Tsetrin

Description overdue on 10.02.2012

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Remedy allergies . Active substance - cetirizine . The principle of action of the drug based on blocking the histamine H1 receptor. Cetirizine is a product of metabolism gibroksizina, competitive antagonist histamine . Tsetrin reduces migration ability basophils, neutrophils, eosinophils, limits the production of inflammatory mediators in the final step   allergic process It acts on the early period of formation of the allergic response. The active ingredient relieves spasm of smooth muscles, prevents the formation of swelling, reduces the permeability of the capillary walls. Cetirizine eliminate skin reaction to a particular allergen, histamine cooling. In bronchial asthma mild Tsetrin reduces the severity gistaminoindutsirovannoy bronchoconstriction . The drug does not render antiserotoninovym, anticholinergic effects. Therapeutic dosage form is not a sedative effect on the nervous system. The drug begins to have effect after 20 minutes after administration, the anti-allergic effect lasts for hours. A course of treatment does not produce tolerance antihistamine effect. Anti-allergic effect persists up to three days. Tsetrin produced in the form of drops, a syrup, a solution, and in a tablet form.

Indications:

Tsetrin shows conjunctivitis and allergic rhinitis genesis (conjunctival hyperemia, tearing, rhinorrhea . sneezing ). The drug is effective in idiopathic urticaria   chronic course, with atopic asthma, angioedema , Skin ulcers, allergic dermatitis, hay fever .

Contraindications:

Tsetrin not prescribe intolerance hydroxyzine, cetirizine, breastfeeding, if carrying a pregnancy. In the elderly, pediatrics, in the pathology of renal drug is prescribed with caution.

Side effects and overdose:

Tsetrin can cause dizziness, drowsiness, headache, dry mouth, allergies, dyspepsia . Higher doses of the drug (50 mg dose) causes an increase in the severity of side effects, increased irritability, anxiety, constipation . urinary retention , Drowsiness. Recommended timely gastric lavage, enterosorbents treatment posimptomnoe. The specific antidote is not developed. Hemodialysis is not shown.

Mode of application:

A tablet form of the drug is washed down with water. Drops Tsetrin before taking to be dissolved in water. Adults 10 mg administered once a day or divided into 2 doses. When kidney disease of the initial dose is 5 mg, a severe form of the disease - 5 mg every other day.

Special instructions:

Receiving more than 10 mg of drug once significantly slows psychomotor reactions. Reception recommended doses does not lead to increased action alcoholic beverages, but in the period of anti-allergic treatment should refrain from receiving ethanol. When performing complex work, driving vehicles, the management of complex mechanisms need to be extremely cautious.

Drug Interactions:

Farmakokinechtiski important drug interactions with Tsetrin azithromycin . erythromycin , Cimetidine, pseudoephedrine, ketoconazole , Glipizide and diazepam   it is noted. Simultaneous treatment with theophylline   It leads to a reduction in drug clearance Tsetrin, while not changing the kinetics of theophylline. Application myelotoxic drugs increases haematotoxicity   cetirizine.