Tsiprolet

Description overdue on 04.05.2012

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Antibiotic . The main ingredient is ciprofloxacin. The active ingredient - a derivative of fluoroquinolone. The mechanism of action directed at the suppression of bacterial DNA gyrase cells, which leads to infringement synthesizing DNA , Slowing the growth and reproduction of microbes. As a result of pronounced morphological changes under the influence of antibacterial Tsiprolet microbial cell dies. The bactericidal effect is manifested in the period and dividing the rest of gram-negative microorganisms. In regard to Gram-positive flora bactericidal effect is manifested only during division. The cells do not contain the microorganism DNA gyrase, which eliminates the toxic effects on the human body. The drug does not cause resistance to other antibiotics. Tsiprolet active against aerobic flora, enterobacteria, gram-negative flora, Chlamydia, Listeria, Mycobacterium tuberculosis, Yersinia, Campylobacter, Proteus, mycoplasma, etc. Tsiprolet does not have a bactericidal and bacteriostatic effect on treponemu pallidum (the causative agent Syphilis ). Tsiprolet discharged as a concentrate, a solution, tablet.

Indications:

Tsiprolet prescribed for bacterial lesions of the respiratory system ( cystic fibrosis , Bronchitis, bronchiectasis, pneumonia), upper respiratory tract ( tonsillitis . pharyngitis , Otitis media, mastoiditis, sinusitis, sinusitis), urinary system (salpingitis, cystitis, pyelonephritis , Oophoritis, tubular abscess adnexitis, prostatitis, gonorrhea, Chlamydia , Chancroid, pelivioperitonit, pyelitis), digestive system (peritonitis, typhoid fever, salmonellosis , Intraperitoneal abscesses, yersiniosis, campylobacteriosis, cholera, shigellosis), skin (cellulitis, abscesses, burns, infected ulcers, wounds), bones and joints (sepsis, septic arthritis, osteomyelitis ). The drug is indicated for the prevention of infectious lesions after surgery.

Contraindications:

Tsiprolet not indicated in pediatric patients up to the age of majority (the formation of the skeletal system, skeleton), intolerance to ciprofloxacin, pregnancy, lactation. In case of violation of cerebral circulation, cerebrovascular at epileptic syndromes , Epilepsy, mental illness, severe liver disease, kidney problems, the elderly prescribed after consulting experts.

Side effect:

The digestive tract:   vomiting, diarrhea syndrome, flatulence, epigastric pain, nausea, abdominal distention . cholestatic jaundice , Decreased appetite, gepatonekroz hepatitis. Nervous system Insomnia, dizziness, anxiety, fatigue, peripheral paralgeziya "Nightmarish" dream, limb tremors, increased intracranial pressure, increased sweating, hallucinations, depression, confusion, various psychotic reactions, thrombosis of cerebral arteries , Fainting, migraine. Senses:   hearing loss, tinnitus, a violation of taste perception, diplopia. Perhaps the development of tachycardia , Drop in blood pressure, cardiac arrhythmia, anemia, granulocytopenia, leukocytosis. Urogenital: polyuria, dysuria, glomerulonephritis, crystalluria, hematuria, interstitial nephritis, renal azotovydeitelnoy violation. Tsiprolet can trigger an allergic response, urticaria, arthralgia , Tenosynovitis, arthritis.

Overdose:

Manifested increased severity of side effects. The specific antidote is not developed. It should be gastric lavage, peritoneal dialysis, hemodialysis.

Mode of application:

Tsiprolet taken orally 2-3 times a day for 0, 25 grams; in severe zaboelvaniya dosage is increased to 0, 5-0, 75 grams. Infections of the urogenital system: twice a day for 0, 25-0, 5 g for 7-10 days. Uncomplicated gonorrhea: single 0, 25-0, 5 grams. Gonococcal infection in conjunction with mycoplasmosis, chlamydiosis: every 12 hours for 0, 75 g, course - 7-10 days. Chancroid: twice a day for 0, 5 g Tsiprolet in tablet form is swallowed completely, washed down with fluid. Intravenous infusion is carried out for half an 0 2 grams. Treatment of osteomyelitis takes about two months. Chronic carriers of salmonella: twice a day for 0, 2 grams, a course of 4 weeks. After intravenous move on to receive a tablet form.

Special instructions:

Requires monitoring of blood pressure, heart rate, ECG, while the introduction of general anesthesia drugs (barbituric acid derivatives), and ciprofloxacin. The excess daily dosage may lead to crystalluria . Tsiprolet affect the management of transport, concentration. Patients with organic brain lesions, vascular disease, epilepsy, seizures in the history of drug Tsiprolet prescribed in exceptional cases, for "vital" indications. Prior to antimicrobial therapy should be excluded pseudomembranous colitis . Treatment was stopped at the first sign tenosynovitis , The appearance of pain in the tendons. It is important during treatment to avoid sun exposure.

Drug Interactions:

Tsiprolet prolongs the half-life, improves concentration anticoagulants , Oral hypoglycemic agents because of the decreased activity of microsomal oxidation in the liver cells hepatocytes. Ciprofloxacin decreases prothrombin index . Combination with other antibacterial agents lead to synergism. Tsiprolet effectively used in conjunction with azlocillin, ceftazidime, beta-lactams, izoksazolpenitsillinami, vancomycin , Clindamycin, metronidazole. The drug increases cyclosporin nephrotoxicity, increases in serum creatinine. Preparations of NSAIDs other than acetylsalicylic acid May cause convulsions. The infusion solution is compatible with infusion solutions for pharmaceutical indices. Never mix intravenous fluids with solutions with a pH greater than 7 index.