Description overdue on 05/14/2014
- Latin name: Genferone Light
- ATC code: L03AB05
- Active substance: Recombinant human interferon alpha-2b (Interferon alfa-2b)
- Manufacturer: JSC "Biocad" Russian
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- For children
- Newborns
- With antibiotics
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Composition suppositories for rectal or nasal administration :
1 suppository (suppository) include a: recombinant human interferon alfa-2b - 250000 IU or 125,000 IU (depending on dose) Taurine - 5 0 mg.
Excipients: macrogol 1500, polysorbate 80, citric acid, emulsifier T2 solid fat, dextran 60,000, hydrocitrate sodium Purified water - the amount necessary to obtain a mass of candles 0, 8 g
Composition a spray for nasal administration :
One dose contains: recombinant human interferon alpha-2b - 50 000 ME, Taurine - 1, 0 mg.
Excipients: dextran 40,000, disodium edetate dihydrate, sodium chloride, potassium dihydrogenphosphate, potassium chloride, polysorbate 80, glycerol, methyl parahydroxybenzoate, sodium hydrogen phosphate dodecahydrate, peppermint oil, water for injection in the necessary amount.
Product form
To Candles :
Candles white or straw-colored. They have a cylindrical shape, a pointed end on a longitudinal section of uniform, but allowed the presence of air inclusions. It is produced in cardboard packets within a single packet 1 or 2 outline package containing 5 suppositories.
To nasal spray :
Light transparent liquid in bottles of darkened glass in the upper part of the dispenser fitted with a safety cap; in a cardboard bundle one bottle. 1 bottle contains 100 doses.
Pharmacological action
The pharmacological action of the drug Genferon Light due to the presence in the composition of interferon alfa-2b and taurine. They have the following properties:
- immunomodulatory effects (harmonization of the functions of immunity);
- antiviral activity;
- antiproliferative effect (inhibition of the growth of bacteria and cancer cells);
- immunostimulatory effects (improving the efficiency of the immune system);
- mediated antimicrobial action;
- inflammatory effect.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
The main active ingredient is Genferon Light interferon alfa-2b . It is obtained by modifying the bacterium Escherichia coli using genetic engineering techniques.
Interferon is able to indirectly influence the intracellular pathogens ( Chlamydia and viruses ), Altering the metabolism of the cells and stopping their intracellular replication and further spread. Interferon also affects neighboring cells that initiate the reactions that lead to the suppression of the production of viral proteins. The result of the impact of interferon on neighboring cells is increased synthesis of substances which reduce protein synthesis. This arrangement is detrimental to the virus, as blocks its further propagation. In addition, interferon activates a number of genes that play important role in the antiviral defense cells and triggers the death of the infected cell.
Another line of action of interferon - activation immunity . The result of this activation is a more effective fight against immune system cells (killer T cells, phagocytes and T-helper cells), viruses and bacteria.
Taurine improves the metabolism of individual cells and tissues in general, stimulates reparative (restoration) processes. It improves and stabilizes the structure of cell membranes. Taurine is an antioxidant - interacting with the active compounds of oxygen in the body, it prevents tissue damage by these compounds.
Pharmacokinetics
For rectal administration of the drug is characterized by bioavailability reaching 80% and more, what is the reason expressed by the local and integrated immunomodulatory effect . For vaginal use of local characteristic pronounced (achieved by a high concentration of the drug in the pathological focus) and negligible systemic effect (the drug does not penetrate into the bloodstream through the mucous membranes of internal genital organs). The result is expressed by the local antiviral, anti-proliferative and anti-bacterial action.
Interferon reaches maximum concentration in the blood within 4-6 hours after administration. Write mainly kidneys. The half - about 12 hours, resulting in the need to double the drug throughout the day.
For intranasal use, is characterized by a pronounced immunostimulatory and antiviral effect (due to high concentration in the pathological focus). Release of the drug in the bloodstream at this route of administration does not reach high values because of the special molecular structure of the membranes of the mucous cells of the nasopharynx. However, some still interferon into the blood stream, causing a complex immunomodulatory effect .
Indications
Genferon Light candles in the shape of a part of the complex therapy and is used in the prevention of the following diseases in adults and children:
- chlamydia;
- genital herpes;
- mycoplasmosis;
- ureaplasmosis;
- bacterial vaginosis;
- HPV infection;
- trichomoniasis;
- cervical erosion;
- vaginal candidiasis;
- bacterial vaginosis;
- vulvovaginitis;
- cervicitis;
- adnexitis;
- urethritis;
- bartholinitis;
- balanitis;
- prostatitis;
- balanoposthitis;
- SARS;
- flu.
Genferon Light in the form of a nasal spray is used for prophylaxis and therapy viral respiratory diseases.
Contraindications
Contraindications for the use of candles Genferon Light:
- individual sensitivity to interferon or other substances in the formulation;
- the first 12 weeks of pregnancy;
- epilepsy or other convulsive conditions;
- severe cardiac condition;
Patients suffering from autoimmune diseases ( Hashimoto's thyroiditis . systemic lupus erythematosus et al.) or allergic attack in the past, Genferon Light candles used under close supervision and control.
Contraindications for use of the nasal spray Genferon Light:
- individual sensitivity to interferon or other substances in the formulation;
- age up to 14 years.
Precautions should use the drug in patients who are prone to nosebleeds.
