Bivalos

Description overdue on 09/26/2014

• Latin name: Bivalos
• ATC code: M05BX03
• Active substance: Strontium ranelate (Strontium ranelate)
• Manufacturer: Les Laboratoires Servier (France)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Bivalos (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One sachet contains 2532 milligrams of the drug Strontium ranelate hydrate   or 2000 milligrams of active substance is equivalent to anhydrous strontium ranelate . As part of the drug Bivalos contain adjuvants such as: mannitol, aspartame, and maltodextrin.

Product form

Bivalos produced in the form of pale yellow powder. The drug is used for the preparation of opaque white suspension. In one carton tend to be 7, 14, 28, 56, 84 or 100 sachets, each containing 2 grams of the active drug compound.

Pharmacological action

The drug helps to correct the metabolism of cartilage and bone.

Pharmacodynamics and pharmacokinetics

The results of the research in the face invitro (i.e., in vitro), it was found that strontium ranelate   promotes formation   bone . Besides being useful compound involved in   collagen synthesis and stimulates the production of precursors osteoblasts .

Bivalos reduces speed bone resorption Thus kupiruya the process of osteoclast differentiation . Under the influence of the drug compound the process of destruction of bone changes in the direction of its formation. One can say that the drug triggers recovery of bone tissue in the human body during osteoporosis.
In long-term therapeutic treatment (over three years), patients have an increase in the level of biochemical markers Responsible for bone formation (I C-terminal propeptide procollagen)   as well as reduced maintenance Markers Which leads to bone resorption (N-terminal and C-terminal telopeptide).

Bivalos effective in treating   postmenopausal osteoporosis in women during which increases the risk fractures . The drug has also shown excellent results when used during osteoarthritis . The active agent is involved in the development of cartilage matrix As well as the impacts on human chondrocytes Thus slowing down the process of tissue destruction. Thanks inhibition of subchondral bone resorption tissue   the drug has a positive effect on the pathophysiology of osteoarthritis .

Indications

The drug used in the treatment of:

• Osteoporosis in the menstrual period in women for the prevention and prevention   fractures;
• Osteoporosis hip or knee joints;
• osteoporosis in men.

Besides Bivalos used as part of a   therapeutic treatment of fractures , eg, hip .

Contraindications

The drug is contraindicated in:

• hypersensitivity;
• VTE (venous thromboembolism);
• vein thrombosis;
• pulmonary embolism;
• immobilization;
• coronary artery disease;
• artery and cerebrovascular diseases;
• hypertension.

Besides Bivalos forbidden to use in the treatment of patients who have not yet reached 18 years of age. With extreme caution and only under medical supervision, you can use the drug to patients suffering from renal failure And when venous thromboembolism .

Side effects

During use of the drug may occur following side effects gastrointestinal tract, nervous and cardiovascular system:

• headache;
• convulsions;
• impaired memory and consciousness;
• diarrhea;
• vomiting;
• nausea;
• diarrhea;
• stomatitis;
• mucous (eg mouth sores);
• venous thromboembolism.

On top of that there may be different allergic reactions   when using this drug, and expressed in appearance rashes on the skin, itching, hives, dermatitis or eczema.

Instructions for use Bivalos (method and dosage)

In accordance with the instructions on Bivalos formulation intended for oral administration. Before direct use should be prepared from the powder in a sachet liquid drug suspension Which it is recommended to use at bedtime. And immediately after taking the medicine should take a horizontal position for maximum therapeutic effect.

The recommended daily dosage is 2 grams Bivalos (ie one sachet). To avoid overdose should not arbitrarily increase the dose of medication without consulting your doctor, since the course of treatment is designed for a long period of time. To prepare the suspension to dissolve one sachet Bivalos at least 1/3 cup of water.

Due to the fact that many of the foods and food supplements containing in its composition   calcium   their use should be avoided for at least two hours before taking the drug, because it reduces absorption of strontium ranelate And, consequently, its effectiveness. During the administration of the drug in patients with shortages vitamin D , and   Calcium   should be given additional medicines that will saturate the body with the necessary elements of the patient.

Overdose

Even though in excess of recommended dosages of the drug in patients rarely have side effects in overdose should still take measures to reduce absorption in the stomach of the active drug contained in the chemical composition of the drug. To do this, use milk or dairy products. In addition, it is recommended to vomit from the body to remove residues of the active compounds.

Cooperation

To avoid reducing the efficiency of BIVALOS should not be taken for at least two hours after eating milk or milk products. The same rules should be followed while using strontium ranelate and antacid drugs. It is worth noting that the efficacy antibiotics,   belonging to quinoline and tetracycline drugs Significantly reduced when concomitantly with Bivalos.

Terms of sale

Buy Bivalos a pharmacy only if you have a prescription.

Storage conditions

Although special storage conditions for the drug is not provided, it is best to store Bivalos dry and inaccessible place for children.

Shelf life

3 years.

Cautions

When using this drug in the treatment of patients with renal failure   should constantly monitor the proper functioning kidney . Since taking Bivalos can develop VTE (venous thromboembolism)   and the reasons for this phenomenon have not been installed by specialists until now, physicians should be aware of this factor in the appointment of the drug to patients at risk.

When receiving the drug may exhibit different skin reactions , eg Stevens-Johnson syndrome, drug rash, eosinophilia, epidermal necrolysis , and DRESS-syndrome . If you have symptoms of the above ailments should immediately stop using Bivalos.

As contained in the product   strontium   affects the results colorimetric Research   attendance   Potassium blood or urine, for the most accurate estimate, use other methods, such as spectrometry, atomic emission or   absorption atomic spectrometry and others.

Contained in the chemical composition Bivalos Aspartame   can provoke unwanted adverse reactions in patients phenylketonuria . The drug does not affect the ability of people to accept it, to drive vehicles or does not interfere with work with dangerous to life and health mechanisms or units.

Analogs Bivalos

Match code ATC 4th level:

• Osteogenon

The list includes the following unique Bivalos drugs:

• Strontium ranelate ;
• Stromos ;
• Strait ;
• Osteogenon ;
• Iksdzheva .

Patients leave the various reviews Bivalos analogues, however, as on the preparation itself.

Babies

The drug is not recommended for use in the treatment of pediatric patients.

During pregnancy (and lactation)

This drug is not recommended for use in the treatment of pregnant   women. It is strictly forbidden to take during Bivalos Lactation As contained in a preparation   strontium ranelate   excreted in breast milk.

Reviews Bivalos

Although the bulk of the patients on Bivalos reviews are positive, some patients taking the drug, a negative to say about this drug. Negative feedback on the forums Bivalos still occur, albeit less frequently, and are reduced primarily to the fact that people complain about the list of contraindications and side effects of the drug.

Price Bivalos where to buy

The cost of the drug depends on the region, but you can buy it in the vast majority of pharmacies. Average price Bivalos in Ukraine (pack with 28 sachets) up to 400 UAH.

