Curantil

Description overdue on 13-05-2012

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Vasodilator drug.   The active component is dipyridamole . The medicament lumen extends coronary blood (mainly arterioles) and leads to a significant increase in blood flow volume rate. Under the influence of the drug Curantil increases the oxygen content in the venous network of the coronary sinus, a positive effect on myocardial tissue oxygen uptake. Under the influence of the drug develops collateral coronary blood supply to It improves microcirculation. Curantil has angioprotective impact . The properties of the drug is due to increased activity of adenosine in the tissue by reducing its capture and destruction. The enzyme adenosine inhibits the process of release of norepinephrine, affects vascular smooth muscle. Curantil inhibits vosfodiesterazu, is an antagonist of adenosine agreganty. The drug increases synthesis of prostacyclin It reduces the release of tormboksana , Inhibits platelet aggregation. Dipyridamole reduces blood supply to the ischemic area, prevents clot formation on the vessel wall, reducing platelet adhesiveness . When the concentration in the blood 0 1mkg / ml manifested antiplatelet effect. To express angtiagregantnogo impact Curantil administered concurrently with aspirin. The drug is capable of extending the period of abnormally shortened life of platelets in a dose-dependent manner. The drug causes the phenomenon of steal And is able to expand the lumen of the coronary arteries unchanged .  Dipyridamole is an inducer of interferon production enhances blood leukocyte interferon (alpha and gamma in vitro), has a modulating effect in relation to the functional activity of interferon .  Curantil increases nonspecific antiviral resistance to viruses .  In the period after the operation under the influence of the Courant reduces the incidence of deep vein thrombosis .  The drug has a positive effect on the venous return, improves microcirculation in the renal glomeruli, retina .  Dipyridamole is effectively used by the dynamic disturbances in the circulation of the brain, the drug lowers the tone of cerebral vessels .  According to the results of angiographic survey it is well established that, in combination with acetylsalicylic acid Curantil reduces the rate of progression of atherosclerosis .  Dipyridamole is used in obstetric practice for the purpose of korrigirovaniya placental blood flow, for the prevention of degenerative changes in the   the placenta   (in the case of threat of pre-eclampsia). The drug contributes to the accumulation of glycogen in the fetal tissues, eliminates hypoxia. Curantil produced in the form of pills, a solution, tablet.

Indications:

Curantil prescribed for thromboembolism Thrombosis, for the prevention of venous, arterial thrombi after surgery on the heart valve prosthesis. The drug is used to prevent occlusion of aortocoronary bypass grafts, stents in combination with acetylsalicylic acid. The drug is indicated for myocardial infarction and for the prevention of myocardial hypertrophy . Dipyridamole is shown at vascular encephalopathy For the treatment, prevention of cerebral circulatory disorders of ischemic type. At complicated pregnancy Curantil prescribed for the prevention of placental insufficiency. In the combined drug therapy is indicated for various violations microcirculation , Occurring in chronic obliterating diseases of blood vessels in the lower extremities, especially complicated by hypertension. The drug is indicated for SARS , Influenza, for the prevention of DIC in children with sepsis, infectious toxicosis, suppression of platelet syndrome. The drug is part of triple therapy glomerulonephritis . Curantil applied during stress echocardiography, perfusion scintigraphy fiznagruzki.

Contraindications:

Curantil not appoint at   unstable angina , Acute myocardial infarction, intolerance dipyridamole released sclerosing atherosclerosis, hypertension, renal disease, hepatic failure system, peptic ulcer disease of the digestive system, hemorrhagic diathesis, severe arrhythmia, COPD, CHF, decompensated form. During the period of breastfeeding for children up to 12 years Curantil used with caution after specialist consultation. Curantil administered during pregnancy in extreme cases.

Side effect:

Cardiovascular system:   drop in blood pressure, coronary steal syndrome, tachycardia , Palpitations, "tides" of blood to the skin of the face, bradycardia. Digestive system:   epigastric pain, diarrhea syndrome, vomiting, nausea. Hemostasis, blood system:   increased bleeding, bleeding, change in functional characteristics of platelets, thrombocytopenia . Curantil can cause dizziness, weakness, noise in the head, congestion in the ears, allergic reactions, rhinitis, flushing of the facial skin, headache, Arthritis , Myalgia.

Mode of application:

Thrombosis prophylaxis: one hour before meals 3-6 times a day for 75 mg. The daily dosage of 300-450 mg, in some cases the dose may be increased to 600 mg per day. Prevention of clotting in aortocoronary bypass grafts, stents, prevention of thromboembolic syndrome: the first day 50 mg chimes in conjunction with acetylsalicylic acid, in the coming days appoint 100mg. Coronary insufficiency: three times a day, 25-50 mg orally, three times with severe disease in the 75 mg per day. Curantil pregnancy prescribed by the standard procedure.

Special instructions:

Curantil is recommended to take with milk to reduce the expressiveness of of dyspeptic disorders. During the period of treatment should refrain from receiving natural tea, coffee, which reduce the effectiveness of the drug. Aminophylline is prescribed to improve intracardiac blood flow   the syndrome of coronary steal.

Drug Interactions:

Curantil increases   antiplatelet activity   indirect anticoagulants, cephalosporin, penicillin antibiotics, aspirin, nicotinic acid, chloramphenicol. Products containing caffeine, xanthine derivatives attenuate the severity antithrombotic effect . Curantil weakens the the impact of of cholinesterase inhibitors. Tetracyclines, beta-lactam antibiotics, chloramphenicol weaken the effect of dipyridamole. Under the influence of antacids reduces absorption and, accordingly, the maximum kontsentratsiya.Trombolitiki, indirect anticoagulants Heparin increases the risk of hemorrhagic complications .