Description overdue on 11/29/2014
- Latin name: Biprol
- ATC code: C07AB07
- Active substance: Bisoprolol (Bisoprolol)
- Manufacturer: LLC "Hemofarm", LLC "Makiz Pharma" Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Biprola
- Contraindications
- Special conditions
- Side effects
- Biprol, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
In tablets, coated membrane Sheath is contained active component - bisoprolol fumarate.
Additional components: MCC, of lactose monohydrate, povidone, starch corn, silicon dioxide colloid, crospovidone, magnesium stearate.
The composition of the shell membrane include: titanium dioxide, macrogol, hypromellose, talc, dye tropeolin-O.
Product form
Biprol produced in the form of tablets, coated foil envelope with an active substance content of 5 mg and 10 mg. The medicine is packaged by 10 pieces in stripes package, 3, 5 or 10 packs in one pack.
Pharmacological action
Tablets have antiarrhythmic . hypotensive and antianginal effect.
Pharmacodynamics and pharmacokinetics
Biprol is a selective beta1-adrenergic blocker with no intrinsic sympathomimetic activity and membrane stabilizing properties.
When you receive this drug decreases the activity Renin plasma, reduces the need for oxygen delivery to the myocardium, the heart rate in a different state. This indicates that, that the preparation possesses hypotensive, antiarrhythmic and antianginal the action of. Low dose Biprola able to block β1-adrenergic receptors of the heart, caused by lowering catecholamines the formation of AMP from ATP, reducing the intracellular current Calcium , Reduce myocardial contractility, oppressing conductivity and anxiety and so on. When the drug is appointed by in high doses, then it is celebrated of his beta2-adrenoceptor blocking effect.
The hypotensive effect of the drug can reduce the minute volume of blood, sympathetic stimulation of peripheral blood vessels, reduce the activity of the renin-angiotensin-aldosterone system helps to restore sensitivity while lowering blood pressure and influence on the central nervous system. During treatment hypertension Initial efficiency is manifested after 2-5 days, and stable effect - 1-2 months.
Antianginal effect of the drug helps to reduce the need for the supply of oxygen to the myocardium by reducing heart rate and contractility, diastolic lengthening and improving myocardial perfusion.
Manifestation of antiarrhythmic effect is due to the elimination of arrhythmogenic factors reducing the rate of spontaneous excitement and so on.
Admission Biprola in high therapeutic doses less pronounced effect on the bodies, which contain the β2-adrenergic receptors, for example: pancreas , Skeletal muscles, smooth muscles of peripheral arteries, the uterus and the bronchi, and carbohydrate metabolism, does not delay the sodium in the body.
Indoor reception is accompanied by a good absorption of the drug from the gastrointestinal tract, is 80-90%. In this food has no effect on this process. The maximum concentration of the active substance plasma is detected later, 1-3 h. Communication with blood plasma proteins reaches almost 30%. It was noted that a small amount of the substance passes into breast milk, through the placental barrier and the blood-brain barrier. The process metabolism predominantly occurs in the liver. Withdrawal is carried out by the kidneys, a small part in bile.
Indications Biprola
The main indications for use of the drug:
- Coronary heart disease: prevention of attacks angina;
- arterial hypertension.
Contraindications
The drug does not appoint at:
- shock, e.g., cardiogenic;
- collapse;
- edema light;
- acute and chronic heart failure;
- AV-block II and III;
- expressed bradycardia;
- the age of 18;
- cinoatrialnoy blockade;
- sick sinus syndrome;
- Prinzmetal angina;
- hypotension;
- asthma and chronic obstruction of the lungs;
- lactation, pregnancy and so on.
Special conditions
When treating Biprolom should regularly monitor the condition of the patient with the measurement of the heart rate and blood pressure, performing an electrocardiogram, blood glucose - for patients diabetes . Elderly patients should follow the work of the kidneys. In addition, since the treatment, it is necessary to investigate the respiratory function if patients are disorders of the respiratory system.
It was found that patients who smoke effect of beta-blockers reduced.
When using of contact lenses need to remember, that in the the period of treatment possible reduction of of products tear fluid.
Treatment of patients with other complicated forms of chronic diseases should be undertaken with caution, as is often the manifestation of some unwanted symptoms masked by others. For example, when diabetes not excluded disguise tachycardia Induced hypoglycemia .
When it is necessary to perform the surgery with general anesthesia preparation cancel 48 hours prior to your appointment. Also Biprolom treatment stops the development of the doldrums.
