Minirin

Description overdue on 19.07.2012

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The agent for treating diabetes insipidus . Active Ingredient - desmopressin . Main substance has antidiuretic effect is analogue vasopressin . Under the action of the drug increases the permeability of the epithelium in the distal convoluted tubules of the water, which leads to an increase in its reabsorption . The impact on the process of coagulation: in patients with von Willebrand disease, hemophilia Minirin 8-1 activates clotting factor, causes an increase in the level of profibrolizina , Without increasing the systemic fibrinolysis. Compared with vasopressin, desmopressin has the least impact on the smooth muscle tissue of internal organs, blood vessels. Minirin issued a visa nasal drops, in tablet dosage form.

Indications:

Minirin prescribed for diabetes insipidus   central origin, polydipsia and polyuria central origin, hypocoagulation   (treatment of hemophilia type A von Willebrand disease ), After surgery on the pituitary gland, brain diseases, traumas, for determining the concentration capabilities renal system, with primary nocturnal enuresis.

Contraindications:

Minirin is not applied when gipoosmolyarnosti plasma Edema syndrome   of different origin, anurii , Desmopressin intolerance at polydipsia   (psychogenic and congenital origin), with decompensated form of chronic heart failure, predisposition to thrombosis, need for diuretics. Intravenous administration of the drug is contraindicated in von Willebrand disease type 2B, when an unstable form of angina. Intranasal form: disturbances of consciousness, infections of the respiratory system, the swelling of the mucous wall of the nasal cavity, nasal congestion, allergic rhinitis, after surgery. During pregnancy, a violation of water-electrolyte balance, the elderly, children under age 1, with fibrosis bladder , Renal insufficiency of Minirin used with caution.

Side effect:

Nausea, increased blood pressure, rhinitis, severe headache, compensatory tachycardia , Tuberculosis, allergic reactions, pain at the injection site, local redness, swelling, water intoxication, decreased lacrimation, conjunctivitis , Abdominal pain, spastic nature.

Overdose:

Manifested water intoxication, gipoosmolyarnostyu plasma , Neurological and mental symptoms, development of seizures. Requires limit fluid intake to the body. In severe conditions is administered by slow intravenous injection of brine, together with furosemide.

Mode of application:

Swelling of the mucous membrane of the nasal cavity Minirin administered sublingually. The average dosage for adults is 10-40mkg per day, which corresponds to 1-4 drops 2-4 times. Children under 12 months appoint 5-30mkg day. Primary nocturnal enuresis: an initial dose of 20 mg at bedtime, to evaluate the effectiveness do week break after 3 months of therapy. Minirin intranasally administered with the patient sitting, lying at his head thrown back. The composition of the gate includes a special dropper bottle, the pressure which regulates the amount allocated drops. When desmopressin patient is recommended to limit fluid intake to 8 hours to empty the bladder. For determining osmolarity   every 4 hours is required to collect the urine of the patient. When registering decline of renal concentrating ability of the procedure is repeated. Tablet form of the drug: diabetes insipidus - 300 micrograms per day for 3 doses. Maintenance dose is 300-600 mg per day, a day is not more than 1200 g. Primary nocturnal diuresis: a daily intake of 200 micrograms Miirina, 3 months make a break for 7 days to determine the effectiveness of therapy. Intravenously, intramuscularly, subcutaneously injected with diabetes insipidus 0, 025 mg / kg or 2.4 mg in the morning and evening. Von Willebrand disease, haemophilia A : 0, 3 micrograms per day in the form of intravenous injections. Babies with diabetes insipidus subcutaneously, intramuscularly or intravenously administered 0, 025 mg / kg or 0, 4 mg.

Special instructions:

For the prevention of volume overload require control over the following group of persons: with high intracranial pressure , With impaired water and electrolyte balance , Adolescents, children, elderly. In marked rhinitis, intranasal administration of desmopressin absorption is broken, so it is recommended sublingual use. When used for diagnostic purposes is not recommended holding forced hydration   (parenterally, orally). Diagnosing Renal concentration capacity of children under 1 year is acceptable to carry out only in a hospital.

Drug Interactions:

Desmopressin is able to increase the effects of hypertensive medications. Clofibrate, carbamazepine Indomethacin, chlorpropamide reinforce antidiuretic effect   drug Minirin. Norepinephrine, tetracycline, glibutida weaken antidiuretic effect.