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Treatment with artrofoon

Description overdue on 10/26/2014

• Latin name: Arthrofon
• ATC code: L03
• Active substance: Affinity-purified antibodies to human tumor necrosis factor alpha (FNOalfa)
• Manufacturer: NPF Materia Medica Holding Company (Russia)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications treatment with artrofoon
• Contraindications
• Side effects
• Instructions for use treatment with artrofoon (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The structure 1 includes 3 mg tablets antibodies FNOalfa (human), - the active substance.

Additional ingredients:

• 267 mg - lactose;
• 30 mg - microcrystalline cellulose;
• 3 mg - magnesium stearate.

Product form

Valium tablets with a facet and Valium, white or cream-colored. On opposite sides of the inscription «ARTHROFON» and «MATERIA MEDICA».

In the audio pack 20, 40, 50, 75 or 100 tablets.

Pharmacological action

Anti-inflammatory, analgesic.

Pharmacodynamics and pharmacokinetics

Tablets are a treatment with artrofoon   Homeopathic medicines Exhibiting anti-inflammatory and analgesic effect and is used for the treatment of inflammatory processes   musculoskeletal system.   The treatment leads to an increase in supply of fabrics, to enhance the microcirculation and replication inhibition of inflammatory mediators. Turning to treatment with artrofoon regimens inflammatory degenerative pathologies of joints, leads to a reduction in the time course of an acute disease, but also to reduce the dosage of other drugs used in the treatment (often NSAIDs ).

Indications treatment with artrofoon

Indications allow the use of a formulation as in monotherapy (during remission primary disease), and in combination with other drugs (during exacerbation underlying disease).

More often prescribed for the treatment of treatment with artrofoon rheumatoid arthritis, osteoarthritis (including spondylarthrosis)   and other painful conditions of the joints.

Contraindications

In the absence of reliable data on the effects of treatment with artrofoon patients under 18 years of age, it is not used in this age category.

Also, a contraindication to its purpose is hypersensitivity   tablet ingredients to a patient.

Side effects

Might appear hypersensitivity reactions   the constituents of the drug.

Instructions for use treatment with artrofoon (method and dosage)

The tablets are taken orally treatment with artrofoon ( sublingually ). It recommends a single dose of two tablets under the tongue until they are completely dissolved. In order to achieve maximum efficiency you should not crush or chew the tablets. The preferred time taking the drug - morning and evening (2 times a day). Generally, therapy lasts no more than six months.

In severe pain, manual treatment with artrofoon in the first 2-4 weeks, allows 4-time receiving 2 tablets per day, with the holding of parallel treatment. When relieving pain gradually moving to the recommended dosage.

Overdose

You may experience dyspepsia Caused by members of the drug ingredients.

Cooperation

Hitherto incompatibilities with other drugs was observed.

It is possible to combine a reception   NSAIDs.

In parallel, it can be used analgesic and antiinflammatory ointment, gel or cream.

Terms of sale

Over the counter.

Storage conditions

The temperature is not above 25 ° C.

Shelf life

36 months.

Cautions

After initiation of therapy, 3-5 hours may a moderate increase in inflammation and pain That is, most often, not in need of correction regimens. In some cases, you can temporarily reduce the dose by half.

Treatment with artrofoon include lactose, and therefore, it is undesirable to prescribe to patients suffering lactase deficiency, galactose malabsorption syndrome or   glucose galactosemia.

Analogs

Match code ATC 4th level:

• Polioksidony
• Derinat
• Interferon
• Neovir
• Nazoferon
• Timalin
• Viferon
• Timogen
• Roncoleukin
• TSikloferon
• Broncho-Vaks
• Infagel
• Uro-Vaks
• IFN-EU-Lipint
• IFN-EU
• IFN-Lipint
• Altevir
• Algeron
• Laferobion

• Alflutop;
• Bischofite;
• Discus compositum;
• Polikatan;
• Sinovial;
• Teraflex;
• Traumeel S;
• Hondrofleks;
• The purpose of the T etc.

Babies

I do not recommend the appointment of treatment with artrofoon 18 years.

During pregnancy (and lactation)

Not studied the safety of therapy when treatment with artrofoon pregnancy and   Lactation . If necessary, its use should be weighed against the risk / benefit.

Reviews of treatment with artrofoon

There is no clear answer about the effectiveness and appropriateness of the destination of the drug treatment with artrofoon. Reviews of doctors who use it in their practice, divided approximately equally.

Some people watch more rapid improvement of the patient during treatment with artrofoon appointment in treatment, the effectiveness of other therapies require other drugs, and does not notice the changes of the disease, both in its application and without. Possibly, depending on the individual characteristics of each patient, as well as the placebo effect.

Treatment with artrofoon price, where to buy

The price depends on the amount of drug included in the packaging of tablets, as well as the region and the pharmacy network.

If you decide to purchase a pill treatment with artrofoon, the price of 100 pieces, on average - 250 rubles.

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Three-regolith

Description overdue on 09/15/2014

• Latin name: Tri-Regol
• ATC code: G03AB03
• Active substance: Ethinyl estradiol (Ethinylestradiol), Levonorgestrel (Levonorgestrel)
• Manufacturer: Gedeon Richter (Hungary)

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• Contraindications
• Side effects
• Instructions for use Three Regola (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
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Composition

Tablets include surfactants such as ethinylestradiol   and levonorgestrel .

Additional components include: talc, colloidal silicon dioxide, lactose monohydrate, corn starch, magnesium stearate.

The shell consists of sucrose, talc, titanium dioxide, macrogol 6000, red iron oxide, calcium carbonate, copovidone, colloidal silicon dioxide, povidone, carmellose sodium.

Product form

Three Regoli produced in the form of coated tablets.

Pharmacological action

Three-phase oral contraceptive.

Pharmacodynamics and pharmacokinetics

The drug belongs to a combined contraceptive drugs.

Levonorgestrel   reduces production gonadotropins , Resulting in slower and ovum matures ovulation   It does not occur.

Ethinylestradiol In turn, increases the viscosity of cervical mucus and reduces the passage of sperm into the uterus.

In addition, the three-regolith helps to normalize the menstrual cycle, as complementary level endogenous hormones .

The drug is well absorbed in the intestine upon oral administration. Processed in the intestine and liver and then eliminated via the kidneys and intestines.

Indications

The need for oral contraception. Treatment of disorders of the menstrual cycle.

Contraindications

Use of the drug is contraindicated in:

• over the age of 40 years;
• pregnancy   and breast-feeding ;
• Heavyweight itching   and idiopathic jaundice   pregnant women in history;
• gallbladder disease;
• smoking at the age of 35 years;
• thromboembolism   and thrombosis And predisposition thereto;
• diabetes   severe;
• improper fat metabolism;
• molar pregnancy ;
• migraine ;
• otosclerosis   with hearing problems;
• recent surgery;
• deficiency of the enzyme, which is needed to digest lactose milk;
• Hypersensitivity to the drug;
• liver disease;
• severe cardiovascular and cerebrovascular changes in history;
• Vaginal bleeding   undetermined etiology;
• sickle cell   and hemolytic anemia ;
• malignancies;
• chronic colitis ;
• Marfan syndrome ;
• phlebitis ;
• extensive injuries.

