With Klenzit

Description overdue on 02/10/2014

• Latin name: Klenzit-C
• ATC code: D10AX30
• Active substance: Adapalene + Clindamycin (Adapalene + Clindamycin)
• Manufacturer: Glenmark Pharmaceuticals Ltd. (India)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

1 g of gel contains 1 mg Adapalene + 10 mg Clindamycin   - Active substance.

Auxiliary ingredients:

• propylene glycol;
• disodium edetate;
• methyl parahydroxybenzoate;
• Carbomer 940 (Carbopol 940);
• phenoxyethanol;
• sodium hydroxide;
• poloxamer 407;
• purified water.

Product form

With Klenzit issued in the form of a gel for topical application.

Package 1 comprises a tube 1 mg + 10 mg / 1 g gel 15 g or '30

Pharmacological action

Anti-inflammatory, komedonoliticheskoe, bacteriostatic.

Pharmacodynamics and pharmacokinetics

Klenzit Gel C is a combination drug for the treatment of acne (acne) For local application. As active substances act Adapalene and clindamycin.

The derivative of a retinoid - Adapalene It exhibits anti-inflammatory activity and komedonoliticheskuyu. It has influence on the public and private comedones , Contributes to the normalization process epidermal differentiation and keratinization . The drug reduces the bonding time follicular epithelial cells That promote the formation of microcomedo And oppresses chemokinetic and chemotactic response polynuclear cells.

The antimicrobial agent Clindamycin   It refers to the group lincosamides   and it has a bacteriostatic activity against many microorganisms . Clindamycin   contacting 50S ribosomal subunit membrane Oppresses replication protein   in a bacterial cell. Also exhibits bactericidal activity against some Gram-positive cocci.

In the treatment conducted using Klenzita C patients acne   notes reduction in the intensity of inflammation, reduction of acne elements , and reducing the number of comedones and a general improvement in the skin of the face.

In connection with the external use of the drug Klenzit With its systemic absorption is negligible.

Indications

Treatment acne (acne).

Contraindications

• Hypersensitivity to adapalene, clindamycin and other ingredients of the formulation;
• period Lactation ;
• period   pregnancy .

Use caution when eczema and dermatitis.

Side effects

Treatment with the gel Klenzit C mostly runs without any serious complications. Some patients are rarely seen redness, irritation, peeling skin . In such cases it is advisable to temporarily suspend treatment and continue treatment after the disappearance of these side effects.

At the beginning of treatment, sometimes there may be a worsening acne,   further extending the therapy.

Described isolated cases of development allergic reactions Which serve as an indication for the full withdrawal of treatment.

Instructions for use (method and dosage)

Klenzit C in gel form intended for external (topical) application.

Just before you apply the gel, instructions for use recommends clean and dry skin problem areas. The drug is applied to point strokes, without rubbing or using on the skin with a damaged integrity and / or burns.

Apply the gel is recommended before going to sleep. When applied in the daytime should be for the next 1-2 hours, to refrain from imposing a make-up and washing.

It is necessary to avoid contact of the drug in the nasal cavity, mouth, eyes and mucous membranes.

The duration of the course of therapy and Regimen Klenzit C determines physician. Depending on the complexity of the disease designate 1 or 2 applications a day. Follow the instructions on the Klenzit with an average duration of treatment is 14-28 days. Perhaps the purpose of re-treatment, after consultation with the attending physician.

Overdose

Due to the fact that the gel Klenzit C applies only externally, its overdose is unlikely.

In case of accidental admission into the gel should immediately conduct gastric lavage and reception enterosorbentnyh funds.

Cooperation

At the same time Klenzitom C should not be used alcohol-based agents, as well as ointments and creams with a drying, irritating effect.

Do not combine the use Klenzita C, and drugs containing Calcium gluconate, aminoglycosides, ampicillin, magnesium sulfate, and vitamin B complex

Perhaps a joint appointment with Benzoyl peroxide.

Concomitant use Klenzita C, Erythromycin   It leads to mutual inefficiencies.

Terms of sale

Prescription.

Storage conditions

The temperature is not above 25 ° C.

Shelf life

24 months.

Cautions

At the beginning of a course of therapy with a gel Klenzit With possible aggravation of acne, which disappear on their own in the future course of treatment.

If symptoms of irritation of the skin should stop applying the gel (temporarily or not at all).

You should avoid natural or artificial (solarium) ultraviolet radiation. If you want to stay long in the sun application of the gel should be carried out 24 hours before and after.

Application of gel on the skin lesions is not allowed.

In case of contact with the gel in the mouth or nose and the mucous eye wash thoroughly with warm water.

Analogs

Match code ATC 4th level:

• Kuriozin

Analogs gel Klenzit With available in dosage forms for topical use and may be: an ointment, cream, gel or topical solution. If it is impossible, for any reason, the application of gel Klenzit With appoint its analogs:

• Klindes;
• Skinoren;
• Resorcinol;
• Aziks-Derm;
• Azelik etc.

During pregnancy (and lactation)

Gel Klenzit C is not prescribed during pregnancy and breastfeeding.

Reviews On Klenzit

Among the reviews on medicines designed to get rid of pimples, reviews about Klenzit C, in the absence of contraindications and allergic reaction to the components completely positive. The drug has a high efficiency at low extending side effects, among which: redness, peeling skin and exacerbation at the beginning of therapy.

It should be remembered that the use of gel Klenzit With recommended for no more than 4 weeks, then move on to the use of Klenzita or other, similar in its effect, the drug.

Price Klenzit From where to buy

Price Klenzit C depends on the mass content of the tube, so the price of the gel 15 g, an average of 550 rubles and buy 30 grams of the drug you can for 750 rubles.

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