However, abruptly stop treatment is contraindicated, as can develop severe arrhythmias or myocardial infarction . Therefore, cancellation is carried out gradually, with reduced dosing for 2 weeks.
During treatment should use caution when operating any type of vehicle or class of other dangerous activities requiring special attention and quick response.
Side effects
When treating Biprolom may develop undesirable effects affecting the nervous, cardiovascular, digestive, respiratory and other systems. This might appear: fatigue, weakness, dizziness and headache , Sleep disorders, depression, anxiety, confusion, asthenia and tremor .
There remains the probability of development: changes in heart rate, cardiac conduction infarction, arrhythmia , Congestive heart failure, lowering blood pressure, nausea, vomiting, problems with stool, pain in the digestive tract, respiratory disorders and so on.
Deviations are not excluded in the work of view, the emergence of allergic and dermatological reactions and general disorders.
Biprol, instructions for use (method and dosage)
According to the instructions for use Biprola, you need to take medicine by mouth, once a day, preferably in the morning with some liquid.
The tablets are generally form. Selection of dosage is performed doctor and depends on the characteristics of the patient, taking into account its heart rate and blood pressure parameters.
For example, when hypertension and coronary heart disease appoint a single daily reception, 5 mg. If necessary, the dose is gradually increased to 10 mg. The therapeutic dosage for patients suffering from hypertension or angina, may be 20 mg, to a single reception day.
Overdose
In cases of overdose Biprolom may occur: Arrhythmia . ventricular arrhythmias, bradycardia and lowering blood pressure, AV-blockade, difficulty breathing, bronchospasm , Dizziness, fainting and a convulsive state, and so on.
At the same time it is usually carried out symptomatic therapy with carrying out: gastric lavage, destination adsorbents and other procedures.
Cooperation
Biprolom concurrent therapy and the use of allergens can cause severe systemic allergic reactions or anaphylaxis.
The combination with the iodine-containing radiopaque drugs increase the risk of symptoms of anaphylactic reactions.
Phenytoin and preparations of general anesthesia increases the severity of the effect and the probability cardiodepressive lowering blood pressure.
Moreover, the efficiency can change Biprol insulin and area points of of oral hypoglycemic of preparations, masks the symptoms of hypoglycemia in the form tachycardia or to enhance the a BP.
Combination therapy with cardiac glycosides, methyldopa . reserpine and guanfacine, verapamil, diltiazem, amiodoronom is capable of lead to the development or aggravate bradycardia, AV-blockade of, cardiac arrest and heart failure.
Nifedipine, diuretics, clonidine, hydralazine, sympatholytic and other hypotensive medications can significantly reduce blood pressure.
It should refrain from simultaneous reception and bisoprolol MAO inhibitors Since it significantly enhances the antihypertensive effect. Usually between treatment courses of these drugs stand interval of 14 days.
Terms of sale
To purchase Biprola require a doctor's prescription.
Storage conditions
The drug store in a dry, dark, protected from children, at temperatures up to 25 C.
Shelf life
3 years.
Analogs Biprola
Nebivolol
Bisoprol
Concor Cor
Lokren
Concor
Niperten
Betaloc ZOK
Betalok
Coronal
Egilok
Nebilet
Atenolol
Metoprolol
Basic analogues of the given preparation: Aritel, Bidop, Bisogamma, Bisoprol, Concor, Kordinorm, Coronal, Niperten and Tiresias .
Alcohol and Biprol
During the reception of the drug should refrain from drinking any alcohol-containing agents, since they lead to increased inhibitory effect bisoprolol on the nervous system.
Reviews Biprole
As the reviews of Biprole, the appointment of the drug in many patients afraid of the list of possible side effects. So often, I read the instructions, people believe that it is not only medical, but also a very dangerous tool, from which tablets are simply forbidden to them.
However, most patients who are already being treated Biprolom, according to its good tolerability in combination with high efficiency. Furthermore, for some patients, this drug solution better than for example, the original Concor .
A similar opinion was expressed about this preparation specialists. Many of them often prescribe it to their patients Biprol. As the clinical practice in the treatment of side effects of these pills are developed in isolated cases and usually occur only headache.
Biprol is one of the most popular and highly effective drugs. If it is taken properly, the treatment brings a stable and lasting effect. The main thing is that the purpose of therapy is to carry a doctor, who can assess its effectiveness.
Price Biprola where to buy
Price Biprola 10 mg per 30 pieces in a package in drugstores Moscow is 125-160 rubles.
Buy tablets of 5 mg per 30 pieces in a pack you can within 67-85 rubles.
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