With care, this drug should be used when:

• asthma ;
• Chronic venous insufficiency   the lower extremities;
• epilepsy ;
• small chorea ;
• porphyria ;
• uterine cancer ;
• depression ;
• diabetes in step compensation (in the absence of vascular complications);
• multiple sclerosis ;
• hypertension   (BP up to 160/100 mm Hg. V.);
• tetany ;
• mastitis ;
• tuberculosis ;
• lack of regular menstrual cycle during adolescence.

Side effects

Adverse effects Three Regola usually following: discomfort when using contact lenses, intermenstrual bleeding, weight changes, nausea, fluid retention, changes in libido, breast sense of tension, acne . irritability . depression , Irritability, breast pain, headache . migraine , Blurred vision, gipomenoreya . amenorrhea .

These side effects are temporary and without special treatment. In rare cases can develop tumors appear lupus erythematosus . ulcerative colitis . hepatitis . Crohn's disease . jaundice .

Furthermore, increasing the number of infrequently observed triglycerides   plasma glucose tolerance reduction, fatigue, increased blood sugar, chorea . otosclerosis . embolism   pulmonary artery thrombophlebitis   deep veins, increased blood pressure, venous thromboembolism . thrombosis , Vomiting, cholelithiasis . diarrhea . pancreatitis , Skin rashes, exudative erythema multiforme , hair loss, hives . erythema nodosum , Change vaginal secretion, chloasma The appearance of secretion from the mammary glands, fungal infections vagina.

There may be side reactions such as dizziness , Worsening epilepsy . hypertrichosis . seborrhea , A feeling of heaviness in the legs.

Instructions for use Three Regola (method and dosage)

Instructions for Three-Regoli discloses that tablets should be taken in one day at the same time. The course from the first day of menstruation and is designed for 21 days. After this has to be a break week for menstrualnopodobnoe bleeding. Then start taking the tablets again on the first package (even if the bleeding is still present). First you need to take 6 pink tablets and then - and after 5 white - 10 yellow.

The order of taking the medicine packaging specified numbers and arrows. If one pack contains 28 tablets after ingestion DY should proceed to brown (do not contain hormones), and the next course should start 28 days without interruption.

If a pill is missed (passed more than 36 hours), reliable contraceptive protection is not guaranteed. On the first and second week of the cycle in the case of the missing instructions for use Three Regola Council adopted the next day just 2 tablets.

If you missed just two pills in a row, following 2 days you need to take 2 tablets, then continue the course, as usual. When you pass on the third week of the course seven-day break is not done.

Skipping tablets does not relate to brown. They contain iron, and they are used to maintain continuity.

If the drug is prescribed for and its dosage is adjusted individually.

Overdose

At doses in excess of the patients have nausea . headache . uterine bleeding . In this case, you must consult your doctor immediately. Treatment is symptomatic, gastric lavage.

Cooperation

Caution is advised to take three-regolith in conjunction with:

• Ampicillin . Chloramphenicol .   Penicillin . tetracyclines . Dihydroergotamine . Phenylbutazone . Rifampicin . Neomycin . sulfonamides Some anticonvulsants and tranquilizers, Ketoconazole   - May decrease the effectiveness of contraception;
• tricyclic antidepressants . beta-blockers . Maprotiline   - Possibly increasing bioavailability and toxicity of these agents;
• Bromocriptine   - Can reduce the effectiveness;
• anticoagulants Derived indandiona   or coumarin   - May be necessary to monitor the prothrombin time, adjusting dosages;
• antidiabetic medicines for oral use, Insulin   - You may need dosage adjustments;
• hepatotoxic   It means - increased risk of increased hepatotoxicity.

Terms of sale

The drug is sold by prescription only.

Storage conditions

Means must be kept out of the reach of small children. The temperature must be below 25 0C.

Shelf life

Shelf life - 5 years.

Reviews of Tri-regolith

Birth control pills Tri-regolith get a variety of responses, as well as most other hormonal contraceptives. For some, they fit perfectly, and someone gets a lot of unwanted side effects. While most reviews of Tri-regolith is still positive. Some girls even "prescribe" it to themselves, without consulting with experts. And in most cases, problems with pregnancy after the cancellation rate was observed.

According to doctors about three-regolith is usually positive. They are often prescribed to patients for the normalization of the menstrual cycle. Doctors about three-regolith boil down to the fact that it is relatively harmless remedy for little money. However, the effect of oral contraceptive use is very individual. Some experts have neglected the need to analyze, so it also happens that the drug is not suitable for a number of indicators of patients who appointed him. This leads to undesirable side reactions. So appoint a three-regolith should be only after the relevant tests.

Price three-Regola where to buy

Price three-Regola compared with a number of similar funds is considered very affordable. That is why it is often recommended specialists. Price three-Regola in packaging designed for the tablet 21, an average of about 200 rubles.

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Miropriston

Description overdue on 07/25/2014

• Latin name: Miropristone
• ATC code: G03XB01
• Active substance: Mifepristone (Mifepristone)
• Manufacturer: JSC "Obninsk chemical and pharmaceutical company" (Russia)

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• Pharmacological action Miropristona
• Pharmacodynamics and pharmacokinetics Miropristona
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• Overdose
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• Shelf life
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• During pregnancy (and lactation)
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Composition medicament

The preparation as an active (active) substances, 200 mg of mifepristone   ( Mifepristone ).

As additional ingredients, the preparation contains:

• 264.4 mg - microcrystalline cellulose ;
• 16.2 mg - talc ;
• 5.4 mg - calcium stearate ;
• 54 mg - sodium carboxymethyl starch .

Product form

Miropriston available as 200 mg tablets in blister №3, pale yellow or greenish color.

Valium pill form, on the outside there is risk and chamfer.

Pharmacological action Miropristona

The drug has Miropriston antigestagens activity (blocks the action of a hormone progesterone   at the receptor level).

Pharmacodynamics and pharmacokinetics Miropristona

Active substance formulation mifepristone   is a synthetic steroid drug antigestagens (blocks the action of the hormone progesterone   at the receptor level) and has, thus, progestogenic activity. Seen antagonism glucocorticosteroids   manifested through competition at the level of drug interactions with receptors.

Mifepristone   It increases the contractile function of the myometrium, thereby stimulating in horiodetsidualnyh cells release IL-8 (interleukin-8) , Increasing the sensitivity of the myometrium   to prostaglandins . The result of the drug is the decidua desquamation and, consequently, the excretion of a fertilized egg.

After receiving a single dose of 600 mg, the maximum content of active substance in plasma at 1, 3 hours (1, 98 mg / l). The bioavailability is approximately 69%.