Side effects
Usually Genferon Light candles in the shape of a well-tolerated by patients. You may experience a local (at the site of injection), itching or burning. These symptoms disappear within three days after stopping the drug. For further treatment is best to consult with your doctor.
There may be systemic reactions such as fever . fever , Fatigue, appetite loss, muscle, joint and headaches, as well as reducing the number of leukocytes and Platelet in blood. But these reactions are often in excess of the total administered dose 10000000 IU per day.
When using spray Genferon Light side effects have been reported.
Instructions for use
To eliminate the possibility of overdose or occurrence of side effects on candles Genferon Light, manual instructs children under 7 years use only candles 125000 IU. For children older than 7 years, it recommended the use of a dosage of 250 thousand IU. Also worth noting, at the same time that it is unacceptable to use nose drops (for the treatment of catarrhal symptoms the nose) and nasal spray Genferon Light, instruction on the application warns about the possible failure of drugs in the event of non-compliance with the rules of separation of administration. For the treatment of pregnant women with terms of 13-40 weeks it is recommended to use a dosage of 250,000 IU of candles.
Recommended treatment regimens
- SARS . flu and other acute viral infections in children: 1 suppository rectally every 12 hours as a supplement to the basic treatment for 5 days. If symptoms persist, possibly an extension of the five-day treatment after a break.
- Chronic viral diseases children: 1 suppository rectally twice daily as a supplement to the basic treatment for 10 days. Then, for 5-15 weeks - 1 suppository every other day in the evening.
- Acute diseases of the genitourinary system infectious nature of children: 1 suppository rectally twice a day for 10 days.
- Diseases of the genitourinary system infectious nature of pregnant women: 1 suppository rectally twice a day for 10 days.
- Diseases of the genitourinary system infectious nature of women: 1 suppository 250,000 IU twice daily for 10 days (vaginal or rectal). In protracted course of the disease is possible to use 1 suppository every other day in the evening for 5-15 weeks.
Spray Genferon Light used by the administration into the nose tip of the bottle and a short press on the dispenser.
When starting Flu or SARS used for both single dose nasal passage three times a day for 5 days (total daily dose should not be greater than 500,000 IU).
To prevent SARS or Flu (in contact with infected) after supercooling is recommended to follow the following dosing scheme: one dose into both nasal passage twice a day for 6-7 days.
Instructions for using the nasal spray.
- remove the protective cap;
- when used for the first time to put pressure on the dispenser several times until a small stream;
- prior to use to give the bottle upright;
- administration of the drug to produce a single short push on the dispenser by turns both nasal passage;
- after use to close the cap.
To prevent the spread of infection, bottle use is strictly individual.
Overdose
With the simultaneous introduction of a large number of random spark (at doses exceeding the prescribed) you must stop using the drug for one day, then you can again resume treatment at the designated scheme.
No data on cases of overdosing spray Genferon Light.
Cooperation
Attendance vitamin C and E enhance the effect of interferon components and retard its denaturation during administration of the drug in the rectum.
Terms of sale
Candles Genferon Light in Russia are sold by prescription, but the nasal spray you can buy without a prescription. In Ukraine, these drugs are dispensed strictly on prescription.
Storage conditions
The drug is advised to keep out of the reach of children, dry and dark place at a temperature range 2- 8 ° C.
Shelf life
Shelf life - 24 months. Do not use the drug after the expiry date (indicated on the package).
Cautions
Genferon Light does not affect the reaction and the ability to perform activities requiring increased attention (driving, equipment, etc.).
Analogs
Interferon
Nazoferon
Viferon
Infagel
IFN-EU-Lipint
IFN-EU
IFN-Lipint
Altevir
Algeron
Genferon
Grippferon
The analogue Genferon in Light spray form It is Nazoferon .
Analogues in Genferon Light form of suppositories are Viferon Fearon, Laferobion, Laferon Farmbiotek, Ruferon.
Also, there are analogues of the drug with other routes of administration: Alfarekin (injection) Virogel (ointment) Grippferon (nasal drops), and others.
For children
It should be noted that the nasal spray is not recommended for use in children under 14 years.
Candles for limiting the use of children by age do not have.
Newborns
The drug can be used by a physician in premature and newborn babies at a dose of 125,000 IU if necessary ( pneumonia . meningitis . sepsis ).
With antibiotics
Sharing Genferon Light candles in the form of a antibacterial, antiviral and antifungal drugs significantly increases the effectiveness of therapy.
Genferon Light during pregnancy
Using Genferon Light "nasal spray" during pregnancy is possible at all stages, and reviews of its application, in general, cheers.
Safe use of candles proved only in pregnant women with the terms of 13-40 weeks, while the women in the earlier stages of pregnancy data on the safety of not. In each clinical case the application Genferon Light decided separately by the attending physician.
Reviews on Genferon Light
Positive reviews about Genferon Light candles used during pregnancy reported in the treatment of infections of the urinary tract. For both children and adults will be important to learn about the absence of reports of adverse events.
Information about the practice of using a nasal spray Genferon Light with influenza and SARS are also often speak of its high performance.
Price Genferon Light
In Russia, the price Light candles Genferon 250,000 IU dose of about 245 rubles, 125 000 IU dosage - 180 rubles. In Ukraine, candles 125000 IU cost about 82 hryvnia, and a spark of 250,000 IU will take 90 hryvnia.
Cost Light spray Genferon in Russia close to 250 rubles, Ukraine - will be equal to 72-80 UAH.
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