doctor: Metamax

Description overdue on 03/12/2014

Latin name: Metamax
ATC code: C01EB
Active substance: Propionate dihydrate
Manufacturer: FF CHAO Darnitsa, Ukraine

Photos of the drug

Composition
Product form
Pharmacological action
Pharmacodynamics and pharmacokinetics
Indications
Contraindications
Side effects
Metamax, instructions for use
Overdose
Cooperation
Terms of sale
Storage conditions
Shelf life
Analogs
Reviews
Price, where to buy

Metamax

Composition

As part 1 Tablet formulation It contains 250 milligrams of 3- (2, 2, 2-trimethylhydrazinium) propionate dihydrate. Auxiliary ingredients: potato starch, magnesium stearate, colloidal anhydrous silicon dioxide.

IN 1 ampoule for injection , 5ml, contains five hundred milligrams of 3- (2, 2, 2-trimethylhydrazinium) propionate dihydrate. Supporting components: water for injection.

Product form

capsules (ten capsules in the same package, the package outline 4 in the stack);
injection (10 vials per pack).

Pharmacological action

Metamax has angioproteguoe action.

It is a synthetic analogue of the g-butyrobetaine, which inhibits the enzyme g-butyrobetaine hydroxylase . The drug lowers the synthesis carnitine . Reduces accumulation in cells and tissues derived atsilkoenzima A and acylcarnitine (activated form of unoxidized fatty acids). This drug activates glycolysis Improves the transport of ATP, restores the balance between consumption and transport of oxygen by cells in the ischemic tissues.

Pharmacodynamics and pharmacokinetics

The drug has a wide range of pharmacological effects due to its mechanism of action. It activates tissue and humoral immunity Has a cardioprotective effect, reduces the severity of symptoms of mental and physical stress, increases the intensity of metabolic processes and the ability to work.

If developed ischemic tissue damage acute, the drug helps to reduce the size of necrotic area and shorten the rehabilitation period. In acute and chronic violations of cerebral blood flow in ischemic medication promotes redistribution of blood flow in the ischemic areas, thereby improving blood circulation.

Patients having chronic heart failure It increases exercise tolerance and increases myocardial contractility.

Patients chronic alcoholism eliminates the dysfunctions and somatic nervous system, and for vascular and dystrophic pathology of the eye bottom improves local blood circulation.

When administered intravenously, the drug, the highest concentration in the blood for fifteen minutes after administration. Half-life of two to four hours depending on the dose. With prolonged use of the drug half-life is increased partially.
When taken orally Metamax fairly rapidly absorbed from the digestive tract. Within one or two hours in the blood plasma is reached maximum concentration. The bioavailability of the drug is 78 percent. Half-life of three to six hours. The drug is excreted mainly by the kidneys.

Indications

Tablets and capsules Metamax appointed at:

ischemic circulatory disorders in the brain;
eye diseases that are associated with abnormal vascular bed with his eyes and macular degeneration;
chronic bronchitis , Chronic obstructive pulmonary disease, allergic, infectious asthma ;
alcoholism , Including for relief abstinence syndrome ;
vascular encephalopathy ;
reduced physical capacity, including people involved in sports;
cerebrovascular insufficiency .

The drug is used to reduce the duration of the rehabilitation period after surgery.

Contraindications

This drug is contraindicated in:

at pregnancy and breast-feeding ;
with increased intracranial pressure (intracranial tumors, violation of the outflow in the veins), organic lesions of the central nervous system;
hypersensitivity to the drug content;
in childhood.

Side effects

The drug causes the following side effects:

On the side Respiratory System : dry cough and breathlessness .
On the side Digestive System : rarely - hyperptyalism or dryness of the mouth, metallic taste in the mouth, dyspepsia , Pain in the abdomen, vomiting . nausea and diarrhea .
On the side CNS : Rarely - excitement, tremor . paresthesia , Psychomotor disturbances dizziness . headache .
On the side hematopoietic system : eosinophilia .
On the side Cardiovascular : In rare cases - changes in blood pressure . arrhythmia . tachycardia .
General disorders and reactions at the injection site: pain and hyperemia .
Allergic reactions: seldom - angioedema . rash . hives , Itching, and redness of the skin, in extremely rare - anaphylactic shock .
Others: increased perspiration . hyperthermia , Weakness, pain in the chest, chills .

Metamax, instructions for use

Capsules Metamax recommended to take in the morning, because it can develop a stimulating effect.

During physical and mental overload advised to take four times a day 250 mg.

At degenerative diseases of the retina and vascular eye diseases injectable form of the drug is used for the first 10 days of administration parabulbarly, then move on to receive capsules once a day from 500 milligrams to 1 gram. The total duration of treatment is four to six weeks.

At Chronic disorders of blood circulation in the brain taken five hundred milligrams per day. The total duration of treatment - from four to six weeks.

At cardiovascular diseases receiving from 500 mg to 1 gram once or twice a day. Duration of treatment - from four to six weeks.

People involved in sports, it is recommended to take into 500 milligrams to 1 gram twice daily before training. Duration of treatment - from 14 to 21 days, during the competition - from ten days to two weeks.

Instructions for use in ampoules MetaMax

Injections MetaMax made during the morning:

cardiovascular diseases (5 to 10 milliliters of 10 percent solution for four to six weeks);
circulatory disorders in the brain (in the acute phase once daily at 0, 5 g);
degenerative diseases and vascular diseases of the retina (subconjunctivally and parabulbarly at 0, 5 mL of 10 percent solution for 10 days);
alcoholism (intramuscularly and intravenously twice daily for 0, 5 grams for seven to ten days).

Overdose

No known cases of overdose MetaMax. When high doses of the drug, symptoms, similar to the side effects. Treatment consists of gastric lavage , The use of enema and laxatives.

Cooperation

With simultaneous use of the drug enhances the effect of cardiac glycosides Some antihypertensive drugs and antianginal drugs .

Metamax can be combined with diuretic . antiarrhythmics . antiplatelet . anticoagulants . antianginal drugs .

You should be careful while using a MetaMax beta-blockers . peripheral vasodilators . Nitroglycerin and Nifedipine Because it can develop hypotension and moderate tachycardia .