Description overdue on 11/29/2014
- Latin name: Bisoprol
- ATC code: C07AB07
- Active substance: Bisoprolol (Visoprolol)
- Manufacturer: "Farmak", Ukraine
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Bisoprola
- Contraindications
- Side effects
- Tablets Bisoprol, instructions for use (method and dosage)
- Special conditions
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
The tablet formulation contains the active ingredient bisoprolol In a dosage of 5 or 10 mg.
Additional components: dibasic calcium phosphate, corn starch, microcrystalline cellulose, crospovidone and magnesium stearate.
The composition of the shell include: hydroxypropyl cellulose, yellow and red iron oxide.
Product form
Bisoprol produced in the form of tablets, coated at 2.5, 5 or 10 mg.
Pharmacological action
Tablets have Bisoprol antianginal and hypotensive effect.
Pharmacodynamics and pharmacokinetics
This drug belongs to β1-selective blockers . Use of the drug in therapeutic doses does not exhibit intrinsic sympathomimetic activity or membrane stabilizing clinically significant symptoms.
Antianginalnoe action Bisoprola exhibits reduced myocardial oxygen demand, after a decrease in heart rate, cardiac output and blood pressure. This increases the maintenance of myocardial oxygen due to the reduction in diastolic blood pressure and diastolic lengthening.
Antihypertensive effect is a decrease in cardiac output, inhibition of renin secretion by the kidneys, the influence of baroreceptors in the aortic arch, carotid sinus. Prolonged use Bisoprola reduces peripheral vascular resistance. In cases of chronic heart failure drugs can inhibit the renin-angiotensin-aldosterone system and activated sympathoadrenal. Sometimes it is possible to effect the smooth muscles of peripheral arteries and bronchial processes metabolism glucose. Effect of the drug after a single reception is stored about a day.
When an internal reception Bisoprola celebrated his good adsorption from the gastrointestinal tract. The bioavailability of the drug is not dependent on the use of food and approximately 90%. Maximum concentration in the composition plasma from the time of reception is attained after 1-3 hours. Binding to plasma proteins of this drug is not less than 30%.
The biotransformation of the drug in the liver, resulting in formation of inactive metabolites . Excreted almost 98% of the active substance is derived using the kidney - intact and metabolites, the rest - in the intestine. The half-life up to 10-12 hours.
Indications Bisoprola
The main indications for use Bisoprola:
- arterial hypertension;
- chronic form of heart failure;
- coronary artery disease.
Contraindications
Bisoprol medicine is not recommended if:
- Heart Failure decompensated;
- SENSITIZATION and its components;
- cardiogenic shock;
- childhood;
- atrioventricular block II and III level;
- sick sinus syndrome;
- During heavy asthma and other obstructive airway disease;
- metabolic acidosis;
- severe sinoatrial blockade;
- psoriasis;
- lactation pregnancy.
Side effects
When treating Bisoprolom may develop undesirable symptoms that affect the nervous, cardiovascular, urinary, respiratory, hepatobiliary, endocrine and other systems. Also marked disturbances of vision and hearing, the digestive tract and so on.
Furthermore, there may be common disorders, for example: asthenia , Increased fatigue .
Tablets Bisoprol, instructions for use (method and dosage)
Abstract According to the drug, which is recommended to take the tablets in the morning, as a whole, with water.
In the treatment of hypertension, stable angina assigned initial daily dosage of 2 mg 5-5, after therapy should not be higher than 20 mg per day.
Patients suffering from moderate or severe form of heart failure with reduced systolic function in a state of stabilization during the previous 6 weeks, appointed single initial daily dosage of 1 to 25 mg. After a week's use of the dosage amount of the drug is increased to 2, 5 mg, and at the third week to 3, 75 mg, and so on. Thus increasing the dose necessary to control parameters in heart rate, blood pressure and general condition of the patient.
In any case, drug dosage is adjusted individually. The duration of treatment depends on the course and nature of the disease. Discontinuation of therapy requires a gradual reduction of the dose.
Special conditions
Caution should be exercised in treating patients suffering from:
- diabetes Accompanied by sharp fluctuations in the level of glucose in the blood, taking into account the possible hidden symptoms hypoglycemia;
Prinzmetal angina; - iperifericheskogo circulatory disorders.
Also, control of the state are on a strict diet, desensitizing therapy and first degree atrioventricular block. Therefore prior to treatment should be a study of respiratory function in patients with asthma.
