Buserelin Depot

Description overdue on 07/09/2014

• Latin name: Buserelin-depo
• ATC code: L02AE01
• Active substance: Buserelin (Buserelin)
• Manufacturer: CJSC "Pharmsynthez», Russia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One vial contained 3 mg 75 buserelina   (3, 93 mg buserelin acetate ) - active substance.

Additional ingredients:

• 2 mg - polysorbate 80;
• 30 mg - carmellose sodium;
• 85 mg - mannitol;
• 200 mg - copolymer of DL-lactic and glycolic acids.

The solvent acts 0 8% solution mannitol   in 2 ml of water for injection.

Product form

Lyophilisate further suspension (depot) used for intramuscular administration. The package contains a lyophilisate vial complete with ampoule of solvent. Also attached the syringe 1, 2 needle, 2 alcohol swabs.

Pharmacological action

Antitumor, anti-androgens.

Pharmacodynamics and pharmacokinetics

Antineoplastic drug Buserelin Depot is a synthetic analogue of GnRH. Competitive binding to cell receptors of the anterior lobe pituitary It leads to a transient increase in blood plasma levels of sex hormones.

Through 12-14 days carrying out of treatment in therapeutic doses, occurs complete blocking gonadotrophic pituitary function   and as a result of inhibited replication of LH and FSH. Through these processes inhibited synthesis of sex hormones in the gonads, which results in a decrease in plasma concentrations of Estradiol   (to values ​​observed in postmenopausal women) and Testosterone   (postcastration period to values ​​in men).

When of continuous therapy throughout 2-3 weeks of the content of Testosterone   reduced to a concentration characteristic in the state   orchiectomy In other words, the drug leads to pharmacological castration.

Buserelin has high bioavailability.

Cmax plasma is observed after about 120-180 minutes after intramuscular injection and maintained for 4 weeks at a sufficient level suppression of pituitary gonadotropins.

Indications

• mammary cancer;
• hormone dependent prostate cancer (prostate cancer);
• uterine fibroids;
• endometriosis   (in the preoperative and postoperative periods);
• hyperplastic changes in the endometrium ;
• therapy infertility , In framework of the program IVF (in vitro fertilization) .

Contraindications

• period pregnancy ;
• period breastfeeding ;
• sensitivity of the patient to the ingredients of the preparation.

Side effects

Allergic symptoms :

• flushing of the skin;
• hives;
• angioneurotic edema.

Central nervous system :

• violation of the phases of sleep ;
• frequent mood swings ;
• headache;
• Depression.

Musculo-skeletal system :

• during long-term therapy was observed deossification   (may be the cause of osteoporosis ).

During the treatment of female patients, the following adverse events: headache . sweating, depression , Changes in libido, abdominal pain, vaginal dryness, menstrual-type bleeding (mainly in the first weeks of therapy).

In cancer therapy,   prostate   men buserelin use may cause progression or worsening of the underlying disease (for the first 2-3 weeks after the first dose). This phenomenon is due to the stimulation synthesis of gonadotropins   and as a consequence testosterone.

It is also possible to develop gynecomastia , Increased sweating, hot flushes, lowering of potency   (sometimes requiring revision of the treatment), transient increase in blood   androgens, urinary retention, feeling of weakness in the lower extremities, swelling of the feet, eyelids and face.

At the start of therapy in patients with prostate cancer   can manifest enhancement of pain in the bones of a temporary nature, is an indication for the symptomatic treatment.

There were marked individual episodes compression of the spinal cord   and development ureteral obstruction.

Very rarely observed dyspeptic disorders   and pulmonary embolism.

Instructions for use (method and dosage)

Buserelin drug depot is exclusively for intramuscular administration.

In therapy hormone-dependent prostate cancer   Buserelin drug depot guide recommends a intramuscular injection in doses of 3, 75 mg, appointed every 4 weeks.

For treatment hyperplastic changes of the endometrium   and Endometriosis   the drug is prescribed in doses of 3, 75 mg. Injections do intramuscularly once every 4 weeks. Initiation of therapy should be combined with the first five days of the menstrual cycle. The course of treatment varies from 4 to 6 months.