Mifepristone in plasma binds to proteins   98% ( albumin   and sour alpha1-glycoprotein ). Excretion of the drug, after the distribution phase is slow, with a decrease of its concentration doubled between 12-72 hours, after 72 hours of removal occurs faster. The half-life of the drug is usually 18 hours.

Indications

• Miropriston drug, in combination with Misoprostol , Applied to interrupt diagnosed masterbatch pregnancy   in its early stages (up to 42 days of amenorrhea).
• Artificial excitement of labor (induction of labor).

Contraindications

• individual sensitivity to this drug;
• acute or chronic disease of the kidneys and liver;
• adrenal insufficiency;
• long-term treatment with glucocorticosteroids ;
• porphyria ;
• anemia   (at the level of Hemoglobin   less than 100 g / l);
• hemostatic disorders   (including an earlier therapy with anticoagulants );
• acute inflammatory diseases of female genital mutilation;
• severe extragenital diseases;
• hysteromyoma ;
• smoking (for patients older than 35 years, without consulting your doctor).

Use for abortion :

• period of the alleged pregnancy of more than 42 days amenorrhea ;
• confirmed ectopic pregnancy   or suspicion of its ability;
• no confirmation of pregnancy;
• the possibility of pregnancy, which occurred against the backdrop of Use intrauterine contraceptive devices ;
• the possibility of pregnancy after cancellation hormonal contraceptive drugs .

Use for field of labor   and preparation of birth:

• Preeclampsia ;
• preeclampsia   severe;
• eclampsia ;
• disparity in the size of the fetal head and pelvis mothers;
• Prolonged or preterm pregnancy;
• unreasonable bleeding from the genital organs;
• abnormal fetal position;
• hemolytic disease of the fetus severe;
• premature discharge of amniotic fluid.

With care prescribe:

• at hypertension ;
• at asthma ;
• chronic obstructive pulmonary diseases system;
• rhythm disturbances of the heart muscle;
• when diagnosed Heart Failure .

Side effects

At reception mifepristone :

• hives ;
• hyperthermia ;
• dizziness ;
• headache ;
• general weakness;
• discomfort in the abdomen;
• nausea and vomiting.

During the procedure medical abortion :

• pain in the abdomen;
• bleeding from the genital tract ;
• inflammation of the uterus and its appendages.

Instructions on Miropriston (method and dosage)

The drug Miropriston as tablets taken orally (by mouth). The drug should be prescribed and used only in specialized hospitals, have trained and trained personnel, as well as the necessary diagnostic and treatment equipment.

To abort an unwanted pregnancy in the early stages

Assign 600 mg (three 200 mg tablets) once through 1-1, 5:00 after eating, drinking plenty of water. The drug is indicated for use only in the presence of the attending physician. After receiving 3 tablets Miropristona 36-48 hours the patient is prescribed Misoprostol   400 mcg and left under dynamic supervision of the attending physician for 2 hours. US control and repeated clinical examination is appointed for 10-14 hours after the start of Mifepristone . If necessary, define the content of human chorionic gonadotropin, in order to confirm a successful medical abortion.

With a negative or incomplete effect of the use of therapy (ongoing pregnancy or incomplete abortion) at 14 days after administration of drugs recommended holding vacuum aspiration to further histological studies.

To prepare and artificial excitation of labor

Prescribers Miropriston as tablets for induction of labor at a dose of 200 mg (1 tablet) once (only in the presence of a doctor). One day (24 hours) to re-appoint 200 mg Miropristona. Assessment of the birth canal is carried out in 48-72 hours after receiving repeated doses of the drug. If needed, apply prostaglandins   and Oxytocin .

Overdose

Receiving Miropriston drug at a dose of 2 grams does not lead to undesirable reactions. Due to the strict conditions of mifepristone, which should only be used in specialized clinics, its overdose is unlikely.

In case of accidental overdose may occur adrenal insufficiency .

Cooperation

When receiving Miropristona is not necessary to conduct therapy with nonsteroidal antiinflammatory drugs (NSAIDs) .

When combined therapy and drugs group Miropristonom glucocorticosteroids It is necessary to adjust the dose glucocorticoids   towards its increase.

Terms of sale

Miropriston drug sold by prescription only and is used only in specialized medical obstetrical institutions that belong to the public health system.

Use of the drug is possible in hospitals, in private or municipal property, if the license for this kind of activity.

Storage conditions

The drug belongs to the list Miropriston A.

Store in a dry place, protected from direct sunlight, out of reach of children.

Storage temperature should not exceed 30 ° C.

Shelf life

5 years (not used after the expiry date).

Cautions

Patients who take Miropriston to terminate an unwanted pregnancy in the early stages, should have complete information about the effects of the drug. In particular, the absence of effect of the drug on day 10-14 ( ongoing pregnancy   or incomplete abortion ), Pregnancy must be interrupted by another doctor recommended way to avoid the risk of congenital malformations in the fetus.

The application requires a warning Miropristona Rh alloimmunization   and other general-purpose events that accompany an abortion.

During pregnancy and lactation

After receiving Miropristona for the purpose of medical abortion should stop for 3 days breast-feeding .

Application Miropristona for initiating labor does not affect the subsequent lactation.

Reviews Miropristone

Reviews on the forums about the drug Miropriston, as a means to terminate an unwanted pregnancy, mostly positive. Among the advantages of this drug more often pay attention to the possibility of an abortion without surgical intervention. Among the shortcomings - pain in the abdomen . vomiting   and discomfort after administration of the drug. Side effects and adverse effects of mifepristone tend to occur while taking the drug at home without a doctor's advice.

Virtually no negative reviews of Miropristone in childbirth. This drug is used in obstetric practice is widely and successfully.

Price Miropristona where to buy

Price Miropristona the pharmacy (Table. 0.2g N3) ranges from 535 to 692 hryvnia, depending on the medical establishment.

In Ukraine, you can buy Miropriston only by prescription, with a further application in a specialized clinic, under the strict supervision of the attending physician.

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Depo-Provera

Description overdue on 09/16/2014

• Latin name: Depo-Provera
• ATC code: G03DA02
• Active substance: Medroxyprogesterone acetate (Medroxyprogesterone acetate)
• Manufacturer: Pfizer (Belgium)

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• Overdose
• Cooperation
• Terms of sale
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• Shelf life
• Reviews
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Composition

The drug in its composition contains such an active substance, such as medroxyprogesterone as acetate .

In addition, it contains the following additional components: polyethylene glycol 3350, sodium chloride, methylparaben, polysorbate 80, propylparaben, water for injection.

Product form

It is produced in the form of sterile suspensions for internal administration.

Pharmacological action

Progestogens   and antitumor agent .

