Description overdue on 08/14/2014
- Latin name: Elevit Pronatal
- ATC code: A11AA
- Active substance: Multivitamins + Minerals (Multivitamins + Multimineral)
- Manufacturer: "Bayer Consumer CARE AG" (Switzerland); "Rottendorf Pharma GmbH", Germany
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Eleven Pronatal, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
The composition of the Elevit Pronatal
The main active component of the pharmaceutical product is a vitamin complex, including biological agents such as:
- Vitamin A (retinol palmitate) - 3600 IU (international units);
- Vitamin B1 (thiamine mononitrate) - 1, 6 mg;
- riboflavin (riboflavin) - 1, 8 mg;
- Vitamin B5 (calcium pantothenate) - 10 mg;
- vitamin B6 (pyridoxine hydrochloride), - 2, 6 mg;
- Vitamin B9 (folic acid) - 0, 8 mg;
- cyanocobalamin (cyanocobalamin) - 4 g;
- Vitamin C (ascorbic acid) - 100 mg;
- Vitamin D (cholecalciferol) - 500 IU;
- Vitamin E (dl-a-tocopherol acetate) - 15 mg;
- vitamin PP (nicotinamide) - 19 mg;
- Vitamin B7 (biotin) - 0, 2 mg.
Composition vitamins in each tablet medicament complemented plenty of diverse mineral substances, microelements and their salts:
- pantothenate and calcium phosphate - 125 mg;
- phosphorus - 125 mg;
- stearate and magnesium phosphate - 100 mg;
- iron fumarate - 60 mg;
- zinc sulfate - 7, 5 mg;
- copper sulfate - 1 mg;
- manganese sulfate - 1 mg.
The composition of the coating film:
- polyethylene glycol 6000 and 400;
- pretsirol Ato 5;
- gelatin;
- microcrystalline cellulose (MCC);
- sodium carboxymethyl starch;
- povidone K 30 and K 90;
- lactose monohydrate;
- mannitol;
- magnesium stearate;
- ethylcellulose.
Product form
Vitamin complex Elevit Pronatal in pharmacy represented as oblong tablets, film-coated, which are fixed in aluminum foil blisters or PVC of 10 or 20 pieces.
Tablets gray-yellow colors have a lenticular shape with characteristic band for breaking one of the surfaces. It may detect a smell, which is not indicative of the unsuitability of the pharmaceutical preparation. Cardboard packaging can accommodate 3 or 10 of the plate contour cell designed for 10 tablets or 5 blisters of 20 pieces.
Pharmacological action
Medicinal effects pharmaceutical preparation Elevit Pronatal should be viewed not comprehensively, but in accordance with Composite components, since all vitamins, microelements and their salt derivatives are biologically active substances.
The main physiological role vitamin A - It coordinating normal education lipids, proteins and mucopolysaccharides in proportions which requires proliferating tissues . Due to this property it supports the body's ability to reparations and regeneration damaged areas. Also vitamin provides normal skin and mucous membranes, have been found in large quantities in the connective tissue and the upper layers epithelial . An integral component of improving the functioning of Elevita visual apparatus In particular the work of the eye in dim light (" twilight vision "), As it stimulates the metabolic processes in the rods, the receptor cells of the retina.
Second name Vitamin B1 - Antinevritichesky as the active component normalizes the nervous system, contributes to the physiological renewal myelin sheath nerve trunks and the natural course of the electrical pulses. Also he play of in regulation of cardiac work - Normalizes heart rate and strengthens the muscle cells of the organ. Vitamin is a stimulating factor in the blood, which provides timely renewal of the blood and improves microcirculation. As coenzyme or specific transporter is involved in carbohydrate, protein, fat and water-salt metabolism.
Riboflavin It is an essential part of the normal cycle of red blood cell formation ( erythrocyte ) And antibodies . It has a beneficial effect on the mucous membrane of the digestive tube and the respiratory tract, as it contributes to strengthen and timely Upgrade epithelium . It eliminates the effect of toxins that enter the body through the respiratory tract. Participates in the physiological development of tissues and organs of the fetus.