Treatment   uterine fibroids   carried out at a dose of 3, 75 mg Buserelin .   administered intramuscularly every 4 weeks. Instructions for applying are encouraged to begin treatment in the first five days of the menstrual cycle. The course of treatment before surgery is 3 months, in other cases, is 6 months.

Infertility Treatment on the IVF program   defines a single dose of the drug - 3, 75 mg. The injection is carried out in the early follicular phase (second day menstrual cycle ) Or closer to the end of the luteal phase (day 21-24 minutes menstrual cycle ), Prior to stimulation. At 12-15 days after injection to determine serum contents estrogen Which should be reduced by 50% or more of the initial level. In the absence of other contraindications were stimulated superovulation   with help gonadotropins . The procedure is performed under the control of concentrations Estradiol   blood and using ultrasound monitoring.

Preparing a suspension can only be experienced medical professional using a solvent and other components (needles, syringes, alcohol swabs), included with the packaging of the drug.

The finished suspension should be used immediately after its preparation.

Overdose

To date, drug overdose Buserelin depot was observed.

Cooperation

Combined application of buserelin-depot with drugs that contain sex hormones   can trigger the development of the syndrome ovarian hyperstimulation.

Pi simultaneous application hypoglycemic agents   buserelin and efficiency may be reduced first.

Terms of sale

Prescription.

Storage conditions

The drug Buserelin Depot belongs to the list B.

It should stored in a dark, inaccessible location for children, at a temperature from 8 ° to 20 ° S.

Shelf life

24 months.

Cautions

For women

In the case of diagnosis, the patient any form depression   or suspected her during therapy with buserelin it should be under constant supervision of a doctor.

Induction of ovulation   It is carried out under strict supervision on the part of medical personnel.

At the beginning of therapy, the formation ovarian cysts.

Prior to his appointment Buserelin therapy with depot should not be possible pregnancy Then stop taking hormonal contraceptives   (if used). However, during the first two months of treatment, it is necessary to use other effective methods of contraception,   in order to prevent unwanted pregnancy in this period.

For men

In the first phase of action buserelin .   for prevention of possible side effects, it is necessary appointment antiandrogens   used for the 14 days before the first injection, and for 14 days thereafter.

Analogs

Match code ATC 4th level:

• Zoladex
• Buserelin Long
• Diferelin
• Buserelin

Analogs drug Buserelin depot presented the following medications:

• Dekapeptil;
• Dekapeptil depot;
• Diferelin;
• Zoladex;
• Lyukrin depot;
• Eligard.

It should be remembered that independently select analogs, substitutes medicines is not recommended, especially those used for tumor therapy in the treatment of other serious diseases.

Synonyms

• Buserelin spray;
• Buserelin Long.

Babies

There is no reliable information on the use of buserelin-depot in childhood.

With alcohol

Do not drink alcohol during treatment with the drug Buserelin depot. At best, such a combination will reduce the effectiveness of the drug, and in the worst alcohol can cause serious complications.

During pregnancy and lactation

Contraindicated.

Reviews Buserelin depot

For professional and user forums on the drug depot Buserelin reviews of doctors applying it more optimistic than patient testimonials.

The doctor conducting the treatment, first of all draws attention to the final result, putting in second place going undesirable symptoms arising in the course of treatment.

The patient is often allocates side effects and adverse drug effects, ascribing a negative impact on your body.

It is worth noting that, unfortunately, there is virtually no drugs, no side effects, and sometimes you have to endure all the negative manifestations, in order to achieve the desired result.

The drug is Buserelin-the depot definitely not a panacea, but really helps many patients, in peculiarities of at carrying out of infertility treatment within the IVF program.

Price Buserelin depot where to buy

One pack of the drug can be bought in Moscow, about 4300 - 4500 rubles.

Price depot buserelin injections depends on their number in various pathologies. Other diseases may require from the 1st injection of up to 6 or more injections.

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