Pharmacodynamics and pharmacokinetics

Depo-Provera when administered intramuscularly characterized by prolonged action. Thus it has no androgenic and estrogenic activity. This tool blunts the secretion of pituitary gonadotropins , Because of which the female patients not ripen follicles   and delayed ovulation . It also inhibits the secretory changes endometrial It increases the viscosity cervical mucus   and the number of intermediate cells in the maturation index vaginal epithelium , Relieves vasomotor symptoms during Menopause .

When Depo Provera is used for protection against pregnancy significantly reduces the risk of inflammatory processes in the reproductive system, vulvovaginal candidiasis . In addition, the possible partial or complete regression of endometrial hyperplasia.

In men, there is a decrease of activity Leydig cells That reduces the endogenous testosterone secretion .

The antitumor effect of the medicine is characterized by a complex effect on pituitary . steroid metabolism   at the tissue level and   estrogen receptor . In high doses, it has   GCS activity .

Maximum plasma concentration of active ingredient is observed after 4-20 days after the first dose. His connection to plasma proteins - about 95%.

Medroxyprogesterone acetate   well supplied through blood-brain barrier . Cleaves to form metabolites . Write mainly in the feces and bile in the form metabolites   or unchanged. Still about 44% is excreted unchanged in the urine. Half-life - six weeks.

Indications

In gynecology, the tool used for:

• treatment Endometriosis ;
• Contraception ;
• treatment vasomotor symptoms   during Menopause .

In oncology, the drug is prescribed for metastases   and / or relapses   Kidney Cancer . endometrial . Breast . prostate .

Contraindications

The drug should not be used when:

• hypersensitivity to its components;
• severe violations of the liver;
• malignancies   breast cancer (if appointed as a contraceptive drug);
• pregnancy   and bleeding from the vagina   unknown etiology.

In addition, the tool should not be used until the menstrual cycle. It is also prescribed with caution when epilepsy . chronic renal   and Heart Failure . asthma , Depressive states, diabetes . migraine .

Side effects

When you receive this drug may cause the following adverse reactions:

• On the side CNS : dizziness . convulsions , Fatigue, obtuse concentration, irritability, problems with vision, depression . headache . euphoria . insomnia . drowsiness .
• On the side genitourinary system : amenorrhea , Pain in the pelvic region, irregular menstruation and cervical secretion . leykoreya , Long anovulation . vaginitis .
• On the side CCC : cerebral infarction   and infarction , Increased blood pressure, thrombosis   retinal artery, tachycardia . thromboembolic complications . heart failure . palpitation . thromboembolism . thrombophlebitis .
• On the side mucous membranes and integuments : acne . hirsutism , Rash, alopecia . itching . hives .
• Mammary gland : galactorrhea , Hypersensitivity, mammalgia .
• On the side The gastrointestinal tract and liver : constipation , Impaired liver function, nausea, dry mouth, flatulence . diarrhea . cholestatic jaundice , Vomiting, pain and discomfort in the abdomen.
• On the side of hematopoiesis : Improving leukocytes   and Platelet .
• Allergies Hypersensitivity, anaphylaxis .
• Other: pain at the injection site, fever , Decreased libido, hot flushes, peripheral swelling , Change in weight, anorgasmia .

Instructions for use Depo-Provera (method and dosage)

Instructions on Depo-Provera advises Shake before use disposable syringe or vial to obtain a homogeneous suspension. Be sure to follow the rules aseptic .

The drug is usually administered in deltoid   or gluteal muscle .

The duration of treatment and dosage are determined after consulting the doctors individually.

In the presence of Breast Cancer   in most cases applied 500-1000 mg per day for 28 days. Then the drug is administered at 500 mg two times per 7 days. The course of treatment lasts until they reach the desired therapeutic effect.

In the presence of   Kidney Cancer and endometrial Usually assigned 400-1000 mg every 7 days. Upon the occurrence of further possible to move to a dosage of 400 mg once a month.

In the presence of metastasis   cancer prostate   specialists usually prescribe use of 500 mg for injections 2 times per 7 days for three months. Then, 500 mg is administered once every 7 days.

For therapy during menopause   prescribe a short course under the supervision of a physician.

With endometriosis Typically taking 50 mg every 7 days or at 100 mg every 2 weeks. The course is usually six months.

In the presence of vasomotor symptoms   during Menopause   assigned 150 mg every 12 weeks.

To Contraception   use of 150 mg every 3 months. The first injection is carried out within 1-5 days of the normal menstrual cycle or after 5 days after delivery   (if not breast-feeding ). In addition, Depo-Provera may be assigned after the cessation of breast-feeding a baby, or 6 weeks after childbirth (if abandon breastfeeding is impossible). This is required to exclude the presence of malignant tumors of the breast and cervix. To protect against unwanted pregnancy guide on the use of Depo-Provera injections recommends an interval of 12 weeks.

Overdose

In the treatment of malignant tumors in the case of excess dose may have symptoms that resemble symptoms Valium overdose . It is recommended to carefully monitor the condition of patients and, if necessary, adjust the dosage.

Cases of acute overdose are not fixed.

Cooperation

Together with Aminoglutethimide   may reduce the concentration of Depo-Provera in plasma and reducing the effectiveness of Aminoglutethimide .

Terms of sale

Sold only in pharmacies by prescription.

Storage conditions

The medicine must be kept in a dry place, protected from direct sunlight. Optimum temperature - not more than 25 ° C.

Shelf life

Store this medication should be no longer than five years.

Reviews of Depo-Provera

Women use this tool primarily for contraception.   This is what most of the action you can find reviews about the Depo-Provera, 150 mg every 3 months are really effective. However, in many cases, the application of this drug observed complications of weight gain, and other adverse reactions.

Doctors about Depo-Provera can meet different. Someone recommends a means to many of his patients, while others, on the contrary, trying to assign it only to women aged. After numerous reviews suggest that this drug can often give complications in pregnancy or impede the child's conception even after a long time.

Someone even at risk to apply this tool to cats as a method of contraception. However, it goes for animals is not without consequences. Experienced breeders say that 90% of cats after this injection forever remain sterile.

Price Depo-Provera, where to buy

Price Depo-Provera 500 mg - about 215 rubles, and in packs of 150 mg - about 160 rubles.

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Mifegin

Description overdue on 08/01/2014

• Latin name: Mifegyne
• ATC code: G03XB01
• Active substance: Mifepristone (Mifepristone)
• Manufacturer: EXELGYN Laboratoires, MACORS Laboratoires (France)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Mifegin (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

As part of a biconvex tablet Mifegin light yellow color, coated with 167V code contains 20 mg. active active compound micronized mifepristone .

Corn starch, colloidal silica, magnesium stearate, microcrystalline cellulose, and povidone   part of the drug as auxiliary substances.

Product form

Mifegin produced in tablet form. In one carton is usually 3 blisters with medicament total nominal volume is 200, 400 or 700 mg.

Pharmacological action

The drug has antiprogestagennoe impact .

