Mikrofollin

Description overdue on 09.04.2012

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Estrogenic agent . The active substance is ethinylestradiol . The mechanism of action is based on the proliferation of the epithelium, on interaction with estrogen receptors in specific organs (vulva, excretory ducts breast, cervix, vagina, the fallopian tubes). Under the influence of the drug increases the sensitivity of muscle mikrofollin fallopian tubes, uterus, to mediators. The drug has a positive effect on the process glucose utilization It increases the level and sensitivity of the alpha-lipoproteins to the effects of insulin, has moderately expressed hypolipidemic effect . Large concentrations of ethinyl estradiol inhibit polycythemia Cause water retention, sodium ions in the body, inhibits the secretion of pituitary FSH. In males the drug inhibits spermatogenesis , Reduces the secretion of androgens causes atrophic changes in the testicles. For the drug is characterized by a weakly expressed   anabolic effect . In some cases, the drug has contraceptive effects , It can be used as part of combination contraceptives. Mikrofollin is available in tablet form.

Indications:

Mikrofollin prescribed for metrorragii , Ovarian hypofunction, dysmenorrhea Secondary amenorrhea , Oligomenorrhea, primary amenorrhea, vaginitis At infertility , Sexual infantilism, hypogonadism, secondary estrogen deficiency, androgenozavisimom prostate cancer, some forms of breast cancer, suppress lactation, acne , Menopausal disorders, post-castration disorders .

Contraindications:

Mikrofollin not indicated for suspected malignant neoplasm (responsive to estrogen), pregnancy, uterine bleeding, acute thromboembolic diseases, thrombophlebitis Diagnosed malignancy. When embolism, thrombosis, thrombophlebitis, endometriosis, pancreatitis . family hyperlipoproteinemia , Jaundice, severe hepatic pathology system, leiomyoma, hepatic porphyria, hypercalcemia used with caution after specialist consultation. It is important to bear in mind that larger doses of estrogen increases the risk of thrombophlebitis, pulmonary vessels, myocardial infarction.

Side effect:

In females there is an increase in libido, the risk of developing breast tumors may cause intermenstrual spotting vaginal discharge, amenorrhea Increase in breast size. In males there is a decrease in libido, gynecomastia, hypersensitivity and breast tenderness. Also recorded diarrhea, intestinal colic, nausea, anorexia , Bloating, biliary colic, gall bladder obstruction, peripheral edema, pancreatitis, hepatitis, headaches, vomiting, dizziness. In treatment of prostate tumors, mammary glands may develop thrombosis thromboembolism .

Mode of application:

Mikrofollin taken orally. Oligomenorrhea, amenorrhea: 20 days to 0, 02-0, 1 mg, then move on to a five-day, intramuscular progesterone. Menopausal disorders in women under 45 years old: mikrofollin at a dose of 0, 05 mg daily. Dysmenorrhea: three receiving 0, 01-0, 03 mg for 20 days, starting from the fourth day of the menstrual cycle every 2-3 months. Malignant neoplasm of breast, prostate: three times a day for 0, 05-0, 1 mg in combination with radiotherapy. The dosage is gradually reduced to 0, 05 mg per day. Inhibition of lactation: three times a day for 0, 02 mg of the first three days after delivery. Acne: puberty at 0, 01-0, 03 mg per day.

Special instructions:

Gynecological, medical examination before prescribing mikrofollin necessary (including diagnosis of the breast).

Drug Interactions:

Mikrofollin enhances the activity lipid-lowering agents . Barbiturates reduce, and thyroid medications, folic acid   increase the activity of ethinyl estradiol. Mikrofollin reduces the effect of anticoagulants, hypoglycemic, hypotensive, diuretic, the male sex hormones.