Zoladex

Description overdue on 09/22/2014

• Latin name: Zoladex
• ATC code: L02AE03
• Active substance: Goserelin Acetate (Goserelin Acetate)
• Manufacturer: AstraZeneca (UK)

Photos of the drug

Tweet

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Zoladex (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

Zoladex (Zoladex) contains, as active substance goserelin acetate And the following additional components: glycolic copolymer   and lactic acid , and low molecular weight   and high molecular weight glycolic   and lactic acid .

Product form

Produced Zoladex 3, 6 and 10 mg, 8 mg capsules for subcutaneous administration.

Pharmacological action

The anti-tumor drug.

Pharmacodynamics and pharmacokinetics

The drug is a synthetic analogue of the natural gonadotropin-releasing hormone . He inhibits   allocation luteinizing hormone   pituitary gland, thereby decreasing the level of Testosterone   in men and concentration Estradiol   women. This leads to a regression of prostate tumors and breast cancer. Furthermore, the drug is effective at endometriosis , Preventing the development of follicles   ovarian and fibroma uterus . It leads to a thinning endometrial .

Effective concentrations Zoladex supported by subcutaneous injection every month. The preparation is characterized by a low degree of association with plasma proteins. Half-life, usually - about 3 hours.

Indications

This tool is indicated for:

• hormone-prostate cancer or breast cancer;
• uterine fibroids ;
• need thinning endometrial   before surgery;
• endometriosis ;
• IVF   (if necessary desensitization   the pituitary gland).

Contraindications

The drug is contraindicated in:

• hypersensitivity to its components and other counterparts gonadotropin-releasing hormone ;
• pregnancy ;
• childhood;
• breast-feeding .

Side effects

Side effects while taking Zoladex following:

• CCC: hypotension   or hypertension ;
• Musculoskeletal system: arthralgia ;
• skin rash;
• nervous system: nonspecific paresthesia   and, in rare cases, apoplexy   pituitary;
• Allergy: anaphylaxis   (in rare cases).

The women also identified the following reactions: dryness of the vaginal mucosa, depression , Increased Sweating , Change of mood, changes in libido, changes in breast size, headache . In the early course of patients the presence of breast cancer can be observed hypercalcemia As well as temporarily expressed manifestation of signs and symptoms of the disease. Women with uterine fibroids   In some cases, there is suppression of fibromatous nodes .

The men were also observed following side effects decrease potency , Swollen and painful breasts, Sweating . In rare cases, observed compression of the spinal cord and the violation of ureteral patency. Patients with prostate cancer early in the course sometimes observed transient increase in bone pain.

Instructions for use Zoladex (method and dosage)

The capsules are administered subcutaneously in the abdominal wall. Instructions on Zoladex 3 6mg reported that drug must be used every 4 weeks. In malignant tumors and benign gynecologic pathology course is designed for 6 capsules.

For thinning endometrial   preoperatively two injections administered capsules, the gap between them - 28 days. Ablation   uterine between four and six weeks after the first use of the capsule.

Instructions for use Zoladex 10, 8 mg reported that the drug should be administered every 90 days.

Overdose

Clinically significant adverse events at higher doses of the drug were noted. In case of overdose symptomatic treatment.

Cooperation

Clinically significant effects in combination with other drugs has not been described.

Terms of sale

Zoladex is sold by prescription only.

Storage conditions

Store this medication should be in its original packaging at a temperature of 25 ° C.

Shelf life

Shelf life of the tool is 3 years. Use it after this time is strictly prohibited.

Analogs

Match code ATC 4th level:

• Buserelin Long
• Buserelin Depot
• Diferelin
• Buserelin

Analogs of Zoladex in pharmacies as follows:

• Dekapeptil ;
• Dekapeptil Depot ;
• Diferelin ;
• Sandoz leuprorelin ;
• Lyukrin Depot ;
• Lyuprayd Depot ;
• Eligard .

Among these, particularly common is the last drug.

Which is better - Eligard and Zoladex?

Many patients are wondering which of the two drugs effective: Eligard   or Zoladex. Experts recommend the use of the latter unambiguously. Zoladex has fewer side reactions, moreover, it does not affect driving. So that active drug is often preferred over its equivalents.

With alcohol

Application analogues gonadotropin-releasing hormone   some men may lead to a decrease in bone mineral density. A special risk group patients, who often take alcohol, are long-term treatment Corticosteroid   or anticonvulsant drugs, smoking, and have osteoporosis   at history . Thus, when using Zoladex must be particularly careful. Men who frequently drink alcohol, the drug should be before using consult your doctor.

Reviews of Zoladex

Patients who leave reviews of Zoladex, frequently reported adverse reactions. They write that there headache . frequent menstruation . sleep disorders . The drug, however, helps. Reviews of Zoladex suggests that for those who have been without side effects, the reception of the funds actually turned out to be painless and effective.

Price Zoladex, where to buy

Buy in Moscow and other Russian cities Zoladex 3 and 6 mg may be an average of 8,400 rubles. The cost of the package 10, 8 mg - about 22 000 rubles. Price Zoladex in Ukraine - about 2,000 hryvnia per package of 3, 6 mg, and 6,000 hryvnia per package of 10, 8 mg.

Get the best price and buy