Pharmacodynamics and pharmacokinetics

Since a part of chemical compounds have drug   antigestagens exposure , At the level of Mifegin receptors   blocks the action progesterone . Due to this connection receptors   When using the drug observed antagonism with GCS .

In addition, the drug stimulates horiodetsidualnyh cells   release process IL-8 Thereby increasing the contractility of at myometrium And sensitivity to prostaglandins .

Under the influence of the drug takes place expulsion of the ovum   and decidua desquamation.   To enhance the effectiveness of Mifegin often combined with synthetic analogs prostaglandin .

The necessary concentration of active compound in the active body reached after 1 and 3 hours after receiving a single medicament. Getting in plasma mifepristone   It binds acidic alpha1-glycoprotein   and albumin   98%.

In step removing the active compound for 12-18 hours, gradually decreases its concentration in the body. Fully mifepristone   excreted from the body within 72 hours after the end use of the product.

Indications

The drug is used, generally at   medical abortion   for up to 42 days, as well as at home as a tool Emergency   Contraception   within 72 hours after unprotected intercourse. Everything else, Mifegin apply for term pregnancy for induction and preparation for Childbirth As well as in the treatment of uterine leiomyoma .

Contraindications

The main contraindications to the use of the drug are the following diseases and conditions:

• adrenal insufficiency;
• kidney or liver failure Including chronic or acute forms of diseases;
• hypersensitivity   to the constituent components of the drug;
• a long period of treatment glucocorticoids ;
• a scar on the uterus ;
• porphyria ;
• heavy extragenital pathology ;
• diseases of the genital organs;
• anemia;
• abnormalities in hemostasis.

It is forbidden to use Mifegin abortion in the presence of:

• suspected ectopic pregnancy;
• pregnancy The duration of which exceeds 42 days after the last menstrual period;
• uterine fibroids .

At induction or preparing for childbirth the drug is not recommended for use in the presence of:

• preeclampsia;
• eclampsia;
• preeclampsia;
• uterine fibroids;
• perenoshennoy   or full-term pregnancy.

The drug is not used during the treatment   uterine leiomyoma   in the presence of:

• pregnancy The duration of which exceeds 12 weeks and lactation;
• ovarian tumors;
• submucosal fibroids location;
• endometrial hyperplasia.

Side effects

When using the drug may experience side effects such as: weakness, discomfort in the lower abdomen, headache, vomiting or nausea, dizziness, diarrhea, skin rash,   and gipetermiya .

Apart from the above ailments with the use of the drug during medical abortion may have more side effects such as the bleeding, worsening of reproductive tract infections and urinary tract infections , and   inflammation of the uterus and appendages .

When sharing and Mifegin Misoprostol may be reduced hemoglobin levels Evolve indigestion, fatigue and vaginitis . Furthermore, there may be fainting and disturb pains in the legs.

Use of a preparation as Emergency Contraception   may cause   menstrual disorders   and   bloody issues . During treatment   leiomyoma   using Mifegin may develop amenorrhea.

Instructions for use Mifegin (method and dosage)

In accordance with the instructions on Mifegin, the drug is intended solely for use under medical supervision in a medical facility. The drug is not recommended for use for permanent Contraception And does not protect against   diseases, sexually transmitted diseases .

To abortion   taking 600 mg. means in the presence of medical personnel that have over 2 hours should monitor the patient. After 48 hours of using the drug, the patient should do US And 14 days - repeat ultrasound and be examined by a gynecologist, to finally confirm the termination of pregnancy.

As a preliminary to the   Childbirth   means taking the drug at a dose of 200 mg. in the presence of physicians. Within 24 hours, shows repeated reception of the drug at the same dose. After a lapse of 72 hours after the second dose, as well as following evaluation condition the birth canal   doctors can appoint Oxytocin   or prostaglandin.

Overdose

When used in the body for safe doses not exceeding 2 years, Mifegin does not cause undesirable side reactions. If overdose occurs adrenal insufficiency.

Cooperation

Effective treatment Mifegin should be avoided within 12 days after treatment using nonsteroidal anti-inflammatory drugs.

Terms of sale

Sold for the needs of specialized medical institutions licensed to provide obstetrical services.

Storage conditions

The drug belongs to the group A and requires a certain temperature storage (not strictly above 25 ° C).

Shelf life

3 years.

Cautions

As used for Mifegin medical abortion Patients should be informed of the need for mandatory medical examination within 14 days after the direct use of the drug. In cases where the drug does not reach its target (continued   pregnancy, incomplete abortion)   immediately conduct vacuum aspiration,   since mifepristone   provokes severe malformations Development fetus.

The drug should be used in a medical facility because prior to his admission as to the operational abortion   you need to pass some specific studies, such as a warning Rh alloimmunization .

During treatment with Mifegin patients   infective endocarditis or artificial heart valve,   to be used simultaneously antibiotics .

Analogs Mifegin

Match code ATC 4th level:

• Esmiya
• Zhenale
• Miropriston
• Ginepriston
• Mifepristone
• Penkrofton

Currently, the following analogs of active Mifegin active component:

• Mifepreks;
• Agesta;
• Gynestril administration;
• Miropriston;
• Penkrofton;
• Mifepristone;
• Ginepriston;
• Zhenale;
• Gynestril administration.

Which is better: Mifepristone or Mifegin?

At its core, both are designed for preparation medical abortion And used in preparation for   Childbirth   stage. Mifepristone, as well as Mifegin   It has an extensive list of contraindications and approved for use only in hospitals, where in the event of side effects or complications, doctors will be able to provide immediate assistance to the patient.

During pregnancy (and lactation)

Nursing mothers should abandon breast-feeding   during use of the product, and during the next 14 days.

Reviews Mifegin

It is not always possible to meet Mifegin positive feedback on the forums. Some women who use the drug for abortion, noted the occurrence of side effects that are not always disappear quickly after use of the drug. Also, quite often there are reports of poor-quality forgeries of the drug and its analogs, which were acquired through the network of electronic pharmacies or informal distributors that do not require a doctor's prescription.

Price Mifegin where to buy

Cost Mifegin tablets may vary depending on the region. It is therefore advisable to specify yourself how much it costs in pharmacies of your city this medication. Buy Mifegin in Moscow, as in other cities of the Russian Federation is not a problem.

The average price in pharmacies Mifegin country will be about 3,000 rubles per pack.

Average price Mifegin in Ukraine reaches 1700 hryvnia per pack.

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Emanera

Description overdue on 10/28/2014

• Latin name: Emanera
• ATC code: A02BC05
• Active substance: Esomeprazole (Esomeprazol)
• Manufacturer: Krka, Slovenia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Emanery (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Reviews
• Price, where to buy

Composition

Produced in two dosages: with 20, 645 mg esomeprazole magnesium   41 or 29 mg esomeprazole magnesium   (which is equivalent to that of esomeprazole 20 mg or 40 mg).