Pyridoxine hydrochloride or vitamin B6 found in many metabolic processes. First, it lowers the concentration cholesterol lipids and low density and very low levels, demonstrating anti-atherogenic effect . It helps improve cardiac contractility, as it increases the supply of mineral nutrients. It normalizes the work of the central and peripheral nervous systems, activating more intense axonal transport trophism and neurons. Strengthen cell structure of bone, teeth, gums, and skin appendages (hair and nails). Stimulates hematopoiesis .
Cyanocobalamine - An essential element for the formation of normal blood cells. In conjunction with Hageman factor Located on the surface of the stomach, participates in the absorption of iron by active diffusion and transport it to the place of synthesis of the major blood cells - red blood cells. This increases the intensity Oxygen metabolism and improved delivery of gas to the peripheral tissues and organs. In case of absence vitamin B12 develops macrocytic megaloblastic anemia As disturbed physiological structure of red blood cells. Also, biologically active component normalizes circadian rhythms Improving sleep and regulating waking hours.
Vitamin C It is a powerful antioxidant factor in the natural world. Linking free radical structure, it keeps the cell wall of their damaging effect. Through stimulating effect on the immune system rises own resistibility of to infectious diseases, because of his recommends that plentifully to take in the winter periods when the SARS threatens everyone. Also ascorbic acid is involved in the maturation connective tissue , Contributing metabolic cycles proline. Thus vitamin plays a role in the formation of bones , Gums, teeth, strengthening the vascular wall of the microvasculature. Participating in the digestive chain contributes to the normal absorption of calcium and iron.
The key role vitamin D3 It is in regulation calcium metabolism and Phosphorus in the body. Due to its pharmacological effects microelements better absorbed from food in the gastrointestinal tract, promptly deposited in bone and dentin, delayed their renal excretion. Comprehensive effect of vitamin allows withstand osteomalacia and softening of bone tissue, tooth decay Due to the effects of endogenous and exogenous nature. Liberally used in the prevention of rickets.
Alpha-tocopherol or a fat-soluble vitamin E, ascorbic acid and the like, has a strong antioxidant properties and participates in the formation of collagen and elastic fibers of the connective tissue and the skin in particular (supports regenerative capabilities the body to compensate for defects). Active ingredient strengthens the walls of capillaries and improves blood circulation in the vascular bed of small diameter, thereby preventing the development of anemia, and local deficiency of blood. It provides the normal functioning of plasma and trombotsitarnoj coagulation systems . Directly involved in education erythrocyte . When pregnancy is alpha-tocopherol boosts education gonadotropins and regulates development placental tissue , To she was responsible all the needs of the fetus.
Folic acid It is one of the most essential vitamins for pregnant women and for planning the future of the child. It promotes the physiological the formation of neuroblasts and neurocyte embryo, which is important for the normal development of the central and Peripheral nervous system . The course of folic acid during pregnancy is able to prevent the emergence of a large number of hereditary diseases, such as neural tube splitting, anencephaly, abnormal development of the spine and so on. Also, this vitamin strengthens the amniotic shell Thereby preventing possible premature birth. For the mother's body folic acid not without its uses - it is involved in hematopoiesis, as a stimulating factor, providing thus antianemic action .
Nicotinamide It is active coenzyme wide range of various metabolic reactions. So, for example, thanks to his the action of, is activated of adipose the exchange and are normalized redox processes. Vitamin promotes the synthesis of adrenal hormones Regulating carbohydrate and water-salt exchange. Participates in immune reactions Providing the normal synthesis of antibodies in response to antigens.
The physiological role Calcium It lies in the formation of normal structure bone the fetus. Due to exogenous trace elements entering the bone is laid embryonic leaf primordia and future dentin. In combination with vitamin D it provides an active prevention of osteomalacia . leaching of calcium from an organism mother and of development of rickets in a child . Trace elements ensures the normal functioning of the cardiovascular system, as directly involved in the mechanism of depolarization cardiomyocytes and muscle contraction. It contributes to the proper operation of the system of blood clotting.
