina unknown etiology.
In addition, the tool should not be used until the menstrual cycle. It is also prescribed with caution when epilepsy . chronic renal and Heart Failure . asthma , Depressive states, diabetes . migraine .
Side effects
When you receive this drug may cause the following adverse reactions:
- On the side CNS : dizziness . convulsions , Fatigue, obtuse concentration, irritability, problems with vision, depression . headache . euphoria . insomnia . drowsiness .
- On the side genitourinary system : amenorrhea , Pain in the pelvic region, irregular menstruation and cervical secretion . leykoreya , Long anovulation . vaginitis .
- On the side CCC : cerebral infarction and infarction , Increased blood pressure, thrombosis retinal artery, tachycardia . thromboembolic complications . heart failure . palpitation . thromboembolism . thrombophlebitis .
- On the side mucous membranes and integuments : acne . hirsutism , Rash, alopecia . itching . hives .
- Mammary gland : galactorrhea , Hypersensitivity, mammalgia .
- On the side The gastrointestinal tract and liver : constipation , Impaired liver function, nausea, dry mouth, flatulence . diarrhea . cholestatic jaundice , Vomiting, pain and discomfort in the abdomen.
- On the side of hematopoiesis : Improving leukocytes and Platelet .
- Allergies Hypersensitivity, anaphylaxis .
- Other: pain at the injection site, fever , Decreased libido, hot flushes, peripheral swelling , Change in weight, anorgasmia .
Instructions for use Depo-Provera (method and dosage)
Instructions on Depo-Provera advises Shake before use disposable syringe or vial to obtain a homogeneous suspension. Be sure to follow the rules aseptic .
The drug is usually administered in deltoid or gluteal muscle .
The duration of treatment and dosage are determined after consulting the doctors individually.
In the presence of Breast Cancer in most cases applied 500-1000 mg per day for 28 days. Then the drug is administered at 500 mg two times per 7 days. The course of treatment lasts until they reach the desired therapeutic effect.
In the presence of Kidney Cancer and endometrial Usually assigned 400-1000 mg every 7 days. Upon the occurrence of further possible to move to a dosage of 400 mg once a month.
In the presence of metastasis cancer prostate specialists usually prescribe use of 500 mg for injections 2 times per 7 days for three months. Then, 500 mg is administered once every 7 days.
For therapy during menopause prescribe a short course under the supervision of a physician.
With endometriosis Typically taking 50 mg every 7 days or at 100 mg every 2 weeks. The course is usually six months.
In the presence of vasomotor symptoms during Menopause assigned 150 mg every 12 weeks.
To Contraception use of 150 mg every 3 months. The first injection is carried out within 1-5 days of the normal menstrual cycle or after 5 days after delivery (if not breast-feeding ). In addition, Depo-Provera may be assigned after the cessation of breast-feeding a baby, or 6 weeks after childbirth (if abandon breastfeeding is impossible). This is required to exclude the presence of malignant tumors of the breast and cervix. To protect against unwanted pregnancy guide on the use of Depo-Provera injections recommends an interval of 12 weeks.
Overdose
In the treatment of malignant tumors in the case of excess dose may have symptoms that resemble symptoms Valium overdose . It is recommended to carefully monitor the condition of patients and, if necessary, adjust the dosage.
Cases of acute overdose are not fixed.
Cooperation
Together with Aminoglutethimide may reduce the concentration of Depo-Provera in plasma and reducing the effectiveness of Aminoglutethimide .
Terms of sale
Sold only in pharmacies by prescription.
Storage conditions
The medicine must be kept in a dry place, protected from direct sunlight. Optimum temperature - not more than 25 ° C.
Shelf life
Store this medication should be no longer than five years.
Reviews of Depo-Provera
Women use this tool primarily for contraception. This is what most of the action you can find reviews about the Depo-Provera, 150 mg every 3 months are really effective. However, in many cases, the application of this drug observed complications of weight gain, and other adverse reactions.
Doctors about Depo-Provera can meet different. Someone recommends a means to many of his patients, while others, on the contrary, trying to assign it only to women aged. After numerous reviews suggest that this drug can often give complications in pregnancy or impede the child's conception even after a long time.
Someone even at risk to apply this tool to cats as a method of contraception. However, it goes for animals is not without consequences. Experienced breeders say that 90% of cats after this injection forever remain sterile.
Price Depo-Provera, where to buy
Price Depo-Provera 500 mg - about 215 rubles, and in packs of 150 mg - about 160 rubles.
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