Also it means comprises auxiliary elements: starch syrup, sucrose, povidone, sodium lauryl sulfate, polysorbate 80, titanium dioxide, polyvinyl alcohol, talc, macrogol 3000, macrogol 6000, hydroxycarbonate, sodium methacrylic to-you-ethyl acrylate copolymer, talc, E172, gelatine.

Product form

The drug in a dosage of 40 mg produced a pale pink capsules, white pellets inside.

Preparation of 20 mg - pink capsule, with the contents of the same kind.

Packages of 7, 14 or 28 pieces each.

Pharmacological action

Antiulcer .

Pharmacodynamics and pharmacokinetics

The active substance - specific an inhibitor of the parietal cell proton alluvium GI . There are two isomers of omeprazole - S-isomer esomeprazole And R-isomer . Their pharmacodynamic   activity similar, but for the treatment and prevention of gastric ulcers typically use esomeprazole .

H + K + -ATRazu   This basal and stimulated acid secretion is also inhibited.

Within an hour of getting the drug into the growing effect of suppressing the production of acid GI . If taken by means of one 20 mg once a day for 5 days, there will be a substantial (almost 91%) reduction in the concentration of hydrochloric acid   in the stomach.

The efficacy depends on its concentration in the blood plasma.

Patients reflux esophagitis   In drug treatment within a month at a dose of 40 mg, healing is 78% if the rate is 2 months, the probability to recover - 93%.

Stomach Ulcer   in 60-80% of cases is caused by bacteria Helicobacter pylori,   if you take esomeprazole   40 mg per day for one week, combining with antibiotics , 90% of patients recovery occurs.

During treatment is a significant reduction of the hydrochloric acid in the stomach in connection with this level gastrin   increases in serum, and may increase the number of enterochromaffin cells .

Also increases the risk of glandular cysts   in the stomach. These cysts are almost always benign and do not require surgical intervention.

The slightly increased risk of infectious diseases, for example, salmonellosis .

Esomeprazole   It can be used for healing ulcers that result from nonsteroidal anti-inflammatory drugs, selective COX-2 inhibitors .

The drug is commonly prescribed for the prevention of stomach ulcers while taking specific medicines.

esomeprazole   decomposes concerning the active substance is in Pellet   and enteric capsule. A small amount of the substance passes into R-isomer .

After entering the GI   the drug is well absorbed, the maximum concentration in plasma is reached after an hour or two.

Bioavailability   - 64%, at regular admission - 89%. For dosage at lower bioavailability (when taking 20 ml, it is 50 and 68% respectively).

The tool is well bound to plasma proteins for 97%.

The effectiveness of the drug does not significantly affect the food eaten along with the tablet.

Metabolism   in the liver using enzyme .

The metabolism involved isozymes CYP2C19   and CYP3A4 . After a single dose plasma clearance  

The half-life - about 1, 5 hours. If the tool used for a long time, the period of excretion prolonged.

Esomeprazole  

Conclusion metabolites is performed by the kidneys or via the gut. Do not changed the substance found in the urine in small quantities (1%).

Individuals with reduced activity of isoenzyme CYP2C19   drug metabolism is due CYP3A4 . The amount of plasma concentrations significantly (almost 60%) increased.

Women value AUC   30% more than men when a single dose. If treatment is prolonged, significant differences in performance depending on the sex of the patient is observed.

In patients with liver and kidney metabolism may be disturbed. When serious violations of the liver, the maximum daily dose is 20 mg.

Pharmacokinetic   figures for people aged 12 years and over was not significantly changed.

Indications

• at GERD ;
• gastric and duodenal ulcers;
• for the prevention of diseases ZHTK Induced by administration NSAIDs ;
• at erosive esophagitis reflyus ;
• in diseases caused by bacteria Helicobacter pylori ;
• for the prevention of peptic yavz , In patients receiving NSAIDs  
• treatment idiopathic hypersecretion ;
• at Zollinger-Ellison syndrome .

Contraindications

The tool does not prescribe:

• at allergies   on the components of the drug;
• when receiving nelfinavir   or atazanavir ;
• fructose intolerance;
• Children up to 12 years;
• at galactose malabsorption glucose-   or deficit sucrase-isomaltase .

Side effects

There may be:

• headache   and dizziness . insomnia . drowsiness . depression . hallucinations
• constipation   or diarrhea . flatulence , Vomiting, dryness of the mouth, abdominal pain, vomiting, hepatitis . , Aggravation or occurrence of liver disease;
• jade . gynecomastia . bronchospasm ;
• thrombocytopenia . agranulocytosis . leukopenia . pancytopenia ;
• myalgia arthralgia ;
• change in taste perception, temporary decrease in vision;
• hives , Skin rash, alopecia . dermatitis Sensitivity to light, Stevens-Johnson syndrome ;
• reaction hypersensitivity   ( angioedema . anaphylactic shock );
• weakness, edema, sweating.

Instructions for use Emanery (method and dosage)

The tablets are taken orally without sharing and without chewing, drinking plenty of fluids.

If patients have difficulty swallowing, the contents of the capsules can be dissolved in non-carbonated water. Drink resulting solution should be not later than 30 minutes after cooking. Pellets should not fully rasvoryatsya in water or remain on the walls of glass.

Perhaps the introduction of the drug through the Levin tube .

Dosage and duration of treatment should be determined by the attending physician.

According to the instructions on Emaneru, the dosage is as follows:

• treatment GERD   40 mg administered funds, 1 per day for a month (the course can be extended to 2 months);
• for prophylaxis GERD   appoint 20 mg 1 time a day;
• at stomach ulcer   esomeprazole   (+1 Grams Amoxicillin   and 500 mg clarithromycin ), 2 times a day for one to two weeks;
• for the treatment of gastric ulcers caused by taking NSAIDs Appoint 20-40 mg a day, a month or two;
• for prophylaxis stomach ulcers   - 20-40 mg 1 time a day;
• if you want to produce prevention of bleeding peptic ulcers after intravenous administration of drugs that lower the level of hydrochloric acid, taking 40 mg means 1 times a day, for a month;
• at Zollinger-Ellison syndrome . idiopathic hypersecretion At the beginning administered 40 mg 2 times per day.

In violation of the liver dose adjustment is required.

Rules of administration through Levin tube :

• Pour the contents of the capsule to the probe primerno25-50 ml of water and 5-10 ml of air.
• Shake the syringe until the suspension is formed.
• Make sure the tip is not blocked pellets .
• Attach the syringe to the probe tip, wherein the tip holding it up.
• Quickly shake the syringe, turn down, enter part of the suspension.
• Again, turn the syringe tip up, and repeat the previous step.
• Enter the contents of the syringe into the tube until the suspension ends.

Overdose

No cases of overdose have been reported.

If you take 280 mg, there will be weakness, malfunctions gastrointestinal tract .

No specific antidote.

Hemodialysis ineffective.

If overdose does happen, it should produce symptomatic therapy.

Cooperation

Emanera can affect the processes of absorption of certain drugs, e.g., the absorption of which depends on the pH of the stomach.