As calcium, phosphorus involved in bone elements tab and teeth. A distinctive feature is the participation in Energy exchange - By means of chemical bonds with nucleotides are formed macroergic compounds, so-called, molecular energetic depot. If necessary, these structures are destroyed by a factor of internal environment and the cell or subcellular organelles receive the necessary amount of energy.
Iron necessary for the synthesis of heme at hemoglobin . This protein structure, which facilitates the transport of oxygen and carbon dioxide erythrocyte. Without a trace element of the body would not be able to receive and pass on all the tissues and organs of such a vital gas, oxygen, and clean up the waste produced in the form of carbon dioxide.
Zinc It is the active component of the various enzymes , Proteinaceous catalysts for chemical reactions which are predominantly involved in the synthesis of corticosteroids, adrenal hormones . Also, its impact extends to the state derivatives of the skin - nails and hair.
Manganese plays an important role in planning pregnancy, since it facilitates the activation of the reproductive function the female body. Trace elements improves memory and reduces irritability that a favorable effect if it is taken during a trace element postpartum depression .
Magnesium , As active component included in absolutely all tissues and organs of the human body. The highest value it has in shaping muscle and bone .
Pharmacodynamics and pharmacokinetics
Eleven is Pronatal complex pharmaceutical preparation Containing a large variety of active ingredients, the pharmacokinetic ability which should be considered separately. But unfortunately, not all of the metabolic chain of active ingredients significantly explored.
Vitamin A quickly and adequately absorbed from the gastrointestinal tract. Maximum plasma concentration achieved retinol after 4 hours after receiving medicament. It is deposited in Kupffer cells Where after the physiological level is gradually released into the main blood flow. Transport vitamin A in the vascular bed is provided by by specific globulins That protects biologically active component from filtering in glomerular apparatus of the kidneys . Retinol is metabolized in the tissue with the end products of metabolism in the form of carbon dioxide, water soluble vitamins and essential fatty acids. The active component of the urine is not found.
Ascorbic acid absorbed their gastrointestinal tract by active transport again the concentration gradient by sodium ascorbate cotransporter Which exhibits properties stereospecificity . Next vitamin C It enters the main gentle and transferred to cells which metabolize it evenly. The urine is found ascorbic acid only at excessively exceeding the dosage of the active component.
Following oral administration of a pharmaceutical formulation Vitamin D It absorbed from the small bowel end with the participation bile acids . In the blood acting component of the binds to the albumin and g-globulins . Cholecalciferol is deposited mainly in fat tissue Because it is inherently soluble vitamins. The metabolic transformations take place in:
- skin - Under the influence of ultraviolet rays;
- kidney - starring PTH Produced by the parathyroid glands, converted to the active metabolite (renal potent hormone having a steroid structure);
- liver - After hydroxylation becomes 25 oksiholekaltsiferolom.
Most of vitamin D allocated by the bile . The half-life is 19 days.
Thiamine absorbed in the intestine through active transport in epithelial cell by using a specific carrier. When large amounts of vitamin B1 can also be absorbed through the active diffusion . After 15 minutes it is already found in plasma (maximum concentration is achieved after 1, 5 hours), but only after half an hour in various body tissues. Deposited Vitamin B1 mainly in the brain, kidneys, adrenals, liver, and heart, as these organs consume thiamine in the largest quantities. Metabolized by the active component of the pharmaceutical preparation by the liver with an average rate of about 1 mg per day. The half-life ranges from 4 to 6 hours, depending on the intensity of the exchange of individual indicators.
Riboflavin It absorbed in the gastro-intestinal tract by active transport, and then subjected to enterohepatic circulation That is, getting into the bloodstream, it passes through the liver. The greatest quantity riboflavin after oral reception is observed in cardiac muscle, liver, kidneys and marrow. About 10 percent of the vitamin excreted in the urine, the remainder of the active ingredient through a cycle reabsorption in the tubules of the kidneys, and then returns to the main and peripheral blood.
