Indap

Description overdue on 17.06.2012

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Vasodilator, diuretic.   The main component - indapamide . The drug has hypotensive effects . The pharmacological properties of the drug Indap similar to thiazide diuretics, the impact of the principle is based on the violation of reabsorption of sodium in the cortical division in the loop of Henle. The drug increases the excretion of sodium, chloride, magnesium, potassium excretion. The drug selectively blocks the "slow" calcium channels, reduces peripheral vascular resistance, increases the elasticity of the vascular walls. Indap no effect on the level of plasma lipids, carbohydrate metabolism, which is important in the treatment of patients with diabetes . Under the influence of Indap reduced sensitivity of the vascular wall to the action of angiotensin-2, norepinephrine. The drug stimulates the production of prostacyclin PgI2, PgE2, reduces the synthesis of stable oxygen and free radicals. High dosages of the drug causes increased urine output, but have no effect on the degree of fall in blood pressure. Repeated, stable application efficacy is recorded in the second week. Indap available in tablet form, in the form of capsules.

Indications, contraindications:

Indap prescribed for hypertension. The drug is contraindicated in hypokalemia . anurii , Renal pathology system, severe liver damage, intolerance indapamide. The drug is not prescribed for decompensated form of diabetes with ketoacidosis In acute cerebral circulatory disorders, with galactosemia , Lactose intolerance, galactose malabsorption or glucose. When ascites, mild renal / hepatic insufficiency, disturbances of water and electrolyte balance, giponetriemii, lengthening the interval QT, in CHF, coronary artery disease, hyperuricemia, breastfeeding, hyperparathyroidism, nefrourolitiaze urate, gout Indap used with caution.

Side effect:

Intensity of side effects depends on the dosage of the drug. Digestive system: dyspepsia , Violations of the chair, epigastric pain, nausea, dry mouth, vomiting, gastralgia, appetite disorders.   Nervous system:   dizziness, nervousness, asthenia , Headaches, vertigo, drowsiness, dizziness, depression, insomnia, agitation, irritability, anxiety, tension, nervousness, lethargy, lethargy , Asthenia, fatigue, malaise, spasm of the muscle fibers. Senses: violation of visual perception, conjunctivitis . Respiratory system: pharyngitis , Cough, rhinitis. Cardiovascular system:   palpitations, Arrhythmia , Hypokalemia, orthostatic hypotension . Urinary system:   polyuria, nocturia, frequent infections of the urinary system. Also recorded flu-like symptoms , Back pain, infectious lesions, pain in the chest, sweating, rhinorrhea, disorders of libido / potency, paresthesias in extremities, weight loss, allergies, hyponatremia, hyperglycemia, hyperuricemia, hypochloremia, glycosuria, hypercreatininemia, hypochloremia, increasing urea nitrogen, hypercalcemia.

Overdose:

Manifest violation of the digestive system, respiratory depression, excessive drop in blood pressure, weakness, vomiting,   water and electrolyte disorders , Nausea. In patients with liver cirrhosis is registered hepatic coma. It requires timely symptomatic treatment, gastric lavage, correction fluid and electrolyte balance. The specific antidote is not developed.

Mode of application:

Indap take in the morning, inside. The initial dose for hypertension is 1, 25-2, 5 mg per day (neprolongirovannogo drug form) or 1, 5 mg of sustained release formulation of the drug per day. In case no fully effective after 4-8 weeks of treatment regimen to add the drug to another mechanism of action. The increase in dosage is not considered appropriate in view of increasing severity of side effects and the lack of achievement of target blood pressure.

Special instructions:

Patients with hyperaldosteronism When taking laxatives, cardiac glycosides is highly recommended regular monitoring of potassium, creatinine. Systematic taking the drug Indap requires control ion levels of magnesium, sodium, potassium in the blood plasma, residual nitrogen, uric acid, sugar, due to the risk of electrolyte abnormalities. More careful monitoring is indicated in patients suffering from cirrhosis of the liver , Ascites due to a high risk of developing metabolic alkalosis , Increased severity of encephalopathy, heart failure, coronary artery disease. Patients with high QT interval on an electrocardiogram are at increased risk. Be sure to analyze the changes in the level of potassium in the body during the first week of therapy. When previously nedignostirovannom hyperparathyroidism may increase calcium levels during treatment with the drug. Patients with diabetes is extremely important glucose control while taking the drug Indap, especially in severe hypokalemia. Reduction glomerular filtration rate The development of acute renal failure may result in significant dehydration. At the beginning of treatment should be carefully monitor the work of the kidneys, if necessary, to compensate for fluid loss. Against the background of the drug can be zaregitrirovan a positive doping test. Indap may cause aggravation systemic lupus erythematosus . Safety and effectiveness in children have not Indap installed.

Drug Interactions:

Indap increases the level of lithium ions in the blood, reducing its elimination through the renal system. Lithium is able to provide express   nephrotoxic effects . Because of dehydration, there is a growing damaging effects on the kidneys in the application of iodinated contrast medicines. Before the procedure is recommended to restore the loss of water. Indap reduces the effect of anticoagulants . When you receive a non-depolarizing neuromuscular blocking agents has increased, with the blockade of neuromuscular transmission. Laxatives, amphotericin B, tetrakozaktid, glucocorticosteroids , Cardiac glycosides, thiazide, loop diuretics, saluretics increases the risk of hypokalemia. The risk of digitalis intoxication increases, while the appointment of cardiac glycosides. Calcium supplementation causes hypercalcemia, metformin - lactic acidosis. Pentamidine, sultopride, erythromycin, astemizole, vincamine, terfenadine, disopyramide, quinidine, antiarrhythmics, bretylium tosylate, amiodarone, sotalol due to synergistic effects may lead to fibrillation of the type "feast". Agonists, terakozaktid, steroids reduce the severity of the hypotensive effects baclofen   - On the contrary. The risk of developing acute renal failure, hypotension increases significantly when using ACE inhibitors. Orthostatic hypotension may otmechaetsya the appointment of antipsychotic drugs, tricyclic / imipraminovyh antidepressants. Hypercreatininemia registered at reception cyclosporine .