Antacids . ketoconazole . itraconazole , Agents that reduce the secretion of gastric glands, are worse assimilated.

  facilities ( atazanavir . rinotavir ) Reduce their effectiveness when combined with the drug.

If involved in drug metabolism isoenzyme CYP2C19 It should not be combined with Emaneroy. Therefore, while taking omeprazole   and diazepam . imiprimina . phenytoin . citalopram . clomipramine . vorikonozola   Be particularly careful.

amoxicillin   and quinidine .

When combined with funds coumarin   or warfarin   Caution should be exercised and monitoring indicators INR.

If you combine the drug with clarithromycin Value AUC   esomeprazole   doubled.

Inhibitors isoenzyme CYP2C19   and CYP3A4   can significantly affect the pharmacokinetic parameters of the drug.

Terms of sale

It requires a prescription.

Storage conditions

Store in a cool place, in original packaging, away from children.

Shelf life

2 years.

Cautions

If you have symptoms of malignant tumors, such as severe weight loss, dysphagia, vomiting of blood, it is necessary to eliminate the risk of cancer, to produce additional studies.

Chronic administration of the drug required to control the treating physician.

It should be remembered that the medicine contains sucrose.

This tool does not affect on the reaction rate and concentration.

Match code ATC 4th level:

• Losek MAPS
• Losek
• Sanpraz
• Omez
• Insta omez
• Rabeprazole
• Kontrolok
• Ortanol
• Nexium
• Nolpaza
• Geerdin
• Omeprazole
• Lansoprazole

The closest analogue Emanery: Pemozar, Ezomealoks, Nexium, Nekspro, Ezoks, Ezolong, esomeprazole, Barolo, Veloz, esomeprazole, Kontrolok, Omez .

Price analogs may differ significantly from the original.

Reviews Emanere

Reviews Emanere mostly positive. Some complain that the drug is expensive or difficult to find in pharmacies.

Price Emanery

Buy drug can be in Moscow for 280 rubles, 14 capsules of 20 ml or 800 rubles 28 capsules of 40 mg.

The average price Emanera 40 mg of 500 rubles per 14 capsules.

Price Emanera 20 mg - 490 rubles per 28 pieces.

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Enzistal

Description overdue on 10/29/2014

• Latin name: Enzystal
• ATC code: A09A
• Active substance: Pancreatin (Pancreatin), the components of bile (Bile components), Hemicellulase (Hemicellulase)
• Manufacturer: Torrent Pharmaceuticals (India)

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• Composition
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• Indications
• Contraindications
• Side effects
• Instructions for use enzistal (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The preparation consists of the following active ingredients: pancreatin . bile components   ( lipase . proteases . amylase . an extract of bovine bile ) hemicellulase .

In addition, it contains additional components such as cellulose acetate phthalate . colloidal silicon dioxide . lactose . diethyl phthalate . talc . gelatin . beeswax . magnesium stearate . sugar . calcium carbonate . acacia . Titanium dioxide . carnauba wax .

Product form

Round biconvex tablets, which are coated with white enteric-coated. Contained in blisters, placed in a cardboard box.

Pharmacological action

Medicine improves digestion .

Pharmacodynamics and pharmacokinetics

The drug is combined . It consists of pancreatic enzymes Helping to normalize digestion. Bile extract acts as choleretic agent   It normalizes the absorption of fat contributes emulsification   Fat improves absorption   fat-soluble vitamins A, K and E, as well as Activity lipase . The product helps improve the function of the gastrointestinal tract and digestion. It helps in cleansing the bowel. Hemicellulase participates in the degradation of plant fiber.

Indications

Indications enzistal following:

• diarrhea ;
• exocrine insufficiency of the intestine, pancreas, gallbladder, liver, and stomach;
• flatulence ;
• cystic fibrosis .

In addition, it is used for wrong diet , Violations chewing function , Sedentary lifestyle, prolonged immobilization Why can happen trouble digesting.

Also, the drug given to US   and X-rays   abdominal organs as a preparation for the rapid absorption of other drugs.

Contraindications

The drug should not be used when hypersensitivity   to its components, jaundice   and obstruction of the biliary tract .

Side effects

At the use of the tablets may occur spastic   abdominal pain, nausea, diarrhea As well as the following allergic reactions : Sneezing, hives , Watery eyes, bronchospasm .

Instructions for use enzistal (method and dosage)

Those who decided to take enzistal, instruction on the application reports that the tablets are designed to oral   use. We need to take one tablet 3 times / day during a meal or immediately after it. If necessary, the daily dosage can be doubled.

Instructions for use enzistal reported that the duration of therapy is selected individually. The course of treatment can be from several days to several months or even years.

Before X-ray inspection   and US   Take 2 tablets 2-3 times / day for 2-3 days prior to the study.

Overdose

At higher doses of the drug may occur hyperuricosuria   or hyperuricemia . Treatment is symptomatic.

Cooperation

Enzistal decreases bioavailability   drugs, which is composed of iron, and also increases the extent of absorption PAS . antibiotics   and sulfonamides . Effect of the drug increases Cimetidine , in the same time antacids Which contain magnesium ions / calcium reduces it.

Terms of sale

In pharmacies without a prescription.

Storage conditions

The optimum temperature not more than 25 ° C. The medicine must be kept in a dry and well-protected against the penetration of sunlight.

Shelf life

Three years from date of manufacture.

Analogs enzistal

Match code ATC 4th level:

• Mikrazim
• Enzistal P
• Pancreatin
• Penzital
• Pangrol
• Ermital
• Creon
• Abomin
• Festal
• Mezim

Pharmacies can be found the following analogues enzistal:

• Zentaze ;
• Kreazim ;
• Creon ;
• Mezim Forte ;
• Pangrol ;
• Panenzim ;
• Panzinorm ;
• Panzinorm Forte ;
• Pankreazim ;
• Pancreatin-Farmeks ;
• Pancreatin-Health ;
• Pancreatin ;
• Pancreatin Forte ;
• Pancreatin-Health Forte ;
• Fermentium ;
• Festal Neo ;
• Enzistal P ;
• Ermital .

During pregnancy (and lactation)

The safety and effect of the drug in pregnancy   It has not been studied. Furthermore, no performance data during enzistal breast-feeding . Therefore, during pregnancy and lactation take this medication is not advisable.

Reviews Enzistale

Different views of this preparation can be read on the forums. Reviews Enzistale suggest that it really facilitates digestion. However, to make it better, after consultation with a specialist. It The enzyme agent   need to be used only when really needed support digestion. Such a state must diagnose a doctor, only he knows, on what and when to help drug. And take enzistal easy to cleanse and strengthen the body is not recommended.

Price enzistal where to buy

Price enzistal, in a package containing 20 tablets - about 80 rubles. Price bundles for 80 tablets, in turn - 270 rubles. Price enzistal considered quite affordable compared to many peers.

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