Pyridoxine absorbed by simple diffusion in the intestine. The blood is its transformation into pyridoxamine , Whereupon a final product exchange 4 piridoksilovaya acid without any biological catalysts. In the tissues of vitamin B6 is phosphorylated to the above mentioned salts of organic acids, which are excreted in the urine. The maximum concentration of the vitamin is found in liver and myocardium, physiological depot active component of the drug Elevit Pronatal.
From bowel is sucked a little more than half of the entire the received Vitamin E . For its normal absorption requires fatty acids . As blood flows through the lymph tocopherol, is associated with the first chylomicrons And plasma since beta-lipoproteins . Accumulating tocopherol pituitary , The testes and the adrenal glands. It displays the active component to a greater extent in bile (about ¾ the entire dose of the drug), and the remainder is excreted in the urine as glucuronide conjugate.
Cyanocobalamine - The only water-soluble vitamins of the complex Elevit Pronatal who has property cumulation . This creates a risk of overdose supplementary active component. The cycle of absorption of vitamin B12 is particularly complicated in mind branched the spatial configuration of molecule. For its complete absorption requires physiological microflora of the digestive tract, two specific receptors and transmembrane transporter identified.
Indications
- gipovitaminoz ;
- beriberi ;
- lack of minerals and trace elements;
- preventive treatment anemia due to a deficiency of folic acid, cyanocobalamin or iron;
- Correction of mineral metabolism and metabolism of vitamins at planning pregnancy ;
- period pregnancy After childbirth and breast-feeding .
Contraindications
- increased individual sensitivity, inherited or acquired intolerance to the constituent components of the pharmaceutical formulation;
- supervitaminosis any of the B vitamins;
- elevated blood calcium;
- violation of the kidney or liver disease;
- urolithiasis disease ;
- nephrolithiasis and urolithiasis ;
- gipermagniemiya ;
- hyperphosphatemia ;
- increased excretion of calcium in the urine;
- violation of digestibility and utilization processes of iron.
Side effects
As a rule, the pharmaceutical preparation is well tolerated, as the prevailing part of the components of the drug is the element of physiological metabolism of the human body. However, in clinical practice are encountered and side effects of various character. Thus, for example, can be observed:
- malfunction of the stomach, intestines (discomfort in the epigastric region, abdominal distention );
- nausea and vomiting ;
- costiveness or diarrhea ;
- hemolytic anemia deficiency of glucose-6-phosphate dehydrogenase;
- hypercalciuria ;
- headache and dizziness ;
- irritability;
- allergic reactions - hives . edema . itching or rashes.
Of special note is the possible side effects from the immune system the body, as when they occur should immediately seek professional medical help:
- anaphylactic reactions up to shock with respective laboratory and clinical manifestations (rare);
- an asthmatic syndrome ;
- not cardiogenic pulmonary edema;
- manifestations on the part of the cardiovascular system.
Before the course of conservative treatment of patients should be warned about some of the consequences of drug therapy that have no clinical significance:
- perhaps staining of urine in intense yellow color due to the large number of Vitamin B2 ;
orally
To pregnant breast-feeding
Overdose
or D
- nausea ;
- vomiting ;
- constipation ;
- headache .
symptomatic therapy
Cooperation
antibiotics groups tetracycline and .
anticoagulants Platelet
Treatment
and
Levodopa . . fluoroquinolones . .
Terms of sale
Storage conditions
Shelf life
2 years.
Cautions
Analogs
Berocca Plus
Pikovit D
Biovital Kinder
Duovit women
Duovit Energy
Duovit
Intensive Selmevit
Selmevit
Triovite
Vitrum with beta-carotene
Vitrum Baby
Vitrum Prenatal
Vitrum
Vitrum Junior of
Vitrum Kids
Vitrum Centuria
Menopace
pregnant . . Vitrum . Complivit . .
Synonyms
. Glutamevit . .
Babies
With alcohol
Vitamin A . and or beta-carotene
vitamin D
and breastfeeding vitamin D .
.