When planning a surgery with general anesthesia, the anesthesiologist should be warned about the use of β-adrenergic blockers. Admission β-adrenoceptor blockers during surgery is contraindicated, as this often increases the risk of Arrhythmia or myocardial ischemia .
Therefore, the dose is gradually reduced and then for 2 days to obtain a general anesthesia stop taking the drug.
This drug contains lactose, for this reason it should not be taken with rare hereditary galactose intolerance, lactase deficiency, glucose-galactose syndrome malabsorption.
Overdose
In cases of overdose can occur: bradycardia, heart failure, hypotension, bronchospasm or hypoglycaemia.
Of treatment include: the abolition of the drug, gastric lavage, reception Activated Carbon , Other, symptomatic therapy.
For example, when bradycardia It recommended the introduction of atropine intravenously.
Hypotension Admission requires a vasoconstrictor or intravenous administration of glucagon. In heart failure will improve the intravenous diuretics .
Atrioventricular block II and III degree It needs infuzionnom ortsiprenalina or Pacing and so on.
Cooperation
The hypotensive effect of the drug potentiate the calcium channel blockers.
Simultaneous use of β-blockers may mask the symptoms of receptors hypoglycemia. Combination therapy with verapamil, diltiazem, methyldopa, clonidine, moksinidinom, reserpine can cause the development or worsening of bradycardia, heart failure, atrioventricular block and reduction in blood pressure.
Using Bisoprola and antiarrhythmic agents, such as: phenytoin, disopyramide, lidocaine, flecainide, amiodarone It leads to disruption of the conduction and negative inotropic effect.
Combination with parasympathomimetics increases the atrioventricular conduction and increase the risk of symptoms of bradycardia, and β-blockers may increase the effect of this drug.
When using a insulin and other anti-diabetic drugs increase the risk of symptoms of hypoglycemia, means for anesthesia increases the risk of myocardial ischemia and arrhythmias.
The attenuation of the hypotensive effect Bisoprolol observed in the treatment with non-steroidal anti-inflammatory agents.
Simultaneous treatment with β-sympathomimetics - dobutamine, orciprenaline , Reduces the effectiveness of all drugs.
Barbiturates, tricyclic antidepressants, phenothiazines MAO inhibitors may increase the hypotensive effect of Bisoprola.
Terms of sale
Prescription medications
Storage conditions
To store the drugs should be dry, dark place, protected from the children, with temperatures up to 25 ° C.
Shelf life
2, the tablet 2, and 3 mg of 5 years for the tablets of 5 and 10 mg.
Analogs Bisoprola
Nebivolol
Biprol
Concor Cor
Lokren
Concor
Niperten
Betaloc ZOK
Betalok
Coronal
Egilok
Nebilet
Atenolol
Metoprolol
Synonyms and analogues presented Bisoprola drugs: Bisokard, Concor, Biprolol, bisoprolol-ratiopharm, Bisostad, Bidop, Bikard and Bisoprofar.
Price ranges analogs 46-200 rubles, depending on the amount of active substance in tablets and packaging.
Is it better or Bisoprol Concor?
Besides Concor in modern pharmacology and there are other synonyms of the drug. However, it is Concor - The original drug and all other drugs are analogues.
It should be noted that it is administered from the same, from which tablets Bisoprol, that is for diseases related to the cardiovascular system. The effectiveness of each of the drug depends on the degree of violation and patient.
Alcohol
In the treatment with this drug should refrain from drinking alcohol.
Reviews Bisoprole
In general reviews about Bisoprole related to the discussion of withdrawal of treatment.
Often there are stories that treatment with this drug can be administered for a long time, but other doctors cancel it. Therefore, in patients with the syndrome occurs Bisoprola, accompanied by increased heart rate, hypertension, seizures, and so on.
Some patients do not know exactly from what medicine and how much it needs to be taken. For this reason, it should only assign a specialist, a prescription for Latin and more therapeutic scheme. The objective is to comply with all patient appointments, and in the event of changes in health status, immediately inform your doctor.
Price Bisoprola where to buy
Price Bisoprola 5 mg per 20 pieces on average 17, 55 UAH.
Price Bisoprola 10 mg 20 pieces varies within 30-45 UAH.
Buy this medicine can be in pharmacies in Ukraine.
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